Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain
In conclusion, DRG macrophages maintain OA pain, but are not required for the induction of OA pain. Myostatin is a key ligand in neuro-immune communication that drives the persistence of pain in OA through nervous tissue macrophages and represent a novel therapeutic target for the treatment of OA pain.PMID:38070625 | DOI:10.1016/j.bbi.2023.12.004 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 9, 2023 Category: Neurology Authors: Christian Mart ín Gil Ramin Raoof Sabine Versteeg Hanneke L D M Willemen Floris P J G Lafeber Simon C Mastbergen Niels Eijkelkamp Source Type: research
Clinical and pharmacological implications for a high rate of unrecognized SARS-CoV-2 infected psychiatric patients
Brain Behav Immun. 2023 Dec 7:S0889-1591(23)00383-5. doi: 10.1016/j.bbi.2023.12.012. Online ahead of print.NO ABSTRACTPMID:38070617 | DOI:10.1016/j.bbi.2023.12.012 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 9, 2023 Category: Neurology Authors: Vai Benedetta Mario Gennaro Mazza Source Type: research
No consistent evidence for the anti-inflammatory effect of vagus nerve stimulation in humans: A systematic review and meta-analysis
In conclusion, while numeric effects were reported in individual studies, the current evidence does not substantiate the claim that VNS impacts inflammatory cytokines in humans. However, it may be beneficial during acute inflammatory events. To assess its full potential, high-quality studies and technological advances are required.PMID:38070618 | DOI:10.1016/j.bbi.2023.12.008 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 9, 2023 Category: Neurology Authors: Carmen Schiweck Sonja Sausmekat Tong Zhao Leona Jacobsen Andreas Reif Sharmili Edwin Thanarajah Source Type: research
CREB: a multifaceted transcriptional regulator of neural and immune function in CNS tumors
Brain Behav Immun. 2023 Dec 7:S0889-1591(23)00375-6. doi: 10.1016/j.bbi.2023.12.002. Online ahead of print.ABSTRACTCancers of the central nervous system (CNS) are unique with respect to their tumor microenvironment. Such a status is due to immune-privilege and the cellular behaviors within a highly networked, neural-rich cellular milieu. During tumor development in the CNS, neural, immune and cancer cells establish complex cell-to-cell communication networks which mimic physiological functions, including paracrine signaling and synapse-like formations. This crosstalk regulates diverse pathological functions resembling neur...
Source: Brain, Behavior, and Immunity - December 9, 2023 Category: Neurology Authors: Marija Dinevska Samuel S Widodo Laura Cook Stanley S Stylli Robert G Ramsay Theo Mantamadiotis Source Type: research
Dissecting the impact of complement component 4A in bipolar disorder
Brain Behav Immun. 2023 Dec 7:S0889-1591(23)00377-X. doi: 10.1016/j.bbi.2023.12.006. Online ahead of print.ABSTRACTThe genetic overlap between schizophrenia (SZ) and bipolar disorder (BD) is substantial. Polygenic risk scores have been shown to dissect different symptom dimensions within and across these two disorders. Here, we focused on the most strongly associated SZ risk locus located in the extended MHC region, which is largely explained by copy numbers of the gene coding for complement component 4A (C4A). First, we utilized existing brain tissue collections (N = 1,202 samples) and observed no altered C4A expression i...
Source: Brain, Behavior, and Immunity - December 9, 2023 Category: Neurology Authors: Elin H örbeck Lina Jonsson Susmita Malwade Robert Karlsson Erik P ålsson Robert Sigstr öm Carl M Sellgren Mikael Land én Source Type: research
