American Journal of Translational Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effect of ultrasound-guided stellate ganglion block on lung protection for patients undergoing one-lung ventilation
CONCLUSION: Ultrasound-guided SGB has lung-protective effects on patients undergoing OLV, which significantly improves patients' OI, reduces intrapulmonary shunts, declines ventilator-induced lung damage, and inhibits inflammatory response as well as oxidative stress (China Clinical Trial Registry, registration number ChiCTR2000033385, https://www.chictr.org.cn).PMID:38586109 | PMC:PMC10994812 | DOI:10.62347/UFZF5671 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Yang Xie Li Han Yue Zhao Lihong Zhao Fen Yang Jianfang Cao Qifeng Tang Source Type: research

Effect of ultrasound-guided stellate ganglion block on cerebral oxygen metabolism and S100B protein during carotid endarterectomy
CONCLUSION: SGB before CEA effectively suppresses the stress response, maintains intraoperative hemodynamic stability, improves brain tissue oxygen supply, and demonstrates a neuroprotective effect.PMID:38586110 | PMC:PMC10994798 | DOI:10.62347/RXRN7802 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Fen Yang Yulong Du Chen Yuan Li Han Yue Zhao Yang Xie Wenyong Peng Source Type: research

Efficacy of the combination of BRII-196/BRII-198 in the treatment of COVID-19 vaccine breakthrough infections
CONCLUSIONS: The initial levels of SARS-CoV-2 IgG antibody and lymphocytes in fully vaccinated patients with breakthrough infections are inversely correlated with the severity of the disease. Early treatment with BRII-196/BRII-198 can shorten NA negative conversion time in severe COVID-19 patients and increase in vivo neutralizing antibody levels post-conversion, providing lasting protection. However, BRII-196/BRII-198 does not influence lymphocyte count recovery in patients with either ordinary and/or severe COVID-19.PMID:38586111 | PMC:PMC10994788 | DOI:10.62347/NDGV1857 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Xiao-Ling Guo Kun Wang Jie Jin Li-Li Dai Source Type: research

Efficacy of levetiracetam combined with oxcarbazepine in the treatment of adults with temporal lobe epilepsy and its impact on memory and cognitive function
CONCLUSION: Levetiracetam combined with oxcarbazepine effectively improves cognitive dysfunction in adults with temporal lobe epilepsy, with superior efficacy to levetiracetam alone, and good safety.PMID:38586112 | PMC:PMC10994801 | DOI:10.62347/KNTE8578 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Zhangxia Li Xiongfei Zhao Guoxun Zhang Cong Xi Liying Yang Source Type: research

Obesity attenuates the beneficial effect of an intrauterine infusion of autologous platelet-rich plasma during in vitro fertilization
CONCLUSION: PRP improved embryo implantation and clinical pregnancy rates; however, these beneficial effects were attenuated by obesity. PRP presumptively promoted a change in the uterine environment to mimic the normal findings associated with normal-weight women.PMID:38586113 | PMC:PMC10994790 | DOI:10.62347/RDXA5841 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Dinorah Hern ández-Melchor H éctor Carrillo Alfredo Mart ín Rivera Leonardo M Porchia Priscila M Bartolo-G ómez Jazm ín Martínez Am érica Padilla-Viveros Martha Elba Gonzalez-Mej ía Esther L ópez-Bayghen Source Type: research

Human immunoglobulin in combination with antimicrobial agents enhances the treatment efficacy and reduces inflammatory response in children with severe pneumonia
CONCLUSION: The combination of human immunoglobulin and antibiotics for the treatment of pediatric severe pneumonia is beneficial, because it improves efficacy, boosts the immune system, and reduces inflammation.PMID:38586114 | PMC:PMC10994785 | DOI:10.62347/KQUW5330 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Wenli Zhang Yue Jin Source Type: research

Decoding the DSCC1 gene as a pan-cancer biomarker in human cancers via comprehensive multi-omics analyses
CONCLUSION: Overall, this study provides comprehensive insights into the pivotal role of DSCC1 in KIRP, LIHC, and LUAD initiation, progression, and therapeutic responsiveness, laying the foundation for further investigations and personalized treatment strategies.PMID:38586115 | PMC:PMC10994803 | DOI:10.62347/YORR3755 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Jingru Wang Sana Fatima Gilani Nazia Noor Muhammad Rashid Ahmed Mehmooda Munazir Ayesha Zubair Rizwana Sultan Mostafa A Abdel-Maksoud Ibrahim A Saleh Naser Zomot Ahmad S Kodous Shebl Salah Ibrahim Mohamed A El-Tayeb Mohammed Aufy Mohamed Y Zaky Syed Sairu Source Type: research

Effects of Shixiao Huoxue Decoction on pain, tumor necrosis factor- α, and interleukin-8 in patients with adenomyosis
CONCLUSION: Xiaoxiao Huoxue Decoction demonstrated a better treatment efficacy in patients with adenomyosis through improving dysmenorrhea and Traditional Chinese Medicine symptoms, as well as reducing the levels of body inflammatory factors, non-menstrual pelvic pain, and dyspareunia, thus contributing to early recovery of patients. Therefore, Xiaoxiao Huoxue Decoction is worthy of promotion in clinical treatment of adenomyosis.PMID:38463587 | PMC:PMC10918143 | DOI:10.62347/VQVR4400 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Weihua Li Chao Shao Jing Liang Source Type: research

Dysregulation of kidney proteases in the pathogenesis of hypertension following unilateral nephrectomy in juvenile mice
CONCLUSION: UNX results in the development of persistent and progressive hypertension. Down-regulation of KLK1 and up-regulation of various cathepsins may contribute to the development of hypertension via multiple mechanisms including a decrease in nitric oxide (NO) production.PMID:38463588 | PMC:PMC10918144 | DOI:10.62347/HONT9617 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Rasha Aly Yunus E Dogan Niharika Bala Carlos Lugo Seena Darwish Lawrence Shoemaker Abdel A Alli Source Type: research

Screening sensibility and antifungal activity after topical application of a synthetic lactoferrin-derived antimicrobial peptide
CONCLUSIONS: This study showed a positive therapeutic effect of a commercial product containing hLF1-11 in the case of 88.9% of the patients with onychomycosis. The present formulation of hLF1-11 into PBS is stable enough to permit storage at room temperature for at least two years.PMID:38463589 | PMC:PMC10918136 | DOI:10.62347/TCOY1289 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Carlo Brouwer Teun Boekhout Saleh Alwasel Mahfuzur Rahman Ruth Janga Mick M Welling Source Type: research

Complex phenotypic heterogeneity of combined hepatocellular-cholangiocarcinoma with a homogenous < em > TERT < /em > promoter mutation
Am J Transl Res. 2024 Feb 25;16(2):690-699. doi: 10.62347/CQJW7490. eCollection 2024.ABSTRACTTo clarify the mechanism underlying the development and poor prognosis of combined hepatocellular-cholangiocarcinoma (cHCC-CCA), we characterized liver cancer driver mutations and poor prognostic markers in both the HCC and intrahepatic CCA (iCCA) components of a cHCC-CCA tumor. The telomerase reverse transcriptase (TERT) promoter mutation C228T was quantified by digital polymerase chain reaction using DNA from multiple microdissected cancer components of a single cHCC-CCA nodule. The protein expression of cancer-related markers, i...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Sumie Ohni Hiromi Yamaguchi Yukari Hirotani Yoko Nakanishi Yutaka Midorikawa Masahiko Sugitani Tomohiro Nakayama Makoto Makishima Mariko Esumi Source Type: research

IL-1RA autoantibodies: insights into mechanisms and associated diseases
Am J Transl Res. 2024 Feb 15;16(2):374-386. doi: 10.62347/NTVU5728. eCollection 2024.ABSTRACTThe association of neutralizing autoantibodies targeting interleukin-1 receptor antagonist (IL-1RA) with multisystem inflammatory syndrome, IgG4-related disease, and vaccine-related myocarditis is increasingly recognized. The detection of IL-1RA autoantibodies can be notably affected by the techniques and methods employed. Two categories of assays are available: solid-phase immunoassays, which detect binding of IL-1RA autoantibodies, and functional IL-1 signaling reporter cell assays, which offer greater specificity by determining ...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Abdellatif Bouayad Source Type: research

Clinical significance of measuring MP-DNA, C-reactive protein, and inflammatory cytokines in children with mycoplasma pneumoniae pneumonia
CONCLUSION: Indicators such as MP-DAN, IL-6, IL-8 are crucial in the development and progression of MPP, playing an important role in diagnosing and treating patients with MPP.PMID:38463592 | PMC:PMC10918132 | DOI:10.62347/VCVW7593 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Wangqiang Li Fang Deng Source Type: research

Primary perihilar bile duct neuroendocrine tumor: a case report and review of the literature
This article chronicles a case study detailing a neuroendocrine tumor's diagnostic and treatment course within the perihilar bile duct. Integrating pertinent literature, it encapsulates the clinical attributes and diagnostic and therapeutic advancements in biliary neuroendocrine tumors. The aspiration is to augment awareness of this category of ailments, mitigating the occurrence of both missed and erroneous diagnoses, and furnishing a reference for forthcoming clinical endeavors.PMID:38463593 | PMC:PMC10918117 | DOI:10.62347/HFBY5551 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Haidong Ai Ting Gong Yongbiao Ma Guixu Ma Jingjing Zhao Xuelin Zhao Source Type: research

Effect of Butylphthalide soft capsules on cognitive function and dementia-related factors in elderly patients with Parkinson's disease dementia during the COVID-19 pandemic
CONCLUSION: Butylphthalide soft capsules have a definite effect and good safety in elderly patients with PDD during the COVID-19 pandemic.PMID:38463594 | PMC:PMC10918146 | DOI:10.62347/ZIPJ6525 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Yushuo Wang Sen Kou Siqi Yang Chao Zhang Shanshan Wang Yunliang Wang Source Type: research