High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration
In conclusion, our studies demonstrate that the adverse influence of early-life HFD consumption on behavior and hippocampal structure is attributed at least in part to microglial overactivation that is accompanied by an elevated serum FFA concentration and microglial aberrations represent a potential preventive and therapeutic target for HFD-related emotional disorders.PMID:38604269 | DOI:10.1016/j.bbi.2024.04.005 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Xiuting Yao Chenxi Yang Xirui Jia Zhehao Yu Conghui Wang Jingyi Zhao Yuxi Chen Bingjie Xie Hong Zhuang Congli Sun Qian Li Xiaomin Kang Yu Xiao Lijie Liu Source Type: research
Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis
CONCLUSION: Altogether, these data unveil a crosstalk between intestinal and central inflammation in EAE and support the use of molecular MRI of intestinal MAdCAM-1 as a new biomarker for prognostic in MS patients.PMID:38604270 | DOI:10.1016/j.bbi.2024.04.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Erwan Baudron Sara Martinez de Lizarrondo Maxime Gauberti Barbara Delaunay-Piednoir Antoine P Fournier Denis Vivien Fabian Docagne Isabelle Bardou Source Type: research
High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration
In conclusion, our studies demonstrate that the adverse influence of early-life HFD consumption on behavior and hippocampal structure is attributed at least in part to microglial overaction that is accompanied by an elevated serum FFA concentration and microglial aberrations represent a potential preventive and therapeutic target for HFD-related emotional disorders.PMID:38604269 | DOI:10.1016/j.bbi.2024.04.005 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Xiuting Yao Chenxi Yang Xirui Jia Zhehao Yu Conghui Wang Jingyi Zhao Yuxi Chen Bingjie Xie Hong Zhuang Congli Sun Qian Li Xiaomin Kang Yu Xiao Lijie Liu Source Type: research
Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis
CONCLUSION: Altogether, these data unveil a crosstalk between intestinal and central inflammation in EAE and support the use of molecular MRI of intestinal MAdCAM-1 as a new biomarker for prognostic in MS patients.PMID:38604270 | DOI:10.1016/j.bbi.2024.04.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Erwan Baudron Sara Martinez de Lizarrondo Maxime Gauberti Barbara Delaunay-Piednoir Antoine P Fournier Denis Vivien Fabian Docagne Isabelle Bardou Source Type: research
Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model
Brain Behav Immun. 2024 Apr 8;119:220-235. doi: 10.1016/j.bbi.2024.04.002. Online ahead of print.ABSTRACTPostpartum depression (PPD) is a severe mental disorder that affects approximately 10---20% of women after childbirth. The precise mechanism underlying PPD pathogenesis remains elusive, thus limiting the development of therapeutics. Gut microbiota dysbiosis is considered to contribute to major depressive disorder. However, the associations between gut microbiota and PPD remain unanswered. Here, we established a mouse PPD model by sudden ovarian steroid withdrawal after hormone-simulated pseudopregnancy-human (HSP-H) in ...
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Qi Xu Lihong Sun Qing Chen Cuicui Jiao Yuan Wang Hua Li Jiaqian Xie Fangfang Zhu Jiangling Wang Wen Zhang Linghua Xie Hui Wu Zhiyi Zuo Xinzhong Chen Source Type: research
Unmasking the mental health scars of COVID-19: A longitudinal investigation of children and adolescents in post-lockdown China
This study provides valuable insights for tailoring mental health support to youths navigating the consequences of the COVID-19 pandemic.PMID:38599498 | DOI:10.1016/j.bbi.2024.04.003 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Yue Zhu Yuenan Yu Yang Wang Fay Womer Xiaoyang Qin Keyin Zhou Rongxin Zhu Wei Du Jie Yang Kuan-Pin Su Fei Wang Source Type: research
How stable are psychoneuroimmune effects over time?
Brain Behav Immun. 2024 Apr 8:S0889-1591(24)00349-0. doi: 10.1016/j.bbi.2024.04.004. Online ahead of print.NO ABSTRACTPMID:38599499 | DOI:10.1016/j.bbi.2024.04.004 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Lennart Seizer Christian Schubert Source Type: research
Association of rheumatological markers with neuronal antibodies, cerebrospinal fluid, electroencephalography, and magnetic resonance imaging findings in 224 patients with psychotic syndromes
DISCUSSION: Rheumatological screening led to suspicion of a possible or probable autoimmune psychotic syndrome in 4%. ANAs were associated with MRI pathologies. Therefore, rheumatological processes may contribute to the development of psychotic syndromes in rare cases.PMID:38599500 | DOI:10.1016/j.bbi.2024.04.001 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Dominique Endres Katharina von Zedtwitz Kathrin Nickel Kimon Runge Alexander Maier Katharina Domschke Ulrich Salzer Harald Pr üss Nils Venhoff Ludger Tebartz van Elst Source Type: research
Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model
Brain Behav Immun. 2024 Apr 8:S0889-1591(24)00347-7. doi: 10.1016/j.bbi.2024.04.002. Online ahead of print.ABSTRACTPostpartum depression (PPD) is a severe mental disorder that affects approximately 10---20% of women after childbirth. The precise mechanism underlying PPD pathogenesis remains elusive, thus limiting the development of therapeutics. Gut microbiota dysbiosis is considered to contribute to major depressive disorder. However, the associations between gut microbiota and PPD remain unanswered. Here, we established a mouse PPD model by sudden ovarian steroid withdrawal after hormone-simulated pseudopregnancy-human (...
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Qi Xu Lihong Sun Qing Chen Cuicui Jiao Yuan Wang Hua Li Jiaqian Xie Fangfang Zhu Jiangling Wang Wen Zhang Linghua Xie Hui Wu Zhiyi Zuo Xinzhong Chen Source Type: research
Unmasking the mental health scars of COVID-19: A longitudinal investigation of children and adolescents in post-lockdown China
This study provides valuable insights for tailoring mental health support to youths navigating the consequences of the COVID-19 pandemic.PMID:38599498 | DOI:10.1016/j.bbi.2024.04.003 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Yue Zhu Yuenan Yu Yang Wang Fay Womer Xiaoyang Qin Keyin Zhou Rongxin Zhu Wei Du Jie Yang Kuan-Pin Su Fei Wang Source Type: research
How stable are psychoneuroimmune effects over time?
Brain Behav Immun. 2024 Apr 8:S0889-1591(24)00349-0. doi: 10.1016/j.bbi.2024.04.004. Online ahead of print.NO ABSTRACTPMID:38599499 | DOI:10.1016/j.bbi.2024.04.004 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Lennart Seizer Christian Schubert Source Type: research
Association of rheumatological markers with neuronal antibodies, cerebrospinal fluid, electroencephalography, and magnetic resonance imaging findings in 224 patients with psychotic syndromes
DISCUSSION: Rheumatological screening led to suspicion of a possible or probable autoimmune psychotic syndrome in 4%. ANAs were associated with MRI pathologies. Therefore, rheumatological processes may contribute to the development of psychotic syndromes in rare cases.PMID:38599500 | DOI:10.1016/j.bbi.2024.04.001 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Dominique Endres Katharina von Zedtwitz Kathrin Nickel Kimon Runge Alexander Maier Katharina Domschke Ulrich Salzer Harald Pr üss Nils Venhoff Ludger Tebartz van Elst Source Type: research
Correspondence to Antici et al. Salivary CRP predicts treatment response to virtual reality exposure therapy for social anxiety disorder
This study highlights systemic inflammation's significance in SAD and the promise of non-invasive biomarkers like salivary CRP for managing psychological disorders. It calls for more research to understand the underlying mechanisms and validate these initial findings.PMID:38579935 | DOI:10.1016/j.bbi.2024.03.053 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Restu Dwi Ariyanto Indriyana Rachmawati Wahyu Nanda Eka Saputra Rikas Saputra Nora Yuniar Setyaputri Source Type: research
Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors
Brain Behav Immun. 2024 Apr 3:S0889-1591(24)00309-X. doi: 10.1016/j.bbi.2024.03.028. Online ahead of print.ABSTRACTDepression is a prevalent psychological condition with limited treatment options. While its etiology is multifactorial, both chronic stress and changes in microbiome composition are associated with disease pathology. Stress is known to induce microbiome dysbiosis, defined here as a change in microbial composition associated with a pathological condition. This state of dysbiosis is known to feedback on depressive symptoms. While studies have demonstrated that targeted restoration of the microbiome can alleviate...
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Courtney R Rivet-Noor Andrea R Merchak Caroline Render Naudia M Gay Rebecca M Beiter Ryan Brown Austin Keeler G Brett Moreau Sihan Li Deniz G Olgun Alexandra D Steigmeyer Rachel Ofer Tobey Mihn Huu Phan Kiranmayi Vemuri Lei Chen Keira E Mahoney Jung-Bum S Source Type: research
Correspondence to Antici et al. Salivary CRP predicts treatment response to virtual reality exposure therapy for social anxiety disorder
This study highlights systemic inflammation's significance in SAD and the promise of non-invasive biomarkers like salivary CRP for managing psychological disorders. It calls for more research to understand the underlying mechanisms and validate these initial findings.PMID:38579935 | DOI:10.1016/j.bbi.2024.03.053 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 5, 2024 Category: Neurology Authors: Restu Dwi Ariyanto Indriyana Rachmawati Wahyu Nanda Eka Saputra Rikas Saputra Nora Yuniar Setyaputri Source Type: research
