The Growing Role of Digital Health Tools in the Care of Patients with Cancer: Current Use, Future Opportunities, and Barriers to Effective Implementation
This article aims to describe the ways in which digital health technologies are currently being used to improve the delivery of cancer care, highlight opportunities to expand their use, and discuss barriers to effective and equitable implementation.Recent FindingsThe utilization of digital health tools and development of novel care delivery models that leverage such tools is expanding. Recent studies have shown feasibility and increased implementation in the setting of oncologic care.SummaryWith technological advances and key policy changes, utilization of digital health tools has greatly increased over the past two decade...
Source: Current Oncology Reports - April 23, 2024 Category: Cancer & Oncology Source Type: research
Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape
AbstractPurpose of ReviewOur review delves into the progress across urological malignancies and discusses ongoing challenges and future directions in antibody –drug conjugate (ADC) development, emphasising their transformative potential in cancer care.Recent FindingsADCs have advanced from hematologic to solid tumours, notably in breast cancer, and are now pivotal in metastatic urological cancers as both monotherapies and in combination regimens, underscored by the FDA ’s approval of enfortumab vedotin and sacituzumab govitecan for metastatic urothelial cancer. Progress in metastatic prostate cancer, particularly with ...
Source: Current Oncology Reports - April 23, 2024 Category: Cancer & Oncology Source Type: research
Navigating Breast Cancer Oligometastasis and Oligoprogression: Current Landscape and Future Directions
ConclusionWhile there is interest in applying local therapies to OM and OP breast cancer, the current randomized data does not back the routine use of surgery or SBRT, particularly when considering the potential for treatment-related toxicities. Future research should refine patient selection through advanced imaging and possibly explore these therapies specifically in patients with hormone receptor-positive or HER2-positive disease. (Source: Current Oncology Reports)
Source: Current Oncology Reports - April 23, 2024 Category: Cancer & Oncology Source Type: research
Update on Percutaneous Ablation for Sarcoma
AbstractPurpose of ReviewTo provide an update on the current state of percutaneous thermal ablation in the treatment of sarcoma.Recent FindingsData continue to accrue in support of ablation for local control and palliation of specific sarcoma subtypes such as extra-abdominal desmoid fibromatosis and for broader indications such as the treatment of oligometastatic disease. The synergistic possibilities of various combination therapies such as cryoablation and immunotherapy represent intriguing areas of active investigation. Histotripsy is an emerging non-invasive, non-thermal ablative modality that may further expand the th...
Source: Current Oncology Reports - April 22, 2024 Category: Cancer & Oncology Source Type: research
Current Status of Partial Laryngeal Surgery for Advanced Laryngeal Cancer: When and Why?
AbstractPurpose of ReviewThis paper aims to evaluate the evolution and current status of partial laryngeal surgery in the treatment of advanced laryngeal cancer (LC). Specifically, recent progress in the selection of both patients and tumors, together with surgical and rehabilitation innovations, have contributed to balancing oncological control with the maintenance of quality of life in na ïve and radiorecurrent patients. The main aspect is represented by the recognized role of open partial horizontal laryngectomies (OPHLs) in this new era of laryngeal cancer treatment.Recent FindingsRecent advancements highlight OPHLs ...
Source: Current Oncology Reports - April 22, 2024 Category: Cancer & Oncology Source Type: research
Changing the Perspective on Fertility Preservation for Women with Metastatic or Advanced Stage Cancer
We describe five key misconceptions surrounding fertility preservation in patients with advanced stage cancer, offering a review of the literature and our approach to challenging topics like desiring fertility preservation in the face of Stage 4 disease, the safety and timing of ovarian stimulation during cancer treatment, and passing away following fertility preservation. We review the importance of assessing perceptions of fertility preservation in patients with metastatic cancer and highlight the lack of research in this area as a call to action. (Source: Current Oncology Reports)
Source: Current Oncology Reports - April 19, 2024 Category: Cancer & Oncology Source Type: research
Ablation of Kidney Tumors in Patients with Substantial Kidney Impairment: Current Status
AbstractPurpose of reviewTo review the current status of kidney tumor ablation in patients with substantial kidney impairment.Recent findingsFew reports of kidney tumor ablation in such patients have recently been published. The reported prevalence of patients with stage 4 or 5 chronic kidney disease (CKD) among patients undergoing ablation is 2.0% –10%. In patients with stage 4 or 5 CKD, local tumor control rates were 88%–100%. The effect of ablation on CKD stage is unclear, and the observed deteriorations in kidney function are consistent with both the effect of cryoablation and the natural course of advanced CKD.Sum...
Source: Current Oncology Reports - April 16, 2024 Category: Cancer & Oncology Source Type: research
Management of Oligometastatic and Locally Recurrent Urothelial Carcinoma
AbstractPurpose of ReviewTo summarize and evaluate the literature on treatment approaches for oligometastatic and locally recurrent urothelial cancer.Recent FindingsThere is no clear definition for oligometastatic urothelial cancers due to limited data. Studies focusing on oligometastatic and locally recurrent urothelial cancer have been primarily retrospective. Treatment options include local therapy with surgery or radiation, and generalized systemic therapy such as chemotherapy or immunotherapy.SummaryOligometastatic and locally recurrent urothelial cancers remain challenging to manage, and treatment requires an interdi...
Source: Current Oncology Reports - April 11, 2024 Category: Cancer & Oncology Source Type: research
Advances in Radionuclide Therapies for Patients with Neuro-endocrine Tumors
AbstractPurpose of ReviewTo provide insights into the role of peptide receptor radionuclide therapy (PRRT) in patients with advanced neuroendocrine tumors (NET) and an overview of possible strategies to combine PRRT with locoregional and systemic anticancer treatments.Recent FindingsResearch on combining PRRT with other treatments encompasses a wide variety or treatments, both local (transarterial radioembolization) and systemic therapies, chemotherapy (i.e., capecitabine and temozolomide), targeted therapies (i.e., olaparib, everolimus, and sunitinib), and immunotherapies (e.g., nivolumab and pembrolizumab). Furthermore, ...
Source: Current Oncology Reports - April 10, 2024 Category: Cancer & Oncology Source Type: research
Current Systemic Therapy in Men with Metastatic Castration-Sensitive Prostate Cancer
AbstractPurpose of ReviewThis review aims to explore the evolving landscape of treatments available for metastatic castration-sensitive prostate cancer (mCSPC) patients.Recent FindingsIn less than a decade, evidence was chronologically provided that (1) systemic treatment intensification with docetaxel improves outcomes, including survival, in men with mCSPC, (2) then that these outcomes are also improved when a second-generation androgen receptor pathway inhibitor (ARPI) is combined with androgen deprivation therapy (ADT), and (3) using a “triplet systemic therapy,” which consists in the combination of ADT, an ARPI an...
Source: Current Oncology Reports - April 9, 2024 Category: Cancer & Oncology Source Type: research
Immune Checkpoint Inhibitors in Geriatric Oncology
AbstractPurpose of ReviewThis manuscript will update prior reviews of immune checkpoint inhibitors (ICIs) in light of basic science, translational, and clinical discoveries in the field of cancer immunology and aging.Recent FindingsICIs have led to significant advancements in the treatment of cancer. Landmark trials of ICIs have cited the efficacy and toxicity experienced by older patients, but most trials are not specifically designed to address outcomes in older patients. Underlying mechanisms of aging, like cellular senescence, affect the immune system and may ultimately alter the host ’s response to ICIs. Validated t...
Source: Current Oncology Reports - April 8, 2024 Category: Cancer & Oncology Source Type: research
Patient Navigation in Cancer Treatment: A Systematic Review
AbstractPurpose of ReviewPatient navigation promotes access to timely treatment of chronic diseases by eliminating barriers to care. Patient navigation programs have been well-established in improving screening rates and diagnostic resolution. This systematic review aimed to characterize the multifaceted role of patient navigators within the realm of cancer treatment.Recent FindingsA comprehensive electronic literature review of PubMed and Embase databases was conducted to identify relevant studies investigating the role of patient navigators in cancer treatment from August 1, 2009 to March 27, 2023.SummaryFifty-nine artic...
Source: Current Oncology Reports - April 6, 2024 Category: Cancer & Oncology Source Type: research
Radionuclide Theranostics in Neuroendocrine Neoplasms: An Update
AbstractPurpose of ReviewThis paper aims to address the latest findings in neuroendocrine tumor (NET) theranostics, focusing on new evidence and future directions of combined diagnosis with positron emission tomography (PET) and treatment with peptide receptor radionuclide therapy (PRRT).Recent FindingsFollowing NETTER-1 trial, PRRT with [177Lu]Lu-DOTATATE was approved by FDA and EMA and is routinely employed in advanced G1 and G2 SST (somatostatin receptor)-expressing NET. Different approaches have been proposed so far to improve the PRRT therapeutic index, encompassing re-treatment protocols, combinations with other ther...
Source: Current Oncology Reports - April 6, 2024 Category: Cancer & Oncology Source Type: research
Current Trends and Challenges of Microbiome Research in Prostate Cancer
AbstractPurpose of ReviewThe role of the gut microbiome in prostate cancer is an emerging area of research interest. However, no single causative organism has yet been identified. The goal of this paper is to examine the role of the microbiome in prostate cancer and summarize the challenges relating to methodology in specimen collection, sequencing technology, and interpretation of results.Recent FindingsSignificant heterogeneity still exists in methodology for stool sampling/storage, preservative options, DNA extraction, and sequencing database selection/in silico processing. Debate persists over primer choice in amplicon...
Source: Current Oncology Reports - April 4, 2024 Category: Cancer & Oncology Source Type: research
Perioperative Neurocognitive Function in Glioma Surgery
AbstractPurpose of ReviewThis review provides a concise overview of the recent literature regarding preoperative and postoperative neurocognitive functioning (NCF) in patients with glioma. Brief discussion also covers contemporary intraoperative brain mapping work, with a focus on potential influence of mapping upon NCF outcomes following awake surgery.Recent FindingsMost patients with glioma exhibit preoperative NCF impairment, with severity varying by germ line and tumoral genetics, tumor grade, and lesion location, among other characteristics. Literature regarding postoperative NCF changes is mixed, though numerous stud...
Source: Current Oncology Reports - April 4, 2024 Category: Cancer & Oncology Source Type: research
