Role of astrocyte senescence regulated by the non- canonical autophagy in the neuroinflammation associated to cerebral malaria

CONCLUSION: our data provide evidence for a novel mechanism through which astrocytes could be involved in the neuropathophysiology of CM. p21 gene expression in blood cell and an elevated plasma CXCL-10 concentration could be valuable biomarkers of CM in humans. In the end, we believe senolytic drugs shall open up new avenues to develop newer treatment options.PMID:38157948 | DOI:10.1016/j.bbi.2023.12.030

Source: Brain, Behavior, and Immunity - December 29, 2023 Category: Neurology Authors: Fatima Hellani In ès Leleu Nasreddine Saidi Nathalie Martin C écile Lecoeur Elisabeth Werkmeister David Koffi Fran çois Trottein H élène Yapo-Etté Bidyut Das Corinne Abbadie Sylviane Pied Source Type: research