Vitamin D inhibits tamoxifen-induced non-alcoholic fatty liver disease through a nonclassical estrogen receptor/liver X receptor pathway
This study investigated the effects and mechanisms of TAM-induced steatosis in the liver. The effects and mechanisms of TAM on hepatocyte lipid metabolism were assessed using C57BL/6 female mice and human hepatoma cells. TAM promoted fat accumulation in the liver by upregulation of Srebp-1c expression. Regarding the molecular mechanism, TAM promoted the recruitment of the auxiliary transcriptional activator, p300, and dissociated the auxiliary transcriptional repressor, nuclear receptor corepressor (NCOR), of the complexes, which led to enhancement of Srebp-1c transcription and an increase of triglyceride (TG) synthesis. V...
Source: Chemico-Biological Interactions - January 8, 2024 Category: Molecular Biology Authors: Maoxuan Wu Jie Wang Wanqing Zhou Mengting Wang Chunyan Hu Ming Zhou Kailin Jiao Zhong Li Source Type: research
Risk factors for male breast cancer
Am J Transl Res. 2023 Dec 15;15(12):6918-6925. eCollection 2023.ABSTRACTMale breast cancer (MBC) presents problems with identification of high-risk groups. Risk factors include hepatic dysfunction, high ambient working temperature, exposure to exhaust fumes and obesity, but none identify a group with a high absolute number of MBC cases. The two significant cohorts are BRCA2 mutation carriers and individuals with Klinefelter's syndrome (KS), responsible for up to 15% of cases. Since >90% of male tumours are ER+ve, endocrine intervention is logical with the likely agent being tamoxifen. In terms of an acceptable endocrine...
Source: American Journal of Translational Research - January 8, 2024 Category: Research Authors: Ian S Fentiman Source Type: research
Prognostic factors and benefit populations of ovarian function suppression in premenopausal HR+/HER2+ early ‐stage breast cancer patients who received trastuzumab: Evidence from a real‐world study with long‐term follow‐up
ConclusionsFor premenopausal HR+ breast cancer patients, HER2 positivity alone is an indication for the addition of OFS in adjuvant endocrine therapy. Age, histological grade, lymph node status, the expression of PR, and OFS treatment were independent prognostic factors in this population. (Source: Thoracic Cancer)
Source: Thoracic Cancer - January 8, 2024 Category: Cancer & Oncology Authors: Jie Ju,
Song ‐Lin Gao,
Jia‐Yu Wang,
Die Sang,
Yi‐Kun Kang,
Xue Wang,
Jian Yue,
You Shuai,
Yi‐Xin Qi,
Peng Yuan Tags: ORIGINAL ARTICLE Source Type: research
GSE224543 Identification of genes enriched in Nkx2-1-positive neurons in the Arc, VMH, and DMH of adult mice
Contributors : Kyohei Tokizane ; Cynthia S Brace ; Shin-ichiro ImaiSeries Type : Expression profiling by arrayOrganism : Mus musculusWe aimed to identify genes enriched in Nkx2-1-positive neurons in the dorsomedial hypothalamus (DMH). Using Nkx2-1-CreERT2 mice crossed with Rosa-ZsGreen mice after tamoxifen induction, we collected ZsGreen-marked Nkx2-1-positive neurons from the DMH, ventromedial hypothalamic nucleus (VMH), and arcuate nucleus (Arc) by laser microdissection and compared their gene expression profiles. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Targeting aromatase to restrain oestrogen production and developing efficacious interventions against ER-positive cancer
Eur J Med Chem. 2023 Dec 31;265:116111. doi: 10.1016/j.ejmech.2023.116111. Online ahead of print.ABSTRACTBeing the most frequently diagnosed disease, breast cancer is mainly classified as ER+ cancers due to the detection of estrogen receptor (ER) expression. Irrespetive of the successes achieved in the treatment of ER+ cancers by the use of selective estrogen receptor modulator (SERM) drugs like tamoxifen, resistance to the drug is a major clinical obstacle. Working on alternative treatment approaches, here, on the basis of mode of action of aromatase for the conversion of androstenedione to oestrogen, a series of compound...
Source: European Journal of Medicinal Chemistry - January 7, 2024 Category: Chemistry Authors: Sudesh Rani Sheetal Vermani Varinder Kaur Palwinder Singh Source Type: research
Targeting aromatase to restrain oestrogen production and developing efficacious interventions against ER-positive cancer
Eur J Med Chem. 2023 Dec 31;265:116111. doi: 10.1016/j.ejmech.2023.116111. Online ahead of print.ABSTRACTBeing the most frequently diagnosed disease, breast cancer is mainly classified as ER+ cancers due to the detection of estrogen receptor (ER) expression. Irrespetive of the successes achieved in the treatment of ER+ cancers by the use of selective estrogen receptor modulator (SERM) drugs like tamoxifen, resistance to the drug is a major clinical obstacle. Working on alternative treatment approaches, here, on the basis of mode of action of aromatase for the conversion of androstenedione to oestrogen, a series of compound...
Source: European Journal of Medicinal Chemistry - January 7, 2024 Category: Chemistry Authors: Sudesh Rani Sheetal Vermani Varinder Kaur Palwinder Singh Source Type: research
USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis
In conclusion, this study highlights the critical role of the USP46/PTBP1/PKM2 axis in TAM resistance in BC. Targeted therapy against USP46 may represent a promising strategy to improve the prognosis of TAM-resistant patients.PMID:38176460 | DOI:10.1016/j.bbadis.2023.167011 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - January 4, 2024 Category: Biochemistry Authors: Shun Gao Yuan Wang Yingkun Xu Li Liu Shengchun Liu Source Type: research
USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis
In conclusion, this study highlights the critical role of the USP46/PTBP1/PKM2 axis in TAM resistance in BC. Targeted therapy against USP46 may represent a promising strategy to improve the prognosis of TAM-resistant patients.PMID:38176460 | DOI:10.1016/j.bbadis.2023.167011 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - January 4, 2024 Category: Biochemistry Authors: Shun Gao Yuan Wang Yingkun Xu Li Liu Shengchun Liu Source Type: research
A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: Evaluation of dermal safety, intra-mammary drug distribution, and biologic effects
Biomed Pharmacother. 2024 Jan 2;171:116105. doi: 10.1016/j.biopha.2023.116105. Online ahead of print.ABSTRACTBreast cancer prevention only requires local exposure of the breast to active drug. However, oral preventive agents entail systemic exposure, causing adverse effects that limit acceptance by high-risk women. Drug-delivery through the breast skin is an attractive option, but requires demonstration of dermal safety and drug distribution throughout the breast. We formulated the tamoxifen metabolite (E/Z)-endoxifen for transdermal delivery and tested it in a placebo-controlled, double-blinded Phase I trial with dose esc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 3, 2024 Category: Drugs & Pharmacology Authors: Oukseub Lee Latifa A Bazzi Yanfei Xu Erik Pearson Minhua Wang Omid Hosseini Azza M Akasha Jennifer Nam Choi Scott Karlan Melissa Pilewskie Masha Kocherginsky Kelly Benante Thomas Helland Gunnar Mellgren Eileen Dimond Marjorie Perloff Brandy M Heckman-Stod Source Type: research
Chemoprevention —Historical Perspectives and Current Trends
AbstractPurpose of ReviewTo explore the landmark clinical trials which shaped contemporary chemoprevention practice, discuss trends in chemoprevention uptake, and highlight the obstacles faced along the way.Recent FindingsPoor chemoprevention uptake has been attributed to numerous factors, most notably fear of side effects and lack of physician recommendation. A lower dose of tamoxifen taken for a shorter period has been shown to be an effective alternative and harbors fewer side effects than the standard regimen for chemoprevention.SummaryDespite new regimens with more favorable side effect profiles and shorter treatment ...
Source: Current Breast Cancer Reports - January 3, 2024 Category: Cancer & Oncology Source Type: research
Male Breast Cancer: a Review on Diagnosis, Treatment, and Survivorship
AbstractPurpose of ReviewMale breast cancer is a relatively uncommon and rare disease that is often managed based on evidence adopted from trials pertaining to female breast cancer due to low accrual rates or exclusion of males. This is despite the known differences in the biology and epidemiology of this condition. This review provides an update regarding the management and surveillance of male breast cancer.Recent FindingsMen with breast cancer tend to undergo more extensive surgery in the breast and axilla. The outcomes of male breast cancer compared to a similar subtype of female breast cancer appear worse when matched...
Source: Current Oncology Reports - January 2, 2024 Category: Cancer & Oncology Source Type: research
GSE192842 RNAseq in Sirt1 wild-type or deleted mouse T-ALLs
Contributors : Olga Lancho ; Amartya Singh ; Hossein Khiabanian ; Daniel HerranzSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusC57BL6 mice harboring Sirt1 conditional knockout NOTCH1-HDDPEST-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of Sirt1. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
493 Effects of chemotherapy agents on placental cells: implications for treating breast cancer during pregnancy
To examine anti-proliferative and cytotoxic effects of three breast cancer chemotherapeutics (5-fluorouracil (5-FU), doxorubicin (DXR), and cyclophosphamide (CP)) on human placental cell lines JAR and JEG-3. Tamoxifen (TAM) a hormone therapy contraindicated in pregnancy was also examined. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Nathan A. Keller, Xiangying Xue, Christine Metz Source Type: research
GSE239777 MeDIP-seq profiles of mouse ApcDHep hepatocytes at day 6 vs wt hepatocytes
Contributors : Ang élique Gougelet ; Sabine ColnotSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusWe analyzed the level of DNA methylation by MeDIPseq in hepatocytes isolated by collagenase perfusion from Apclox/loxlivers, six days after injection of 2mg tamoxifen vs wt hepatocytes. Our aims was to study the impact of the beta-catenin on DNA methylation during the early steps of liver tumorigenesis (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research
GSE221439 Expression data from T47D/S2 (control) and T47D/TR-2 (tamoxifen-resistant) cell lines
Contributors : Sewon Hwang ; Mi-Ock LeeSeries Type : Expression profiling by arrayOrganism : Homo sapiensBasal expression profiling was performed to understand molecualr pathways specifically altered in tamoxifen-resistant cells.Tamoxifen is the most accepted targeted agent for treating patients with estrogen receptor (ER)-positive breast cancer (BC), but its efficacy has been limited due to drug resistance, manifested as disease recurrence and eventually death. Metabolic reprogramming of lipids has recently been recognized as a new mode of therapeutic resistance in various cancers. Therefore, we investigated previously ...
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
