Screening of key genes associated with m6A methylation in diabetic nephropathy patients by CIBERSORT and weighted gene coexpression network analysis
In this study, we analyzed differentially expressed genes (DEG) in the GEO database (GSE96804) and paid attention to genes with m6A methylation. 623 DEGs in glomerular tissue were identified by comparing diabetic nephropathy with normal. Correlation analysis with 21 genes involved in m6A modification showed that 492 genes were associated with m6A methylation. According to the CIBERSORT algorithm, the infiltration of M1 macrophages in DN patients was significantly higher than that in normal samples. Weighted gene coexpression network analysis (WGCNA) was used to screen for the modules most correlated with the clinical featu...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Shaohua Yin Wen Li Junjie Wang Han Wu Ji Hu Yu Feng Source Type: research

High expression of RASAL1, a hub gene in the progression of liver cancer, suggests a poor prognostis
CONCLUSION: RASAL1 is a hub gene that influences LC progression, constituting a novel biomarker and molecular target in the future diagnosis and therapy of LC.PMID:35559415 | PMC:PMC9091118 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Ruiwei Shen Xiaona Shao Dawei Chen Chen Wang Ting Lu Dahua Chen Xian Zhu Jieqiong Lin Qunqun Ye Liang Zhao Xingfeng Ge Kai Wang Juan Yi Source Type: research

The correlation between lncRNA NEAT1 and serum hepcidin in the peripheral blood of non-alcoholic fatty liver disease patients
CONCLUSION: lncRNA NEAT1 is abnormally overexpressed in the PBMCs of patients with NAFLD. The regulatory effect of lncRNA NEAT1 on NAFLD may be related to the mechanism of HEPC, which is expected to be a potential biological indicator for the prevention and treatment of NAFLD.PMID:35559416 | PMC:PMC9091126 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Wenyong Zhou Kongjun Qiu Source Type: research

PNMA5 accelerated cellular proliferation, invasion and migration in colorectal cancer
CONCLUSION: The results revealed that PNMA5 increased cellular proliferation, invasion and migration in colorectal cancer. PNMA5 plays a key role in promoting CRC carcinogenesis and progression for patients with CRC.PMID:35559417 | PMC:PMC9091092 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Jie Lin Xiaokang Zhang Fan Meng Fanlin Zeng Weiyou Liu Xin He Source Type: research

Effect of early olfactory training on olfactory recovery after nasal endoscopy in patients with chronic rhinosinusitis and olfactory impairment
CONCLUSION: Early comprehensive olfactory training can improve the olfactory threshold and odor discrimination of patients with chronic rhinosinusitis combined with olfactory impairment after nasal endoscopy, improve the quality of life, and have a positive effect on olfactory recovery.PMID:35559418 | PMC:PMC9091090 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Jinfeng Zhang Yong Feng Wei Liu Lei He Xiaocheng Qiao Source Type: research

Comparative analysis and influencing factors of hospitalization expenses of three single diseases in a tertiary Class A general hospital
CONCLUSIONS: In order to reasonably control inpatient medical expenses, comprehensive intervention should be carried out in clinical work, from rational drug use and selection of consumables, to shorten the hospitalization days to an appropriate level and reduce the waste of medical resources.PMID:35559419 | PMC:PMC9091100 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Chenyu Wang Xi Chen Liming Pan Hao Lin Xiaoling Shang Guogang Xu Xiantao Huang Source Type: research

YY1 as a promoter regulating the circ_0001946/miR-671-5p/EGFR axis to promote chemotherapy resistance in breast cancer cells
CONCLUSION: Circ_0001946 absorbs miR-671-5p to target EGFR to promote the growth and malignant invasion of drug-resistant BC cells, thereby increasing the resistance to tamoxifen. This effect of circ_0001946 may be achieved by transcriptional activation of YY1.PMID:35559420 | PMC:PMC9091114 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Ge Gao Xiaoyan Li Jiabeini Zhang Hong Yu Source Type: research

Anxiety and depression in graduating university students during the COVID-19 pandemic: a longitudinal study
CONCLUSION: Anxiety and depression were rife within the graduating Chinese university students during the period of the COVID-19 pandemic and were both associated with monthly family income. Treatments tailored to specific targets are needed for graduating university students with mental problems.PMID:35559421 | PMC:PMC9091131 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Nan Yang Xiaolei Yang Source Type: research

Effects of silver foam combined with Dermlin wound healing dressing on inflammation and quality of life in patients with diabetic lower limb ulcers
CONCLUSION: The treatment of diabetic lower limb ulcers with silver foam combined with Dermlin dressing can effectively promote wound healing, reduce pain intensity, and improve quality of life in patients with diabetic lower limb ulcers. Such effects may be attributed to lower levels of inflammatory factor levels, regulation of oxidative stress, and improvement of angiogenesis.PMID:35559422 | PMC:PMC9091129 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yuanling Xu Yongsheng Li Kangmin Yu Zhiyong Chen Yun Shen Binshan Zha Hong Zhang Qianqian Xu Hong Zhao Source Type: research

Erratum: Influence of GLP-1 receptor agonist on insulin dosage and blood glucose control of patients with type 2 diabetes mellitus
Am J Transl Res. 2022 Apr 15;14(4):2767. eCollection 2022.ABSTRACT[This corrects the article on p. 11814 in vol. 13, PMID: 34786110.].PMID:35559423 | PMC:PMC9091095 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yimei Shen Xiaohua Yang Xiaojun Han Wei Xi Lihua Jiang Shuqin Wang Haifeng Zhong Yunjuan Gu Source Type: research

Machine learning-based algorithm demonstrates differences in del19 and L858R EGFR subgroups in non-small cell lung cancer: a single center experience
CONCLUSION: This study used machine learning modeling with fair accuracy to demonstrate that ECOG PS, age at diagnosis, and smoking status are the three main predictive factors of PFS in these patients.PMID:35559374 | PMC:PMC9091123 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Ullas Batra Shrinidhi Nathany Mansi Sharma Anurag Mehta Surender Dhanda Joslia T Jose Source Type: research

Curable congestive heart failure in patients with primary aldosteronism: two cases reports
We report two male patients who were admitted because of severe cardiac systolic dysfunction induced by primary aldosteronism. Their cardiac function improved significantly after target therapy. Patient A was a 33 year old male with serum aldosterone concentration (PAC) 251.3 pg/ml, renin activity (PRA) 0.04 ng/ml/h, and aldosterone-to-renin ratio (ARR) 627.5. Computed tomography (CT) revealed a tumor in the left adrenal gland, while no dominant secretion function was found in the left side after the adrenal veins sampling (lateralization index 0.99). Bilateral adrenal hyperplasia was diagnosed and spironolactone was presc...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Zijun Chen Zhe Zhang Qianlan Xi Guimei Huang Liya Wang Source Type: research

Active Stat3 and Her-2 as combined survival predictors show superiority to TNM staging system for postoperative patients with gastric cancer
CONCLUSIONS: We conclude that area under the ROC curve (AUC) can be used to quantify SPP powers for biomarkers, making cross-comparisons possible among different survival predictors. This study has first established a multi-factor survival prediction model by which the p-Stat3+Her-2 combination has the best discriminative capability to differentiate low-risk patients from high-risk patients in terms of survival prognosis.PMID:35559376 | PMC:PMC9091078 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Ke Sun Meng Qing Xu Hai Jun Zhang Dan Dan Zhang Wen Yue Miao Miao Ma Lin Tao Wen Jie Zhang Source Type: research

Cranio-maxillofacial post-operative face prediction by deep spatial multiband VGG-NET CNN
Am J Transl Res. 2022 Apr 15;14(4):2527-2539. eCollection 2022.ABSTRACTCurrent plastic and reconstructive surgery computational techniques are not precise and take a long time to perform. Therefore, these limitations reduced the adoption of computational techniques. Although computer-aided surgical preparation systems may help to enhance clinical results, minimize operating time and costs, they are too complicated and require detailed manual information, which restricts their usage in doctor-patient communication and clinical decision-making. In order to obtain the optimal aesthetic and reconstruction treatment results, th...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Rizwan Ali Rui Lei Haifei Shi Jinghong Xu Source Type: research

Curcumin treats endometriosis in mice by the HIF signaling pathway
CONCLUSION: Curcumin played a role in the treatment of EM by modulating the HIF signaling pathway, improving the local hypoxia of the lesion, and reducing the inflammatory state of EM.PMID:35559378 | PMC:PMC9091111 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Jie Ding Shanshan Mei Wen Cheng Zhexin Ni Chaoqin Yu Source Type: research