American Journal of Translational Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Obesity attenuates the beneficial effect of an intrauterine infusion of autologous platelet-rich plasma during in vitro fertilization
CONCLUSION: PRP improved embryo implantation and clinical pregnancy rates; however, these beneficial effects were attenuated by obesity. PRP presumptively promoted a change in the uterine environment to mimic the normal findings associated with normal-weight women.PMID:38586113 | PMC:PMC10994790 | DOI:10.62347/RDXA5841 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Dinorah Hern ández-Melchor H éctor Carrillo Alfredo Mart ín Rivera Leonardo M Porchia Priscila M Bartolo-G ómez Jazm ín Martínez Am érica Padilla-Viveros Martha Elba Gonzalez-Mej ía Esther L ópez-Bayghen Source Type: research

Human immunoglobulin in combination with antimicrobial agents enhances the treatment efficacy and reduces inflammatory response in children with severe pneumonia
CONCLUSION: The combination of human immunoglobulin and antibiotics for the treatment of pediatric severe pneumonia is beneficial, because it improves efficacy, boosts the immune system, and reduces inflammation.PMID:38586114 | PMC:PMC10994785 | DOI:10.62347/KQUW5330 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Wenli Zhang Yue Jin Source Type: research

Decoding the DSCC1 gene as a pan-cancer biomarker in human cancers via comprehensive multi-omics analyses
CONCLUSION: Overall, this study provides comprehensive insights into the pivotal role of DSCC1 in KIRP, LIHC, and LUAD initiation, progression, and therapeutic responsiveness, laying the foundation for further investigations and personalized treatment strategies.PMID:38586115 | PMC:PMC10994803 | DOI:10.62347/YORR3755 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Jingru Wang Sana Fatima Gilani Nazia Noor Muhammad Rashid Ahmed Mehmooda Munazir Ayesha Zubair Rizwana Sultan Mostafa A Abdel-Maksoud Ibrahim A Saleh Naser Zomot Ahmad S Kodous Shebl Salah Ibrahim Mohamed A El-Tayeb Mohammed Aufy Mohamed Y Zaky Syed Sairu Source Type: research

Exploration of the molecular mechanism guiding Xinfeng capsule regulatory mechanism for rheumatoid arthritis inflammation
CONCLUSIONS: XFC could effectively improve the clinical inflammatory indexes of RA. The active ingredients of XFC improved the inflammatory state of RA by regulating the TLR-signaling pathway.PMID:38586085 | PMC:PMC10994809 | DOI:10.62347/TPOQ4910 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Ziheng Zhu Lei Wan Source Type: research

Effects of the novel sodium-dependent phosphate cotransporter 2b inhibitor DZ1462 on hyperphosphatemia in chronic kidney disease
CONCLUSIONS: This study revealed that a GI-restricted NPT2b inhibitor DZ1462 potently inhibits NPT2b in vitro and blocks intestinal phosphate uptake in multiple animal models with potential to reduce various cardiovascular events in CKD models. Therefore, DZ1462 may be useful to treat renal disease patients who have shown an unsatisfactory response to phosphate binders.PMID:38586086 | PMC:PMC10994808 | DOI:10.62347/UGTW5471 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Xiao Lu Ling-Zhi Yu Qiu-Li Guo Lin Zhang Shan-Xiang Jiang Source Type: research

Effects of multidisciplinary team continuous care model on psychological behavior and quality of life in children with β-thalassemia major
CONCLUSION: The MDT continuous care model can effectively promote mental health in children with β-TM, improve their quality of life, medical satisfaction, ameliorate the degree of anemia in children, reduce the incidence of complications and improve the prognosis; thus, it is worthy of wide clinical application.PMID:38586087 | PMC:PMC10994799 | DOI:10.62347/OBWD7382 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Xiuping Huang Jian Lu Rongxian Huang Qingmei Lu Yanni Luo Xiaoxiao Huang Liqiao An Yuke Chen Source Type: research

Electroacupuncture protects the intestinal mucosal barrier in diarrhea-predominant Irritable Bowel Syndrome rats by regulating the MCs/Tryptase/PAR-2/MLCK pathway
CONCLUSION: EA has a good therapeutic effect on IBS-D rats. Regulating the MCs/Tryptase/PAR-2/MLCK pathway may be a mechanism to protect the intestinal mucosal barrier.PMID:38586088 | PMC:PMC10994796 | DOI:10.62347/VZJL1218 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Xiao-Yu Han Xiao-Ge Song Wen-Li Ma Ming Fang Jing-Wei Zhu Jing-Ru Ruan Kui-Wu Li Ling Zou Lu-Min Liao Xiao-Min Li Zi-Ye Wang Yu-Cheng Fang Hao-Ran Chu Source Type: research

Artificial intelligence in cardiology: a bibliometric study
CONCLUSIONS: Enhancing cooperation between different countries and institutions is a critical step in leading to breakthroughs in the application of AI in cardiology. It is foreseeable that the application of machine learning and deep learning in various areas of cardiology will be a research priority in the coming years.PMID:38586089 | PMC:PMC10994793 | DOI:10.62347/HSFE6936 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Yalan Zhang Jingwen Xie Enlong Fu Wan Cai Wentan Xu Source Type: research

Thorough examination of the potential biological implications of the cuproptosis-related gene LIPT2 in the prognosis and immunotherapy in pan-cancer
CONCLUSION: Overall, our study highlights LIPT2 as a versatile player in cancer, influencing diverse aspects from molecular processes to clinical outcomes across different cancer types.PMID:38586090 | PMC:PMC10994786 | DOI:10.62347/QNNE5428 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Mi Luo Abdul Rehman Soha Haque Saba Izhar Fauzia Perveen Muhammad Haris Mostafa A Abdel-Maksoud Ibrahim A Saleh Naser Zomot Abdul Malik Abdulaziz Alamri Ahmad S Kodous Mohammed Aufy Mohamed Y Zaky Muhammad Zaeem Yasir Hameed Junwei Li Source Type: research

Serum monocyte chemotactic protein 1 and soluble mannose receptor aid predictive diagnosis of pediatric sepsis
CONCLUSIONS: Serum sMR and MCP-1 levels can help predict the diagnosis of pediatric sepsis.PMID:38586091 | PMC:PMC10994783 | DOI:10.62347/FZMM3162 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Danyang Song Xiurong Zheng Source Type: research

Significant enhancement of swallowing function and oral hygiene following multidisciplinary team nursing in tongue cancer patients after radical resection
CONCLUSION: MDT nursing have a positive impact on oral hygiene as well as the swallowing function of patients after radical resection of TC, and MDT is a protective factor for swallowing function in the patients after radical resection.PMID:38586092 | PMC:PMC10994800 | DOI:10.62347/TQFJ8242 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Lan Xiao Xie Yu Miao He Yi Men Source Type: research

Changes in TNF- α, IL-33, and MIP-1α before and after artificial liver support treatment and their prognostic value
CONCLUSION: ALST can significantly reduce TNF-α, IL-33, and MIP-1α levels in patients with ACLF, and postoperative TNF-α, IL-33, and MIP-1α levels have a high predictive value for patients' prognosis.PMID:38586093 | PMC:PMC10994792 | DOI:10.62347/CBKR4894 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Jian Zhou Zhengmao Yang Xiaoqing Yang Zhaoxun Wang Source Type: research

Clinical value of ultrasound parameters PI, TTP, and MTT in assessing cervical lymph node metastasis of papillary thyroid carcinoma
CONCLUSION: PI, TTP, and MTT all decrease in PTC patients with CLNM, and TTP has a strong predictor for CLNM in them, with an AUC of 0.855.PMID:38586094 | PMC:PMC10994806 | DOI:10.62347/QWDR4613 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Qingfeng Kong Yangping Yu Qian Qian Hongjun Sun Source Type: research

Targeting super-enhancer activity for colorectal cancer therapy
Am J Transl Res. 2024 Mar 15;16(3):700-719. doi: 10.62347/QKHB5897. eCollection 2024.ABSTRACTIn addition to genetic variants and copy number alterations, epigenetic deregulation of oncogenes and tumor suppressors is a major contributor in cancer development and propagation. Regulatory elements for gene transcription regulation can be found in promoters which are located in the vicinity of transcription start sites but also at a distance, in enhancer sites, brought to interact with proximal sites when occupied by enhancer protein complexes. These sites provide most of the specific regulatory sequences recognized by transcri...
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Ioannis A Voutsadakis Source Type: research

Efficacy and safety of tranexamic acid in the treatment of gastric cancer complicated with upper gastrointestinal bleeding
CONCLUSION: TXA can be an effective treatment for patients with gastric cancer complicated by GI bleeding.PMID:38586096 | PMC:PMC10994787 | DOI:10.62347/KOLI5819 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Zongjiang Bai Lantao Wang Bin Yu Dong Xing Jie Su Hao Qin Source Type: research