Author Reply - Letter to the Editor "Regulatory T-cell phenotypes in prenatal psychological distress"
Brain Behav Immun. 2024 Mar 7:S0889-1591(24)00288-5. doi: 10.1016/j.bbi.2024.03.008. Online ahead of print.NO ABSTRACTPMID:38460803 | DOI:10.1016/j.bbi.2024.03.008 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 9, 2024 Category: Neurology Authors: Kyle S Wiley Dayoon Kwon Delaney A Knorr Molly M Fox Source Type: research
ATP-P2X7 signaling mediates brain pathology while contributing to viral control in perinatal Zika virus infection
Brain Behav Immun. 2024 Mar 7:S0889-1591(24)00278-2. doi: 10.1016/j.bbi.2024.02.035. Online ahead of print.ABSTRACTZika virus (ZIKV), the causative agent of Zika fever, is a flavivirus transmitted by mosquitoes of the Aedes genus. Zika virus infection has become an international concern due to its association with severe neurological complications such as fetal microcephaly. Viral infection can induce the release of ATP in the extracellular environment, activating receptors sensitized by extracellular nucleotides, such as the P2X7 receptor. This receptor is the primary purinergic receptor involved in neuroinflammation, neu...
Source: Brain, Behavior, and Immunity - March 9, 2024 Category: Neurology Authors: Ra íssa Leite-Aguiar Fabiana Cristina-Rodrigues Roberta Ciarlini-Magalh ães Danillo Pereira Dantas Vin ícius Santos Alves Daniel Gavino-Leopoldino R ômulo Leão Silva Neris Felipe Schmitz Josiane Silva Silveira Eleonora Kurtenbach Angela T S Wyse Juli Source Type: research
The choroid plexus: A biomarker for schizophrenia?
Brain Behav Immun. 2024 Mar 7:S0889-1591(24)00286-1. doi: 10.1016/j.bbi.2024.03.006. Online ahead of print.NO ABSTRACTPMID:38460805 | DOI:10.1016/j.bbi.2024.03.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 9, 2024 Category: Neurology Authors: Maree J Webster Source Type: research
Letter regarding "Regulatory T-cell phenotypes in prenatal psychological distress"
Brain Behav Immun. 2024 Mar 7:S0889-1591(24)00287-3. doi: 10.1016/j.bbi.2024.03.007. Online ahead of print.NO ABSTRACTPMID:38460802 | DOI:10.1016/j.bbi.2024.03.007 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 9, 2024 Category: Neurology Authors: Yan Ren Xingbo Song Minjin Wang Source Type: research
Author Reply - Letter to the Editor "Regulatory T-cell phenotypes in prenatal psychological distress"
Brain Behav Immun. 2024 Mar 7:S0889-1591(24)00288-5. doi: 10.1016/j.bbi.2024.03.008. Online ahead of print.NO ABSTRACTPMID:38460803 | DOI:10.1016/j.bbi.2024.03.008 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 9, 2024 Category: Neurology Authors: Kyle S Wiley Dayoon Kwon Delaney A Knorr Molly M Fox Source Type: research
ATP-P2X7 signaling mediates brain pathology while contributing to viral control in perinatal Zika virus infection
Brain Behav Immun. 2024 Mar 7:S0889-1591(24)00278-2. doi: 10.1016/j.bbi.2024.02.035. Online ahead of print.ABSTRACTZika virus (ZIKV), the causative agent of Zika fever, is a flavivirus transmitted by mosquitoes of the Aedes genus. Zika virus infection has become an international concern due to its association with severe neurological complications such as fetal microcephaly. Viral infection can induce the release of ATP in the extracellular environment, activating receptors sensitized by extracellular nucleotides, such as the P2X7 receptor. This receptor is the primary purinergic receptor involved in neuroinflammation, neu...
Source: Brain, Behavior, and Immunity - March 9, 2024 Category: Neurology Authors: Ra íssa Leite-Aguiar Fabiana Cristina-Rodrigues Roberta Ciarlini-Magalh ães Danillo Pereira Dantas Vin ícius Santos Alves Daniel Gavino-Leopoldino R ômulo Leão Silva Neris Felipe Schmitz Josiane Silva Silveira Eleonora Kurtenbach Angela T S Wyse Juli Source Type: research
The choroid plexus: A biomarker for schizophrenia?
Brain Behav Immun. 2024 Mar 7:S0889-1591(24)00286-1. doi: 10.1016/j.bbi.2024.03.006. Online ahead of print.NO ABSTRACTPMID:38460805 | DOI:10.1016/j.bbi.2024.03.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 9, 2024 Category: Neurology Authors: Maree J Webster Source Type: research
Depletion of complement factor 3 delays the neuroinflammatory response to intracortical microelectrodes
In this study, we investigated the role of C3 in the IME inflammatory response by comparing the neuroinflammatory gene expression at the microelectrode implant site between C3 knockout (C3-/-) and wild-type (WT) mice. We have found that, like in WT mice, implantation of intracortical microelectrodes in C3-/- mice yields a dramatic increase in the neuroinflammatory gene expression at all post-surgery time points investigated. However, compared to WT mice, C3 depletion showed reduced expression of many neuroinflammatory genes pre-surgery and 4 weeks post-surgery. Conversely, depletion of C3 increased the expression of many n...
Source: Brain, Behavior, and Immunity - March 8, 2024 Category: Neurology Authors: Sydney S Song Lindsey N Druschel Jacob H Conard Jaime J Wang Niveda M Kasthuri E Ricky Chan Jeffrey R Capadona Source Type: research
Depletion of complement factor 3 delays the neuroinflammatory response to intracortical microelectrodes
In this study, we investigated the role of C3 in the IME inflammatory response by comparing the neuroinflammatory gene expression at the microelectrode implant site between C3 knockout (C3-/-) and wild-type (WT) mice. We have found that, like in WT mice, implantation of intracortical microelectrodes in C3-/- mice yields a dramatic increase in the neuroinflammatory gene expression at all post-surgery time points investigated. However, compared to WT mice, C3 depletion showed reduced expression of many neuroinflammatory genes pre-surgery and 4 weeks post-surgery. Conversely, depletion of C3 increased the expression of many n...
Source: Brain, Behavior, and Immunity - March 8, 2024 Category: Neurology Authors: Sydney S Song Lindsey N Druschel Jacob H Conard Jaime J Wang Niveda M Kasthuri E Ricky Chan Jeffrey R Capadona Source Type: research
Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat
Brain Behav Immun. 2024 Mar 5:S0889-1591(24)00283-6. doi: 10.1016/j.bbi.2024.03.003. Online ahead of print.ABSTRACTIn opioid use disorder (OUD) patients, a decrease in brain grey matter volume (GMV) has been reported. It is unclear whether this is the consequence of prolonged exposure to opioids or is a predisposing causal factor in OUD development. To investigate this, we conducted a structural MRI longitudinal study in NIH Heterogeneous Stock rats exposed to heroin self-administration and age-matched naïve controls housed in the same controlled environment. Structural MRI scans were acquired before (MRI1) and after (MRI...
Source: Brain, Behavior, and Immunity - March 7, 2024 Category: Neurology Authors: Nazzareno Cannella Stefano Tambalo Veronica Lunerti Giulia Scuppa Luisa de Vivo Sarah Abdulmalek Analia Kinen James Mackle Brittany Kuhn Leah C Solberg Woods Dongjun Chung Peter Kalivas Laura Soverchia Massimo Ubaldi Gary Hardiman Angelo Bifone Roberto Ci Source Type: research
Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat
Brain Behav Immun. 2024 Mar 5:S0889-1591(24)00283-6. doi: 10.1016/j.bbi.2024.03.003. Online ahead of print.ABSTRACTIn opioid use disorder (OUD) patients, a decrease in brain grey matter volume (GMV) has been reported. It is unclear whether this is the consequence of prolonged exposure to opioids or is a predisposing causal factor in OUD development. To investigate this, we conducted a structural MRI longitudinal study in NIH Heterogeneous Stock rats exposed to heroin self-administration and age-matched naïve controls housed in the same controlled environment. Structural MRI scans were acquired before (MRI1) and after (MRI...
Source: Brain, Behavior, and Immunity - March 7, 2024 Category: Neurology Authors: Nazzareno Cannella Stefano Tambalo Veronica Lunerti Giulia Scuppa Luisa de Vivo Sarah Abdulmalek Analia Kinen James Mackle Brittany Kuhn Leah C Solberg Woods Dongjun Chung Peter Kalivas Laura Soverchia Massimo Ubaldi Gary Hardiman Angelo Bifone Roberto Ci Source Type: research
Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice
Brain Behav Immun. 2024 Mar 4:S0889-1591(24)00281-2. doi: 10.1016/j.bbi.2024.03.001. Online ahead of print.ABSTRACTxCT (Slc7a11), the specific subunit of the cystine/glutamate antiporter, is present in the brain and on immune cells, where it is known to modulate behavior and inflammatory responses. In a variety of cancers -including pancreatic ductal adenocarcinoma (PDAC)-, xCT is upregulated by tumor cells to support their growth and spread. Therefore, we studied the impact of xCT deletion in pancreatic tumor cells (Panc02) and/or the host (xCT-/- mice) on tumor burden, inflammation, cachexia and mood disturbances. Deleti...
Source: Brain, Behavior, and Immunity - March 6, 2024 Category: Neurology Authors: Olaya Lara Pauline Janssen Marco Mambretti Laura De Pauw Gamze Ates Liselotte Mackens Jolien De Munck Jarne Walckiers Zhaolong Pan Pauline Beckers Elisa Espinet Hideyo Sato Mark De Ridder Daniel L Marks Kurt Barb é Joeri L Aerts Emmanuel Hermans Ilse Roo Source Type: research
Comment on "No consistent evidence for the anti-inflammatory effect of vagus nerve stimulation in humans: A systematic review and meta-analysis"
Brain Behav Immun. 2024 Mar 4:S0889-1591(24)00289-7. doi: 10.1016/j.bbi.2024.03.009. Online ahead of print.NO ABSTRACTPMID:38447885 | DOI:10.1016/j.bbi.2024.03.009 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 6, 2024 Category: Neurology Authors: Colin Reardon Source Type: research
Our understanding of microglia involvement in neuropathic pain has expanded
Brain Behav Immun. 2024 Mar 3;118:190-191. doi: 10.1016/j.bbi.2024.02.033. Online ahead of print.NO ABSTRACTPMID:38442784 | DOI:10.1016/j.bbi.2024.02.033 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 5, 2024 Category: Neurology Authors: Marina Sanz-Gonzalez Ji Zhang Source Type: research
Our understanding of microglia involvement in neuropathic pain has expanded
Brain Behav Immun. 2024 Mar 3:S0889-1591(24)00276-9. doi: 10.1016/j.bbi.2024.02.033. Online ahead of print.NO ABSTRACTPMID:38442784 | DOI:10.1016/j.bbi.2024.02.033 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 5, 2024 Category: Neurology Authors: Marina Sanz-Gonzalez Ji Zhang Source Type: research
