Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain

In conclusion, DRG macrophages maintain OA pain, but are not required for the induction of OA pain. Myostatin is a key ligand in neuro-immune communication that drives the persistence of pain in OA through nervous tissue macrophages and represent a novel therapeutic target for the treatment of OA pain.PMID:38070625 | DOI:10.1016/j.bbi.2023.12.004

Source: Brain, Behavior, and Immunity - December 9, 2023 Category: Neurology Authors: Christian Mart ín Gil Ramin Raoof Sabine Versteeg Hanneke L D M Willemen Floris P J G Lafeber Simon C Mastbergen Niels Eijkelkamp Source Type: research