Meta-analysis of the prognosis after surgical treatment of osteosarcoma complicated by pathologic fracture
CONCLUSION: Complicated with pathologic fracture is a negative prognostic indicator of osteosarcoma, and its poor survival rates (both OS and DFS) may be associated with a higher DMR. For osteosarcoma patients with pathologic fractures treated with standard treatment, LRR and DMR exhibit no significant difference between amputation and limb-salvage surgery.PMID:35559384 | PMC:PMC9091088 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Wei Zhong Ziyi Wu Yuhao Yuan Wei Luo Source Type: research

CD24 is expressed on FoxP3 < sup > + < /sup > regulatory T cells and regulates their function
Am J Transl Res. 2022 Apr 15;14(4):2291-2300. eCollection 2022.ABSTRACTCD24 is a glycosyl-phosphatidylinositol (GPI) anchored cell surface glycoprotein with a variety of immunomodulatory functions such as inhibition of thymic generation of autoreactive T cells, regulation of antigen presenting cell functions, and mediation of autoimmunity. Given the autoimmune nature of FoxP3+ regulatory T cells and their importance in autoimmune diseases, we hypothesize that CD24 regulates the generation and functions of Treg cells. Through the analysis of the Treg repertoire in two strains of CD24-deficient mice, we found that CD24 does ...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yun Shi Jing Zhu Jin-Qing Liu Fatemeh Talebian Mingsong Li Xue-Feng Bai Source Type: research

Methods for identifying biomedical translation: a systematic review
In conclusion, there is still a lack of a gold-standard method for evaluating biomedical translational research.PMID:35559386 | PMC:PMC9091120 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Javier Padilla-Cabello Antonio Santisteban-Espejo Ruben Heradio Manuel J Cobo Miguel A Martin-Piedra Jose A Moral-Munoz Source Type: research

Effect of intravenous thrombolysis combined with mechanical thrombectomy on neurological function and short-term prognosis of patients with acute cerebral infarction
CONCLUSION: Intravenous thrombolysis combined with mechanical thrombectomy can accelerate the recovery of neurological function in patients with ACI, and yield a more promising outcome in terms of the patient's vascular recanalization rate compared with the monotherapy. It can also reduce the adverse reaction rate of patients to ensure a better short-term prognosis.PMID:35559387 | PMC:PMC9091080 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yongchang Liu Zhen Hong Yan Li Shaoquan Li Qingran Liu Songwang Xie Junyong Wang Jian Wang Mingming Zheng Source Type: research

Awake fiberoptic intubation in a patient with a large thyroid tumor invading the trachea: a case report
We report a case of a patient with a large thyroid tumor invading the trachea, causing trachea narrowing and resulting in breathing difficulties, who required awake tracheal intubation (ATI). A 54-year-old woman underwent surgery for the removal of a thyroid tumor under general anesthesia. The tumor was invading and compressing the trachea, causing difficulty in breathing. To facilitate surgery, thyrocricocentesis and nerve block were considered, but they were difficult to implement. Extracorporeal membrane oxygenation (ECMO) is expensive and has risks of several complications, such as failure of the oxygenation membrane, ...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Guo Ran Meng Ning Xu Zhang Source Type: research

Upregulation of SPI1 during myocardial infarction aggravates cardiac tissue injury and disease progression through activation of the TLR4/NF κB axis
CONCLUSION: This study demonstrated that upregulation of SPI1, caused by reduced DNA methylation, augmented development of myocardial infarction by activating the TLR4/NFκB axis.PMID:35559389 | PMC:PMC9091125 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Zhengling Liu Shuai Huang Source Type: research

Effect of nimodipine combined with fasudil on vascular endothelial function and inflammatory factors in patients with cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage
CONCLUSIONS: NM combined with fasudil in the treatment of aSAH induced CVS can effectively improve the VEF, alleviate IFs, and enhance the cognitive function and quality of life of patients, which is worth popularizing in clinic.PMID:35559390 | PMC:PMC9091089 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Hui Ye Zaiming Liu Long Zhou Qiang Cai Source Type: research

5-aminolevulinic acid-mediated photodynamic therapy effectively ameliorates HPV-infected cervical intraepithelial neoplasia
CONCLUSION: ALA-PDT can effectively treat HPV-infected CIN and promote HPV clearance.PMID:35559391 | PMC:PMC9091109 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yi Chen Ying Xu Zhengrong Zhang Zhenhong Xiong Dan Wu Source Type: research

Analysis of perioperative complications and related risk factors of thoracotomy and complete video-assisted thoracoscopic surgery lobectomy
CONCLUSION: Compared with conventional thoracotomy, c-VATS lobectomy brings a lower incidence of postoperative complications, and age, BMI and operation mode were independent risk factors for postoperative complications.PMID:35559392 | PMC:PMC9091098 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Hongwei Su Guorong Yan Zijian Li Lin Fu Lingdi Li Source Type: research

Integrated analyses of an RNA binding protein-based signature related to tumor immune microenvironment and candidate drugs in osteosarcoma
CONCLUSION: We evaluated the prognostic value and clinical application of an RBPs-based prognostic signature and identified promising biomarkers to predict immune cell infiltration and immunotherapy response in osteosarcoma.PMID:35559393 | PMC:PMC9091083 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Abdulraheem Gul Mohammad Dapeng Li Rong He Xuan Lei Lianghao Mao Bing Zhang Xinyu Zhong Zhengyu Yin Wenbing Cao Wenchao Zhang Ruoxuan Hei Qiping Zheng Yiming Zhang Source Type: research

LncRNA TTN-AS1 confers tamoxifen resistance in breast cancer via sponging miR-107 to modulate PI3K/AKT signaling pathway
CONCLUSION: Our findings suggest that the lncRNA TTN-AS1 can encourage tamoxifen-resistance in BC by modulating the miR-107/ZNRF2 axis and stimulating the PI3K/AKT pathway.PMID:35559394 | PMC:PMC9091103 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Jun Fang Kun Li Chen Huang Huimin Xue Qichao Ni Source Type: research

Morphometric analysis of the nasal septum in normal Chinese individuals using a three-dimensional model of the nasal septum with facial CT scanning
CONCLUSIONS: The reconstructed 3D model of the nasal septum demonstrates that the septal volume was larger in males than in females, and the ratio of vomer volume and cartilage volume to total septal volume changed with age, which may provide a reference for clinical treatment.PMID:35559395 | PMC:PMC9091117 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Qingwei Wu Na Xue Peihua Wang Chenjie Xu Lin Hu Tao Wang Yiyuan Sun Source Type: research

The promising role and prognostic value of miR-198 in human diseases
The objective of this article is to explore the abnormal expression of miR-198 in a variety of human diseases. The relationships between abnormally expressed miR-198 and clinicopathological characteristics are also summarized. Its roles in various diseases and potential molecular mechanisms include involvement in many biological processes, such as cell cycle regulation, proliferation, invasion, migration, apoptosis, and drug resistance. The potential value of miR-198 for disease diagnosis, treatment, and especially, prognosis, are discussed. More in-depth research on miRNA will support the conversion from basic research to...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Xiaoping Wang Yanxia Zhu Qiuli Xie Source Type: research

Laminoplasty and simultaneous C2 semi-laminectomy with internal fixation in treating ossification of the posterior longitudinal ligament in cervical discs at C2 segment
CONCLUSION: Compared to LF, LSLF could better improve neck functions, and reduce the severity of axial symptoms and the occurrence of C5 palsy for patients with OPLL at C2 segment.PMID:35559397 | PMC:PMC9091121 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yipeng Yang Yu Wang Junming Cao Tao Lei Zongyou Yang Hehuan Xia Source Type: research

Clinical characteristics and prognostic factors of lymphoma patients initially presenting with fever of unknown origin
CONCLUSION: We found that the subtypes of lymphoma initially presenting with FUO were mostly B-NHL and T-NHL. The detection of ferritin levels during the hospital stay may help predict the long-term survival rate in patients with FUO.PMID:35559398 | PMC:PMC9091104 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Min Wu Fulati Wulipan Jiexian Ma Wensi Qian Shunrong Sun Pingping Chen Yu Xu Mingyue Chen Wenjing Yang Yanhui Xie Lin Shen Source Type: research