Unlocking the diagnostic, prognostic roles, and immune implications of BAX gene expression in pan-cancer analysis
CONCLUSION: In sum, our comprehensive BAX study not only enhances our understanding of its significance as a biomarker gene but also offers novel avenues for therapeutic interventions, contributing to the ongoing quest for more effective cancer treatments and improved patient care.PMID:38322551 | PMC:PMC10839381 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Mostafa A Abdel-Maksoud Sajid Ullah Amun Nadeem Aisha Shaikh Muhammad Khurram Zia Adel M Zakri Taghreed N Almanaa Akram A Alfuraydi Ayman Mubarak Yasir Hameed Source Type: research

Nourishing Yin traditional Chinese medicine: potential role in the prevention and treatment of type 2 diabetes
Am J Transl Res. 2024 Jan 15;16(1):234-254. eCollection 2024.ABSTRACTType 2 diabetes mellitus (T2DM), a common and frequently occurring disease in contemporary society, has become a global health threat. However, current mainstream methods of prevention and treatment, mainly including oral hypoglycemic drugs and insulin injections, do not fundamentally block the progression of T2DM. Therefore, it is imperative to find new ways to prevent and treat diabetes. Traditional Chinese medicine is characterized by multiple components, pathways, and targets with mild and long-lasting effects. Pharmacological studies have shown that ...
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Yu-Ping Dai Yan Duan Yu-Ting Lu Xiao-Ting Ni Yun-Kun Zhang Juan Li Shun-Xiang Li Source Type: research

Prebiotic supplements correct oral probiotic deficiency for lasting allergy relief
Am J Transl Res. 2024 Jan 15;16(1):136-146. eCollection 2024.ABSTRACTThe prevalence of allergic rhinitis (common allergies) has increased in the last fifty years, from less than one percent to more than twenty-six percent of the population. Today, more than one hundred million people in the US suffer seasonal or yearlong allergies. The hygiene hypothesis was proposed 30 years ago as a potential explanation for this phenomenon, and we built on it with the specific oral hygiene hypothesis. Our longitudinal pilot study suggested that oral probiotic deficiency is the cause of allergic rhinitis. This clinical trial served to ve...
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Cliff Shunsheng Han Source Type: research

The deubiquitinase OTUB2 promotes cervical cancer growth through stabilizing FOXM1
CONCLUSION: OTUB2 promotes CC progression through deubiquitinating and stabilizing FOXM1.PMID:38322554 | PMC:PMC10839374 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Jing Xiao Liqun Wang Yuan Zhuang Qizhou Zhu Weimei Li Hong Liao Xiaofang Chen Zhaoxia Liu Source Type: research

Prognosis of infants with congenital pulmonary airway malformations after surgery: a short and mid-term evaluation
CONCLUSION: Over half of CPAM infants have normalized lung function one year after operation and the choice of lobectomy and segmentectomy had no significant difference on prognosis of infants.PMID:38322555 | PMC:PMC10839395 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Jiachi Liao Minhua Lin Jiahang Zeng Fenghua Wang Jue Tang Qinglin Yang Dongmei Huang Zefeng Lin Jianhua Liang Le Li Source Type: research

Application of mineral trioxide aggregate pulpotomy in the treatment of early pulpitis of primary molars
CONCLUSIONS: MTA pulpotomy outperformed root canal treatment for superior efficacy in children with early pulpitis of primary molars, with a positive effect on improving QoL, and patient prognosis.PMID:38322556 | PMC:PMC10839389 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Wen Tao Guoyong Tian Qingqing Song Zhijun Lv Source Type: research

Ganoderic acid A attenuated hepatic impairment by down-regulating the intracellular JAK2-STAT3 signaling pathway in induced mushroom poisoning
CONCLUSION: Ganoderma lucidum is very effective in treating mushroom poisoning by α-amanita and is worth promoting.PMID:38322557 | PMC:PMC10839386 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Chenggen Xiao Guoqing Huang Xiaoxia Cao Xiangmin Li Source Type: research

Effects of "Timing It Right" nursing on clinical outcome and psychological resilience for lung cancer patients undergoing radical thoracoscopic surgery
CONCLUSION: TIR nursing can effectively enhance the self-care ability of lung cancer patients undergoing radical thoracoscopic surgery, improve their psychological elasticity, enhance their quality of life, shorten the hospitalization time, and reduce the incidence of adverse reactions.PMID:38322558 | PMC:PMC10839382 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Meilian Yi Yan Pan Source Type: research

Hypermethylated SHOX2 in circulating cell-free DNA post renal cell carcinoma surgery as TNM-independent biomarker for recurrence risk
CONCLUSIONS: mSHOX2 effectively identifies high-risk RCC patients post-surgery, indicating minimal residual disease. This easy to implement biomarker has potential for guiding of adjuvant therapy decisions.PMID:38322559 | PMC:PMC10839385 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Thomas B üttner Romina Zarbl Philipp Krausewitz Sebastian Strieth Glen Kristiansen Markus Eckstein Damian J Ralser Michael H ölzel Manuel Ritter J örg Ellinger Dimo Dietrich Niklas Kl ümper Source Type: research

Association between immune-related hub genes < em > CD36, CXCL13, FGFR4, GABBR1, LAMP3, MMP12 < /em > , and < em > PPM1H < /em > and colorectal cancer prognosis
In conclusion, our findings provide evidence that seven immune-related hub genes can be considered as gene signatures to predict CRC prognosis and to differentiate CRC patient benefit, ultimately serving as a guide for individualized immunotherapy.PMID:38322560 | PMC:PMC10839376 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Liuli Wang Xiaohua Dong Miao Yu Xiazi Nie Mengmeng Du Xiashuang Zhao Yipeng Zhang Hui Cai Source Type: research

LncRNA AL645608.3 mediates malignant progression of acute myeloid leukemia
CONCLUSION: AL645608.3 is expressed in different AML cell lines, and mediates the expression of CBL, IRF6, IFNB1, and MMP-9. These findings might deepen our comprehension of the molecular mechanisms underlying AML.PMID:38322561 | PMC:PMC10839383 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Jin-Hua Yan Kai-Qiong Liao Ling Yao Jian-Lan Chen Li-Fang Xiong Xu-Zhang Tao Source Type: research

Effect of exercise-nutrition-psychology oriented nursing in patients undergoing interventional embolization for intracranial aneurysm
CONCLUSIONS: Exercise-nutrition-psychology oriented nursing can improve patients' self-management ability and quality of life, reduce the risk of complications, and promote the recovery of the condition.PMID:38322562 | PMC:PMC10839397 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Guifang Lin Xiaorong Long Source Type: research

Comprehensive analysis of clinicopathological profiles in adenosquamous carcinoma of the lung
CONCLUSIONS: In conclusion, we describe an overview of ASC in the Chinese population, and upon stratifying into predominant pathological subgroups, we observed a higher frequency of driver gene mutations in AC-predominant ASC. We found that the AC component in ASC has a higher propensity for lymph node metastasis. These findings may suggest the predominant role of the AC component within the context of ASC.PMID:38322563 | PMC:PMC10839401 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Yuanyuan Wang Haoyue Guo Likun Hou Yuhan Wu Xuefei Li Chao Zhao Lei Cheng Anwen Xiong Source Type: research

Genotype analysis of 55,281 cases of thalassemia in northern Guangxi
CONCLUSION: The population in northern Guangxi exhibited rich ethnic diversity, with high allelic carrying rates among the Zhuang, Yao and Dong ethnic groups. Thalassemia gene mutations are diverse, encompassing a variety of gene types, with α thalassemia predominating, notably the --SEA/αα gene type. The prevalence of intermedia or severe types of thalassemia is not low, but there are still some carriers of thalassemia in people who are initially tested negative.PMID:38322564 | PMC:PMC10839378 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Dan Zeng Zhizhong Chen Yifeng Yang Jun Li Baodong Tian Limin Mo Source Type: research

Relationship between anion gap and in-hospital mortality in intensive care patients with liver failure: a retrospective propensity score matching analysis
CONCLUSIONS: AG is associated with in-hospital mortality in intensive care patients with liver failure and demonstrates a moderate predictive value, which is comparable to the predictive power of the MELD score. AG may serve as an indirect marker of in-hospital mortality of patients with liver failure by reflecting the degree of metabolic acidosis.PMID:38322565 | PMC:PMC10839379 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - February 7, 2024 Category: Research Authors: Wei Yu Yao Wen Yu Shao Tianyang Hu Xiaoqiang Wan Source Type: research