Platelet-rich plasma promotes MSCs exosomes paracrine to repair acute kidney injury via AKT/Rab27 pathway
In this study, we proposed a possible therapeutic use of MSCs stimulated by platelet-rich plasma (PRP-MSCs) in a glycerin-induced AKI murine model. In vivo and in vitro studies, showed that PRP-MSCs could significantly attenuate serum blood urea nitrogen and creatinine levels, and reverse the histopathological kidney damage. PRP-MSCs treatment reduced renal tubular cell apoptosis stimulated by glycerin. We confirmed that PRP promoted the proliferation and reinforced the stemness of MSCs by inducing YAP nucleus expression, and that PRP promoted MSCs exosomes in a paracrine manner to repair AKI through an activated AKT/Rab27...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Cheng Ji Jiahui Zhang Zixuan Zhou Hui Shi Wanzhu Liu Fengtian Sun Chenxiao Zhang Leilei Zhang Zixuan Sun Hui Qian Source Type: research

Inhibition of CXCR4 ameliorates hypoxia-induced pulmonary arterial hypertension in rats
Am J Transl Res. 2021 Mar 15;13(3):1458-1470. eCollection 2021.ABSTRACTPulmonary vascular remodeling due to aberrant proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) is the main characteristic of pulmonary arterial hypertension (PAH). CXCR4 is a specific stem cell surface receptor of cytokine CXCL12 which could regulate homing of hematopoietic progenitor cells and their mobilization. There is evidence that bone marrow-derived CXCR4 proangiogenic cell accumulation take an important part in the development of pulmonary arterial hypertension; however, the underlying mechanisms still remain unknown....
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Jingjing Xu Xiangnan Li Siqi Zhou Rui Wang Mengxi Wu Cheng Tan Jingyu Chen Zhiping Wang Source Type: research

Ginkgo biloba extract improves cognitive function and increases neurogenesis by reducing A β pathology in 5×FAD mice
In this study, different doses of EGb 761 (0, 10, 20, and 30 mg/kg; intraperitoneal injections once every day for four months) were tested on 5×FAD mice. After consecutive 4-month injections, mice were tested in learning memory tasks, Aβ, and neurogenesis in the dentate gyrus (DG) of hippocampus and morphological characteristics of neurons in DG of hippocampus. Results indicated that EGb 761 (20 and 30 mg/kg) ameliorated memory deficits. Further analysis indicated that EGb 761 can reduce the number of Aβ positive signals in 5×FAD mice, increase the number of newborn neurons, and increase dendritic bra...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Wei Ge Chao Ren Lei Xing Lina Guan Caiyi Zhang Xuwen Sun Guoping Wang Haichen Niu Sen Qun Source Type: research

Astaxanthin provides neuroprotection in an experimental model of traumatic brain injury via the Nrf2/HO-1 pathway
CONCLUSIONS: Based on our study, ATX possibly affords neuroprotection by activating the Nrf2/HO-1 signaling pathway in mice after TBI.PMID:33841672 | PMC:PMC8014407 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Fei Gao Xiao Wu Xiang Mao Fei Niu Bin Zhang Jinqian Dong Baiyun Liu Source Type: research

Anlotinib suppresses MLL-rearranged acute myeloid leukemia cell growth by inhibiting SETD1A/AKT-mediated DNA damage response
In conclusion, Anlotinib exerts anti-leukemia function by inhibiting SETD1A/AKT-mediated DNA damage response and highlights a novel mechanism underlying Anlotinib in the treatment of MLL-r AML.PMID:33841673 | PMC:PMC8014360 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Jinzhu Chen Juan Feng Zhihong Fang Jing Ye Qinwei Chen Qiuling Chen Kai Chen Xiaoming Xiong Guowei Li Haihan Song Bing Xu Source Type: research

Hsa-miR-155 regulates the cell cycle and barrier function of corneal endothelial cells through E2F2
In conclusion, Has-miR-155 regulates the cell cycle of corneal endothelial cells and improves their barrier function by down regulating E2F2.PMID:33841674 | PMC:PMC8014374 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Shuyi Yuan Guanghui He Lihua Li Source Type: research

miR-30a-5p targets Becn1 to ameliorate high-glucose-induced glomerular podocyte injury in immortalized rat podocyte cell line
In this study, we found a target relationship between miR-30a-5p and Becn1, of which there are few studies about the role in podocyte injury. We therefore used immortalized rat podocyte cell line to explore the role and molecular mechanism of miR-30a-5p targeting Becn1 gene in high-glucose-induced glomerular podocyte injury.METHODS: The mRNA and protein expressions of miR-30a-5p and Becn1 were detected respectively by quantitative reverse transcriptase PCR and western blotting. The proliferation, apoptosis, and the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α were detected by MTT assay, flow cytomet...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Xiu Yang Ming Yang Yuemei Chen Yingying Qian Xiao Fei Chanjuan Gong Ming Wang Xiangcheng Xie Zhen Wang Source Type: research

Efficacy and safety of crizotinib plus bevacizumab in < em > ALK/ROS-1/c-MET < /em > positive non-small cell lung cancer: an open-label, single-arm, prospective observational study
This study demonstrated that crizotinib plus bevacizumab showed benefit in treating naive ALK rearrangement NSCLC patients, and the toxicity was relatively tolerant. Our results suggested that crizotinib plus bevacizumab might be a promising treatment strategy in ALK/ROS-1/c-MET positive NSCLC patients.PMID:33841676 | PMC:PMC8014364 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Ziwei Huang Qi Xiong Zhi Cui Haitao Tao Sujie Zhang Lijie Wang Pengfei Cui Shixue Chen Di Huang Bo Yang Yi Hu Source Type: research

Role of kynurenine in promoting the generation of exhausted CD8 < sup > + < /sup > T cells in colorectal cancer
In conclusion, our study revealed a novel mechanism underlying the metabolic factors found in tumor microenvironment which could induce CD8+ T cells exhaustion. Our findings provided a new strategy of restoring the antitumor activity of CD8+ T cells through combined targeting of the IDO1/Kyn and PD-1/PD-L1 pathways in patients with CRC.PMID:33841677 | PMC:PMC8014392 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Dandan Wu Yufeng Zhu Source Type: research

Dysbiosis of intestinal microbiota in critically ill patients and risk of in-hospital mortality
CONCLUSIONS: Dysbiosis of intestinal microbiota with variable degrees of reduction in Bifidobacterium abundance exhibited promising performance in the predicting of in-hospital mortality and provides incremental prognostic value to existing scoring systems in the adult intensive care unit (ICU) setting.PMID:33841678 | PMC:PMC8014420 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Ru Wei Xu Chen Linhui Hu Zhimei He Xin Ouyang Silin Liang Shixue Dai Weihong Sha Chunbo Chen Source Type: research

General anesthesia versus monitored anesthesia care during endovascular therapy for vertebrobasilar stroke
CONCLUSION: For patients who underwent endovascular therapy for vertebrobasilar occlusion strok caused by occlusions in the posterior circulation, MAC appears to be as effective as GA. However, MAC is associated with bigger final infarct volume. Future studies are warranted to confirm our findings.PMID:33841679 | PMC:PMC8014376 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Guangjun Hu Zhen Shi Bixi Li Weidong Shao Bo Xu Source Type: research

Prediction model of objective response after neoadjuvant chemotherapy in patients with locally advanced gastric cancer
CONCLUSIONS: We found gender, LNmax and signet ring cell carcinoma component were independent predictors for objective response. The prediction model is a good tool to predict the objective response for LAGC patients treated with NAC, which can be applied to guide clinical practice.PMID:33841680 | PMC:PMC8014384 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Wei Xu Zhiyuan Fan Lingquan Wang Changyu He Zhentian Ni Zichen Hua Zhenglun Zhu Zhongyin Yang Yanan Zheng Runhua Feng Chao Yan Chen Li Xuexin Yao Mingmin Chen Min Yan Zhenggang Zhu Wentao Liu Source Type: research

CircRNAs as promising biomarkers of inflammatory bowel disease and its associated-colorectal cancer
Am J Transl Res. 2021 Mar 15;13(3):1580-1593. eCollection 2021.ABSTRACTIn recent years, research on the pathogenesis of inflammatory bowel disease (IBD) and its associated-colorectal cancer has been well documented to involve environmental, genetic, immune, and intestinal microbiota factors. Evidence indicates that, regardless of the current high global incidence of IBD with over 3.5 million cases in Europe and North America only, it continues to emerge in newly industrialized countries across Asia, Middle East, and South America. Individuals with IBD have significant increased risk of gastrointestinal and extra-intestinal...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Yuting Xu Xinwei Xu Dickson Kofi Wiredu Ocansey Hua Cao Wei Qiu Qiang Tu Fei Mao Source Type: research

Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer
Am J Transl Res. 2021 Mar 15;13(3):1594-1606. eCollection 2021.ABSTRACTTriple-negative breast cancer (TNBC) patients have the worst outcome among all breast cancer subtypes. In oral squamous carcinoma cells, miR-378 was reported to target the mRNA of kallikrein-related peptidase 4 (KLK4), resulting in inhibition of cell proliferation, migration and invasion, induction of apoptosis, and reduction of tumor growth in vivo. Similarly, a miR-378/KLK4 axis has been proposed in prostate cancer. Here, we analyzed the correlation between miR-378 and KLK4 mRNA expression and determined the prognostic impact of both factors in TNBC. ...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Weiwei Gong Caixia Zhu Yueyang Liu Alexander Muckenhuber Holger Bronger Andreas Scorilas Marion Kiechle Julia Dorn Viktor Magdolen Tobias Dreyer Source Type: research

Comparison of self-expandable stents and balloon-mounted stents in the treatment of symptomatic intracranial vertebral artery atherosclerotic stenosis
CONCLUSION: Both SES and BMS showed high safety and efficacy for the treatment of SIVAAS. SES was more recommended for the stenotic lesions with tortuous interventional access. BMS was more recommended for the lesions located at the dural-entry zone of VA or proximal to PICA origin.PMID:33841683 | PMC:PMC8014385 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Chunou Tian Bin Liu Jianmin Liu Bo Hong Puyuan Zhao Liangliang Yang Qiuping Li Zhigang Yang Source Type: research

Psychosocial phenotyping as a personalization strategy for chronic disease self-management interventions
CONCLUSIONS: Our literature review with case example analysis demonstrates the potential usefulness of psychosocial phenotyping as a tool to enhance personalized self-management interventions for people with chronic diseases, with implications for future research.PMID:33841684 | PMC:PMC8014371 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Miyong T Kim Kavita Radhakrishnan Elizabeth M Heitkemper Eunju Choi Marissa Burgermaster Source Type: research

Effects on quality of life and psychosocial wellbeing in Chinese patients with keloids
Am J Transl Res. 2021 Mar 15;13(3):1636-1642. eCollection 2021.ABSTRACTKeloids are defined as raised scar tissue that grows excessively and invasively beyond the original wound borders during abnormal, fibroproliferative wound healing. The effects of these lesions on quality of life (QoL) and psychosocial wellbeing have not been assessed in keloid-endemic environments such as China. The purpose of our study was to investigate the QoL and mental health status of patients with keloids in China. The Dermatology Life Quality Index (DLQI) questionnaire and the Symptom Checklist-90 (SCL-90) were used to explore the effects of ke...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Wensheng Lu Haifeng Chu Xiaodong Zheng Source Type: research

LINC01303 promotes the proliferation and migration of laryngeal carcinoma by regulating miR-200c/TIMP2 axis
CONCLUSION: LINC01303 plays a carcinogenic part in LSCC carcinogenesis through regulating miR-200c/TIMP2 axis, which may become a promising target of LSCC therapy.PMID:33841686 | PMC:PMC8014399 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Dong Xiao Xiangyan Cui Ning Fang Shujian Yu Xin Wang Source Type: research

The anti-hypoxic effects of oat ( < em > Avena sativa < /em > L.) oligopeptides in mice
CONCLUSION: OOPs have anti-hypoxic effects, and the mechanism may involve improving the blood's oxygen carrying capacity and oxygen utilization rate minimizing the lipid peroxidation lesions, increasing the brain's ability to buffer against lactic acidosis in mice, and promoting angiogenesis and regulating the hypoxic response.PMID:33841687 | PMC:PMC8014377 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Di Li Jinwei Ren Qian Du Peng Liu Yong Li Source Type: research

Immunomodulatory function of the active ingredients in traditional Chinese prescriptions on early stage esophageal cancer with dysplasia
Am J Transl Res. 2021 Mar 15;13(3):1667-1675. eCollection 2021.ABSTRACTOBJECTIVE: To explore the effects of the ingredients in a traditional Chinese prescription on the immune regulation of esophageal cancer in patients with early atypical hyperplasia.METHODS: A total of 60 C57BL mice were randomly selected as the positive control group; another 240 C57BL mice were randomly divided into a blank control group (n=30), a 4NQO group (n=60) and an experimental group (n=120). The experimental group was divided into the prevention group which received carcinogens and the prescription composition simultaneously, and the treatment ...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Wenbo Jiang Ning Qin Tao Chen Junwei Xu Source Type: research

Effect of combined application of iguratimod in the treatment of active rheumatoid arthritis on bone metabolism, Th17 cells and Treg cells
This study was designed to analyse the effect of combined application of iguratimod with methotrexate in the treatment of active rheumatoid arthritis (RA).METHODS: A total of 115 patients with active RA admitted to our hospital were enrolled and divided into group A (n=58) and group B (n=57) according to the method of random number table. Patients in group B were treated with methotrexate alone, while patients in group A were treated with methotrexate combined with iguratimod. The curative efficacy was compared between the two groups.RESULTS: At 6 months after treatment, the levels of CTX-1 and RANKL in group A were higher...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Li Wen Wei Jiang Meiqun Zhou Zhenxia Wu Source Type: research

The association between postoperative complications and prognosis in patients receiving extracorporeal membrane oxygenation in cardiac care unit
CONCLUSION: ECMO can significantly improve the survival rate of patients in CCU. When the serum levels of STB, ALT, Cr and Lac decrease and urine volume increases, liver and kidney function injury is mild, with less postoperative complications and good prognosis. Therefore, monitoring STB, ALT, Cr, Lac and urine volume is able to adjust treatment plan in time, reduce postoperative complications and improve prognosis quality, thus has great positive clinical significance.PMID:33841690 | PMC:PMC8014358 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Liwen Liang Liyuan Liu Yamin Zhang Xiaoying Fan Ling Tao Source Type: research

The clinical value of color Doppler ultrasonography in measuring the hemodynamics of liver cirrhosis patients' portal and splenic veins
Am J Transl Res. 2021 Mar 15;13(3):1692-1700. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the clinical value of color Doppler ultrasonography (CDUS) in measuring the hemodynamics of liver cirrhosis (LC) patients' portal and splenic veins.METHODS: The clinical data of 81 LC patients admitted to our hospital were collected retrospectively and classified into Group A, and the clinical data from 51 healthy volunteers were classified into Group B. All the patients were examined with CDUS, and the ultrasonography images were analyzed. The hemodynamic indices of the portal and splenic veins were compared, and the differenc...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Ran Hui Zhe Li Zongjie Liu Xiuping Liu Heping Deng Source Type: research

Influence of anesthetic induction of propofol combined with esketamine on perioperative stress and inflammatory responses and postoperative cognition of elderly surgical patients
Am J Transl Res. 2021 Mar 15;13(3):1701-1709. eCollection 2021.ABSTRACTOBJECTIVE: To analyze the influence of anesthetic induction of propofol combined with esketamine on perioperative stress and inflammatory responses and postoperative cognition in elderly surgical patients.METHODS: A total of 80 elderly surgical patients were randomly divided into a control group (n=40) and a study group (n=40). The control group received anesthetic induction with propofol combined with sufentanil, while the study group received anesthetic induction with propofol combined with esketamine. Hemodynamics, stress and inflammatory responses a...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Wencai Tu Haibo Yuan Shaojin Zhang Fang Lu Lin Yin Chuanfeng Chen Jianhua Li Source Type: research

The relationship between neutrophil-lymphocyte ratio and early renal fibrosis and renal prognosis in patients with lupus nephritis
CONCLUSION: NLR affects some important renal functions to a certain extent and is not the only risk factor for renal prognosis in patients with LN.PMID:33841693 | PMC:PMC8014417 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Guming Zou Hongmei Gao Source Type: research

Effect of predictive nursing on postoperative rehabilitation and complications of patients undergoing hip replacement and maintenance hemodialysis
Am J Transl Res. 2021 Mar 15;13(3):1717-1725. eCollection 2021.ABSTRACTOBJECTIVE: To analyze the effect of predictive nursing on postoperative rehabilitation index and complications in patients after hip replacement with maintenance hemodialysis.METHODS: A total of 81 cases of patients underwent hip replacement and maintenance hemodialysis in our hospital were selected as the research objects and divided into study group (n=41) and control group (n=40) with retrospective analysis method based on different intervention method. Patients in the study group received predictive nursing, while patients in the control group recei...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Mingzhi Lin Fang Zhang Source Type: research

The effect of conservative therapy combined with rehabilitation nursing on elderly compression fracture patients
Am J Transl Res. 2021 Mar 15;13(3):1726-1733. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the effect of rehabilitation nursing combined with conservative therapy on patients undergoing compression fracture surgery.METHODS: 86 patients with compression fractures admitted to our hospital for rehabilitation from November 2018 to November 2019 were recruited as the study cohort. The patients were provided with conservative traditional Chinese medicine treatment along with rehabilitation methods such as rehabilitation nursing, lumbar pillows, and the prevention and cure of complications. The post-treatment effects and re...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Xiaoqin Liu Ying Cai Source Type: research

Study of the therapeutic effects of betamethasone injection combined with musculoskeletal ultrasonography compared with radial shock wave therapy in the treatment of tenosynovitis of the long head of the biceps brachii
Am J Transl Res. 2021 Mar 15;13(3):1734-1741. eCollection 2021.ABSTRACTOBJECTIVE: To compare the therapeutic effects of compound betamethasone injection (CBI) combined with musculoskeletal ultrasonography (MSUS) and radial shock wave therapy (RSWT) in the treatment of tenosynovitis of the long head of the biceps brachii tendon (TLHBBT).METHODS: A total of 93 patients with TLHBBT admitted to our hospital were selected and randomly divided into an observation group (n=48) and a control group (n=45). The control group received RSWT, while the observation group received CBI combined with MSUS. The therapeutic effects were comp...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Lizhen Xiao Jing Zou Fengkai Fang Source Type: research

Effects of off-pump coronary artery bypass grafting on clinical efficacy, cardiac function and the incidence of major adverse cardiovascular events in patients with coronary heart disease
Am J Transl Res. 2021 Mar 15;13(3):1742-1749. eCollection 2021.ABSTRACTOBJECTIVE: To explore the effects of off-pump coronary artery bypass grafting (OPC) on clinical efficacy, cardiac function and the occurrence of major adverse cardiovascular events (MACE) in patients with coronary heart disease.METHODS: According to different surgical methods, 93 patients with coronary heart disease who were hospitalized and treated in our hospital were collapsed into the off-pump coronary artery bypass grafting group (OPC group) and the extracorporeal circulation coronary artery bypass grafting group (PC group). The perioperative index...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Qing Ma Jiancheng Liu Chunbo Li Dong Wang Source Type: research

The immunomodulatory effects of vitamin D drops in children with recurrent respiratory tract infections
Am J Transl Res. 2021 Mar 15;13(3):1750-1756. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the effects of vitamin D drops on immune function in children with recurrent respiratory tract infections (RRTI).METHODS: The clinical data of 119 children with RRTI in our hospital were retrospectively retrieved, and they were divided into group A (n=59, receiving routine treatment) and group B (n=60, receiving vitamin D drops) based on their treatment modality. The clinical efficacy, symptom disappearance time, immune function index, insulin-like growth factor (IGF-1), 25-hydroxyvitamin D3 [25-(OH)D3], serum y-interferon (INF...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Jianqiu Xiao Wei He Source Type: research

Effect of care bundles in the nursing of severe pneumonia
Am J Transl Res. 2021 Mar 15;13(3):1757-1763. eCollection 2021.ABSTRACTOBJECTIVE: To explore the effect of care bundles and analyze the influence of different angles of turning over on the sputum excretion of mechanically ventilated patients with severe pneumonia.METHODS: 120 patients with severe pneumonia in our hospital from October 2016 to October 2019 were equally randomized into four groups, each with 30, according to the date of admission. The control group was given conventional nursing and placed in a position of left 30°-half lying-right 30°; the group A was given comprehensive care bundles and placed in a...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Jing Li Meiqin Wang Lingling Peng Hongjuan Zhang Huiling He Yanhua Zhao Source Type: research

Ibandronate sodium and zoledronate sodium in the treatment of senile osteoporosis: efficacy, impact on quality of life and cost-effectiveness analysis
Am J Transl Res. 2021 Mar 15;13(3):1764-1771. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the efficacy of ibandronate sodium and zoledronate sodium in the treatment of senile osteoporosis and their impact on quality of life, and to analyze the cost-effectiveness.METHODS: A retrospective study was conducted on 215 patients with senile osteoporosis, who were admitted to our hospital from January 2017 to June 2019. Among them, 115 cases treated with ibandronate sodium were set to group A and 100 cases treated with zoledronate sodium were set to group B. The clinical efficacy, bone mineral density (BMD) before and after...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Shuang Liang Shaozhen Hu Hong Guo Leilei Dong Guoqiang Liu Yang Liu Source Type: research

Effects of miR-151-3p-mediated GLCCl1 expression on biological function in children with nephrotic syndrome
This study aimed to confirm the association of miR-151-3p with nephrotic syndrome (NS) in children and to explore the molecular mechanisms by which glucocorticoid-induced transcript 1 gene (GLCCI1) targets cellular biological functions in children with nephrotic syndrome.METHODS: miR-151-3p levels were detected in 20 children with hormone-sensitive nephrotic syndrome (SSNS), 15 children with steroid-dependent nephrotic syndrome (SDNS) and 20 children with steroid-resistant nephrotic syndrome (SRNS), using qRT-PCR before and after glucocorticoid treatment, and TargetScan information software was used to predict the biologic...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Chengliang Xu Yanping Li Source Type: research

Exercise intervention can reduce the degree of drug dependence of patients with amphetamines/addiction by improving dopamine level and immunity and reducing negative emotions
Am J Transl Res. 2021 Mar 15;13(3):1779-1788. eCollection 2021.ABSTRACTOBJECTIVE: Exercise intervention can reduce drug dependence of patients with amphetamines addiction by improving dopamine level and immunity, and reducing negative emotions.METHODS: Altogether 90 male patients with amphetamines addiction from March 2018 to June 2019 were selected and grouped. The routine rehabilitation group (RG) (30 cases) was given conventional rehabilitation treatment, while group 1 (30 cases) was given conventional rehabilitation treatment+aerobic exercise for 1 hour. Group 2 (30 cases) received routine rehabilitation+aerobic exerci...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Qinghua He Jingqiong Wu Xin Wang Fuxuan Luo Kaihui Yan Wenjun Yu Zaimei Mo Xinping Jiang Source Type: research

Effects of acupoint catgut embedding on the postmenopausal osteoporosis patients and related mechanism
Am J Transl Res. 2021 Mar 15;13(3):1789-1798. eCollection 2021.ABSTRACTOBJECTIVE: To study the effect and mechanism of acupoint catgut embedding on patients of postmenopausal osteoporosis (PMOP).METHODS: In this prospective study, 90 patients with PMOP who received treatment in our hospital were randomly divided into the drug treatment group (n=45) and drug treatment + catgut embedding group (n=45) according to SPSS random table method. The drug treatment group was given conventional western medicine treatment, and the drug treatment + catgut embedding group was given point embedding therapy. Bone mineral density (BMD), ca...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Na Shi Chunli Zhao Chenglong Fang Dongning Zhang Zhou Zhou Gang Ouyang Source Type: research

Effects of care bundles for patients with pressure ulcers and the impact on self-care efficacy
Am J Transl Res. 2021 Mar 15;13(3):1799-1807. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the effects of care bundles for patients with pressure ulcers and the impact on self-care efficacy.METHOD: A total of 160 patients with pressure ulcers were enrolled and divided into two groups using a lottery method. The control group (n=80) was cared for with routine nursing while the observation group (n=80) was additionally nursed with care bundles for 3 months. Both groups were compared in terms of grading of pressure ulcers, self-care efficacy, pressure ulcer management, awareness rate, and quality of life.RESULTS: At 3 m...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Xiaodan Mao Lipeng Zhu Source Type: research

Effect of endovascular therapy on the expression levels of serum T lymphocyte subsets, Notch1 and TACE proteins in patients with abdominal aortic aneurysm
Am J Transl Res. 2021 Mar 15;13(3):1808-1816. eCollection 2021.ABSTRACTTo investigate the effect of endovascular therapy on the expression levels of serum T lymphocyte subsets, Notch1 and TACE proteins in patients with abdominal aortic aneurysm (AAA). A total of 84 AAA patients treated in the General Hospital of Northern Theater Command of Chinese PLA from January 2018 to October 2019 were equally divided into the control group and research group according to different surgical methods. The control group underwent laparotomy and the research group received endoluminal repair. The expression levels of serum T-cell subsets, ...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Hao Yan Hong Jiang Qian Xia Wei Shan Liwei Zhang Fan Zhao Source Type: research

Effect of percutaneous transhepatic cholangial drainag + radiofrequency ablation combined with biliary stent implantation on the liver function of patients with cholangiocarcinoma complicated with malignant obstructive jaundice
Am J Transl Res. 2021 Mar 15;13(3):1817-1824. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the effect of percutaneous transhepatic cholangial drainage (PTCD) + radiofrequency ablation (RFA) combined with biliary stent implantation on the liver function of patients with cholangiocarcinoma complicated with malignant obstructive jaundice.METHODS: Retrospective analysis of 120 patients with cholangiocarcinoma complicated with malignant obstructive jaundice were divided into the research group (n=60) and the control group (n=60) according to different treatments. The research group received PTCD + RFA combined with biliar...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Shuangyu Qi Huijun Yan Source Type: research

The diagnostic value of miR-145 and miR-205 in patients with cervical cancer
Am J Transl Res. 2021 Mar 15;13(3):1825-1832. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the diagnostic value of miRNA-145 (miR-145) and miRNA-205 (miR-205) in cervical cancer patients.METHODS: Cervical tissue samples were collected from 144 patients diagnosed with and suspected to have cervical cancer in our hospital. Confirmed by pathology, 84 samples were obtained from cervical cancer patients and 60 samples were from patients with cervical intraepithelial neoplasia. Meanwhile, 30 patients with cervicitis were also selected, and the expression levels of miR-145, miR-205 and human papillomavirus (HPV) were detect...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Furong Yu Jie Liu Weilei Dong Jing Xie Xia Zhao Source Type: research

Practical value of hierarchical teaching combined with simulation scenario training for operating-room nurses
This study explored the application value of combined training by hierarchical teaching with situational simulations for operating-room (OR) nurses.METHODS: A total of 41 nurses that received pre-job training for the operating room from January 2018 to December 2019 were selected as the research subjects and randomly divided into a control group and a study group. The control group was given the hierarchical nurse-teaching method, while the study group was given combined training with the hierarchical teaching and scenario simulations. In this study, the operating room capability, clinical work ability, results of theoreti...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Min Zhang Li Fan Yanling Zhou Source Type: research

Study on the effects of desloratadine citrate disodium on the postoperative complications and inflammatory response in patients with chronic sinusitis undergoing endoscopic sinus surgery
Am J Transl Res. 2021 Mar 15;13(3):1840-1846. eCollection 2021.ABSTRACTOBJECTIVE: To explore the effects of desloratadine citrate disodium on the postoperative complications and inflammatory markers in patients with chronic sinusitis undergoing endoscopic sinus surgery.METHODS: From June 2019 to December 2020, the patients with chronic sinusitis who received treatment in our hospital were selected and divided into the control group (CG) and experimental group (EG). In both groups, patients were given endoscopic sinus surgery. On this basis, patients were treated with desloratadine citrate disodium in the EG. The total effe...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Ming Ma Longsheng Liu Wei Jin Hong Chen Tao Zhou Busheng Tong Source Type: research

The application effect analysis of personalized health education in acute leukemia nursing
Am J Transl Res. 2021 Mar 15;13(3):1847-1853. eCollection 2021.ABSTRACTOBJECTIVE: To analyze the effectiveness of personalized health education care in the nursing of patients with acute leukemia.METHODS: A total of 108 patients with leukemia who were admitted to our hospital were randomly selected as research subjects. A random number table was used to allocate the patients into the observation group and the control group, with 54 patients in each group. The control group had routine health education care and the observation group received personalized health education care in addition to treatment given to the control gr...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Cuiping Zhang Yanqin Mao Fang Tang Xiang Xu Source Type: research

Association between the platelet to lymphocyte ratio, neutrophil to lymphocyte ratio and axillary lymph node metastasis in cT1N0 breast cancer patients
Am J Transl Res. 2021 Mar 15;13(3):1854-1861. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the relationship between platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and axillary lymph node metastasis in cT1N0 breast cancer patients.METHODS: The clinicopathological data of 154 patients with cT1N0 breast cancer from January 2015 to June 2020 were retrospectively analyzed. All patients underwent sentinel lymph node (SLN) biopsy. The differences of PLR and NLR levels among groups with different clinicopathological factors (age, tumor size, ER, PR, HER-2, Ki67, p53 expression levels, vascular tumor...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Li Yang Hongbiao Wang Jinping Ma Jinyan Hao Chunxia Zhang Qiang Ma Bin Wang Source Type: research

Study on the mental health status of anesthesiologists and its influencing factors
CONCLUSION: The mental state of anesthesiologists is often at a poor level, and measures should be taken to improve the mental health of anesthesiologists and improve their quality of life.PMID:33841712 | PMC:PMC8014373 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Ping Zheng Siwei Du Yongqiao Mao Lu Yin Yuan Zhong Xiaorong Yin Source Type: research

Effect of enhanced recovery after surgery on patients with malignant obstructive jaundice complicated with diabetes mellitus
Am J Transl Res. 2021 Mar 15;13(3):1870-1876. eCollection 2021.ABSTRACTOBJECTIVE: To explore the effect of enhanced recovery after surgery on patients with malignant obstructive jaundice complicated with diabetes mellitus.METHODS: Patients with malignant obstructive jaundice complicated with diabetes mellitus received surgery in Hengshui People's Hospital were divided into two groups: patients in one group received routine care (routine care group, RC group), and patients in another group received enhanced recovery after surgery on the basis of routine care (accelerated care group, AC group). The differences in patients' s...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Huijun Yan Shuangyu Qi Linlin Cui Binghui Xu Guimei Du Source Type: research

Effects of rehabilitation nursing care on deep vein thrombosis of the lower limbs following spinal fractures
Am J Transl Res. 2021 Mar 15;13(3):1877-1883. eCollection 2021.ABSTRACTOBJECTIVE: To explore the preventive effect of rehabilitation nursing care for deep vein thrombosis (DVT) of the lower limbs following spinal fractures, and to analyze its influence on the hemorheology of patients.METHODS: A total of 99 patients with spinal fractures were allocated into a study group (n=50) and control group (n=49), and they were treated with internal fixation plus vertebroplasty. Afterwards, patients in the control group were given routine care and postoperative rehabilitation, and those in the study group received rehabilitation nursi...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Zhijuan Zhao Qifeng Tian Benyan Zhang Source Type: research

Risk factors for cognitive impairment in patients with first-time ischemic stroke
Am J Transl Res. 2021 Mar 15;13(3):1884-1889. eCollection 2021.ABSTRACTOBJECTIVE: To determine the risk factors for cognitive impairment (CI) in patients with first-time ischemic stroke.METHODS: The clinical data of 180 patients with ischemic stroke who were admitted to our hospital from January 2018 to December 2019 was retrospectively analyzed. Patients with MMSE score ≤24 were included into the CI group and the rest of the patients were placed into the normal group. Multivariate logistic regression was applied to describe risk factors for CI in patients with first-time ischemic stroke.RESULTS: Among the patients with...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Guotao Yang Conghui Li Wenhui Wang Chunyu Wang Aiqin Dong Fang Wang Hailiu Zhang Source Type: research

Clinical significance of T lymphocyte subsets, immunoglobulin and complement expression in peripheral blood of children with steroid-dependent nephrotic syndrome/frequently relapsing nephrotic syndrome
Am J Transl Res. 2021 Mar 15;13(3):1890-1895. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the clinical significance of T lymphocyte subsets, immunoglobulin and complement expression in the peripheral blood of children with steroid-dependent nephrotic syndrome/frequently relapsing nephrotic syndrome (SDNS/FRNS).METHODS: A prospective study was conducted on 285 children with nephrotic syndrome (NS). Among the 285 patients, 187 children had steroid-sensitive nephrotic syndrome (SSNS) and 98 children had SDNS/FRNS according to their sensitivity to hormones. Meanwhile, 50 healthy children in the same period were selected...
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Shulian Chen Jianxin Wang Shishan Liang Source Type: research

Clinicopathologic features and treatment of thymic lymphoepithelioma-like carcinoma: two case reports and literature review
We report two cases of thymic LELC with a review of previously published cases to summarize knowledge of their clinicopathological characteristics, which is necessary for accurate diagnosis and clinical treatment.PMID:33841717 | PMC:PMC8014405 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Xin Guan Di Zhang Yang Han Qingchang Li Enhua Wang Guangping Wu Huanyu Zhao Source Type: research

Erratum: Urine-derived stem cells accelerate the recovery of injured mouse hepatic tissue
Am J Transl Res. 2021 Mar 15;13(3):1904. eCollection 2021.ABSTRACT[This corrects the article on p. 5131 in vol. 12, PMID: 33042410.].PMID:33841718 | PMC:PMC8014404 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 12, 2021 Category: Research Authors: Chaoqun Hu Yun He Shuyu Fang Na Tian Mengjia Gong Xiaohui Xu Li Zhao Yi Wang Tong-Chuan He Yuanyuan Zhang Yang Bi Source Type: research