Ipratropium bromide and noninvasive ventilation treatment for COPD
CONCLUSION: Ipratropium bromide combined with noninvasive ventilation is effective in the treatment of patients with both COPD and respiratory failure.PMID:35702113 | PMC:PMC9185084 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Sheng Lin Xiaoqin Li Baosong Xie Wenxiang Yue Xiujuan Yao Ming Lin Source Type: research

Aneurysmal bone cyst secondary to giant cell tumor of the extremities: a case series of 30 patients
Am J Transl Res. 2022 May 15;14(5):3198-3206. eCollection 2022.ABSTRACTThe purpose was to investigate the clinical features, diagnosis, treatment, and prognosis of aneurysmal bone cyst (ABC) secondary to giant cell tumors (GCT) of the extremities. Data from patients with ABC secondary to GCT of the extremities were obtained from the medical records. Clinical features, imaging findings, pathologic diagnosis, surgical methods, and prognosis were analyzed. The median age of the patients was 33 years (range 15 to 52 years) and 83.3 percent were between 20 to 40 years. The lesions were mainly located in the proximal tibia and d...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Huijiang Liu Dehuai Liu Xiaohong Jiang Zhaojie Qin Dingkang Lv Dihua Meng Yun Liu Haijun Tang Xinli Zhan Source Type: research

Successful treatment of symptomatic facet joint synovial cysts using C-arm fluoroscopy-guided percutaneous aspiration: report of two cases
Am J Transl Res. 2022 May 15;14(5):3547-3553. eCollection 2022.ABSTRACTLumbar facet-joint synovial cysts are an important cause of back pain and radiculopathy. Treatment options for facet-joint synovial cysts include surgical excision, facet-joint steroid injections, and facet-joint cyst aspiration. Although percutaneous facet-joint synovial cyst aspiration is an effective and minimally invasive procedure for treating patients with symptomatic facet-joint synovial cysts, its success rate is known to be low. Here, we report out experience with treating two men using this approach. The men presented with back pain or radicul...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Hyeon Tae Kim Jung Hee Choi Young Duck Shin Tae Yul Kim Joo Yong Lee Source Type: research

Integrated analysis reveals prognostic value and mesenchymal identity suppression by glycoprotein M6B in glioma
In this study, we analyzed the clinical and molecular characteristics of GPM6B using RNA sequencing data of glioma samples from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) datasets. Quantitative real-time PCR (qRT-PCR), western blot (WB), and immunohistochemistry (IHC) were performed for further validation. Moreover, a neurosphere formation assay, extreme limiting dilution assay, and bioluminescent imaging were employed to validate the therapeutic effects targeted on GPM6B in vitro and in vivo. We found lower expression of GPM6B in aggressive glioma. Receiver operating characteristic (ROC) ana...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Zong Miao Liangyuan Geng Lei Xu Yangfan Ye Chao Wu Wei Tian Ning Liu Source Type: research

Characteristics of bile microbiota in cholelithiasis, perihilar cholangiocarcinoma, distal cholangiocarcinoma, and pancreatic cancer
This study retrospectively analyzed the differences in biliary microbes among patients with perihilar cholangiocarcinoma (pCCA), distal cholangiocarcinoma (dCCA), pancreatic cancer (PC), and cholelithiasis (CH). Bile samples were obtained from 53 patients who underwent endoscopic retrograde cholangiopancreatography (ERCP), and the bile microbiota was analyzed through 16S rRNA gene analysis and next-generation sequencing. Based on the results of linear discriminant analysis effect size (LEfSe), the top three biomarkers for pCCA at the genus level were Pseudomonas, Sphingomonas, and Halomonas; for dCCA were Streptococcus, Pr...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Zhengqi Li Jiangtao Chu Feixiong Su Xuan Ding Yueming Zhang Lizhou Dou Yong Liu Yan Ke Xudong Liu Yumeng Liu Guiqi Wang Linheng Wang Shun He Source Type: research

Dynamic transcriptome landscape of pulmonary tissues of rats infected with < em > Paragonimus proliferus < /em >
Am J Transl Res. 2022 May 15;14(5):3395-3406. eCollection 2022.ABSTRACTParagonimiasis (pulmonary fluke disease) is a foodborne parasitic disease caused by trematode infections. Paragonimus proliferus is a characteristic Paragonimus species that was first identified in Yunnan Province of China. No direct evidence has yet proven that P. proliferus can infect humans. However, we previously found that P. proliferus infects and damages rat lung tissues via an unclear mechanism. Here, we infected Sprague Dawley rats with P. proliferus and sequenced their lung transcriptomes at various intervals thereafter. We detected P. prolife...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Guoji Chang Na Li Qingqing Wang Jie Ding Siqi Liu Lijuan Hua Shenghao Li Wenlin Wang Source Type: research

Expression of CD147 after neoadjuvant chemotherapy and its relationship with prognosis in patients with triple negative breast cancer
CONCLUSION: CD147 can promote the proliferation and invasion of breast cancer cells, which underlines its value in the diagnosis and treatment of TNBC.PMID:35702119 | PMC:PMC9185091 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Wei Zhang Hui Liu Junjie Jiang Yunyun Yang Wenjie Wang Zhengyan Jia Source Type: research

Social characterization of COVID-19 in the state of Amazonas, Brazil
CONCLUSIONS: The national drop in deaths from diseases not associated with COVID between March and August 2020 in Brazil is misleading and may be due to the result of misreported causes of death.PMID:35702120 | PMC:PMC9185070 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Zanair Soares Vasconcelos Eleine Weimann Fabiola Estefany Botelho de Lima C ésar Rogério da Silva Gonçalves Eliane Carvalho Dos Santos Alba Regina Jorge Brand ão Katia Nascimento Couceiro Adriano Gomes da Silva Jorge Augusto de Oliveira Guerra Maria d Source Type: research

The effect of cold therapy combined with ERAS in the postoperative care of patients undergoing total knee arthroplasty
CONCLUSION: The cold therapy combined with ERAS for patients undergoing TKA can improve the postoperative swelling and pain of the affected limb, inspire patients' autonomy in postoperative rehabilitation training, shorten the time to out-of-bed activity, prevent patients from developing venous thrombosis, promote recovery of knee function, and improve patients' postoperative self-care ability and quality of life.PMID:35702121 | PMC:PMC9185063 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Xinli Liao Xin Xu Source Type: research

Biomechanics of the unilateral posterosuperior, unipedicular, and bipedicular approaches for treatment by percutaneous vertebroplasty: a comparative study
This study compared the biomechanical performance of a single vertebral body after PVP by the unilateral posterosuperior, unipedicular, and bipedicular approaches. Twenty-one vertebral bodies from the osteoporotic spine segments (T11-L1) of seven older female cadavers were randomly assigned to the unipedicular (group A), bipedicular (group B), or unilateral posterosuperior approach group (group C). After constructing the fracture compression model, PVP was performed by the different approaches. CT scans showed symmetrical, evenly distributed bone cement in groups B and C and unilaterally distributed cement in group A. The ...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Chenxi Gu Anquan Huang Yefeng Wang Dongzhu Liang Peidong Sun Zhenfeng Zhang Xiaoqiang Cai Jun Shen Jun Ou-Yang Tianming Zou Xiao Yu Source Type: research

BMI1 governs the maintenance of mouse GC-2 cells through epigenetic repression of < em > Foxl1 < /em > transcription
CONCLUSIONS: Collectively, our study revealed for the first time the existence of an epigenetic mechanism involving BMI1-mediated gene silencing in GC-2 cells development and provided potential targets for the treatment of male infertility.PMID:35702123 | PMC:PMC9185053 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Bo Zheng Juanjuan Liu Xiaodan Shi Jinfu Xu Ke Zhang Hui Zhou Tiantian Wu Xiaoyan Huang Cong Shen Yuting Liang Dan Zhao Yueshuai Guo Source Type: research

Predictive value of NT-proBNP, procalcitonin and CVP in patients with new-onset postoperative atrial fibrillation after cardiac surgery
CONCLUSION: NT-proBNP, procalcitonin and CVP were closely related with atrial fibrillation after cardiac surgery. The combination of NT-proBNP, procalcitonin and CVP had a better discriminative ability for new atrial fibrillation after cardiac surgery compared to either of them alone.PMID:35702124 | PMC:PMC9185093 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Zhiwei Xu Long Qian Lijuan Zhang Yang Gao Su Huang Source Type: research

Single nucleotide polymorphism array in genetic evaluation of fetal ultrasound abnormalities: a retrospective follow-up study
Am J Transl Res. 2022 May 15;14(5):3516-3524. eCollection 2022.ABSTRACTFetal ultrasound abnormalities may be complicated by cognitive dysfunction or developmental retardation, and ultrasonography cannot detect these problems; therefore, chromosome detection is required in fetuses with ultrasound abnormalities. To examine the effectiveness of single nucleotide polymorphism (SNP) array in genetic diagnosis of fetal ultrasound abnormalities, the prenatal samples of 805 pregnant women with fetal ultrasound abnormalities were collected for SNP array and karyotyping analysis. A 95.5% percentage of normal karyotypes and 4.5% perc...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Hailong Huang Meiying Cai Huili Xue Liangpu Xu Na Lin Source Type: research

IL-4 and CCR7 play an important role in the development of keloids in patients with a family history
CONCLUSION: Having a family history of keloids is a risk factor for increased severity of keloids. IL-4 and CCR7 play an important role in the development of keloids in patients with a family history of the condition and may represent new targets for the treatment of keloids.PMID:35702126 | PMC:PMC9185030 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Mengjie Shan Hao Liu Yan Hao Tian Meng Cheng Feng Kexin Song Youbin Wang Source Type: research

Effect of liraglutide combined with metformin or acarbose on glucose control in type 2 diabetes mellitus and risk factors of gastrointestinal adverse reactions
CONCLUSION: Compared with liraglutide and acarbose, liraglutide and metformin has better glucose control effect in T2DM. Although there is no obvious difference in eliminating inflammation, liraglutide combined with acarbose will increase the incidence of gastrointestinal adverse reactions in patients. So, liraglutide combined with metformin is recommended for T2DM treatment.PMID:35702127 | PMC:PMC9185051 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Gaofei Ren Xiaojun Ma Pengfei Jiao Source Type: research