Association of rheumatological markers with neuronal antibodies, cerebrospinal fluid, electroencephalography, and magnetic resonance imaging findings in 224 patients with psychotic syndromes
DISCUSSION: Rheumatological screening led to suspicion of a possible or probable autoimmune psychotic syndrome in 4%. ANAs were associated with MRI pathologies. Therefore, rheumatological processes may contribute to the development of psychotic syndromes in rare cases.PMID:38599500 | DOI:10.1016/j.bbi.2024.04.001 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Dominique Endres Katharina von Zedtwitz Kathrin Nickel Kimon Runge Alexander Maier Katharina Domschke Ulrich Salzer Harald Pr üss Nils Venhoff Ludger Tebartz van Elst Source Type: research
Correspondence to Antici et al. Salivary CRP predicts treatment response to virtual reality exposure therapy for social anxiety disorder
This study highlights systemic inflammation's significance in SAD and the promise of non-invasive biomarkers like salivary CRP for managing psychological disorders. It calls for more research to understand the underlying mechanisms and validate these initial findings.PMID:38579935 | DOI:10.1016/j.bbi.2024.03.053 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Restu Dwi Ariyanto Indriyana Rachmawati Wahyu Nanda Eka Saputra Rikas Saputra Nora Yuniar Setyaputri Source Type: research
Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors
Brain Behav Immun. 2024 Apr 3:S0889-1591(24)00309-X. doi: 10.1016/j.bbi.2024.03.028. Online ahead of print.ABSTRACTDepression is a prevalent psychological condition with limited treatment options. While its etiology is multifactorial, both chronic stress and changes in microbiome composition are associated with disease pathology. Stress is known to induce microbiome dysbiosis, defined here as a change in microbial composition associated with a pathological condition. This state of dysbiosis is known to feedback on depressive symptoms. While studies have demonstrated that targeted restoration of the microbiome can alleviate...
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Courtney R Rivet-Noor Andrea R Merchak Caroline Render Naudia M Gay Rebecca M Beiter Ryan Brown Austin Keeler G Brett Moreau Sihan Li Deniz G Olgun Alexandra D Steigmeyer Rachel Ofer Tobey Mihn Huu Phan Kiranmayi Vemuri Lei Chen Keira E Mahoney Jung-Bum S Source Type: research
Correspondence to Antici et al. Salivary CRP predicts treatment response to virtual reality exposure therapy for social anxiety disorder
This study highlights systemic inflammation's significance in SAD and the promise of non-invasive biomarkers like salivary CRP for managing psychological disorders. It calls for more research to understand the underlying mechanisms and validate these initial findings.PMID:38579935 | DOI:10.1016/j.bbi.2024.03.053 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Restu Dwi Ariyanto Indriyana Rachmawati Wahyu Nanda Eka Saputra Rikas Saputra Nora Yuniar Setyaputri Source Type: research
Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors
Brain Behav Immun. 2024 Apr 3:S0889-1591(24)00309-X. doi: 10.1016/j.bbi.2024.03.028. Online ahead of print.ABSTRACTDepression is a prevalent psychological condition with limited treatment options. While its etiology is multifactorial, both chronic stress and changes in microbiome composition are associated with disease pathology. Stress is known to induce microbiome dysbiosis, defined here as a change in microbial composition associated with a pathological condition. This state of dysbiosis is known to feedback on depressive symptoms. While studies have demonstrated that targeted restoration of the microbiome can alleviate...
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Courtney R Rivet-Noor Andrea R Merchak Caroline Render Naudia M Gay Rebecca M Beiter Ryan Brown Austin Keeler G Brett Moreau Sihan Li Deniz G Olgun Alexandra D Steigmeyer Rachel Ofer Tobey Mihn Huu Phan Kiranmayi Vemuri Lei Chen Keira E Mahoney Jung-Bum S Source Type: research
Correspondence to Antici et al. Salivary CRP predicts treatment response to virtual reality exposure therapy for social anxiety disorder
This study highlights systemic inflammation's significance in SAD and the promise of non-invasive biomarkers like salivary CRP for managing psychological disorders. It calls for more research to understand the underlying mechanisms and validate these initial findings.PMID:38579935 | DOI:10.1016/j.bbi.2024.03.053 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Restu Dwi Ariyanto Indriyana Rachmawati Wahyu Nanda Eka Saputra Rikas Saputra Nora Yuniar Setyaputri Source Type: research
Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors
Brain Behav Immun. 2024 Apr 3:S0889-1591(24)00309-X. doi: 10.1016/j.bbi.2024.03.028. Online ahead of print.ABSTRACTDepression is a prevalent psychological condition with limited treatment options. While its etiology is multifactorial, both chronic stress and changes in microbiome composition are associated with disease pathology. Stress is known to induce microbiome dysbiosis, defined here as a change in microbial composition associated with a pathological condition. This state of dysbiosis is known to feedback on depressive symptoms. While studies have demonstrated that targeted restoration of the microbiome can alleviate...
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Courtney R Rivet-Noor Andrea R Merchak Caroline Render Naudia M Gay Rebecca M Beiter Ryan Brown Austin Keeler G Brett Moreau Sihan Li Deniz G Olgun Alexandra D Steigmeyer Rachel Ofer Tobey Mihn Huu Phan Kiranmayi Vemuri Lei Chen Keira E Mahoney Jung-Bum S Source Type: research
Correspondence to Antici et al. Salivary CRP predicts treatment response to virtual reality exposure therapy for social anxiety disorder
This study highlights systemic inflammation's significance in SAD and the promise of non-invasive biomarkers like salivary CRP for managing psychological disorders. It calls for more research to understand the underlying mechanisms and validate these initial findings.PMID:38579935 | DOI:10.1016/j.bbi.2024.03.053 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Restu Dwi Ariyanto Indriyana Rachmawati Wahyu Nanda Eka Saputra Rikas Saputra Nora Yuniar Setyaputri Source Type: research
Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors
Brain Behav Immun. 2024 Apr 3:S0889-1591(24)00309-X. doi: 10.1016/j.bbi.2024.03.028. Online ahead of print.ABSTRACTDepression is a prevalent psychological condition with limited treatment options. While its etiology is multifactorial, both chronic stress and changes in microbiome composition are associated with disease pathology. Stress is known to induce microbiome dysbiosis, defined here as a change in microbial composition associated with a pathological condition. This state of dysbiosis is known to feedback on depressive symptoms. While studies have demonstrated that targeted restoration of the microbiome can alleviate...
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Courtney R Rivet-Noor Andrea R Merchak Caroline Render Naudia M Gay Rebecca M Beiter Ryan Brown Austin Keeler G Brett Moreau Sihan Li Deniz G Olgun Alexandra D Steigmeyer Rachel Ofer Tobey Mihn Huu Phan Kiranmayi Vemuri Lei Chen Keira E Mahoney Jung-Bum S Source Type: research
Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation
Brain Behav Immun. 2024 Apr 2;119:154-170. doi: 10.1016/j.bbi.2024.03.051. Online ahead of print.ABSTRACTHyperglycemia-induced pathological microglial responses and subsequent neuronal damage are notable characteristics of diabetes-associated cognitive impairment (DACI). Cholesterol accumulation in the brain is a prevalent consequence of diabetes mellitus (DM), exacerbating pathological microglial responses. Regarding disordered glucose and lipid metabolism, the Sterol Regulatory Element-Binding Protein (SREBP) cleavage-activating protein (SCAP), a cholesterol sensor, exhibits increased expression and abnormal translocatio...
Source: Brain, Behavior, and Immunity - April 3, 2024 Category: Neurology Authors: Wenwen Zhu Haoqiang Zhang Tong Niu Kunyu Liu Huzaifa Fareeduddin Mohammed Farooqui Ruoyu Sun Xiu Chen Yang Yuan Shaohua Wang Source Type: research
TNFR1/p38 αMAPK signaling in Nex + supraspinal neurons regulates estrogen-dependent chronic neuropathic pain
In this study, we interrogated the intersect between supraspinal TNFR1 mediated neuronal signaling and sex specificity by selectively removing TNFR1 in Nex + neurons in adult mice (NexCreERT2::TNFR1f/f). We determined that mechanical hypersensitivity induced by chronic constriction injury (CCI) decreases over time in males, but not in females. Subsequently, we investigated two downstream pathways, p38MAPK and NF-κB, important in TNFR1 signaling and injury response. We detected p38MAPK and NF-κB activation in male cortical tissue; however, p38MAPK phosphorylation was reduced in NexCreERT2::TNFR1f/f males. We observed a si...
Source: Brain, Behavior, and Immunity - April 3, 2024 Category: Neurology Authors: Kathryn A Swanson Kayla L Nguyen Shruti Gupta Jerome Ricard John R Bethea Source Type: research
Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation
Brain Behav Immun. 2024 Apr 1:S0889-1591(24)00331-3. doi: 10.1016/j.bbi.2024.03.051. Online ahead of print.ABSTRACTHyperglycemia-induced pathological microglial responses and subsequent neuronal damage- are notable characteristics of diabetes-associated cognitive impairment (DACI). Cholesterol accumulation in the brain is a prevalent consequence of diabetes mellitus (DM), exacerbating pathological microglial responses. Regarding disordered glucose and lipid metabolism, the Sterol Regulatory Element-Binding Protein (SREBP) cleavage-activating protein (SCAP), a cholesterol sensor, exhibits increased expression and abnormal t...
Source: Brain, Behavior, and Immunity - April 3, 2024 Category: Neurology Authors: Wenwen Zhu Haoqiang Zhang Tong Niu Kunyu Liu Huzaifa Fareeduddin Mohammed Farooqui Ruoyu Sun Xiu Chen Yang Yuan Shaohua Wang Source Type: research
TNFR1/p38 αMAPK signaling in Nex + supraspinal neurons regulates estrogen-dependent chronic neuropathic pain
In this study, we interrogated the intersect between supraspinal TNFR1 mediated neuronal signaling and sex specificity by selectively removing TNFR1 in Nex + neurons in adult mice (NexCreERT2::TNFR1f/f). We determined that mechanical hypersensitivity induced by chronic constriction injury (CCI) decreases over time in males, but not in females. Subsequently, we investigated two downstream pathways, p38MAPK and NF-κB, important in TNFR1 signaling and injury response. We detected p38MAPK and NF-κB activation in male cortical tissue; however, p38MAPK phosphorylation was reduced in NexCreERT2::TNFR1f/f males. We observed a si...
Source: Brain, Behavior, and Immunity - April 3, 2024 Category: Neurology Authors: Kathryn A Swanson Kayla L Nguyen Shruti Gupta Jerome Ricard John R Bethea Source Type: research
Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation
Brain Behav Immun. 2024 Apr 1:S0889-1591(24)00331-3. doi: 10.1016/j.bbi.2024.03.051. Online ahead of print.ABSTRACTHyperglycemia-induced pathological microglial responses and subsequent neuronal damage- are notable characteristics of diabetes-associated cognitive impairment (DACI). Cholesterol accumulation in the brain is a prevalent consequence of diabetes mellitus (DM), exacerbating pathological microglial responses. Regarding disordered glucose and lipid metabolism, the Sterol Regulatory Element-Binding Protein (SREBP) cleavage-activating protein (SCAP), a cholesterol sensor, exhibits increased expression and abnormal t...
Source: Brain, Behavior, and Immunity - April 3, 2024 Category: Neurology Authors: Wenwen Zhu Haoqiang Zhang Tong Niu Kunyu Liu Huzaifa Fareeduddin Mohammed Farooqui Ruoyu Sun Xiu Chen Yang Yuan Shaohua Wang Source Type: research
TNFR1/p38 αMAPK signaling in Nex + supraspinal neurons regulates estrogen-dependent chronic neuropathic pain
In this study, we interrogated the intersect between supraspinal TNFR1 mediated neuronal signaling and sex specificity by selectively removing TNFR1 in Nex + neurons in adult mice (NexCreERT2::TNFR1f/f). We determined that mechanical hypersensitivity induced by chronic constriction injury (CCI) decreases over time in males, but not in females. Subsequently, we investigated two downstream pathways, p38MAPK and NF-κB, important in TNFR1 signaling and injury response. We detected p38MAPK and NF-κB activation in male cortical tissue; however, p38MAPK phosphorylation was reduced in NexCreERT2::TNFR1f/f males. We observed a si...
Source: Brain, Behavior, and Immunity - April 3, 2024 Category: Neurology Authors: Kathryn A Swanson Kayla L Nguyen Shruti Gupta Jerome Ricard John R Bethea Source Type: research
