Association between doxycycline use and long-term functioning in patients with schizophrenia
CONCLUSIONS: In this observational study, doxycycline exposure is associated with a reduced incidence of disability pension. These data support further studies on the potential long term neuroprotective effects of doxycycline and level of functioning in schizophrenia patients.PMID:38169245 | DOI:10.1016/j.bbi.2023.12.036 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 3, 2024 Category: Neurology Authors: Lot D de Witte Thomas Munk Laursen Cheryl M Corcoran Trine Munk-Olsen Veerle Bergink Source Type: research
Levels of cytokines in the cerebrospinal fluid of patients with psychotic disorders compared to individually matched healthy controls
CONCLUSIONS: We found no evidence of increased IL-6 and IL-8 in patients with recent-onset psychotic disorders in contrary to previous findings in meta-analyses of CSF cytokines. Secondary analyses found indication of higher IL-4, decreased IL-16, and borderline increased IFN-γ in patients, neither of which have previously been reported on in CSF analyses of individuals with psychotic disorders.PMID:38160934 | DOI:10.1016/j.bbi.2023.12.035 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 31, 2023 Category: Neurology Authors: Rose Jeppesen Nis Borbye-Lorenzen Rune Haubo Bojesen Christensen Nina Vindegaard S ørensen Ole K öhler-Forsberg Kristin Skogstrand Michael Eriksen Benros Source Type: research
Levels of cytokines in the cerebrospinal fluid of patients with psychotic disorders compared to individually matched healthy controls
CONCLUSIONS: We found no evidence of increased IL-6 and IL-8 in patients with recent-onset psychotic disorders in contrary to previous findings in meta-analyses of CSF cytokines. Secondary analyses found indication of higher IL-4, decreased IL-16, and borderline increased IFN-γ in patients, neither of which have previously been reported on in CSF analyses of individuals with psychotic disorders.PMID:38160934 | DOI:10.1016/j.bbi.2023.12.035 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 31, 2023 Category: Neurology Authors: Rose Jeppesen Nis Borbye-Lorenzen Rune Haubo Bojesen Christensen Nina Vindegaard S ørensen Ole K öhler-Forsberg Kristin Skogstrand Michael Eriksen Benros Source Type: research
The MR1/MAIT cell axis in CNS diseases
Brain Behav Immun. 2023 Dec 27:S0889-1591(23)00411-7. doi: 10.1016/j.bbi.2023.12.029. Online ahead of print.ABSTRACTMucosal-associated invariant T (MAIT) cells are a subpopulation of innate-like T cells that can be found throughout the body, predominantly in mucosal sites, the lungs and in the peripheral blood. MAIT cells recognize microbial-derived vitamin B (e.g., riboflavin) metabolite antigens that are presented by the major histocompatibility complex class I-like protein, MR1, found on a variety of cell types in the periphery and the CNS. Since their original discovery, MAIT cells have been studied predominantly in th...
Source: Brain, Behavior, and Immunity - December 29, 2023 Category: Neurology Authors: Rashmi Shrinivasan Season K Wyatt-Johnson Randy R Brutkiewicz Source Type: research
Differential effects of sleep deprivation on behavior and microglia in a brain-region-specific manner in young and aged male mice
In this study, we confirmed brain region-specific changes in microglial density and morphology in the accumbens nucleus (Acb), amygdala (AMY), cerebellum (Cb), corpus callosum (cc), caudate putamen, hippocampus (HIP), hypothalamus (HYP), medial prefrontal cortex (mPFC), and thalamus (TH) of young mice. In addition, the density of microglia in old mice was higher than that in young mice. Compared with young mice, old mice showed a markedly increased microglial size, decreased total length of microglial processes, and decreased maximum length. Importantly, we found that 48-h SD decreased microglial density and morphology in ...
Source: Brain, Behavior, and Immunity - December 29, 2023 Category: Neurology Authors: Rong-Jun Ni Yi-Yan Wang Wen-Jun Pu Ying-Ying Wei Jin-Xue Wei Lian-Sheng Zhao Xiao-Hong Ma Source Type: research
Title: Though shall not pass: Blocking lymphocytes from recirculating to the gut as a potential therapeutic approach for autism
Brain Behav Immun. 2023 Dec 27:S0889-1591(23)00414-2. doi: 10.1016/j.bbi.2023.12.032. Online ahead of print.NO ABSTRACTPMID:38157947 | DOI:10.1016/j.bbi.2023.12.032 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 29, 2023 Category: Neurology Authors: Paul Ashwood Source Type: research
Role of astrocyte senescence regulated by the non- canonical autophagy in the neuroinflammation associated to cerebral malaria
CONCLUSION: our data provide evidence for a novel mechanism through which astrocytes could be involved in the neuropathophysiology of CM. p21 gene expression in blood cell and an elevated plasma CXCL-10 concentration could be valuable biomarkers of CM in humans. In the end, we believe senolytic drugs shall open up new avenues to develop newer treatment options.PMID:38157948 | DOI:10.1016/j.bbi.2023.12.030 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 29, 2023 Category: Neurology Authors: Fatima Hellani In ès Leleu Nasreddine Saidi Nathalie Martin C écile Lecoeur Elisabeth Werkmeister David Koffi Fran çois Trottein H élène Yapo-Etté Bidyut Das Corinne Abbadie Sylviane Pied Source Type: research
Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
Brain Behav Immun. 2023 Dec 25;116:303-316. doi: 10.1016/j.bbi.2023.12.034. Online ahead of print.ABSTRACTBinge drinking is rising among aged adults (>65 years of age), however the contribution of alcohol misuse to neurodegenerative disease development is not well understood. Both advanced age and repeated binge ethanol exposure increase neuroinflammation, which is an important component of neurodegeneration and cognitive dysfunction. Surprisingly, the distinct effects of binge ethanol exposure on neuroinflammation and associated degeneration in the aged brain have not been well characterized. Here, we establish a model...
Source: Brain, Behavior, and Immunity - December 27, 2023 Category: Neurology Authors: Paige E Anton Lauren N Rutt Michael L Kaufman Nicolas Busquet Elizabeth J Kovacs Rebecca L McCullough Source Type: research
Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
Brain Behav Immun. 2023 Dec 25;116:303-316. doi: 10.1016/j.bbi.2023.12.034. Online ahead of print.ABSTRACTBinge drinking is rising among aged adults (>65 years of age), however the contribution of alcohol misuse to neurodegenerative disease development is not well understood. Both advanced age and repeated binge ethanol exposure increase neuroinflammation, which is an important component of neurodegeneration and cognitive dysfunction. Surprisingly, the distinct effects of binge ethanol exposure on neuroinflammation and associated degeneration in the aged brain have not been well characterized. Here, we establish a model...
Source: Brain, Behavior, and Immunity - December 27, 2023 Category: Neurology Authors: Paige E Anton Lauren N Rutt Michael L Kaufman Nicolas Busquet Elizabeth J Kovacs Rebecca L McCullough Source Type: research
Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
Brain Behav Immun. 2023 Dec 25;116:303-316. doi: 10.1016/j.bbi.2023.12.034. Online ahead of print.ABSTRACTBinge drinking is rising among aged adults (>65 years of age), however the contribution of alcohol misuse to neurodegenerative disease development is not well understood. Both advanced age and repeated binge ethanol exposure increase neuroinflammation, which is an important component of neurodegeneration and cognitive dysfunction. Surprisingly, the distinct effects of binge ethanol exposure on neuroinflammation and associated degeneration in the aged brain have not been well characterized. Here, we establish a model...
Source: Brain, Behavior, and Immunity - December 27, 2023 Category: Neurology Authors: Paige E Anton Lauren N Rutt Michael L Kaufman Nicolas Busquet Elizabeth J Kovacs Rebecca L McCullough Source Type: research
Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
Brain Behav Immun. 2023 Dec 25;116:303-316. doi: 10.1016/j.bbi.2023.12.034. Online ahead of print.ABSTRACTBinge drinking is rising among aged adults (>65 years of age), however the contribution of alcohol misuse to neurodegenerative disease development is not well understood. Both advanced age and repeated binge ethanol exposure increase neuroinflammation, which is an important component of neurodegeneration and cognitive dysfunction. Surprisingly, the distinct effects of binge ethanol exposure on neuroinflammation and associated degeneration in the aged brain have not been well characterized. Here, we establish a model...
Source: Brain, Behavior, and Immunity - December 27, 2023 Category: Neurology Authors: Paige E Anton Lauren N Rutt Michael L Kaufman Nicolas Busquet Elizabeth J Kovacs Rebecca L McCullough Source Type: research
Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
Brain Behav Immun. 2023 Dec 25;116:303-316. doi: 10.1016/j.bbi.2023.12.034. Online ahead of print.ABSTRACTBinge drinking is rising among aged adults (>65 years of age), however the contribution of alcohol misuse to neurodegenerative disease development is not well understood. Both advanced age and repeated binge ethanol exposure increase neuroinflammation, which is an important component of neurodegeneration and cognitive dysfunction. Surprisingly, the distinct effects of binge ethanol exposure on neuroinflammation and associated degeneration in the aged brain have not been well characterized. Here, we establish a model...
Source: Brain, Behavior, and Immunity - December 27, 2023 Category: Neurology Authors: Paige E Anton Lauren N Rutt Michael L Kaufman Nicolas Busquet Elizabeth J Kovacs Rebecca L McCullough Source Type: research
Challenges with embedding an integrated sex and gender perspective into pain research: Recommendations and opportunities
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00409-9. doi: 10.1016/j.bbi.2023.12.027. Online ahead of print.ABSTRACTThe focus of this article, within this BBI horizons special issue, is on sex, gender, and pain. We summarise what is currently known about sex- and gender-related variations in pain, exploring intersectional biological and psychosocial mechanisms, and highlight gaps in knowledge and understanding. Five key challenges with the exploration of sex and gender in pain research are presented, relating to: conceptual imprecision, research bias, limitations with binary descriptions, integrating sex and gender, and ti...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Edmund Keogh Katelynn E Boerner Source Type: research
Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00410-5. doi: 10.1016/j.bbi.2023.12.028. Online ahead of print.ABSTRACTPost-operative cognitive dysfunction (POCD) is an abrupt decline in neurocognitive function arising shortly after surgery and persisting for weeks to months, increasing the risk of dementia diagnosis. Advanced age, obesity, and comorbidities linked to high-fat diet (HFD) consumption such as diabetes and hypertension have been identified as risk factors for POCD, although underlying mechanisms remain unclear. We have previously shown that surgery alone, or 3-days of HFD can each evoke sufficient neuroinflammat...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Stephanie M Muscat Michael J Butler Menaz N Bettes James DeMarsh Emmanuel A Scaria Nicholas P Deems Ruth M Barrientos Source Type: research
Challenges with embedding an integrated sex and gender perspective into pain research: Recommendations and opportunities
Brain Behav Immun. 2023 Dec 23:S0889-1591(23)00409-9. doi: 10.1016/j.bbi.2023.12.027. Online ahead of print.ABSTRACTThe focus of this article, within this BBI horizons special issue, is on sex, gender, and pain. We summarise what is currently known about sex- and gender-related variations in pain, exploring intersectional biological and psychosocial mechanisms, and highlight gaps in knowledge and understanding. Five key challenges with the exploration of sex and gender in pain research are presented, relating to: conceptual imprecision, research bias, limitations with binary descriptions, integrating sex and gender, and ti...
Source: Brain, Behavior, and Immunity - December 25, 2023 Category: Neurology Authors: Edmund Keogh Katelynn E Boerner Source Type: research
