Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway

CONCLUSIONS: This study demonstrated that downregulation of MENA promoted tamoxifen resistance in the HR+ breast cancer tissues and cells by enhancing the AKT signaling pathway. Therefore, MENA is a promising prediction biomarker for determining tamoxifen sensitivity in patients with HR+ breast cancer.PMID:38459605 | DOI:10.1186/s13062-024-00464-3

Source: Cancer Control - March 8, 2024 Category: Cancer & Oncology Authors: Lifang He Chuanghong She Sen Jiang Zhaochang Qi Zihao Deng Likeng Ji Yukun Cui Jundong Wu Source Type: research