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What is DIOS?
Discussion Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor (CFTR). It is found in the epithelium of the bronchi, intestine, pancreatic duct and biliary tree. It regulates chloride, bicarbonate and water secretion. The heterozygous state helps prevent against secretory diarrhea, but the homozygous state causes thickened secretions in the hollow tubes of the lungs and digestive tract. There are multiple mutations (> 2000) which have been currently classified into classes depending on their protein production and activity. CF patients generally are l...
Source: PediatricEducation.org - December 18, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

The hunt for opioid alternatives: Researchers look to sensory blocking substances from the ocean
(Natural News) Over two million people in the U.S. have become dependent on opioid drugs, with approximately 52,000 overdose deaths in 2015. The country’s opioid crisis is leading scientists and researchers to find new ways to treat pain, and they’re making a lot of progress. A team of researchers from the University of Utah Health... (Source: NaturalNews.com)
Source: NaturalNews.com - December 17, 2017 Category: Consumer Health News Source Type: news

Denver-based DEA opioid probe of McKesson was 'hijacked,' says Washington Post-'60 Minutes' report
After years of investigation of McKesson Corp., led by a Denver-based Drug Enforcement Administration team, over the pharmaceutical giant's distribution of powerful opioid drugs in Colorado and elsewhere, DEA agents say they thought they had gathered enough evidence to warrant criminal charges, fines of more than $1 billion and blocking distribution of opioid pain pills from McKesson warehouses in Aurora and elsewhere. The DEA probe examined whether San Francisco-based McKesson (NYSE: MCK) failed… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - December 17, 2017 Category: Biotechnology Authors: Mark Harden Source Type: news

Denver-based DEA opioid probe of McKesson was 'hijacked,' says Washington Post-'60 Minutes' report
After years of investigation of McKesson Corp., led by a Denver-based Drug Enforcement Administration team, over the pharmaceutical giant's distribution of powerful opioid drugs in Colorado and elsewhere, DEA agents say they thought they had gathered enough evidence to warrant criminal charges, fines of more than $1 billion and blocking distribution of opioid pain pills from McKesson warehouses in Aurora and elsewhere. The DEA probe examined whether San Francisco-based McKesson (NYSE: MCK) failed… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - December 17, 2017 Category: Health Management Authors: Mark Harden Source Type: news

What is Dissociation & Multiple Personality Disorder?
Dissociation is a mental process, which produces a lack of connection in a person’s thoughts, memories, feelings, actions, or sense of identity. During the period of time when a person is dissociating, certain information is not associated with other information as it normally would be. For example, during a traumatic experience, a person may dissociate the memory of the place and circumstances of the trauma from his ongoing memory, resulting in a temporary mental escape from the fear and pain of the trauma and, in some cases, a memory gap surrounding the experience. Because this process can produce changes in memory...
Source: Psych Central - December 17, 2017 Category: Psychiatry Authors: John M. Grohol, Psy.D. Tags: Disorders Dissociation Dissociative General Personality Source Type: news

Medical News Today: What is prolotherapy and what is it used to treat?
Learn all about prolotherapy, an alternative form of treatment for joint and back pain. We take a look at how it works, what to expect, and its efficacy. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 17, 2017 Category: Consumer Health News Tags: Complementary Medicine / Alternative Medicine Source Type: news

Acupressure Technique Decreases Pain in Acute Musculoskeletal Injuries
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - December 17, 2017 Category: Orthopaedics Tags: CME Article Source Type: news

Joint pain? Don't blame it on the rain
Also in this edition: How media literacy can help combat conspiracy theories; lifestyle vs. drugs in Type 2 diabetes prevention; and plants can actually be sedated. (Source: CBC | Health)
Source: CBC | Health - December 16, 2017 Category: Consumer Health News Tags: News/Health Source Type: news

Suffering from heartburn? Try THESE nine ways to ensure symptoms don’t ruin your sleep
HEARTBURN symptoms include nausea and difficulty swallowing. Combat the pain while sleeping by making these changes to your diet. (Source: Daily Express - Health)
Source: Daily Express - Health - December 16, 2017 Category: Consumer Health News Source Type: news

The family that doesn't feel pain
The experience of six related Italians may help to find a new treatment for people with chronic pain. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - December 16, 2017 Category: Consumer Health News Source Type: news

The family which doesn't feel pain
The experience of six related Italians may help to find a new treatment for people with chronic pain. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - December 16, 2017 Category: Consumer Health News Source Type: news

Italian family are unable to feel pain
Researchers from the University College London found the family's inability to feel pain lets certain relatives tolerate dangerously high temperatures and eat copious amounts of chillies. (Source: the Mail online | Health)
Source: the Mail online | Health - December 15, 2017 Category: Consumer Health News Source Type: news

Tips for Flying with a Baby
Katie Parker, CPNPFrom the desk of Katie Parker, CPNP   Over 93 million people travel over the winter holiday season.  Below are travel safety tips from the American Academy of Pediatrics (AAP) to help keep your family safe while traveling!Tips for flying with a baby:*Babies tend to sleep more reliably at nighttime than they do during naptime travel after the first few weeks of life.  If you and your baby can sleep on the plane, a late-night flight may be the right way to go!*It is recommended that babies have their 2 month vaccinations prior to flying.Purchasing airline tickets:*Turbulence is the ...
Source: Pediatric Health Associates - December 15, 2017 Category: Pediatrics Tags: Safety Vaccination Information Source Type: news

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Katie Parker, CPNPFrom the desk of Katie Parker, CPNP   Over 93 million people travel over the winter holiday season.  Below are travel safety tips from the American Academy of Pediatrics (AAP) to help keep your family safe while traveling!Tips for flying with a baby:*Babies tend to sleep more reliably at nighttime than they do during naptime travel after the first few weeks of life.  If you and your baby can sleep on the plane, a late-night flight may be the right way to go!*It is recommended that babies have their 2 month vaccinations prior to flying.Purchasing airline tickets:*Turbulence is the ...
Source: Pediatric Health Associates - December 15, 2017 Category: Pediatrics Tags: Safety Vaccination Information Source Type: news

Reading to teach and heal: More books for 8-12 year olds
The holiday season is a time to reflect, find gratitude and show kindness, especially to those who may be struggling. It’s also a great time to escape the chaos and hunker down with a good book. Why not do both? Today, there are more and more books about children and teens coping with physical and mental health issues that help young readers empathize with these characters but also relate, especially if they’re faced with a similar condition. We’ve selected five books that will not only make great gifts for the kids on your list, but also will stay with them long after those holiday decorations are put aw...
Source: Thrive, Children's Hospital Boston - December 15, 2017 Category: Pediatrics Authors: Patty Lenz Bovie Tags: Parenting autism clubfoot dyslexia eating disorder OCD Source Type: news

Egalet wins tentative FDA nod for intranasal abuse-deterrent pain-killer
Egalet (NSDQ:EGLT) said today that the FDA tentatively approved an expanded label for its Arymo extended-release pain-relief tablets. The new label includes data from a intranasal human abuse potential study and an intranasal abuse-deterrent claim. The FDA previously excluded this data from Arymo ER’s label due to exclusivity given to another company, Egalet reported. The FDA is slated to give full approval to Arymo ER’s new label when that exclusivity period ends on Oct. 2, 2018. Get the full story at our sister site, Drug Delivery Business News. The post Egalet wins tentative FDA nod for intranasal abuse...
Source: Mass Device - December 15, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Food & Drug Administration (FDA) Pain Management Pharmaceuticals Wall Street Beat egalet Source Type: news

Egalet Receives FDA Tentative Approval for Expanded Label for ARYMO(R) ER (morphine sulfate) C-II, an Extended-Release Morphine Product Formulated with Abuse-Deterrent Properties for Treatment of Chronic Pain
Intranasal abuse-deterrent claim to be added to ARYMO ER prescribing information label WAYNE, Pa., Dec. 15, 2017 -- (Healthcare Sales & Marketing Network) -- Egalet Corporation (Nasdaq: EGLT) (Egalet), a fully integrated specialty pharmaceutical compan... Biopharmaceuticals, FDA Egalet Corp, ARYMO ER, morphine (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 15, 2017 Category: Pharmaceuticals Source Type: news

Best supplements for arthritis: THIS £3 pill could reduce joint pain in osteoarthritis
ARTHRITIS affects about 10 million people in the UK, including people of all ages. Taking between 50mg and 100mg of this daily supplement could help to reduce joint pain and inflammation, it ’s been claimed. (Source: Daily Express - Health)
Source: Daily Express - Health - December 15, 2017 Category: Consumer Health News Source Type: news

Feistein Institute launches bioelectronic medicine trial for treating Lupus
Researchers at the Feinstein Institute launched a clinical trial looking to explore the efficacy of bioelectronic medicine specifically designed to manage pain associated with lupus. The study is exploring the use of a proprietary device, designed based upon previous research at the Feinstein Institute, which emits electrical pulses through a patient’s ear for five minutes a day over four days. “Lupus is a painful disease, notoriously hard to diagnose and difficult to treat – new treatment options are desperately needed. This trial will study an innovative approach to controlling symptoms of a d...
Source: Mass Device - December 14, 2017 Category: Medical Devices Authors: Fink Densford Tags: Blog The Feinstein Institute for Medical Research Source Type: news

Genetics may explain chronic post-surgery pain
Some patients experience chronic pain after surgery. New research suggests genetics likely plays a role. (Source: Health News - UPI.com)
Source: Health News - UPI.com - December 14, 2017 Category: Consumer Health News Source Type: news

More Teens Vaping, Fewer Misusing Opioids More Teens Vaping, Fewer Misusing Opioids
The latest federal data on adolescent drug use show that both vaping and marijuana are more popular than traditional cigarettes, and abuse of opioid pain relievers is down.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 14, 2017 Category: Consumer Health News Tags: Psychiatry News Source Type: news

MRI contrast agent could aid inflammation imaging
Researchers from Binghamton University in Binghamton, NY, and Temple University...Read more on AuntMinnie.comRelated Reading: PET/MR enterography offers potential in Crohn's disease MRI shows pancreatic inflammation in diabetics PET/MRI spots neuroinflammation from chronic back pain (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 14, 2017 Category: Radiology Source Type: news

Insights into Pain Relief from the Family That Can't Feel Pain
Source: HealthDay Related MedlinePlus Pages: Genes and Gene Therapy, Pain (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - December 14, 2017 Category: Consumer Health News Source Type: news

Medical News Today: Ten causes of epigastric pain
Epigastric pain is felt in the upper abdomen, below the ribcage but above the intestines. Learn about the possible causes, including GERD and indigestion. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 14, 2017 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news

FDA panel votes against recommending Intrinsic Therapeutics ’ Barricaid spinal prosthesis
An FDA advisory panel voted 5 to 8 against recommending approval for Intrinsic Therapeutics’s Barricaid prosthesis designed for partial annulus replacement in patients with herniated discs, according to a MedPage Today report. The negative recommendation came based on concerns over the safety of the device, including breakage rate and certain endplate lesions of unknown origin. The same panel voted 12 to 1 in favor of the device’s efficacy, according to the report. “There was a high rate of breakage of the device, a high rate of migration, and [there was] the unknown nature of [some endplate] lesions,&rdq...
Source: Mass Device - December 14, 2017 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Regulatory/Compliance Spinal Intrinsic Therapeutics Source Type: news

NanoVibronix inks UK UroShield distro deal with IMS Ultrasound
NanoVibronix (NSDQ:NAOV) said today it inked a deal with the U.K.’s IMS Ultrasound to make it the exclusive U.K. distributor of its UroShield device, designed to prevent catheter-acquired urinary tract infections. The UroShield device from the Elmsford, N.Y.-based company is designed to decrease pain and discomfort associated with urinary catheter use while also preventing bacterial colonization and biofilm on indwelling catheters to reduce UTIs. “CAUTI is a major health concern in the UK and around the world, leading to extended hospital stays, increased costs, as well as increased patient mortality. We a...
Source: Mass Device - December 14, 2017 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Distribution Ultrasound nanovibronix Source Type: news

Colorado biotech's knee osteoarthritis drug gets good results, stock soars
Shares in Ampio Pharmaceuticals Inc. were soaring in early Thursday trading after the Douglas County biotech reported good results from a trial of its knee osteoarthritis drug Ampion. Shares in Ampio (NYSE: AMPE) were up more than 40 percent early Thursday, rising 80 cents to $2.55. Ampio said patients in the trial experienced, on average a 53 percent decrease in pain, a 50 percent improvement in function, and a 45 percent improvement in quality of life. "We are very pleased with the positive… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - December 14, 2017 Category: Biotechnology Authors: Ben Miller Source Type: news

I ’m OK (sort of): The Unpredictability of OCD
When people ask me how I’m doing, I say that I’m doing ok. And sometimes I really am. The problem is that when you’re someone like me, someone who lives with Obsessive Compulsive Disorder (OCD), you’re basically ok until suddenly you’re not. Let me explain. OCD is unpredictable. It’s that schoolyard bully that sneaks up behind you to pull your pigtails just when you found a spot in the shade to sit and read your book peacefully. It’s the unpredictable storm, the one that you think has passed, only to be followed by scattered thunderstorms an hour later. It’s the questions of...
Source: Psych Central - December 14, 2017 Category: Psychiatry Authors: Rebecca Cushman Tags: Obsessive-Compulsive Disorder Personal Stories Psychology Students Treatment college coping obsessions. compulsions Ocd support worry Source Type: news

Medical News Today: How a gene mutation could help to treat chronic pain
Researchers suggest that a rare gene mutation that causes insensitivity to pain could be utilized to uncover new treatments for chronic pain. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 14, 2017 Category: Consumer Health News Tags: Pain / Anesthetics Source Type: news

Vaping popular among teens; opioid misuse at historic lows
NIH ’s 2017 Monitoring the Future survey shows both vaping and marijuana are more popular than traditional cigarettes or pain reliever misuse. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - December 14, 2017 Category: American Health Source Type: news

Insights Into Pain Relief From the Family That Can't Feel Pain
THURSDAY, Dec. 14, 2017 -- Six members of a family in Italy live a strangely pain-free life, and scientists want to know why. The Marsili clan " can burn themselves or experience pain-free bone fractures without feeling any pain, " explained study... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 14, 2017 Category: General Medicine Source Type: news

Medical News Today: How to treat a toothache at home
In this article, we examine a number of home remedies for relieving the pain of a toothache. We also look at when someone should see a dentist. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 14, 2017 Category: Consumer Health News Tags: Dentistry Source Type: news

The surprising early warning sign of a DEADLY heart attack
HEART attack symptoms include chest pain, shortness of breath and lightheadedness. But, the life-threatening condition could be spotted early by this surprising sign. (Source: Daily Express - Health)
Source: Daily Express - Health - December 14, 2017 Category: Consumer Health News Source Type: news

10 early signs of cancer in MEN including weight loss and bleeding
CANCER symptoms affect men more than women, but spotting them early could help survival rates. Signs of the disease include diarrhoea, weight loss and back pain. (Source: Daily Express - Health)
Source: Daily Express - Health - December 14, 2017 Category: Consumer Health News Source Type: news

Drug May Help Surgical Patients Stop Opioids Sooner
Title: Drug May Help Surgical Patients Stop Opioids SoonerCategory: Health NewsCreated: 12/13/2017 12:00:00 AMLast Editorial Review: 12/14/2017 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - December 14, 2017 Category: Anesthesiology Source Type: news

The Perioperative Surgical Home and the Acute Pain Service The Perioperative Surgical Home and the Acute Pain Service
The authors describe how a comprehensive perioperative pain service can be integrated into a Perioperative Surgical Home model, with the aim of improving outcomes and reducing costs.Anesthesia & Analgesia (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 14, 2017 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Genetics may play role in chronic pain after surgery
(American Society of Anesthesiologists) Genetics may play a role in determining whether patients experience chronic pain after surgery, suggests a study published today in the Online First edition of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA). Aside from genetic factors, the study also found patients younger than 65 years old, males and those with a prior history of chronic pain were at increased risk. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 14, 2017 Category: Biology Source Type: news

Neurobiology of sexual assault and osteopathic considerations for trauma-informed care and practice - Cuevas KM, Balbo J, Duval K, Beverly EA.
Sexual assault is a traumatic event with potentially devastating lifelong effects on physical and emotional health. Sexual assault is associated with gastrointestinal, neurologic, and reproductive symptoms, as well as obesity, diabetes, and chronic pain. W... (Source: SafetyLit)
Source: SafetyLit - December 14, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The BMJ Holiday Issue: Rain Doesn't Mean More Joint Pain; Wine Glasses Getting Bigger
In the spirit of the holidays, we've selected two light-hearted studies from The BMJ's Christmas issue. In the first, doctors'visits for joint or... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - December 14, 2017 Category: Primary Care Source Type: news

Leap forward towards gene therapy cure for haemophilia A
Scientists around the world congratulate the team that has made a major advance in finding a cure for the life-threatening blood disorderScientists believe they are on the way to finding a cure for haemophilia A, the bleeding disorder that currently requires sufferers to inject themselves every other day to avoid life-threatening complications.One dose of a gene therapy given experimentally to 13 patients by NHS doctors in the UK has allowed them all to come off treatment. These were men – most sufferers are – who would not only bleed without stopping from an injury but would bleed into their joints even in the...
Source: Guardian Unlimited Science - December 14, 2017 Category: Science Authors: Sarah Boseley Health editor Tags: Science Health & wellbeing Life and style Society Source Type: news

France nabs foreign climate science talent
(Source: ScienceNOW)
Source: ScienceNOW - December 14, 2017 Category: Science Authors: Pain, E. Tags: European News, Scientific Community, Science and Policy In Depth Source Type: news

Rain May Not Cause Achy Joints After All
Source: HealthDay Related MedlinePlus Pages: Arthritis, Back Pain, Joint Disorders (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - December 14, 2017 Category: Consumer Health News Source Type: news

Can the Weather Make Bones and Joints Ache?
A new study concludes that changes in the weather do not bring on pain. (Source: NYT Health)
Source: NYT Health - December 13, 2017 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Weather Bones Joints (Body Part) Rain Source Type: news

Featured Review: Antioxidants for preventing and reducing muscle soreness after exercise
Taking antioxidant supplements to reduce muscles soreness after exercise could have almost no effect, according to a new   Cochrane ReviewPeople engaging in intense exercise often take antioxidant supplements, such as vitamin C and/or E or antioxidant-enriched foods, before and after exercise in the anticipation that these will help reduce muscle soreness. In anew review published in the Cochrane Library, researchers   looked at the evidence from 50 studies. These all compared high-dose antioxidant supplementation with a placebo and their participants all engaged in strenuous exercise that was sufficient to cause...
Source: Cochrane News and Events - December 13, 2017 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Springfield Smoked Fish Recalls Smoked Salmon Because Of Possible Health Risk
Springfield Smoked Fish of Springfield, Ma.is recalling its 1lb. packages Prescliced Nova Salmon because they have the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea. (Source: Food and Drug Administration)
Source: Food and Drug Administration - December 13, 2017 Category: Food Science Source Type: news

Scientists Race to Regrow Lost Knee Cartilage Scientists Race to Regrow Lost Knee Cartilage
About 14 million Americans have osteoarthritis of the knees severe enough to cause pain and inflammation, according to the Arthritis Foundation, and more people are getting the condition -- also known as OA -- as they age.WebMD Health News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 13, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Assessment of Tapentadol API abuse liability with the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS) System - Vosburg SK, Severtson SG, Dart RC, Cicero TJ, Kurtz SP, Parrino MW, Green JL.
Tapentadol, a Schedule II opioid with a combination of µ-opioid activity and norepinephrine reuptake inhibition, is used for the management of moderate to severe acute and chronic pain. Its dual-mechanism of action is thought to reduce opioid-related side... (Source: SafetyLit)
Source: SafetyLit - December 13, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Genetic study defies 'one-size-fits-all' approach to prescribing Opioids for chronic pain
(Florida Atlantic University) In a novel study, researchers are assessing clinical and genetic characteristics of a large patient cohort suffering from chronic musculoskeletal pain and receiving prescription opioids. With this information, the multidisciplinary team will derive a clinical and genetic profile of prescription opioid-use disorder and use this knowledge to develop an 'addiction risk score.' Findings from this study will be key in identifying those who are at low-risk from those who are at high-risk of prescription opioid-use disorder. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 13, 2017 Category: International Medicine & Public Health Source Type: news

Disposal of unused pain medications
(Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - December 13, 2017 Category: Consumer Health News Source Type: news

Can treatment during surgery reduce postoperative opioid use?
©iStock/windslegend With the current concerns related to opioid addiction and overdose, researchers from the National Institute on Drug Abuse (NIDA) are exploring ways to reduce the use of opioids for pain relief, while still effectively managing pain. In a randomized clinical trial, 422 patients. .. (Source: NIDA News)
Source: NIDA News - December 13, 2017 Category: Addiction Source Type: news