High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration

In conclusion, our studies demonstrate that the adverse influence of early-life HFD consumption on behavior and hippocampal structure is attributed at least in part to microglial overaction that is accompanied by an elevated serum FFA concentration and microglial aberrations represent a potential preventive and therapeutic target for HFD-related emotional disorders.PMID:38604269 | DOI:10.1016/j.bbi.2024.04.005

Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Xiuting Yao Chenxi Yang Xirui Jia Zhehao Yu Conghui Wang Jingyi Zhao Yuxi Chen Bingjie Xie Hong Zhuang Congli Sun Qian Li Xiaomin Kang Yu Xiao Lijie Liu Source Type: research