The Haoqin-Huaban formula alleviates UVB-induced skin damage through HOXA11-AS-mediated stabilization of EZH2
In this study, we found that administration of HQHB inhibited, in a dose-dependent manner, UVB-induced skin damage by eliminating oxidative stress. HQHB was found to upregulate HOXA11-AS expression by activating HIF-1α. Furthermore, HOXA11-AS stabilized the EZH2 protein by inhibiting its ubiquitination and proteasomal degradation. Consequently, rescue assays demonstrated that HOXA11-AS promoted proliferation and inhibited apoptosis in HaCaT cells by reducing oxidative stress. Taken together, our results help to elucidate the function and regulatory mechanism of HQHB in reducing UVB-induced skin damage.PMID:35559404 | PMC:...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Xuying Xu Siyi Wang Dongmei Zhou Jianhua Qu Cang Zhang Yichuan Xu Liyun Sun Source Type: research

The curative effect of Shenfu-injection in the treatment of burn sepsis and its effect on the patient's immune function, HMGB, and vWF
CONCLUSION: SFI can effectively improve the immunity of patients with burn-injured sepsis, reduce the expression of cytokines such as HMGB and vWF, and is of great help for the improvement of clinical prognosis.PMID:35559405 | PMC:PMC9091091 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Chuanzhen Xu Yongfu Xia Zhuting Jia Shasha Wang Tongzhen Zhao Liqiang Wu Source Type: research

Overexpression of galectin2 (LGALS2) predicts a better prognosis in human breast cancer
CONCLUSION: In conclusion, LGALS2 has potential as a valuable biomarker for envisaging a satisfactory prognosis in patients with breast tumours, particularly those with luminal and basal B types, all stages and grade III tumours.PMID:35559406 | PMC:PMC9091085 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Mandika Chetry Adheesh Bhandari Ruiling Feng Xinming Song Pintian Wang Jing Lin Source Type: research

Comparison of clinical efficacy and safety of transvaginal natural endoscopic surgery and transumbilical single port laparoscopy surgery for endometrial cancer
CONCLUSION: Transvaginal natural cavity endoscopy had better surgical results with faster postoperative recovery and higher safety compared with TSPLS, making it valuable in clinical application and worthy of further popularization.PMID:35559407 | PMC:PMC9091124 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Guna He Lingyu Liu Xiaomei Liu Hui Guo Lingling Chen Rongzi Li Source Type: research

Effects of total laparoscopic hysterectomy on the clinical outcomes of patients with uterine fibroids
CONCLUSIONS: TLH is a feasible and safe alternative than traditional TAH for UFs, as it can effectively improve patients' sex hormone levels and QOL, and reduce the incidence of complications, which is worthy of clinical promotion.PMID:35559408 | PMC:PMC9091122 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Lang Zheng Dan Liu Chunyan Hu Source Type: research

Emerging role of epigenetic regulations in periodontitis: a literature review
Am J Transl Res. 2022 Apr 15;14(4):2162-2183. eCollection 2022.ABSTRACTPeriodontitis is mainly initiated by periodontal pathogens including Porphyromonas gingivalis, and bad living habits such as smoking aggravate its incidence and severity. The development of periodontitis is closely related to the host's immune responses and the secretion of various cytokine networks. Moreover, periodontitis has an important connection with the development of systemic diseases. Recently, epigenetics which is a fast-developing hot research area has provided new insights into the research of various diseases including periodontitis. Epigen...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Jing Huang Yi Zhou Source Type: research

Research on antibody changes and nucleic acid clearance in COVID-19 patients treated with convalescent plasma
CONCLUSIONS: The application of convalescent plasma significantly increases the antibody content in severe and critical inpatients, effectively enhances immune function, accelerates the clearance of virus and the nucleic acid negative conversion rate, and significantly promotes early improvement in COVID-19 patients.PMID:35559410 | PMC:PMC9091113 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Li Duan Yudi Xie Qiang Wang Xianli Sun Wenlong Guan Jun Xu Zhiqiang Lin Quan Wang Ying Qin Chi Zhang Yuanda Li Xiaojuan Qu Ling Li Jianping Li Guoyue Lin Source Type: research

LINC01272 activates epithelial-mesenchymal transition through miR-153-5p in Crohn's disease
CONCLUSION: LINC01272 activated the epithelial-mesenchymal transition through miR-153-5p in CD.PMID:35559411 | PMC:PMC9091119 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Lin Fang Mengcheng Hu Fei Xia Wenxia Bai Source Type: research

Factors influencing quality of life and work of male nurses in Hainan Province: logistic regression analysis
CONCLUSION: Male nurses in Hainan Province mostly worked in departments with high work intensity and pressure, and the overall quality of life, social support and job satisfaction were significantly lower than those of female nurses. Therefore, psychological guidance for male nurses should be strengthened, the salary of male nurses should be increased, higher social support should be provided, to reduce job burnout and thus improve their quality of life.PMID:35559412 | PMC:PMC9091086 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yan Zou Haiyan Wang Yedan Chen Hai Xie Yingyao Chen Guangwei Wang Source Type: research

Changes in transepithelial electrical resistance and intracellular ion concentration in TGF- β-induced epithelial-mesenchymal transition of retinal pigment epithelial cells
CONCLUSION: TGF-β1 and TGF-β2 disrupted the ARPE-19 cell monolayer, disturbed TJs integrity, downregulated TEER values, and changed intracellular ion permeability. These findings might help further understand the EMT of RPE cells during PVR.PMID:35559413 | PMC:PMC9091112 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Minli Wang Jiayi Wei Hui Li Fang Wang Source Type: research

Screening of key genes associated with m6A methylation in diabetic nephropathy patients by CIBERSORT and weighted gene coexpression network analysis
In this study, we analyzed differentially expressed genes (DEG) in the GEO database (GSE96804) and paid attention to genes with m6A methylation. 623 DEGs in glomerular tissue were identified by comparing diabetic nephropathy with normal. Correlation analysis with 21 genes involved in m6A modification showed that 492 genes were associated with m6A methylation. According to the CIBERSORT algorithm, the infiltration of M1 macrophages in DN patients was significantly higher than that in normal samples. Weighted gene coexpression network analysis (WGCNA) was used to screen for the modules most correlated with the clinical featu...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Shaohua Yin Wen Li Junjie Wang Han Wu Ji Hu Yu Feng Source Type: research

High expression of RASAL1, a hub gene in the progression of liver cancer, suggests a poor prognostis
CONCLUSION: RASAL1 is a hub gene that influences LC progression, constituting a novel biomarker and molecular target in the future diagnosis and therapy of LC.PMID:35559415 | PMC:PMC9091118 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Ruiwei Shen Xiaona Shao Dawei Chen Chen Wang Ting Lu Dahua Chen Xian Zhu Jieqiong Lin Qunqun Ye Liang Zhao Xingfeng Ge Kai Wang Juan Yi Source Type: research

The correlation between lncRNA NEAT1 and serum hepcidin in the peripheral blood of non-alcoholic fatty liver disease patients
CONCLUSION: lncRNA NEAT1 is abnormally overexpressed in the PBMCs of patients with NAFLD. The regulatory effect of lncRNA NEAT1 on NAFLD may be related to the mechanism of HEPC, which is expected to be a potential biological indicator for the prevention and treatment of NAFLD.PMID:35559416 | PMC:PMC9091126 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Wenyong Zhou Kongjun Qiu Source Type: research

PNMA5 accelerated cellular proliferation, invasion and migration in colorectal cancer
CONCLUSION: The results revealed that PNMA5 increased cellular proliferation, invasion and migration in colorectal cancer. PNMA5 plays a key role in promoting CRC carcinogenesis and progression for patients with CRC.PMID:35559417 | PMC:PMC9091092 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Jie Lin Xiaokang Zhang Fan Meng Fanlin Zeng Weiyou Liu Xin He Source Type: research

Effect of early olfactory training on olfactory recovery after nasal endoscopy in patients with chronic rhinosinusitis and olfactory impairment
CONCLUSION: Early comprehensive olfactory training can improve the olfactory threshold and odor discrimination of patients with chronic rhinosinusitis combined with olfactory impairment after nasal endoscopy, improve the quality of life, and have a positive effect on olfactory recovery.PMID:35559418 | PMC:PMC9091090 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Jinfeng Zhang Yong Feng Wei Liu Lei He Xiaocheng Qiao Source Type: research