Safety and Early Efficacy Studies of Psychedelic-Assisted Therapy for Chronic Pain in Older Adults (UG3/UH3 Clinical Trial Required)
Funding Opportunity RFA-AG-25-004 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to support a multi-center consortium that will function as a clinical trials network to collect safety and early efficacy data in defined groups of older adults with specific chronic pain conditions. This funding opportunity will use a UG3/UH3 phased innovation mechanism, and responsive applications must include a research plan describing both UG3 and UH3 phases. UG3 (1st phase) studies, lasting up to 2 years, should involve preliminary studies in healthy older adults across a broad age range to eval...
Source: NIH Funding Opportunities (Notices, PA, RFA) - April 24, 2024 Category: Research Source Type: funding
HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)
Funding Opportunity PAR-24-197 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO. This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the charac...
Source: NIH Funding Opportunities (Notices, PA, RFA) - April 17, 2024 Category: Research Source Type: funding
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-25-012 from the NIH Guide for Grants and Contracts. This funding opportunity is part of a suite of NOFOs within the NIH HEAL Initiative to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal is to encourage initial translational efforts that will support a drug discovery program and advance projects to the point where they meet the entry criteria for the Pain Therapeutics Development Program. The scope will therefore be focused on development of assays to support a distinct testing funnel, screening efforts to identify hits, and initial characteri...
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 26, 2024 Category: Research Source Type: funding
Notice of Intent to Publish HEAL KIDS (Knowledge, Innovation and Discovery Studies): Chronic Pain Program (UC2 Clinical Trial Optional)
Notice NOT-AR-24-006 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 31, 2024 Category: Research Source Type: funding
Notice of Change to Key Dates for RFA-NS-24-023: HEAL INITIATIVE: Development and validation of remote or patient wearable device derived objective biosignatures or functional assessments to monitor pain for use as endpoints in clinical trials (UG3/UH3)
Notice NOT-NS-24-029 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 4, 2023 Category: Research Source Type: funding
Notice of Change to Receipt Dates for RFA-NS-22-069: "HEAL Initiative Integrated Basic and Clinical Team-based Research in Pain (RM1 Clinical Trial Optional)"
Notice NOT-NS-23-099 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 4, 2023 Category: Research Source Type: funding
Notice of NIBIB's Participation in RFA-NS-24-023,"HEAL INITIATIVE: Development and validation of remote or patient wearable device derived objective biosignatures or functional assessments to monitor pain for use as endpoints in clinical trials (UG3/UH3)"
Notice NOT-EB-23-020 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 22, 2023 Category: Research Source Type: funding
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
Funding Opportunity RFA-NS-24-019 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-20-010: The purpose of this funding opportunity announcement (FOA) is to support preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics to treat pain. The goal of the program is to accelerate the optimization and development of promising small molecule and biologic hits/leads towards clinical trials. Applicants must have a promising hit/lead, robust biological rationale for the intended approach, and identified assays for optimization of the agent. The scope of...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 31, 2023 Category: Research Source Type: funding
Notice of NIDCR Participation in RFA-NS-23-007, "HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)"
Notice NOT-DE-24-005 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 16, 2023 Category: Research Source Type: funding
Notice of NIDCR Participation in RFA-NS-23-006, "HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed)"
Notice NOT-DE-24-004 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 16, 2023 Category: Research Source Type: funding
Feedback Sought on Cephalopod Care and Use
Cephalopods are aquatic invertebrate animals that include octopuses, squid, cuttlefish, and nautiluses. Earlier this month, we released a Request for Information (NOT-OD-23-176) seeking public input on the humane care and use of laboratory cephalopods at Assured institutions. The proposed guidance acknowledges the evidence suggesting these animals would benefit from oversight, but also that there are not yet specific care and use standards to allow them to be regulated under the Public Health Service Policy for the Humane Care and Use of Laboratory Animals (PHS Policy). Instead, the U.S. Government Principles p...
Source: NIH Extramural Nexus - September 20, 2023 Category: Research Authors: Mike Lauer Tags: blog Open Mike Animal Welfare Request For Information (RFI) rigor Source Type: funding
Notice announcing HEAL Initiative Technical Assistance Webinar: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trials and U24 Resource and Data Center)
Notice NOT-HD-23-025 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 11, 2023 Category: Research Source Type: funding
HEAL INITIATIVE: Development and validation of remote or patient wearable device derived objective biosignatures or functional assessments to monitor pain for use as endpoints in clinical trials (UG3/UH3 - Clinical Trial Optional)
Funding Opportunity RFA-NS-24-023 from the NIH Guide for Grants and Contracts. To enable the development and validation of real-world remote digital endpoints from wearable devices for monitoring pain experience and progression, response to interventions, and impact on quality of life. In the context of this RFA, endpoints will include biosignatures derived from functional and physiological assessments detected from wearable devices. These biosignatures can be used to monitor the effects of therapeutics developed for the treatment of pain. (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 1, 2023 Category: Research Source Type: funding
HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required)
Funding Opportunity RFA-HD-24-011 from the NIH Guide for Grants and Contracts. As part of the NIH's Helping to End Addiction Long-term (HEAL) Initiative, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and participating NIH Institutes and Centers invite applications to this U01 Cooperative Agreement funding opportunity to support innovative, multi-site, large-scale investigator-initiated clinical trials to advance the understanding, assessment, measurement, treatment, and prevention of acute pain in infants, children, and adolescents, including those with disabilities and/or experienc...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 18, 2023 Category: Research Source Type: funding
HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-HD-24-012 from the NIH Guide for Grants and Contracts. As part of the NIH's Helping to End Addiction Long-term (HEAL) Initiative, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and participating NIH Institutes and Centers invite applications for a single HEAL KIDS Pain Resource and Data Center (RDC) to provide the following: leadership in data collection and management, data curation, data harmonization, and the development of data standards; administrative and logistical support including oversight of NIH HEAL-related requirements; and coordination of shared ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 18, 2023 Category: Research Source Type: funding
