Effect of gangliosides combined with mouse NGF on the expression of serum HIF-1 α, NSE, and sICAM-1 levels in neonates with HIE
This study was intended to evaluate the effects of gangliosides combined with mouse nerve growth factor (NGF) on the expression of serum hypoxia-inducible factor-1α (HIF-1α), neuron-specific enolase (NSE), and soluble intercellular adhesion molecule-1 (sICAM-1) levels in neonates with ischemic-hypoxic encephalopathy (HIE).METHODS: One hundred and thirty neonates with HIE admitted to our hospital from May 2017 to April 2019 were grouped into two groups according to the protocol of a randomized controlled trial, with 65 cases in each group. The control group received ganglioside treatment, while the combined grou...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Wenling Ding Renchang Liu Ruobing Shan Source Type: research

The effects of hemodynamic monitoring using the PiCCO system on critically ill patients
Am J Transl Res. 2021 Sep 15;13(9):10578-10585. eCollection 2021.ABSTRACTOBJECTIVE: We aimed to evaluate the effects of hemodynamic monitoring using the pulse index continuous cardiac output (PiCCO) system with critically ill patients.METHODS: In total, 292 patients with primary physiological abnormalities of hypotension (n = 180) or hypoxemia (n = 112) were evaluated. The attending physicians completed a questionnaire before each catheterization. After each catheterization, the attending physicians reviewed each chart to determine the possibility of altering the therapy.RESULTS: In the hypotension subgroup, the attending ...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Chen Li Shupeng Wang Hui Wang Yina Wu Junyu Ma Wen Li Jun Duan Source Type: research

Effects of graded emergency nursing on resuscitation outcomes, prognosis, and nursing satisfaction in patients with acute myocardial infarction
This study was conducted to explore the effect of graded emergency nursing on the resuscitation outcomes, prognosis and nursing satisfaction of patients with acute myocardial infarction (AMI).METHOD: Ninety-five patients with AMI admitted to the emergency department of our hospital from May 2018 to May 2020 were enrolled as the study subjects and were randomly divided into the control group (n=47) and the experimental group (n=48). Patients in the control group received routine care, and patients in the experimental group received graded nursing. The two groups were compared in terms of resuscitation outcomes, prognosis an...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Qinqun Zhang Yilan Yu Source Type: research

Analysis of the application and efficacy of "Trinity" rehabilitation nursing in management of bronchial asthma
Am J Transl Res. 2021 Sep 15;13(9):10593-10598. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the application and clinical efficacy of "Trinity" nursing mode in bronchial asthma health management.METHODS: A total of 100 patients with bronchial asthma admitted to our hospital from June 2017 to June 2020 were divided into a reference group and a research group according to the order of admission (50 cases in each group). The reference group received conventional nursing, while the research group received "Trinity" nursing. The control of asthma, health literacy, hospitalization, treatment compliance ...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Zhen Wang Cuiyin Zhou Yun Guo Tong Zhou Chunxiang Zhou Haihong Gan Source Type: research

Analysis of poor prognostic factors of cerebral nerve after deep hypothermic circulatory arrest in patients with type A aortic dissection
Am J Transl Res. 2021 Sep 15;13(9):10599-10607. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the influences of deep hypothermic circulatory arrest (DHCA) on postoperative cranial nerve function in patients undergoing surgery for type A aortic dissection.METHODS: A total of 100 patients undergoing DHCA during the surgery for type A aortic dissection in our hospital were selected as the study subjects. After surgery, 32 patients with neurological complications were assigned to Group A, and 68 patients without neurological complications were assigned to Group B. The clinical outcomes were compared between the two groups...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Xinghua Peng Ganhua Zeng Yan Li Longren Cai Source Type: research

Effects of alteplase on neurological deficits and expression of GFAP and GAP-43 in brain tissue of rats with acute cerebral infarction
Am J Transl Res. 2021 Sep 15;13(9):10608-10616. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the effects of alteplase on neurological deficits, as well as on the expressions of glial fibrillary acidic protein (GFAP) and growth-associated protein-43 (GAP-43) in brain tissues of rats with acute cerebral infarction (ACI).METHODS: Sprague Dawley (SD) rats (n = 50) were enrolled in a trial to establish a ACI rat model; of these, 48 rats were succeeefully modeled and were randomized into either the model or alteplase group, whereas another 24 SD rats were included in the sham-operated group.FINDINGS: No significant differe...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Dongping Chen Shuhong Hou Yangui Chen Source Type: research

Analysis of polymorphonuclear cell apoptosis and inflammatory cytokines in trauma patients in the emergency department
CONCLUSION: Findings of laboratory tests targeting trauma patients who required hospitalization showed that levels of inflammatory cytokines such as TNF-α were increased in ICU-hospitalized patients. PMN cell apoptosis was reduced according to the initial laboratory data of patients with hemorrhagic shock in the emergency department.PMID:34650734 | PMC:PMC8507036 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Sung-Hyuk Choi Jung-Youn Kim Young-Hoon Yoon Source Type: research

Nursing countermeasures for VSD treatment of orthopedic trauma and infected wounds
This study intended to investigate the effect of vacuum sealing drainage (VSD) in the treatment of orthopedic trauma and its role in the clinical care.METHODS: A total of 104 patients with orthopedic trauma infection admitted to our hospital from January 2019 to January 2020 were divided into control group (n=53, receiving VSD) and study group (n=51, receiving VSD and nursing interventions) by random number table. Surgical outcomes, satisfaction, size of trauma and visual analogue scoring scale (VAS) scores were compared between the two groups.RESULTS: The study group had shorter time to achieve granulation tissue coverage...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Xin Xu Yanhua Sun Source Type: research

The effect of art therapy on reoccurring smoking among youths
Am J Transl Res. 2021 Sep 15;13(9):10633-10640. eCollection 2021.ABSTRACTOBJECTIVE: To evaluate the effect of art therapy on reoccurring smoking among youths.METHODS: A total of 114 smokers admitted to the smoking cessation clinic of our hospital were enrolled and randomly divided into the control group (n=61) and the study group (n=53). The control group was given health education intervention, and the study group was given art therapy intervention. The blood lipid level, symptom checklist score, lung function, and high-density lipoprotein cholesterol (HDL-C) and serum total cholesterol (TC) levels of different length of ...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Feiran Wang Ying Chen Siqi Li Source Type: research

Establishment and evaluation of a nomogram prediction model for recurrence risk of atrial fibrillation patients after radiofrequency ablation
Am J Transl Res. 2021 Sep 15;13(9):10641-10648. eCollection 2021.ABSTRACTOBJECTIVE: To explore the risk factors for recurrence of atrial fibrillation (AF) in patients after radiofrequency ablation and construction of a targeted nomogram prediction model.METHODS: A prospective cohort study design was used to select 312 patients who were separated into two groups; a recurrence group (n = 79) and a non-recurrence group (n = 233) with or without AF, who underwent radiofrequency ablation for the first time between January 2017 and December 2017, with a completed a 12-month follow-up after surgery. The recurrence of AF within 12...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Xiao-Juan Zhou Li-Xiang Zhang Jian Xu Hong-Jun Zhu Xia Chen Xue-Qi Wang Mei Zhao Source Type: research

Effects of bundled nursing combined with peer support on psychological state and self-efficacy of patients with cervical cancer undergoing chemotherapy
This study analyzed the effects of bundled nursing combined with peer support on psychological state and self-efficacy of cervical cancer patients undergoing chemotherapy.METHODS: A total of 86 patients with cervical cancer undergoing chemotherapy who were hospitalized from July 2019 to July 2020 were enrolled as study subjects. According to the method of a random number table, the selected patients were divided into a control group and an observation group and each group contained 43 patients. The control group was treated with bundled nursing care, while the observation group underwent combining treatment of both bundled...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Ling Tong Meng He Yongping Zou Zhenge Li Source Type: research

Clinical nursing pathway improves disease cognition and quality of life of elderly patients with hypertension and cerebral infarction
CONCLUSION: The application of clinical nursing pathway can improve the disease cognition and quality of life of elderly patients with hypertension and cerebral infarction, and promote their recovery.PMID:34650739 | PMC:PMC8506990 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Yingying Liao Tingting Ye Siying Liang Xiaoxiao Xu Yuncao Fan Xiaofang Ruan Mengjie Wu Source Type: research

The therapeutic effect of the digestive endoscopy tunneling technique on upper gastrointestinal muscularis propria tumors
Am J Transl Res. 2021 Sep 15;13(9):10663-10669. eCollection 2021.ABSTRACTOBJECTIVE: To analyze the therapeutic effect of digestive endoscopy tunneling technology on upper gastrointestinal muscularis propria tumors.METHODS: A total of 120 patients with upper gastrointestinal tumors in the muscularis propria treated in our hospital in the past two years were recruited as the study cohort. They were treated using the digestive endoscopic tunneling technique, specifically, endoscopic submucosal tunneling tumor resections, and their clinical data, surgical conditions, pathological results, incidences of complications (CR), and ...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Xu Zhang Xing Li Yajie Liu Fugang Liu Source Type: research

Predictive value of miR-374a-5p of peripheral blood mononuclear cells in deep venous thrombosis for elderly patients after total hip arthroplasty
This study analyzed the predictive value of peripheral blood mononuclear cells' (PBMCs) miR-374a-5p in deep vein thrombosis (DVT) after total hip arthroplasty in the elderly.METHODS: There was a total of 112 elderly patients that underwent elective total hip arthroplasty in our hospital and were enrolled as the research subjects. According to the color Doppler ultrasound of lower limbs 5 d postoperatively, subjectswere classified into thrombosis group (n=31) and non-thrombosis group (n=81). We detected the expression levels of miR-374a-5p in PBMCs and plasma D-dimer of the two groups of patients 1 d before surgery, and 1 d...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Jie Tang Chaoyi Li Pijun Zhang Wei Lin Yi Yang Source Type: research

Influences of Hiao's double-C nursing model combined with pain care on postoperative satisfaction with pain control and complications in patients with mixed hemorrhoids
Am J Transl Res. 2021 Sep 15;13(9):10676-10684. eCollection 2021.ABSTRACTOBJECTIVE: To explore the influences of Hiao's double-C nursing model combined with pain care on postoperative satisfaction with pain control and complications in patients with mixed hemorrhoids.METHODS: A total of 80 patients with mixed hemorrhoids admitted to our hospital from January 2019 to October 2020 were selected as the study subjects, and they were divided into a regular group (n = 43) and a combined group (n = 37) based on different nursing methods. The regular group was treated with routine nursing care, while the combined group was treated...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Shuhua Xu Jianwen Qiu Hongwei Zhang Jing Lu Weixin Huang Source Type: research

Effect of different depth of aspiration on patients without effective cough response
Am J Transl Res. 2021 Sep 15;13(9):10685-10693. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the nursing effect of deep or shallow sputum suction in the treatment of patients without cough response.METHODS: A total of 144 patients receiving mechanical ventilation without an effective cough reaction were randomly divided into two groups: deep suction group (n=73) and shallow suction group (n=71). Heart rate, breathing, blood pressure, analgesia and sedation score, residual sputum volume, frequency of suction, sputum volume, improvement of phlegm sound, airway bleeding and oxygen before and after intervention were obse...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Xiaozhen Li Xiuping Chai Sujuan Xu Yao Xu Source Type: research

Application of Guijiaosan Shenque acupoint paste can improve the scores of obesity, endocrine and TCM symptoms in treating obese polycystic ovary syndrome
CONCLUSION: The application of Guijiaosan paste at the Shenque acupoint can effectively improve the obesity and endocrine functions of obese patients with PCOS and improve their clinical symptoms, so it is worthy of clinical promotion.PMID:34650744 | PMC:PMC8506986 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Chao Shao Wei Dong Hong Zhang Source Type: research

Effects of targeted community healthcare on the prevention of thrombotic adverse events in patients with coronary heart disease under the guidance of behavior change theory
Am J Transl Res. 2021 Sep 15;13(9):10703-10711. eCollection 2021.ABSTRACTOBJECTIVE: To explore the effects of targeted community healthcare on the prevention of thrombotic adverse events in patients with coronary heart disease under the guidance of behavior change theory.METHODS: A total of 89 patients with coronary heart disease who were admitted to our hospital were selected prospectively as subjects and divided into a research group (n=45, receiving targeted community healthcare under the guidance of behavior change theory) and a control group (n=44, receiving regular community healthcare) using a random number table me...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Peipei Yu Xunying He Juan Chang Source Type: research

Value of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy to treat malignant peritoneal mesothelioma
CONCLUSION: CRS combined with HIPEC for MPM has a favorable treatment efficacy and prolongs the survival of MPM patients. Additionally, TNM stage, ECOG score, and treatment modality are independent risk factors for the prognosis of MPM patients.PMID:34650746 | PMC:PMC8506998 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Tongfei Wang Haitao Li Biaofei Ye Da Zhang Source Type: research

Effects of continuing nursing care under cognitive behavioral intervention on psychological state and living quality in patients with double J catheter after ureterolithiasis surgery
Am J Transl Res. 2021 Sep 15;13(9):10721-10728. eCollection 2021.ABSTRACTOBJECTIVE: The effects of continuing nursing care under cognitive behavioral intervention on the psychological state and living quality of patients with double J catheter after ureterolithiasis surgery were analyzed in this research.METHODS: The research subjects in this study were 142 patients who were discharged from our hospital with a double J tube after ureterolithiasis surgeries from June 2019 to June 2020. According to the patient care plan, the subjects were divided into the control group (n=71) and the observation group (n=71) and respectivel...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Nannan Mu Shuling Wu Hui Wang Shaona Chen Jiaxiang Lu Shaoqing Huang Xiaoli Fu Source Type: research

Efficacy and safety of coronary stent intervention for coronary heart disease and its impact on short-term and long-term prognosis
Am J Transl Res. 2021 Sep 15;13(9):10729-10736. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the effect of coronary stent intervention on the efficacy, safety, and short-term and long-term prognosis of patients with coronary heart disease (CHD).METHODS: From March 2016 to November 2017, 60 cases of CHD patients receiving coronary stent interventiontherapy (research group) and 42 cases of patients receiving conventional drug therapy (control group) in our hospital were recruited as research objects. The clinical efficacy, safety and prognosis in the two groups were compared, and the levels of matrix metalloproteinase-...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Ning Zhang Duhui Wei Source Type: research

Effect of 5A nursing mode combined with fine nursing management on perioperative self-efficacy and living quality of hysteromyoma
In this study, we investigated the effects of 5A nursing mode combined with fine nursing management on perioperative self-efficacy and living quality of hysteromyoma.METHODS: 116 hysteromyoma patients admitted to our hospital during August 2018 to August 2020 were enrolled as the research objects, and divided into control group and observation group by random-number-table method. Each group contained 58 cases. The control-group patients were treated with conventional basic nursing, while the observation-group patients received combined treatment of 5A nursing mode and fine nursing management. Subsequently, the changes of s...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Meng He Ling Tong Yongping Zou Zhenge Li Source Type: research

Applied research on confocal microscopy through focusing detection of tarsal glands shape following phacoemulsification for cataract
CONCLUSION: IVCM plays a vital role in the early diagnosis, in the severity grading, and in the evaluation of the clinical effectiveness of MGD-related diseases, by which the morphological changes of the tarsal gland after phacoemulsification can be observed in a timely manner to predict the occurrence of MGD.PMID:34650750 | PMC:PMC8507046 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Mengke Yuan Qin Zhang Libin Chang Source Type: research

A correlation study between nursing staff's knowledge level of hospice care and the psychology, emotion and attitude towards deaths
Am J Transl Res. 2021 Sep 15;13(9):10751-10757. eCollection 2021.ABSTRACTOBJECTIVE: We investigated the relationship between nursing staff's knowledge of hospice care and psychological states, including grief and attitude towards death.METHODS: From October 2018 to December 2018, a total of 1900 professional nursing staff of secondary and tertiary levels in Qinghai Province were chosen as the research subjects. Professional questionnaires were used to evaluate their knowledge level of Hospice Care (HC), psychological states, grief and attitude towards death, while the correlation between HC knowledge level and the latter t...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Mingqin Luo Shiqin Pan Jianzhi Xie Yuemei Li Source Type: research

Nursing effect of Nasoscopically assisted nasogastri tube and nasojejunal tube placement
Am J Transl Res. 2021 Sep 15;13(9):10758-10764. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the nursing effect of nasoscopically assisted nasogastri tube and nasojejunal tube placement.METHODS: 94 patients who need to place nasogastric tube and nasojejunal tube to establish enteral nutrition were randomly divided into two groups: the observation group (n=49) and control group (n=45). The patients in the observation group received nasogastric tube placement and jejunal nutrition tube placement, and the patients in the control group received general gastroscope and placed gastric tube and jejunal nutrition tube throug...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Bing Lu Aihong Xu Jun Li Zhiyu Xu Haiping Li Zhongyan Zhao Source Type: research

Prevention of deep venous thrombosis in patients undergoing knee arthroplasty by intermittent pneumatic compression apparatus
This study discussed and analyzed the preventive value of intermittent pneumatic compression combined with early rehabilitation training for deep vein thrombosis (DVT) in patients undergoing total knee arthroplasty (TKA).METHODS: During January 2019 to April 2020, 85 patients who underwent TKA in our hospital were selected as subjects, and were randomly divided into an observation group (n=44) and control group (n=41) by table of random numbers. The control group patients received conventional nursing care after TKA surgery, while the observation group received combinative treatment of intermittent pneumatic compression th...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Shengying Wang Haiying Lu Shuangling Li Source Type: research

Combination of color Doppler ultrasound and CT for diagnosing breast cancer
Am J Transl Res. 2021 Sep 15;13(9):10771-10776. eCollection 2021.ABSTRACTOBJECTIVE: This research aimed to estimate the diagnostic value of the combination of color Doppler ultrasound (CDU) and computed tomography (CT) in breast cancer (BC).METHODS: Among the 90 BC patients treated in our hospital from May 2018 to December 2020, 43 were examined by CDU before surgery and they served as the control group (CG), while the other 47 were examined with CDU and CT and were considered as the research group (RG). Lesions were confirmed as BC by postoperative pathological examination. The diagnosis rate for BC in the two groups was ...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Ruquan Wen Jianjun Dong Yan Wang Lei Wang Source Type: research

Failure mode and effects analysis on the control effect of multi-drug-resistant bacteria in ICU patients
CONCLUSION: Through the application of FMEA to prevent MDR bacterial infection in ICU patients, nursing staff can accurately pay attention to the keynotes in nursing process, and as such reduce the proportion and mortality of MDR infection in ICU patients and promote the patients' satisfaction with nursing, which are all worthy of clinical application.PMID:34650755 | PMC:PMC8507006 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Lixia Lin Rui Wang Taiming Chen Jing Deng Yujuan Niu Min Wang Source Type: research

The effects of specialized emergency and intensive nursing team on arterial blood gas and pulmonary function in pulmonary infection with respiratory failure
Am J Transl Res. 2021 Sep 15;13(9):10785-10792. eCollection 2021.ABSTRACTOBJECTIVE: To investigate effects of specialized emergency and intensive nursing team on arterial blood gas and pulmonary function in pulmonary infected patients with respiratory failure.METHODS: 126 patients with pulmonary infection and respiratory failure admitted to our hospital were chosen and randomly divided into observation group and control group, with 63 cases in each group. The control-group received specialized routine nursing care, and the observation-group was treated with the emergency and intensive nursing care. Subsequently, the arteri...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Hong Zou Xiaoping Wang Ling Liu Chunyan Zhang Dapeng Ren Source Type: research

Effect of standardized enteral nutrition on AECOPD patients with respiratory failure
Am J Transl Res. 2021 Sep 15;13(9):10793-10800. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the effects of standardized enteral nutrition (EN) on nutritional indicators and immunological functioning of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients with respiratory failure.METHODS: We selected 92 cases of AECOPD patients with respiratory failure as the research objects, and classified them into two groups (control/observation group, n=46 respectively) according to random number table. Both groups were given conventional anti-infection and symptomatic treatment. In addition, the contro...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Chunyan Zhang Dapeng Ren Chifen Ouyang Qinqin Wang Ling Liu Hong Zou Source Type: research

Nursing effect of continuous blood purification therapy in treatment of severe sepsis
Am J Transl Res. 2021 Sep 15;13(9):10801-10808. eCollection 2021.ABSTRACTOBJECTIVE: To explore the nursing effect of continuous blood purification therapy in the treatment of severe sepsis patients.METHODS: A total of 142 patients with severe sepsis in our hospital were divided into two groups, 70 patients in the experimental group who received an optimize nursing plan, while 72 patients in the control group were given routine nursing intervention. The SF-36 questionnaire, nursing satisfaction and serious adverse events and complications were collected.RESULTS: The nursing intervention effect of the two groups after interv...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Rui Wang Lixia Lin Qunying Zhu Yujuan Niu Min Wang Taiming Chen Source Type: research

Effect of thalidomide combined with TP chemotherapy on serum VEGF and NRP-1 levels advanced esophageal cancer patients
This study aimed to investigate the effect of thalidomide combined with pacilitaxel plus cisplatin (TP) chemotherapy on serum vascular endothelial growth factor (VEGF) and neuropilin-1 (NRP-1) levels in advanced esophageal cancer patients.METHOD: A total of 133 patients with advanced esophageal cancer receiving treatment in Danzhou People's Hospital from February 2017 to July 2019 were recruited and divided into a control group (CG, n = 53) and a study group (SG, n = 80) randomly. Patients in the CG (53 cases) were treated with TP chemotherapy, and patients in the SG (80 cases) were treated with thalidomide on the basis ab...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Wenhong Zheng Lijuan Fu Source Type: research

Clinical efficacy of tanshinone capsules combined with varying concentrations of 5-ALA-PDT in the treatment of cystic acne
Am J Transl Res. 2021 Sep 15;13(9):10816-10822. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the clinical effectiveness and safety of tanshinone capsules combined with varying concentrations of 5-aminoketovaleric acid photodynamic therapy (5-ALA-PDT) in the treatment of cystic acne.METHODS: A total of 97 patients with cystic acne treated in our hospital were enrolled in the study and divided into group A (n = 34, tanshinone capsules combined with 5% 5-ALA-PDT), group B (n = 31, tanshinone capsules combined with 7.5% 5-ALA-PDT), and group C (n = 32, tanshinone capsules combined with 10% 5-ALA-PDT). The number of skin ...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Yan Yao Jing Zuo Li Chen Source Type: research

The effects of alprostadil combined with α-lipoic acid in the treatment of senile diabetic nephropathy
This study aimed to investigate the clinical efficacy of alprostadil combined with α-Lipoic acid (α-LA) in the treatment of senile diabetic nephropathy (SDN) and the combination's effect on the serum chemerin and neutrophil gelatinase-associated lipocalin (NGAL) expressions.METHODS: Seventy-six patients with diabetic nephropathy (DN) admitted to our hospital from March 2018 to October 2019 were recruited as the research cohort. Among them, 36 patients who were administered alprostadil monotherapy were placed in the control group (CG), and the remaining 40 patients administered α-LA in addition to the alpr...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Xiaohong Cao Ping Chen Source Type: research

The correlation between high-risk HPV infection and precancerous lesions and cervical cancer
CONCLUSION: The distribution of HPV subtypes in cervical cancer is closely related to the pathological types, lesion grades, and stages of cervical cancer. The incidence of cervical lesions varies with age, suggesting that high-risk groups should be well monitored and receive regular screening and timely HPV vaccination to effectively prevent cervical cancer.PMID:34650762 | PMC:PMC8507010 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Xiangwei Ma Ming Yang Source Type: research

Intermittent pneumatic compression (IPC) combined with an electric stimulator in the prevention of venous thromboembolism in stroke patients
Am J Transl Res. 2021 Sep 15;13(9):10837-10842. eCollection 2021.ABSTRACTOBJECTIVE: To explore the clinical value of intermittent pneumatic compression (IPC) combined with an electric stimulator in the prevention of venous thromboembolism in stroke patients.METHODS: 58 stroke patients with hemiplegia admitted to the Department of Neurology in our hospital were recruited as the study cohort and randomly placed into a control group or an observation group, with 29 patients in each group. The control group was administered routine care and IPC, and the observation group was administered electric stimulation in addition to the...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Xiao Chen Yafei Wang Rufu Jia Yusen Du Haiyun Wu Tingting Wang Guimei Yin Lijun Jin Source Type: research

Clinical effect of Chinese herbal medicine for removing blood stasis combined with acupuncture on sequelae of cerebral infarction
Am J Transl Res. 2021 Sep 15;13(9):10843-10849. eCollection 2021.ABSTRACTOBJECTIVE: To assess the clinical efficacy of Chinese herbal medicine for removing blood stasis combined with acupuncture in the treatment of sequelae of cerebral infarction.METHODS: Ninety patients with cerebral infarction admitted to our hospital from April 2018 to April 2020 were enrolled and equally allocated to an experimental group and a control group. The control group was treated with aspirin, and the experimental group was treated with Chinese herbal medicine for removing blood stasis combined with acupuncture. The recovery of the ability of ...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Jilin Yan Yu Dong Lihui Niu Jing Cai Lili Jiang Congmin Wang Jijun Xing Source Type: research

Flexor carpi radialis brevis muscle, a rare anomalous muscle of the forearm; a case report and literature review
Am J Transl Res. 2021 Sep 15;13(9):10850-10855. eCollection 2021.ABSTRACTThe flexor carpi radialis brevis (FCRB) is a rare abnormal muscle of the distal forearm or wrist. Its incidence varies in different reports, which oscillating between 2-8%. This paper reports a case of FCRB found in the anatomy of the forearm. The abnormal muscle, which started from the facies volaris distal radii, occupies the terminus of pronator quadratus, and was observed with dysplasia in the pronator quadratus. We also reviewed the literature on FCRB anatomy, especially the surgical exposure of distal radius fractures and the clinical symptoms c...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Cong Xiao Zhixiang Gao Shaoyun Zhang Nengji Long Wei Yu Yishan Jiang Source Type: research

Expression of c-MET, EGFR and HER-2 in gastric adenocarcinoma tissue and its relationship with clinicopathological characteristics
Am J Transl Res. 2021 Sep 15;13(9):10856-10862. eCollection 2021.ABSTRACTOBJECTIVE: To determine the expression of tyrosine protein kinase Met (c-MET), epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER-2) in cases with gastric adenocarcinoma (GA).METHODS: The positive rates of the c-MET, EGFR, and HER-2 proteins between cancerous tissues and normal tissues sampled from 87 patients with GA were compared. The patients were assigned to different subgroups according to their clinicopathological characteristics and analyzed. Then the relationship between the above three indexes and the p...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Jing Wang Shoufeng Wang Jilei Sun Lanlan Qiu Source Type: research

Comparison of pyrotinib or lapatinib with chemotherapy for patients with HER2 positive breast cancer after first-line treatment failure: a retrospective study
Am J Transl Res. 2021 Sep 15;13(9):10863-10870. eCollection 2021.ABSTRACTOBJECTIVE: To explore the difference in efficacy and safety of pyrotinib or lapatinib combined with chemotherapy in human epidermal growth factor receptor-2 (HER-2) positive breast cancer patients who failed the first-line trastuzumab-containing treatment.METHODS: The present retrospective study included 164 HER-2 positive breast cancer patients admitted to our hospital. Among them, 68 cases received pyrotinib combined with chemotherapy after the failure of trastuzumab first-line treatment (pyrotinib group), and the other 96 cases received lapatinib c...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Huihui Yang Wei Wang Source Type: research

Analysis of < em > CYP2J2 < /em > mutations in the Chinese Uyghur population
Am J Transl Res. 2021 Sep 15;13(9):10871-10881. eCollection 2021.ABSTRACTGenetic characteristics of CYP2J2 in different populations may be helpful to explore interethnic variability in drug response and disease susceptibility. There is no information about the genetic profile of CYP2J2 in the Chinese Uyghur population. We used PCR and first-generation sequencing technology to investigate CYP2J2 mutations in 100 unrelated healthy Chinese Uyghurs. The chi-square test was used to compare genotyping data of CYP2J2 in the Chinese Uyghur population with other ethnic groups. The SIFT and PolyPhen-2 online tools were used to predi...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Haiyue Li Yongjun He Li Wang Shishi Xing Linna Peng Dongya Yuan Tianbo Jin Source Type: research

Value of ST-T changes and heart rate variability in pulmonary heart disease during 24 h dynamic electrocardiography examination
This study was designed to analyze the value of 24 h dynamic electrocardiography (DCG) examination in the diagnosis of pulmonary heart disease (PHD).METHODS: Ninety cases of patients with PHD were included as the observation group, and 50 cases of healthy patients were enrolled as the healthy group. Both groups received DCG examination.RESULTS: The proportion of ST depression and elevation as well as the magnitude and duration of ST depression differed significantly between the observation and healthy group (P
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Hairong Ye Dandan Qiu Feng Jia Source Type: research

Unexpected intradural disc herniation instead of space-occupying tumor at L3-L4 level: a case report and literature review
CONCLUSION: IDH has a low incidence and is sporadically reported. Misdiagnosis is very common preoperatively as well as intraoperatively. IDH usually develops more rapidly compared with intradural tumors. Adhesion between dura mater and posterior longitudinal ligament may play a critical role in the disease onset.PMID:34650770 | PMC:PMC8506989 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Yangyi Yu Zhong Yang Yucheng Xiang Yong Wan Hongtao Jin Pengjie Fan Guangheng Li Guoyong Gao Source Type: research

LncRNA GAS5 enhances radiosensitivity of hepatocellular carcinoma and restricts tumor growth and metastasis by miR-144-5p/ATF2
CONCLUSION: Overexpression of GAS5 upregulates ATF2 through miR-144-5p and is able to enhance the radiosensitivity of HCC.PMID:34650771 | PMC:PMC8506991 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Chuanyun Yu Yi Liang Yiqiang Jin Qinghuan Li Source Type: research

Baicalin promotes chondrocyte viability and the synthesis of extracellular matrix through TGF- β/Smad3 pathway in chondrocytes
CONCLUSION: BA promotes chondrocyte viability and the cell matrix synthesis through TGF-β/Smad3 pathway in IL-1β-treated chondrocytes and DMM treated mice. BA is a potential therapeutic target for OA.PMID:34650772 | PMC:PMC8507001 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Pengzhen Wang Jian Liu Shaoheng Zhang Pingping Zhu Xifeng Xiong Chaosheng Yu Aiguo Li Zhihe Liu Source Type: research

A crucial role for the long non-coding RNA < em > CASC11 < /em > in the pathogenesis of human cancers
Am J Transl Res. 2021 Sep 15;13(9):10922-10932. eCollection 2021.ABSTRACTLong non-coding RNAs (lncRNAs) are non-coding RNAs more than 200 nucleotides in length. Although they do not encode proteins, lncRNAs can regulate gene expression at the transcriptional, post-transcriptional, and epigenetic levels. Emerging data show that lncRNAs are important for tumorigenesis and cancer progression. Cancer susceptibility candidate 11 (CASC11) is a prominent lncRNA that is upregulated in various types of cancers. Moreover, its overexpression correlates with larger tumor size, more advanced cancer stages, cancer metastasis, and poor o...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Lian Zheng Zhenjie Guan Miaomiao Xue Source Type: research

Influence of epidural anesthesia and general anesthesia on thromboembolism in patients undergoing total knee arthroplasty
CONCLUSION: Epidural anesthesia can improve blood coagulation and cognitive function in patients undergoing TKA and reduce the incidence of DVT and the degree of postoperative pain.PMID:34650774 | PMC:PMC8507049 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Dongzhi Liu Chengliang Sun Xiuli Zhang Zhibin Zhao Source Type: research

Study on effects of care bundles on patients with severe pneumonia complicated with respiratory failure
This study was designed to determine the effects of care bundles on patients with severe pneumonia complicated with respiratory failure and to discuss the adverse reaction rate in prognosis.METHODS: A total of 64 patients with both severe pneumonia and respiratory failure admitted to the intensive care unit (ICU) of our hospital from January 2019 to December 2020 were enrolled as research objects. These patients were equally divided into a control group and an experimental group in a random manner. The experimental group was given care bundles, while the control group was given conventional nursing. Then the nursing effect...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Tingting Xiao Fang Chen Zhengmin Wan Source Type: research

The cardioprotective effect of the sodium-glucose cotransporter 2 inhibitor dapagliflozin in rats with isoproterenol-induced cardiomyopathy
This study was designed to investigate the effects of SGLT2i dapagliflozin (dapa) on cardiomyopathy induced by isoproterenol (ISO) and its potential mechanisms. Fifty male Sprague Dawley rats were randomly assigned to the control (n=10) and the ISO (2.5 mg/kg/day)-treated groups (n=40). After 2 weeks, the 28 surviving rats with obvious left ventricular dysfunction in the ISO group were randomized into three medication groups, including the angiotensin receptor neprilysin inhibitor (ARNI) sacubitril/valsartan group (S/V, n=9), the dapa group (n=9), and the ISO group (n=10) for 4 weeks. Next, electrical programmed stimulatio...
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: Fang-Zheng Wang Wen-Bo Wei Xin Li Jun-Yu Huo Wan-Ying Jiang Hong-Yu Wang Pei Qian Zhen-Zhen Li Ye-Bo Zhou Source Type: research

Comment on effects of botulinum toxin type A on mood and cognitive function in patients with Parkinson's disease and depression
Am J Transl Res. 2021 Sep 15;13(9):10962-10963. eCollection 2021.NO ABSTRACTPMID:34650777 | PMC:PMC8507031 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - October 15, 2021 Category: Research Authors: M Axel Wollmer Tillmann H C Kr üger Source Type: research