Effects of radical cystectomy combined with GC chemotherapy in the treatment of invasive bladder cancer and its influence on the incidence of adverse reactions
CONCLUSION: Radical cystectomy combined with GC for the treatment of invasive bladder cancer reduces the incidence of adverse reactions and enhances the 5-year survival of patients, with a promising long-term efficiency.PMID:35035724 | PMC:PMC8748082 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Dewen Ban Wei Lu Zheng Lu Bin Li Naichun Zhou Source Type: research

The effect of coenzyme Q10 plus trimetazidine on acute viral myocarditis treatment
CONCLUSIONS: CoQ10 plus TMZ yields a favorable clinical effectiveness in the treatment of AVMC, and it can effectively promote cardiac function recovery, alleviate oxidative stress and inflammatory reactions, and bolster patients' QoL.PMID:35035725 | PMC:PMC8748115 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Yong-Jun Yin Si-Lu Zeng Yan-Wei Li Zhou Wu Da-Jun Huang Han-Zhang Tang Source Type: research

Torque variability of the plantar flexors in people with Huntington's disease
CONCLUSIONS: People with prodromal HD exhibited greater torque variability than healthy controls. Torque variability worsened for both groups when visual feedback was removed. These findings support further investigation into the utilisation of torque variability measurements as markers of disease progression in people with prodromal HD.PMID:35035726 | PMC:PMC8748091 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Mitchell Turner Alvaro Reyes Tim Rankin Danielle Bartlett Gabriel Trajano Tim Pulverenti Travis Cruickshank Source Type: research

Long-term follow-up of diabetic patients with non-ST-segment elevation myocardial infarction
CONCLUSIONS: Multiple risk factors contribute to a higher incidence of composite outcomes in diabetic patients with MI. STEMI poses a greater threat to adverse events, which warrants more investigations.PMID:35035727 | PMC:PMC8748141 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Zhifeng Li Shaopeng Huang Rui Yang Jieyuan Li Guoqiang Chen Source Type: research

Clinical effect evaluation and complication analysis of different auricle reconstruction of congenital microtia
This study compared the clinical efficacy and complications of autogenous rib cartilage stent and Medpor stent auricle reconstruction in patients with congenital microtia. A total of 300 patients with congenital microtia were selected as the research objects. 150 patients in the auricle reconstruction group with autologous rib cartilage stent and 150 patients in the auricle reconstruction group with Medpor stent were selected. Postoperative follow-up was conducted to observe whether the shape, color, size, and position of the reconstructed auricle were good, and to compare whether the cranial auricle Angle was consistent w...
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Min Wang Zhirong Xiao Min Huang Jun Xie Guangliang Liu Source Type: research

Efficacy and safety of bevacizumab combined with temozolomide in the treatment of recurrent malignant gliomas and its influence on serum tumor markers
CONCLUSIONS: BZ+TMZ is effective in treating recurrent malignant gliomas, which can improve the QoL and survival of patients.PMID:35035729 | PMC:PMC8748084 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Jun Lei Zhi Zhou Source Type: research

Application of vincristine and cisplatin combined with intensity-modulated radiation therapy in the treatment of patients with advanced cervical cancer
CONCLUSION: Vincristine and cisplatin combined with IMRT for patients with advanced cervical cancer can effectively optimize the clinical indicators of patients and improve their quality of life, with a high safety.PMID:35035730 | PMC:PMC8748177 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Heling Zhang Ye Zhang Source Type: research

Effect of different doses of apatinib mesylate combined with chemotherapy on advanced oral cancer
CONCLUSION: Apatinib mesylate (250 mg) combined with chemotherapy can reach optimal efficacy with highest safety but least adverse effects for patients with advanced oral cancer.PMID:35035731 | PMC:PMC8748138 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Wei Yan Jiaxuan Yan Yong Chen Qiang Li Yanjun Guo Source Type: research

Clinical efficacy and safety of urinary kallindinogenase combined with butylphthalide in the treatment of progressive cerebral infarction
CONCLUSION: HUK combined with NBP can reduce the neurological dysfunction and disability rate of patients and improve their independence rate and life quality. It is a safe and effective method for the treatment of PCI.PMID:35035732 | PMC:PMC8748135 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Jie Bai Source Type: research

Anti-TNF therapy and immunogenicity in inflammatory bowel diseases: a translational approach
Am J Transl Res. 2021 Dec 15;13(12):13916-13930. eCollection 2021.ABSTRACTInflammatory bowel diseases are chronic illnesses that involve intestinal inflammation and are usually diagnosed as Crohn's disease or ulcerative colitis. As these diseases do not have a cure, the goal of treatment is to induce and maintain remission. Monoclonal antibodies have been recognized as the most advanced therapy to avoid complications and reduce the need for surgical approaches. However, although their effectiveness has been proven by several studies, they can trigger the immune system, induce the occurrence of immunogenicity, which may lea...
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: L ívia Moreira Genaro Lu ís Eduardo Miani Gomes Ana Paula Menezes de Freitas Franceschini Hugo Dugolin Ceccato Rafael Nascimento de Jesus Amanda Pereira Lima Cristiane Kibune Nagasako Jo ão José Fagundes Maria de Lourdes Setsuko Ayrizono Raquel Franco Source Type: research

CalliSpheres < sup > ® < /sup > microspheres drug-eluting bead transhepatic artery chemoembolization with or without sorafenib for the treatment of large liver cancer: a multi-center retrospective study
CONCLUSION: DEB-TACE combined with sorafenib is safe and well tolerated in the treatment of large liver cancer. It can improve the tumor control rate and prolong the survival time.PMID:35035734 | PMC:PMC8748101 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Song Liu Guangji Yu Qingdong Wang Long Li Ying Liu Ke Du Fei Zhang Bangli Zhao Guangsheng Zhao Source Type: research

Value of ultrasound elastography combined with contrast-enhanced ultrasound and micro-flow imaging in differential diagnosis of benign and malignant breast lesions
CONCLUSIONS: The combination of UE, CEUS and MFI has the highest specificity and accuracy in the differential diagnosis of benign and malignant breast lesions compared to any one used singly.PMID:35035735 | PMC:PMC8748137 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Zuopeng Ding Weiyong Liu Nianan He Xiaopeng Ma Lili Fu Lei Ye Source Type: research

Effect of targeted nursing intervention plus psychological counseling on quality of life, negative emotions, and complications in patients with extensively drug-resistant tuberculosis
CONCLUSION: Compared to routine nursing, targeted nursing intervention combined with psychological counseling substantially ameliorates the life quality and negative emotions of patients with XDR-TB and lowers the incidence of complications.PMID:35035736 | PMC:PMC8748094 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Yanhua Lu Hongqian Wang Jianfeng Zhu Na Wang Dan Cui Lingdi Li Source Type: research

Gender differences in degenerative lumbar scoliosis spine flexibilities
CONCLUSIONS: In lumbar scoliosis specimens, the rigidness of spines was higher in males than in females and more pronounced in right than in left scoliosis, but only in males.PMID:35035737 | PMC:PMC8748112 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Jie Zheng Boyle Cheng Daniel Cook Yonghong Yang Source Type: research

Analysis of the influencing factors of the clinical effect of respiratory humidifier in treating AIDS complicated with severe Pneumocystis jiroveci pneumonia
CONCLUSION: The clinical effect of respiratory humidifier in the treatment of AIDS patients with severe PCP was related to PaO2/FiO2, PaO2, ROX index, SOFA score, and IL-6 and IL-8 levels.PMID:35035738 | PMC:PMC8748140 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - January 17, 2022 Category: Research Authors: Qi Cao Wei Zeng Jingmin Nie Yongjun Ye Yanchao Chen Source Type: research