Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosis of synapses in a mouse model of depression

CONCLUSIONS: The study suggests that the C1q/C3-CR3 complement signaling pathway, which mediates abnormal microglial phagocytosis of synapses, presents a novel potential therapeutic target for depression treatment.PMID:38642614 | DOI:10.1016/j.bbi.2024.04.018

Source: Brain, Behavior, and Immunity - April 20, 2024 Category: Neurology Authors: Qiu-Qin Han Shi-Yu Shen Ling-Feng Liang Xiao-Rong Chen Jin Yu Source Type: research