Letter to the editor
Brain Behav Immun. 2024 Mar 28:S0889-1591(24)00306-4. doi: 10.1016/j.bbi.2024.03.026. Online ahead of print.NO ABSTRACTPMID:38555002 | DOI:10.1016/j.bbi.2024.03.026 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 30, 2024 Category: Neurology Authors: Rainer H Straub Source Type: research
Food insecurity, inflammation, and immune function among older US adults: Findings from the health and Retirement study
CONCLUSION: In this nationally representative sample of older adults, FI was positively associated with multiple markers of systemic inflammation and impaired immune functioning. Public health efforts that directly work to reduce FI among older adults are warranted and may result in further improvements in their health and well-being.PMID:38552920 | DOI:10.1016/j.bbi.2024.03.034 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Abeer A Aljahdali Elizabeth Ludwig-Borycz Cindy W Leung Source Type: research
Immune gene expression and epigenetic potential affects the consumption of risky food by female house sparrows
Brain Behav Immun. 2024 Mar 27:S0889-1591(24)00314-3. doi: 10.1016/j.bbi.2024.03.033. Online ahead of print.ABSTRACTWhen organisms move into new areas, they are likely to encounter novel food resources. Even if they are nutritious, these foods can also be risky, as they might be contaminated by parasites. The behavioural immune system of animals could help them avoid the negative effects of contaminated resources, but our understanding of behavioural immunity is limited, particularly whether and how behavioural immunity interacts with physiological immunity. Here, we asked about the potential for interplay between these tw...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Cedric Zimmer Haley E Hanson Marisa Garrison Darrys Reese Roi Dor J ørgen S Søraker Phuong Ho Thu Elizabeth L Sheldon Lynn B Martin Source Type: research
Resolving neuroinflammatory and social deficits in ASD model mice: Dexmedetomidine downregulates NF- κB/IL-6 pathway via α2AR
This study provides the first evidence of the beneficial effects of dexmedetomidine on core symptoms of ASD and offers a theoretical basis and potential therapeutic approach for the clinical treatment of ASD.PMID:38552922 | DOI:10.1016/j.bbi.2024.03.040 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Zheng-Kai Liang Wei Xiong Chen Wang Li Chen Xin Zou Jing-Wen Mai Bo Dong Chongqi Guo Wen-Jun Xin De-Xing Luo Ting Xu Xia Feng Source Type: research
Pyroptosis-mediator GSDMD promotes parkinson's disease pathology via microglial activation and dopaminergic neuronal death
Brain Behav Immun. 2024 Mar 27:S0889-1591(24)00319-2. doi: 10.1016/j.bbi.2024.03.038. Online ahead of print.ABSTRACTGSDMD-mediated pyroptosis occurs in the nigrostriatal pathway in Parkinson's disease animals, yet the role of GSDMD in neuroinflammation and death of dopaminergic neurons in Parkinson's disease remains elusive. Here, our in vivo and in vitro studies demonstrated that GSDMD, as a pyroptosis executor, contributed to glial reaction and death of dopaminergic neurons across different Parkinson's disease models. The ablation of the Gsdmd attenuated Parkinson's disease damage by reducing dopaminergic neuronal death,...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Xiaoshuang Zhang Yunhe Zhang Boya Wang Chuantong Xie Jinghui Wang Rong Fang Hongtian Dong Guangchun Fan Mengze Wang Yongtao He Chenye Shen Yufei Duan Jiayin Zhao Zhaolin Liu Qing Li Yuanyuan Ma Mei Yu Jian Wang Jian Fei Lei Xiao Fang Huang Source Type: research
Instability of excitatory synapses in experimental autoimmune encephalomyelitis and the outcome for excitatory circuit inputs to individual cortical neurons
Brain Behav Immun. 2024 Mar 27:S0889-1591(24)00320-9. doi: 10.1016/j.bbi.2024.03.039. Online ahead of print.ABSTRACTSynapses are lost on a massive scale in the brain and spinal cord of people living with multiple sclerosis (PwMS), and this synaptic loss extends far beyond demyelinating lesions. Post-mortem studies show the long-term consequences of multiple sclerosis (MS) on synapses but do not inform on the early impacts of neuroinflammation on synapses that subsequently lead to synapse loss. How excitatory circuit inputs are altered across the dendritic tree of individual neurons under neuroinflammatory stress is not wel...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Rebecca L Gillani Eseza N Kironde Sara Whiteman Theodore J Zwang Brian J Bacskai Source Type: research
CSMD1 regulates brain complement activity and circuit development
Brain Behav Immun. 2024 Mar 27:S0889-1591(24)00322-2. doi: 10.1016/j.bbi.2024.03.041. Online ahead of print.ABSTRACTComplement proteins facilitate synaptic elimination during neurodevelopmental pruning, but neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 (CSMD1) can regulate complement activity in vitro, is expressed in the brain, and is associated with increased schizophrenia risk. Beyond this, little is known about CSMD1 including whether it regulates complement activity in the brain or otherwise plays a role in neurodevelopment. We used biochemical, immunohistochemical, and proteomi...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Matthew L Baum Daniel K Wilton Rachel G Fox Alanna Carey Yu-Han H Hsu Ruilong Hu Henna J J äntti Jaclyn B Fahey Allie K Muthukumar Nikkita Salla William Crotty Nicole Scott-Hewitt Elizabeth Bien David A Sabatini Toby B Lanser Arnaud Frouin Frederick Gerg Source Type: research
Microglial sex differences in innate high anxiety and modulatory effects of minocycline
We report striking sex differences, especially in the major microglia clusters of HABs, indicating a higher expression of genes associated with phagocytosis and synaptic engulfment in the female compared to the male. On a functional level, we show that female HAB microglia engulf a greater amount of hippocampal vGLUT1+ excitatory synapses compared to the male. We moreover showed that female HAB microglia engulf more synaptosomes compared to the male HAB in vitro. Due to previously reported effects of minocycline on microglia, we finally administered oral minocycline to HABs of both sexes and showed a significant reduction ...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Bilge Ugursu Anupam Sah Simone Sartori Oliver Popp Philip Mertins Ildiko R Dunay Helmut Kettenmann Nicolas Singewald Susanne A Wolf Source Type: research
Food insecurity, inflammation, and immune function among older US adults: Findings from the health and Retirement study
CONCLUSION: In this nationally representative sample of older adults, FI was positively associated with multiple markers of systemic inflammation and impaired immune functioning. Public health efforts that directly work to reduce FI among older adults are warranted and may result in further improvements in their health and well-being.PMID:38552920 | DOI:10.1016/j.bbi.2024.03.034 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Abeer A Aljahdali Elizabeth Ludwig-Borycz Cindy W Leung Source Type: research
Immune gene expression and epigenetic potential affects the consumption of risky food by female house sparrows
Brain Behav Immun. 2024 Mar 27:S0889-1591(24)00314-3. doi: 10.1016/j.bbi.2024.03.033. Online ahead of print.ABSTRACTWhen organisms move into new areas, they are likely to encounter novel food resources. Even if they are nutritious, these foods can also be risky, as they might be contaminated by parasites. The behavioural immune system of animals could help them avoid the negative effects of contaminated resources, but our understanding of behavioural immunity is limited, particularly whether and how behavioural immunity interacts with physiological immunity. Here, we asked about the potential for interplay between these tw...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Cedric Zimmer Haley E Hanson Marisa Garrison Darrys Reese Roi Dor J ørgen S Søraker Phuong Ho Thu Elizabeth L Sheldon Lynn B Martin Source Type: research
Resolving neuroinflammatory and social deficits in ASD model mice: Dexmedetomidine downregulates NF- κB/IL-6 pathway via α2AR
This study provides the first evidence of the beneficial effects of dexmedetomidine on core symptoms of ASD and offers a theoretical basis and potential therapeutic approach for the clinical treatment of ASD.PMID:38552922 | DOI:10.1016/j.bbi.2024.03.040 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Zheng-Kai Liang Wei Xiong Chen Wang Li Chen Xin Zou Jing-Wen Mai Bo Dong Chongqi Guo Wen-Jun Xin De-Xing Luo Ting Xu Xia Feng Source Type: research
Pyroptosis-mediator GSDMD promotes parkinson's disease pathology via microglial activation and dopaminergic neuronal death
Brain Behav Immun. 2024 Mar 27:S0889-1591(24)00319-2. doi: 10.1016/j.bbi.2024.03.038. Online ahead of print.ABSTRACTGSDMD-mediated pyroptosis occurs in the nigrostriatal pathway in Parkinson's disease animals, yet the role of GSDMD in neuroinflammation and death of dopaminergic neurons in Parkinson's disease remains elusive. Here, our in vivo and in vitro studies demonstrated that GSDMD, as a pyroptosis executor, contributed to glial reaction and death of dopaminergic neurons across different Parkinson's disease models. The ablation of the Gsdmd attenuated Parkinson's disease damage by reducing dopaminergic neuronal death,...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Xiaoshuang Zhang Yunhe Zhang Boya Wang Chuantong Xie Jinghui Wang Rong Fang Hongtian Dong Guangchun Fan Mengze Wang Yongtao He Chenye Shen Yufei Duan Jiayin Zhao Zhaolin Liu Qing Li Yuanyuan Ma Mei Yu Jian Wang Jian Fei Lei Xiao Fang Huang Source Type: research
Instability of excitatory synapses in experimental autoimmune encephalomyelitis and the outcome for excitatory circuit inputs to individual cortical neurons
Brain Behav Immun. 2024 Mar 27:S0889-1591(24)00320-9. doi: 10.1016/j.bbi.2024.03.039. Online ahead of print.ABSTRACTSynapses are lost on a massive scale in the brain and spinal cord of people living with multiple sclerosis (PwMS), and this synaptic loss extends far beyond demyelinating lesions. Post-mortem studies show the long-term consequences of multiple sclerosis (MS) on synapses but do not inform on the early impacts of neuroinflammation on synapses that subsequently lead to synapse loss. How excitatory circuit inputs are altered across the dendritic tree of individual neurons under neuroinflammatory stress is not wel...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Rebecca L Gillani Eseza N Kironde Sara Whiteman Theodore J Zwang Brian J Bacskai Source Type: research
CSMD1 regulates brain complement activity and circuit development
Brain Behav Immun. 2024 Mar 27:S0889-1591(24)00322-2. doi: 10.1016/j.bbi.2024.03.041. Online ahead of print.ABSTRACTComplement proteins facilitate synaptic elimination during neurodevelopmental pruning, but neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 (CSMD1) can regulate complement activity in vitro, is expressed in the brain, and is associated with increased schizophrenia risk. Beyond this, little is known about CSMD1 including whether it regulates complement activity in the brain or otherwise plays a role in neurodevelopment. We used biochemical, immunohistochemical, and proteomi...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Matthew L Baum Daniel K Wilton Rachel G Fox Alanna Carey Yu-Han H Hsu Ruilong Hu Henna J J äntti Jaclyn B Fahey Allie K Muthukumar Nikkita Salla William Crotty Nicole Scott-Hewitt Elizabeth Bien David A Sabatini Toby B Lanser Arnaud Frouin Frederick Gerg Source Type: research
Microglial sex differences in innate high anxiety and modulatory effects of minocycline
We report striking sex differences, especially in the major microglia clusters of HABs, indicating a higher expression of genes associated with phagocytosis and synaptic engulfment in the female compared to the male. On a functional level, we show that female HAB microglia engulf a greater amount of hippocampal vGLUT1+ excitatory synapses compared to the male. We moreover showed that female HAB microglia engulf more synaptosomes compared to the male HAB in vitro. Due to previously reported effects of minocycline on microglia, we finally administered oral minocycline to HABs of both sexes and showed a significant reduction ...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Bilge Ugursu Anupam Sah Simone Sartori Oliver Popp Philip Mertins Ildiko R Dunay Helmut Kettenmann Nicolas Singewald Susanne A Wolf Source Type: research
