BMI1 governs the maintenance of mouse GC-2 cells through epigenetic repression of < em > Foxl1 < /em > transcription
CONCLUSIONS: Collectively, our study revealed for the first time the existence of an epigenetic mechanism involving BMI1-mediated gene silencing in GC-2 cells development and provided potential targets for the treatment of male infertility.PMID:35702123 | PMC:PMC9185053 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Bo Zheng Juanjuan Liu Xiaodan Shi Jinfu Xu Ke Zhang Hui Zhou Tiantian Wu Xiaoyan Huang Cong Shen Yuting Liang Dan Zhao Yueshuai Guo Source Type: research

Predictive value of NT-proBNP, procalcitonin and CVP in patients with new-onset postoperative atrial fibrillation after cardiac surgery
CONCLUSION: NT-proBNP, procalcitonin and CVP were closely related with atrial fibrillation after cardiac surgery. The combination of NT-proBNP, procalcitonin and CVP had a better discriminative ability for new atrial fibrillation after cardiac surgery compared to either of them alone.PMID:35702124 | PMC:PMC9185093 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Zhiwei Xu Long Qian Lijuan Zhang Yang Gao Su Huang Source Type: research

Single nucleotide polymorphism array in genetic evaluation of fetal ultrasound abnormalities: a retrospective follow-up study
Am J Transl Res. 2022 May 15;14(5):3516-3524. eCollection 2022.ABSTRACTFetal ultrasound abnormalities may be complicated by cognitive dysfunction or developmental retardation, and ultrasonography cannot detect these problems; therefore, chromosome detection is required in fetuses with ultrasound abnormalities. To examine the effectiveness of single nucleotide polymorphism (SNP) array in genetic diagnosis of fetal ultrasound abnormalities, the prenatal samples of 805 pregnant women with fetal ultrasound abnormalities were collected for SNP array and karyotyping analysis. A 95.5% percentage of normal karyotypes and 4.5% perc...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Hailong Huang Meiying Cai Huili Xue Liangpu Xu Na Lin Source Type: research

IL-4 and CCR7 play an important role in the development of keloids in patients with a family history
CONCLUSION: Having a family history of keloids is a risk factor for increased severity of keloids. IL-4 and CCR7 play an important role in the development of keloids in patients with a family history of the condition and may represent new targets for the treatment of keloids.PMID:35702126 | PMC:PMC9185030 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Mengjie Shan Hao Liu Yan Hao Tian Meng Cheng Feng Kexin Song Youbin Wang Source Type: research

Effect of liraglutide combined with metformin or acarbose on glucose control in type 2 diabetes mellitus and risk factors of gastrointestinal adverse reactions
CONCLUSION: Compared with liraglutide and acarbose, liraglutide and metformin has better glucose control effect in T2DM. Although there is no obvious difference in eliminating inflammation, liraglutide combined with acarbose will increase the incidence of gastrointestinal adverse reactions in patients. So, liraglutide combined with metformin is recommended for T2DM treatment.PMID:35702127 | PMC:PMC9185051 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Gaofei Ren Xiaojun Ma Pengfei Jiao Source Type: research