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Anti-malaria drug shows promise as Zika virus treatment
(Sanford-Burnham Prebys Medical Discovery Institute) California researchers have discovered that a medication used to prevent and treat malaria may also be effective for Zika virus. The drug, called chloroquine, has a long history of safe use during pregnancy, and is relatively inexpensive. The research was published today in Scientific Reports. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 17, 2017 Category: Infectious Diseases Source Type: news

Nigeria:Why We Use Mosquito Net to Protect Plants - Farmers
[Daily Trust] Sokoto -Mosquito net is used for protection against the malarial vector's bite and killer infection in human beings but some peasant farmers in Sokoto have extended its use to also protect their plant nurseries. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - November 16, 2017 Category: Infectious Diseases Source Type: news

Nigeria:CRS Distributes 2.4 Million Free LLIN to Fight Malaria in Ondo
[Guardian] Akure -Catholic Relief Services (CRS) has declared that a total of 2,444,036 Long Lasting Insecticidal Nets (LLIN) were distributed to residents of Ondo State. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - November 16, 2017 Category: Infectious Diseases Source Type: news

Southern Africa:Southern Africa Is Slipping Again After Coming Close to Eliminating Malaria
[The Conversation Africa] In the last five years, South Africa, Botswana, Namibia and Swaziland have all been on the verge of eliminating malaria. In fact, progress had been so good that the southern African region had been tipped to be malaria free by 2018. But a spike in cases this year means that it's unlikely to meet the target. A new target has been set for 2020. The Conversation Africa's Health and Medicine editor Candice Bailey asked Professor Rajendra Maharaj to explain why. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 16, 2017 Category: African Health Source Type: news

Africa:New Breath Examination for Malaria
[East African] People with malaria exhale a distinctive "breathprint," insights scientists have used to develop a new breath test for diagnosing the killer disease in a group of African children, according to a new study published in the American Society of Tropical Medicine and Hygiene. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - November 16, 2017 Category: Infectious Diseases Source Type: news

A structural clue to attacking malaria's 'Achilles heel'
(Scripps Research Institute) New research could boost the development of a more potent vaccine against the global killer. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 16, 2017 Category: Infectious Diseases Source Type: news

New chief of Global Fund says accountability is 'imperative'
The new executive director of the Global Fund to Fight AIDS, Tuberculosis and Malaria says he is committed to ensuring the group is as transparent as possible about how billions of dollars are dispersed to fight the three killer diseases (Source: ABC News: Health)
Source: ABC News: Health - November 15, 2017 Category: Consumer Health News Tags: Health Source Type: news

New chief of Global Fund says accountability is "imperative"
The new executive director of the Global Fund to Fight AIDS, Tuberculosis and Malaria says he is committed to ensuring the group is as transparent as possible about how billions of dollars are dispersed to fight the three killer diseases (Source: ABC News: Health)
Source: ABC News: Health - November 15, 2017 Category: Consumer Health News Tags: Health Source Type: news

Malawi:Media Key in the Fight Against Malaria
[Malawi News Agency] Lilongwe -National Malaria Control Programme has viewed the media in the country as a key stakeholder in the dissemination of information to the public in the fight against malaria. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 15, 2017 Category: African Health Source Type: news

Malawi:Malaria Vaccine Trial in July 2018
[Malawi News Agency] Lilongwe -Malaria vaccine trial is expected to be conducted in the country in July, 2018 in a pilot phase. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 15, 2017 Category: African Health Source Type: news

Angola:Over 40,000 Cases of Malaria Recorded in Saurimo
[ANGOP] Saurimo -At least 43,604 cases of malaria have been recorded in the last 10 months, against the 55,243 cases in the same period of last year in the municipality of Saurimo, northeastern Lunda Sul province. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - November 15, 2017 Category: Infectious Diseases Source Type: news

Peter Sands Named Head of Global Disease-Fighting Agency
The new executive director of the Global Fund to Fight AIDS, Tuberculosis and Malaria faces an uphill battle: raising more money as lethal epidemics keep cropping up. (Source: NYT Health)
Source: NYT Health - November 14, 2017 Category: Consumer Health News Authors: DONALD G. McNEIL Jr. Tags: Appointments and Executive Changes Acquired Immune Deficiency Syndrome Tuberculosis Malaria Foreign Aid Global Fund to Fight AIDS, Tuberculosis and Malaria Standard Chartered Bank PLC Sands, Peter Alexander Source Type: news

Nigeria:Global Fund Gets Chevron's N2 Billion to Reduce HIV Infections, Boost Treatment
[Guardian] Determined to reduce estimated 220,000 new Human Immuno-deficiency Virus (HIV) infections, 160, 000 Acquired Immune Deficiency Syndrome (AIDS)-related deaths, 37,000 Mother-To-Child Transmission (MTCT) of the virus as well as improve access to treatment for people living with the disease, Chevron Nigeria Limited, (CNL), an affiliate of Chevron Corporation (Chevron), has announced the disbursement of US$5 million (N2 billion) to the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund). (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - November 14, 2017 Category: Infectious Diseases Source Type: news

Nigeria:Chevron Contributes $5 Million to HIV Fund to in Nigeria
[Vanguard] Chevron Nigeria Limited, (CNL), an affiliate of Chevron Corporation (Chevron), announced today the disbursement of US$2.5 million donated by Chevron to the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund), for the implementation of the Chevron-Global Fund Anti-Retroviral Treatment Service Maintenance Program (ART Program), in Delta, Bayelsa, Ondo and Lagos States. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 14, 2017 Category: African Health Source Type: news

Nigeria:'97 Percent of Nigerians At Risk of Malaria'
[Leadership] Sokoto -No fewer than 97 per cent of Nigerians are at the risk of having malaria, Senior Technical Adviser, on Social Mobilization to United States Agency For International Development (USAID) in Nigeria has said. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 14, 2017 Category: African Health Source Type: news

Nigeria:Expert - 5 Million People Die of Diabetes Annually
[This Day] Bauchi -Diabetes has been described as one of the most deadly diseases in the world that claims lives frequently more than other epidemics like the Human Immune Deficiency Virus (HIV), malaria, tuberculosis etc, as about five million patients in the world die of the disease annually. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 14, 2017 Category: African Health Source Type: news

Deaths and parasuicides associated with mefloquine chemoprophylaxis: a systematic review - Tickell-Painter M, Saunders R, Maayan N, Lutje V, Mateo-Urdiales A, Garner P.
BACKGROUND: Mefloquine is recommended in international health guidelines for preventing malaria in travellers. Reports of psychosis and suicide are often alluded to but are not clearly established. METHODS: We carried out a systematic review to ide... (Source: SafetyLit)
Source: SafetyLit - November 13, 2017 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Malawi:Malaria Remains a Threat to Under-Five, Pregnant Women
[Malawi News Agency] Lilongwe -National Malaria Control Programme said malaria remains the major cause of death among under-5 children and pregnant women in the country. (Source: AllAfrica News: Pregnancy and Childbirth)
Source: AllAfrica News: Pregnancy and Childbirth - November 13, 2017 Category: OBGYN Source Type: news

Weekly Postings
See something of interest? Please share our postings with colleagues in your institutions! Spotlight Funding available! The National Network of Libraries of Medicine, Middle Atlantic Region, is accepting applications for health information outreach, health literacy initiatives, emergency preparedness partnerships and health sciences library projects. Applications will be due by COB on December 1. See a recent blog post from Executive Director, Kate Flewelling for details, or review our funding opportunities and start your application today! Rural Health Week begins on Monday, November 13! Wondering how you can participate?...
Source: NN/LM Middle Atlantic Region Blog - November 10, 2017 Category: Databases & Libraries Authors: Hannah Sinemus Tags: Weekly Postings Source Type: news

Tanzania:Malaria Deaths Drop From 560 to Record 59 People in Musoma
[Citizen] Musoma -Deaths caused by malaria have dropped from 560 in 2014 to a record 59 people this year (by September) in Musoma Municipal Council, authorities say. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - November 9, 2017 Category: Infectious Diseases Source Type: news

Parasites suck it up
(Harvard Medical School) Depletion of a fatty molecule in human blood propels malaria parasites to stop replicating and causing illness in people and instead to jump ship to mosquitoes to continue the transmission cycle, according to a new study by an international research team. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 9, 2017 Category: Infectious Diseases Source Type: news

New technologies can SMELL sickness
Two groups of scientists have developed experimental technologies that can detect disease including malaria, Parkinson's and cancer using the smell of your breath. (Source: the Mail online | Health)
Source: the Mail online | Health - November 7, 2017 Category: Consumer Health News Source Type: news

Brain MRI shows long-term adverse effects of West Nile virus
MR images of people who develop neurological complications from West Nile virus...Read more on AuntMinnie.comRelated Reading: MRI finds something fishy in outbreak of brain infections French researchers describe Zika on MRI scans NEJM: MRI links brain swelling and cerebral malaria deaths FDG-PET, scintigraphy offer a break in fever of unknown origin (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 7, 2017 Category: Radiology Source Type: news

Malaria breath test shows promise
People with the disease give off a distinctive "breath-print" that could aid rapid diagnosis, say experts. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 7, 2017 Category: Consumer Health News Source Type: news

Artemis Therapeutics Receives Orphan Drug Designation From U.S. Food And Drug Administration For Artemisone For The Treatment Of Malaria
NEW YORK, Nov. 6, 2017 -- (Healthcare Sales & Marketing Network) -- Artemis Therapeutics, Inc. (OTCQB: ATMS), ("Artemis" or the "Company"), a pharmaceutical company developing new therapies for the treatment of life-threatening infecti... Biopharmaceuticals, FDA Artemis Therapeutics, Artemisone, malaria (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 6, 2017 Category: Pharmaceuticals Source Type: news

Malawi:Code Sangala Raising Funds for Queens Hospital Paediatric Unit
[Nyasa Times] Malaria Tour 2017-18 a brain child of Malawi's celebrated former Big Brother Africa representative, Code Sangala, will on November 16,2017 hold a fundraising event to raise funds for paediatric accident and emergency wards at Queen Elizabeth Central Hospital (QECH) in Blantyre. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 6, 2017 Category: African Health Source Type: news

Could this be malaria's Achilles heel?
(Instituto de Medicina Molecular) Portuguese researchers at Instituto de Medicina Molecular (iMM) Lisboa have identified a defence mechanism by which the malaria parasite can survive inside its host's liver cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 6, 2017 Category: International Medicine & Public Health Source Type: news

Age-old malaria treatment found to improve nanoparticle delivery to tumors
(Houston Methodist) A new study shows that a 70-year-old malaria drug can block immune cells in the liver so nanoparticles can arrive at their intended tumor site, overcoming a significant hurdle of targeted drug delivery. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 6, 2017 Category: Cancer & Oncology Source Type: news

At ASTMH Annual Meeting, researchers report breakthrough in malaria breathprinting that could pave way to electronic nose to ‘ smell ’ disease
(Burness) Scientists have discovered that people with malaria exhale a distinctive 'breathprint,' insights they have used to develop a new breath test which was highly successful in diagnosing malaria in a group of African children, according to a new study presented today at the American Society of Tropical Medicine and Hygiene (ASTMH) Annual Meeting. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 6, 2017 Category: Infectious Diseases Source Type: news

Nigeria:Three Malaria Research Works Clinch NLNG's $.1 Million Science Prize
[Guardian] Three research works on malaria have won the $100,000 tag for the 2017 Nigeria LNG Limited (NLNG) Prize for Science. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - November 3, 2017 Category: Infectious Diseases Source Type: news

Study refutes using anti-malaria drug to treat diabetes
(University of California - Davis) A drug used to treat malaria does not, after all, create new insulin-producing cells, according to a new paper from researchers at UC Davis. The work, published in Cell Metabolism Nov. 3, refutes a study published in Cell in January. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 3, 2017 Category: International Medicine & Public Health Source Type: news

Uganda:UK Launches New U.S.$59 Million Malaria Programme
[Independent (Kampala)] The United Kingdom Department for International Development (DFID) has today marked the launch of a new programme to tackle malaria in Uganda. Over the next five years, the UK government will invest up to sh215 billion ($59m) to tackle malaria in the country. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 2, 2017 Category: African Health Source Type: news

Nigeria:Malaria Campaign Saving Young Lives in Nigeria
[WHO] Following an 8-year conflict in north-eastern Nigeria, two-thirds of health facilities have been completely or partially destroyed leaving some 3.7 million internally displaced persons (IDPs) at risk of life-threatening diseases. In Borno State, the number of malaria cases and deaths has soared, particularly among young children. WHO recently launched a special campaign aimed at rapidly reducing the malaria burden among children under 5 years of age. Dr Pedro Alonso, Director of the WHO Global Malaria Prog (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 31, 2017 Category: African Health Source Type: news

South Africa:Health On Malaria Cases in Vhembe and Mopani Districts
[Govt of SA] High numbers of malaria cases are being reported in the malaria transmission areas (Vhembe and Mopani districts) in Limpopo (including some cases in farms along the Lephalale River, Waterberg) and in Bushbuckridge in Mpumalanga province. Compared to previous years, a modest increase in cases in the Kruger National Park and private reserves in the area has been confirmed. This follows a very busy 2017 malaria season in the entire southern African region, which peaked in April and May and extended into June. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 31, 2017 Category: African Health Source Type: news

Tanzania:Curbing Malaria - How Treated Bed Nets Solve EAC Malaria Puzzle
[Citizen] Dar es Salaam -On the beaches of Zanzibar where the waters of the Indian Ocean kiss sandy landings all day and all night, malaria is on the way out. It is almost eliminated through years of research, sensitisation and vector control via, primarily, the bed net. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - October 31, 2017 Category: Infectious Diseases Source Type: news

GHIT Fund accelerates promising efforts to find new treatments, vaccines and diagnostics
(Burness) The Global Health Innovative Technology (GHIT) Fund, a unique Japanese public-private partnership formed to battle infectious diseases around the globe, today announced US$16.7 million to support development of new compounds for fighting malaria and tuberculosis, a leishmaniasis vaccine and drug, and a treatment for a long-ignored flesh-eating infection. The new investments also will allow scientists to pursue a critically needed diagnostic tool for detecting a relapsing form of malaria when it is hiding in the liver during its dormant phase. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 31, 2017 Category: Infectious Diseases Source Type: news

Papers of note in Science 358 (6362)
This week’s articles describe how bacteria sense surfaces; the lysine acylation of host proteins mediated by a Vibrio cholerae toxin; and druggable proteases of malaria parasites. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 31, 2017 Category: Science Authors: VanHook, A. M. Tags: STKE Editors ' Choice Source Type: news

Steady Progress Toward a Malaria Vaccine Steady Progress Toward a Malaria Vaccine
Have recent advances led to the development of an effective malaria vaccine?Current Opinion in Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 30, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Cochrane review looks at the effectiveness and side effects of mefloquine
(Liverpool School of Tropical Medicine) Researchers from LSTM Cochrane Infectious Diseases Group publish two systematic reviews this week about the safety of mefloquine (Lariam) for preventing malaria in travellers. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 30, 2017 Category: Infectious Diseases Source Type: news

Malaria parasite in the Americas is more genetically diverse than previously thought
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) Researchers discover that populations of Plasmodium vivax on the continent are as genetically diverse as in Southeast Asia, where malaria transmission is more frequent. Vivax's greater genetic diversity in the Americas in comparison with Falciparum species might be explained by a wider range of migratory routes. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 27, 2017 Category: Biology Source Type: news

NIH study identifies new targets for anti-malaria drugs
The deadliest malaria parasite needs two proteins to infect red blood cells. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - October 26, 2017 Category: American Health Source Type: news

Angola:Lunda Norte Records Over 6,000 Cases of Malaria
[ANGOP] Cuango -At least 6,370 cases of malaria were diagnosed at Cuango's Medical Centre in the north-eastern Lunda Norte Province, from February to October this year. (Source: AllAfrica News: Malaria)
Source: AllAfrica News: Malaria - October 26, 2017 Category: Infectious Diseases Source Type: news

NIH study identifies new targets for anti-malaria drugs
(NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development) The deadliest malaria parasite needs two proteins to infect red blood cells and exit the cells after it multiplies, a finding that may provide researchers with potential new targets for drug development, according to researchers funded by the National Institutes of Health. Their study appears in the latest issue of Science. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 26, 2017 Category: Infectious Diseases Source Type: news

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion
Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied extensively but the functions of plasmepsins IX and X (PMIX and PMX) were unknown. Here we show that PMIX is essential for erythrocyte invasion, acting on rhoptry secretory organelle biogenesis. In contrast, PMX is essential for both egress and invasion, controlling maturation of the subtilisin-like serine protease SUB1 in exoneme secretory vesicles. We have identified compounds...
Source: ScienceNOW - October 26, 2017 Category: Science Authors: Nasamu, A. S., Glushakova, S., Russo, I., Vaupel, B., Oksman, A., Kim, A. S., Fremont, D. H., Tolia, N., Beck, J. R., Meyers, M. J., Niles, J. C., Zimmerberg, J., Goldberg, D. E. Tags: Microbiology reports Source Type: news

A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress
Regulated exocytosis by secretory organelles is important for malaria parasite invasion and egress. Many parasite effector proteins, including perforins, adhesins, and proteases, are extensively proteolytically processed both pre- and postexocytosis. Here we report the multistage antiplasmodial activity of the aspartic protease inhibitor hydroxyl-ethyl-amine–based scaffold compound 49c. This scaffold inhibits the preexocytosis processing of several secreted rhoptry and microneme proteins by targeting the corresponding maturases plasmepsins IX (PMIX) and X (PMX), respectively. Conditional excision of PMIX revealed its...
Source: ScienceNOW - October 26, 2017 Category: Science Authors: Pino, P., Caldelari, R., Mukherjee, B., Vahokoski, J., Klages, N., Maco, B., Collins, C. R., Blackman, M. J., Kursula, I., Heussler, V., Brochet, M., Soldati-Favre, D. Tags: Cell Biology, Microbiology reports Source Type: news

Kenya:Malaria Cases Still Reported in Lamu Amid Heavy Rains
[Nation] Malaria cases are still being reported in Lamu County, with expectant mothers at high risk of infection due to lack of antenatal care following the nurses' strike and the rains pounding the Coast. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 25, 2017 Category: African Health Source Type: news

Angola:CICA Announces Social Projects
[ANGOP] Luanda -The Council of Christian Churches in Angola (CICA) will implement a malaria prevention programme in the provinces of Cunene and Cuando Cubango. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 24, 2017 Category: African Health Source Type: news

Tanzania:468 Mosquito Nets Provided for Free to Control Malaria
[Citizen] Magu -A delegate from the US Malaria Initiative last week toured Sese Primary School in Magu District to witness free distribution of treated mosquito nets as part of the initiatives to prevent malaria infection. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 24, 2017 Category: African Health Source Type: news

Engineering malaria resistance in mosquitoes
Mosquitoes genetically modified to resist the parasite that causes malaria mated with wild mosquitoes and transferred the resistance to offspring in laboratory experiments. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - October 24, 2017 Category: Consumer Health News Source Type: news

Pollution Kills Three Times More Than AIDS, TB And Malaria Combined [Infographic]
According to research published in The Lancet last week, polluted air, water and soil caused nine million premature deaths across the globe in 2015. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - October 23, 2017 Category: Pharmaceuticals Authors: Niall McCarthy, Contributor Source Type: news