Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00410-5. doi: 10.1016/j.bbi.2023.12.028. Online ahead of print.ABSTRACTPost-operative cognitive dysfunction (POCD) is an abrupt decline in neurocognitive function arising shortly after surgery and persisting for weeks to months, increasing the risk of dementia diagnosis. Advanced age, obesity, and comorbidities linked to high-fat diet (HFD) consumption such as diabetes and hypertension have been identified as risk factors for POCD, although underlying mechanisms remain unclear. We have previously shown that surgery alone, or 3-days of HFD can each evoke sufficient neuroinflammat...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Stephanie M Muscat Michael J Butler Menaz N Bettes James DeMarsh Emmanuel A Scaria Nicholas P Deems Ruth M Barrientos Source Type: research
Challenges with embedding an integrated sex and gender perspective into pain research: Recommendations and opportunities
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00409-9. doi: 10.1016/j.bbi.2023.12.027. Online ahead of print.ABSTRACTThe focus of this article, within this BBI horizons special issue, is on sex, gender, and pain. We summarise what is currently known about sex- and gender-related variations in pain, exploring intersectional biological and psychosocial mechanisms, and highlight gaps in knowledge and understanding. Five key challenges with the exploration of sex and gender in pain research are presented, relating to: conceptual imprecision, research bias, limitations with binary descriptions, integrating sex and gender, and ti...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Edmund Keogh Katelynn E Boerner Source Type: research
Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00410-5. doi: 10.1016/j.bbi.2023.12.028. Online ahead of print.ABSTRACTPost-operative cognitive dysfunction (POCD) is an abrupt decline in neurocognitive function arising shortly after surgery and persisting for weeks to months, increasing the risk of dementia diagnosis. Advanced age, obesity, and comorbidities linked to high-fat diet (HFD) consumption such as diabetes and hypertension have been identified as risk factors for POCD, although underlying mechanisms remain unclear. We have previously shown that surgery alone, or 3-days of HFD can each evoke sufficient neuroinflammat...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Stephanie M Muscat Michael J Butler Menaz N Bettes James DeMarsh Emmanuel A Scaria Nicholas P Deems Ruth M Barrientos Source Type: research
Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion
Brain Behav Immun. 2023 Dec 22:S0889-1591(23)00407-5. doi: 10.1016/j.bbi.2023.12.025. Online ahead of print.ABSTRACTMicroglia, the resident immune cells of the central nervous system (CNS), play a major role in damage progression and tissue remodeling after acute CNS injury, including ischemic stroke (IS) and spinal cord injury (SCI). Understanding the molecular mechanisms regulating microglial responses to injury may thus reveal novel therapeutic targets to promote CNS repair. Here, we investigated the role of microglial tumor necrosis factor receptor 2 (TNFR2), a transmembrane receptor previously associated with pro-surv...
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Stefano Raffaele Estrid Thougaard Cathrine C H Laursen Han Gao Katrine M Andersen Pernille V Nielsen Natalia Ort í-Casañ Morten Blichfeldt-Eckhardt Simon Koch Milani Deb-Chatterji Tim Magnus Jane Stubbe Kirsten Madsen Morten Meyer Matilda Degn Ulrich L Source Type: research
An immunological puzzle: The adaptive immune system fuels Alzheimer's disease pathology
Brain Behav Immun. 2023 Dec 22:S0889-1591(23)00408-7. doi: 10.1016/j.bbi.2023.12.026. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by a concerning rise in prevalence. It is projected that the number of affected individuals will reach a staggering 150 million by 2050. While recent advancements in monoclonal antibodies targeting Aβ have shown some clinical effects, there is an urgent need for improved therapies to effectively address the impeding surge of AD patients worldwide. To achieve this, a deeper understanding of the intricate mechanisms underlying t...
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Lien Van Hoecke Jonas Castelein Junhua Xie Lore Van Acker Griet Van Imschoot Elien Van Wonterghem Ine Vlaeminck Daan Verhaege Wouter Claeys Keimpe Wierda Zsuzsanna Callaerts-Vegh Roosmarijn E Vandenbroucke Source Type: research
RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation
CONCLUSIONS: These findings indicate that RAGE in inflammatory cells is necessary to mediate stimuli of latent chronic inflammation that cause brain inflammation and cognitive decline, potentially by orchestrating monocyte activation via regulation of PSGL-1 expression. Our results also suggest esRAGE-mediated inflammatory regulation as a potential therapeutic option for cognitive dysfunction in MetS with latent chronic inflammation.PMID:38142917 | DOI:10.1016/j.bbi.2023.12.022 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Dasen Ye Akio Miyoshi Tomoe Ushitani Manabu Kadoya Masataka Igeta Kosuke Konishi Takuhito Shoji Koubun Yasuda Shiho Kitaoka Hideshi Yagi Etsushi Kuroda Yasuhiko Yamamoto Jidong Cheng Hidenori Koyama Source Type: research
Maternal selenium dietary supplementation alters sociability and reinforcement learning deficits induced by in utero exposure to maternal immune activation in mice
This study demonstrates that while Se may be beneficial in ameliorating sociability deficits caused by MIA, it may have negative effects in other behavioural domains. Caution in the use of Se supplementation during pregnancy is therefore warranted.PMID:38142918 | DOI:10.1016/j.bbi.2023.12.024 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Brendan Gillespie Michael J Houghton Katherine Ganio Christopher A McDevitt Daniel Bennett Ariel Dunn Sharvada Raju Anna Schroeder Rachel A Hill Barbara R Cardoso Source Type: research
Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease
In conclusion, high-fibre intake was effective in enhancing gastrointestinal function, cognition and affective behaviors in HD mice. These findings indicate that dietary fibre interventions may have therapeutic potential in Huntington's disease to delay clinical onset, and have implications for related disorders exhibiting dysfunction of the gut-brain axis.PMID:38142919 | DOI:10.1016/j.bbi.2023.12.023 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Carolina Gubert Geraldine Kong Callum Costello Cameron D Adams Bethany A Masson Wendy Qin Jocelyn Choo Vinod K Narayana Geraint Rogers Thibault Renoir John B Furness Anthony J Hannan Source Type: research
Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review
CONCLUSION: Results from several studies are consistent with the hypothesis that signals often classified as "proinflammatory" are elevated in threshold pediatric psychotic disorders. Data are less clear for immune markers in subthreshold psychosis and redox markers across the subthreshold and threshold psychosis spectrum. Immune and redox biomarker intervention studies are lacking, and research investigating interventions targeting the immune system in threshold pediatric psychosis is especially warranted.PMID:38141839 | DOI:10.1016/j.bbi.2023.12.019 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 23, 2023 Category: Neurology Authors: Jerome Henry Taylor Julieta Bermudez-Gomez Marina Zhou Oscar Gomez Casey Ganz-Leary Cesar Palacios Zeeshan M Huque Ran Barzilay David R Goldsmith Raquel E Gur Source Type: research
Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner
Brain Behav Immun. 2023 Dec 21:S0889-1591(23)00402-6. doi: 10.1016/j.bbi.2023.12.020. Online ahead of print.ABSTRACTNeuroinflammation and microglial iron load are significant hallmarks found in several neurodegenerative diseases. In in vitro systems, microglia preferentially upregulate the iron importer, divalent metal transporter 1 (DMT1, gene name Slc11a2) in response to inflammatory stimuli, and it has been shown that iron can augment cellular inflammation, suggesting a feed-forward loop between mechanisms involved in iron import and inflammatory signaling. However, it is not understood how microglial iron import mechan...
Source: Brain, Behavior, and Immunity - December 23, 2023 Category: Neurology Authors: Katrina Volk Robertson Michael W Schleh Fiona E Harrison Alyssa H Hasty Source Type: research
Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review
CONCLUSION: Results from several studies are consistent with the hypothesis that signals often classified as "proinflammatory" are elevated in threshold pediatric psychotic disorders. Data are less clear for immune markers in subthreshold psychosis and redox markers across the subthreshold and threshold psychosis spectrum. Immune and redox biomarker intervention studies are lacking, and research investigating interventions targeting the immune system in threshold pediatric psychosis is especially warranted.PMID:38141839 | DOI:10.1016/j.bbi.2023.12.019 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 23, 2023 Category: Neurology Authors: Jerome Henry Taylor Julieta Bermudez-Gomez Marina Zhou Oscar Gomez Casey Ganz-Leary Cesar Palacios Zeeshan M Huque Ran Barzilay David R Goldsmith Raquel E Gur Source Type: research
Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner
Brain Behav Immun. 2023 Dec 21:S0889-1591(23)00402-6. doi: 10.1016/j.bbi.2023.12.020. Online ahead of print.ABSTRACTNeuroinflammation and microglial iron load are significant hallmarks found in several neurodegenerative diseases. In in vitro systems, microglia preferentially upregulate the iron importer, divalent metal transporter 1 (DMT1, gene name Slc11a2) in response to inflammatory stimuli, and it has been shown that iron can augment cellular inflammation, suggesting a feed-forward loop between mechanisms involved in iron import and inflammatory signaling. However, it is not understood how microglial iron import mechan...
Source: Brain, Behavior, and Immunity - December 23, 2023 Category: Neurology Authors: Katrina Volk Robertson Michael W Schleh Fiona E Harrison Alyssa H Hasty Source Type: research
Role of stress in skin diseases: A neuroendocrine-immune interaction view
Brain Behav Immun. 2023 Dec 19:S0889-1591(23)00376-8. doi: 10.1016/j.bbi.2023.12.005. Online ahead of print.ABSTRACTPsychological stress is a crucial factor in the development of many skin diseases, and the stigma caused by skin disorders may further increase the psychological burden, forming a vicious cycle of psychological stress leading to skin diseases. Therefore, understanding the relationship between stress and skin diseases is necessary. The skin, as the vital interface with the external environment, possesses its own complex immune system, and the neuroendocrine system plays a central role in the stress response of...
Source: Brain, Behavior, and Immunity - December 21, 2023 Category: Neurology Authors: Hanyi Zhang Mi Wang Xue Zhao Yujie Wang Xiang Chen Juan Su Source Type: research
Role of stress in skin diseases: A neuroendocrine-immune interaction view
Brain Behav Immun. 2023 Dec 19:S0889-1591(23)00376-8. doi: 10.1016/j.bbi.2023.12.005. Online ahead of print.ABSTRACTPsychological stress is a crucial factor in the development of many skin diseases, and the stigma caused by skin disorders may further increase the psychological burden, forming a vicious cycle of psychological stress leading to skin diseases. Therefore, understanding the relationship between stress and skin diseases is necessary. The skin, as the vital interface with the external environment, possesses its own complex immune system, and the neuroendocrine system plays a central role in the stress response of...
Source: Brain, Behavior, and Immunity - December 21, 2023 Category: Neurology Authors: Hanyi Zhang Mi Wang Xue Zhao Yujie Wang Xiang Chen Juan Su Source Type: research
Role of stress in skin diseases: A neuroendocrine-immune interaction view
Brain Behav Immun. 2023 Dec 19:S0889-1591(23)00376-8. doi: 10.1016/j.bbi.2023.12.005. Online ahead of print.ABSTRACTPsychological stress is a crucial factor in the development of many skin diseases, and the stigma caused by skin disorders may further increase the psychological burden, forming a vicious cycle of psychological stress leading to skin diseases. Therefore, understanding the relationship between stress and skin diseases is necessary. The skin, as the vital interface with the external environment, possesses its own complex immune system, and the neuroendocrine system plays a central role in the stress response of...
Source: Brain, Behavior, and Immunity - December 21, 2023 Category: Neurology Authors: Hanyi Zhang Mi Wang Xue Zhao Yujie Wang Xiang Chen Juan Su Source Type: research
