Upregulation of SPI1 during myocardial infarction aggravates cardiac tissue injury and disease progression through activation of the TLR4/NF κB axis
CONCLUSION: This study demonstrated that upregulation of SPI1, caused by reduced DNA methylation, augmented development of myocardial infarction by activating the TLR4/NFκB axis.PMID:35559389 | PMC:PMC9091125 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Zhengling Liu Shuai Huang Source Type: research

Effect of nimodipine combined with fasudil on vascular endothelial function and inflammatory factors in patients with cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage
CONCLUSIONS: NM combined with fasudil in the treatment of aSAH induced CVS can effectively improve the VEF, alleviate IFs, and enhance the cognitive function and quality of life of patients, which is worth popularizing in clinic.PMID:35559390 | PMC:PMC9091089 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Hui Ye Zaiming Liu Long Zhou Qiang Cai Source Type: research

5-aminolevulinic acid-mediated photodynamic therapy effectively ameliorates HPV-infected cervical intraepithelial neoplasia
CONCLUSION: ALA-PDT can effectively treat HPV-infected CIN and promote HPV clearance.PMID:35559391 | PMC:PMC9091109 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yi Chen Ying Xu Zhengrong Zhang Zhenhong Xiong Dan Wu Source Type: research

Analysis of perioperative complications and related risk factors of thoracotomy and complete video-assisted thoracoscopic surgery lobectomy
CONCLUSION: Compared with conventional thoracotomy, c-VATS lobectomy brings a lower incidence of postoperative complications, and age, BMI and operation mode were independent risk factors for postoperative complications.PMID:35559392 | PMC:PMC9091098 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Hongwei Su Guorong Yan Zijian Li Lin Fu Lingdi Li Source Type: research

Integrated analyses of an RNA binding protein-based signature related to tumor immune microenvironment and candidate drugs in osteosarcoma
CONCLUSION: We evaluated the prognostic value and clinical application of an RBPs-based prognostic signature and identified promising biomarkers to predict immune cell infiltration and immunotherapy response in osteosarcoma.PMID:35559393 | PMC:PMC9091083 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Abdulraheem Gul Mohammad Dapeng Li Rong He Xuan Lei Lianghao Mao Bing Zhang Xinyu Zhong Zhengyu Yin Wenbing Cao Wenchao Zhang Ruoxuan Hei Qiping Zheng Yiming Zhang Source Type: research

LncRNA TTN-AS1 confers tamoxifen resistance in breast cancer via sponging miR-107 to modulate PI3K/AKT signaling pathway
CONCLUSION: Our findings suggest that the lncRNA TTN-AS1 can encourage tamoxifen-resistance in BC by modulating the miR-107/ZNRF2 axis and stimulating the PI3K/AKT pathway.PMID:35559394 | PMC:PMC9091103 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Jun Fang Kun Li Chen Huang Huimin Xue Qichao Ni Source Type: research

Morphometric analysis of the nasal septum in normal Chinese individuals using a three-dimensional model of the nasal septum with facial CT scanning
CONCLUSIONS: The reconstructed 3D model of the nasal septum demonstrates that the septal volume was larger in males than in females, and the ratio of vomer volume and cartilage volume to total septal volume changed with age, which may provide a reference for clinical treatment.PMID:35559395 | PMC:PMC9091117 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Qingwei Wu Na Xue Peihua Wang Chenjie Xu Lin Hu Tao Wang Yiyuan Sun Source Type: research

The promising role and prognostic value of miR-198 in human diseases
The objective of this article is to explore the abnormal expression of miR-198 in a variety of human diseases. The relationships between abnormally expressed miR-198 and clinicopathological characteristics are also summarized. Its roles in various diseases and potential molecular mechanisms include involvement in many biological processes, such as cell cycle regulation, proliferation, invasion, migration, apoptosis, and drug resistance. The potential value of miR-198 for disease diagnosis, treatment, and especially, prognosis, are discussed. More in-depth research on miRNA will support the conversion from basic research to...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Xiaoping Wang Yanxia Zhu Qiuli Xie Source Type: research

Laminoplasty and simultaneous C2 semi-laminectomy with internal fixation in treating ossification of the posterior longitudinal ligament in cervical discs at C2 segment
CONCLUSION: Compared to LF, LSLF could better improve neck functions, and reduce the severity of axial symptoms and the occurrence of C5 palsy for patients with OPLL at C2 segment.PMID:35559397 | PMC:PMC9091121 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yipeng Yang Yu Wang Junming Cao Tao Lei Zongyou Yang Hehuan Xia Source Type: research

Clinical characteristics and prognostic factors of lymphoma patients initially presenting with fever of unknown origin
CONCLUSION: We found that the subtypes of lymphoma initially presenting with FUO were mostly B-NHL and T-NHL. The detection of ferritin levels during the hospital stay may help predict the long-term survival rate in patients with FUO.PMID:35559398 | PMC:PMC9091104 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Min Wu Fulati Wulipan Jiexian Ma Wensi Qian Shunrong Sun Pingping Chen Yu Xu Mingyue Chen Wenjing Yang Yanhui Xie Lin Shen Source Type: research

The effects of vasopressin injection technique on ovarian reserve in laparoscopic cystectomy of bilateral ovarian endometrioma: a retrospective cohort study
CONCLUSION: VIT effectively protected ovarian reserve in laparoscopic cystectomy of bilateral ovarian endometrioma.PMID:35559399 | PMC:PMC9091081 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Lingli Xin Mei Ye Lina Yang Ling Chen Lirong Wang Qingxiang Hou Source Type: research

Association between chronic kidney disease and cancer including the mortality of cancer patients: national health and nutrition examination survey 1999-2014
CONCLUSION: CKD is significantly associated only with genitourinary cancer among different types of cancer. CKD is an independent risk factor for survival in cancer patients, regardless of the type of cancer. Monitoring and maintaining the renal function of cancer patients is essential for prolonging their life.PMID:35559400 | PMC:PMC9091102 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Kanglin Guo Zufeng Wang Ran Luo Yichun Cheng Shuwang Ge Gang Xu Source Type: research

Endoscopic- versus x-ray-guidance for placement of nasojejunal tubes in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
Am J Transl Res. 2022 Apr 15;14(4):2134-2146. eCollection 2022.ABSTRACTNasojejunal tubes (NJTs) are increasingly used in critically ill patients. NJT insertion with endoscopic- or x-ray-guidance can be achieved with success rates above 90%. This systematic review and meta-analysis of randomized controlled trials (RCTs) compares the efficiency and safety of these two methods in critically ill patients. We searched Chinese and English databases for RCTs comparing endoscopy- and x-ray-guided NJT placement published up to July 5, 2021. Meta-analyses were performed using RevMan5 software to compute mean differences (MDs) and od...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Guanzhen Lu Qin Xiang Sha Wang Mingyue Pan Xu Xiang Yanling Yang Xinyan Shi Source Type: research

Trend analysis of drug overdose deaths before and during the COVID-19 pandemic
Am J Transl Res. 2022 Apr 15;14(4):2685-2688. eCollection 2022.ABSTRACTData from a single state indicated there was an increase in opioid overdose related emergency services during the COVID-19 pandemic. The current study examined the provisional rolling 12-month drug overdose deaths between January 2019 and October 2021 at the national, state, and specific-drug levels, to identify trends in drug-overdose deaths before and during the COVID-19 pandemic. The trend in provisional U.S. drug overdose deaths accelerated at the beginning of the pandemic (December 2019). This acceleration slowed in the middle of pandemic (October ...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Cynthia Chen Shiqian Shen Source Type: research

Comparison of Intra- and postoperative effectiveness of erector spinae plane block and patient controlled analgesia in patients undergoing coronary artery bypass grafting surgery
Am J Transl Res. 2022 Apr 15;14(4):2469-2479. eCollection 2022.ABSTRACTThe aim of our study was to compare bilateral erector spinae plane block (ESPB) efficacy on pain management with patient controlled analgesia (PCA) during the perioperative period in patients scheduled for coronary artery bypass grafting (CABG). After ethics committee approval (2019-7/31 dated 09.04.2019) from the Bursa Uludağ University Medical Trials Ethics Committee, (https://uludag.edu.tr/buuetikkurulu) ASA II-III, 50 patients aged between 18-80 years were included. They were randomly divided into two groups, ESPB (n=25) and control (n=25). In the ...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Lale O ğur Selcan Akesen Suna G ören İrem İris Kan Elif Ba şağan Moğol Alp Gurbet Source Type: research