Dynamic transcriptome landscape of pulmonary tissues of rats infected with < em > Paragonimus proliferus < /em >
Am J Transl Res. 2022 May 15;14(5):3395-3406. eCollection 2022.ABSTRACTParagonimiasis (pulmonary fluke disease) is a foodborne parasitic disease caused by trematode infections. Paragonimus proliferus is a characteristic Paragonimus species that was first identified in Yunnan Province of China. No direct evidence has yet proven that P. proliferus can infect humans. However, we previously found that P. proliferus infects and damages rat lung tissues via an unclear mechanism. Here, we infected Sprague Dawley rats with P. proliferus and sequenced their lung transcriptomes at various intervals thereafter. We detected P. prolife...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Guoji Chang Na Li Qingqing Wang Jie Ding Siqi Liu Lijuan Hua Shenghao Li Wenlin Wang Source Type: research

Expression of CD147 after neoadjuvant chemotherapy and its relationship with prognosis in patients with triple negative breast cancer
CONCLUSION: CD147 can promote the proliferation and invasion of breast cancer cells, which underlines its value in the diagnosis and treatment of TNBC.PMID:35702119 | PMC:PMC9185091 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Wei Zhang Hui Liu Junjie Jiang Yunyun Yang Wenjie Wang Zhengyan Jia Source Type: research

Social characterization of COVID-19 in the state of Amazonas, Brazil
CONCLUSIONS: The national drop in deaths from diseases not associated with COVID between March and August 2020 in Brazil is misleading and may be due to the result of misreported causes of death.PMID:35702120 | PMC:PMC9185070 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Zanair Soares Vasconcelos Eleine Weimann Fabiola Estefany Botelho de Lima C ésar Rogério da Silva Gonçalves Eliane Carvalho Dos Santos Alba Regina Jorge Brand ão Katia Nascimento Couceiro Adriano Gomes da Silva Jorge Augusto de Oliveira Guerra Maria d Source Type: research

The effect of cold therapy combined with ERAS in the postoperative care of patients undergoing total knee arthroplasty
CONCLUSION: The cold therapy combined with ERAS for patients undergoing TKA can improve the postoperative swelling and pain of the affected limb, inspire patients' autonomy in postoperative rehabilitation training, shorten the time to out-of-bed activity, prevent patients from developing venous thrombosis, promote recovery of knee function, and improve patients' postoperative self-care ability and quality of life.PMID:35702121 | PMC:PMC9185063 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Xinli Liao Xin Xu Source Type: research

Biomechanics of the unilateral posterosuperior, unipedicular, and bipedicular approaches for treatment by percutaneous vertebroplasty: a comparative study
This study compared the biomechanical performance of a single vertebral body after PVP by the unilateral posterosuperior, unipedicular, and bipedicular approaches. Twenty-one vertebral bodies from the osteoporotic spine segments (T11-L1) of seven older female cadavers were randomly assigned to the unipedicular (group A), bipedicular (group B), or unilateral posterosuperior approach group (group C). After constructing the fracture compression model, PVP was performed by the different approaches. CT scans showed symmetrical, evenly distributed bone cement in groups B and C and unilaterally distributed cement in group A. The ...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Chenxi Gu Anquan Huang Yefeng Wang Dongzhu Liang Peidong Sun Zhenfeng Zhang Xiaoqiang Cai Jun Shen Jun Ou-Yang Tianming Zou Xiao Yu Source Type: research

BMI1 governs the maintenance of mouse GC-2 cells through epigenetic repression of < em > Foxl1 < /em > transcription
CONCLUSIONS: Collectively, our study revealed for the first time the existence of an epigenetic mechanism involving BMI1-mediated gene silencing in GC-2 cells development and provided potential targets for the treatment of male infertility.PMID:35702123 | PMC:PMC9185053 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Bo Zheng Juanjuan Liu Xiaodan Shi Jinfu Xu Ke Zhang Hui Zhou Tiantian Wu Xiaoyan Huang Cong Shen Yuting Liang Dan Zhao Yueshuai Guo Source Type: research

Predictive value of NT-proBNP, procalcitonin and CVP in patients with new-onset postoperative atrial fibrillation after cardiac surgery
CONCLUSION: NT-proBNP, procalcitonin and CVP were closely related with atrial fibrillation after cardiac surgery. The combination of NT-proBNP, procalcitonin and CVP had a better discriminative ability for new atrial fibrillation after cardiac surgery compared to either of them alone.PMID:35702124 | PMC:PMC9185093 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Zhiwei Xu Long Qian Lijuan Zhang Yang Gao Su Huang Source Type: research

Single nucleotide polymorphism array in genetic evaluation of fetal ultrasound abnormalities: a retrospective follow-up study
Am J Transl Res. 2022 May 15;14(5):3516-3524. eCollection 2022.ABSTRACTFetal ultrasound abnormalities may be complicated by cognitive dysfunction or developmental retardation, and ultrasonography cannot detect these problems; therefore, chromosome detection is required in fetuses with ultrasound abnormalities. To examine the effectiveness of single nucleotide polymorphism (SNP) array in genetic diagnosis of fetal ultrasound abnormalities, the prenatal samples of 805 pregnant women with fetal ultrasound abnormalities were collected for SNP array and karyotyping analysis. A 95.5% percentage of normal karyotypes and 4.5% perc...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Hailong Huang Meiying Cai Huili Xue Liangpu Xu Na Lin Source Type: research

IL-4 and CCR7 play an important role in the development of keloids in patients with a family history
CONCLUSION: Having a family history of keloids is a risk factor for increased severity of keloids. IL-4 and CCR7 play an important role in the development of keloids in patients with a family history of the condition and may represent new targets for the treatment of keloids.PMID:35702126 | PMC:PMC9185030 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Mengjie Shan Hao Liu Yan Hao Tian Meng Cheng Feng Kexin Song Youbin Wang Source Type: research

Effect of liraglutide combined with metformin or acarbose on glucose control in type 2 diabetes mellitus and risk factors of gastrointestinal adverse reactions
CONCLUSION: Compared with liraglutide and acarbose, liraglutide and metformin has better glucose control effect in T2DM. Although there is no obvious difference in eliminating inflammation, liraglutide combined with acarbose will increase the incidence of gastrointestinal adverse reactions in patients. So, liraglutide combined with metformin is recommended for T2DM treatment.PMID:35702127 | PMC:PMC9185051 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Gaofei Ren Xiaojun Ma Pengfei Jiao Source Type: research

Correlation of serum NLR, PLR and HALP with efficacy of neoadjuvant chemotherapy and prognosis of triple-negative breast cancer
CONCLUSIONS: Lymph node metastasis, TNM stage III, high NLR, high PLR and low HALP are risk factors for the poor efficacy of NAC for TNBC. High expression of NLR, PLR and low expression of HALP may indicate a poor prognosis of TNBC patients who failed NAC.PMID:35702128 | PMC:PMC9185079 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Caiyu Lou Fenyuan Jin Qiang Zhao Hongming Qi Source Type: research

Effects of WeChat platform-based nursing intervention on disease severity and maternal and infant outcomes of patients with gestational diabetes mellitus
CONCLUSION: WeChat platform-based interactive continuous nursing intervention can help patients master comprehensive self-management skills to achieve good control of GDM, improve their satisfaction toward nursing and lower the risk of adverse outcome.PMID:35702129 | PMC:PMC9185075 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Lufang Chen Wei Zhang Aiping Fu Lin Zhou Shuixian Zhang Source Type: research

A novel method for potentiation of chemotherapy in soft tissue sarcomas with BromAc
Am J Transl Res. 2022 May 15;14(5):2894-2909. eCollection 2022.ABSTRACTSingle-agent doxorubicin currently forms part of standard care for patients with sarcomas. However, efficacy is limited by the presence of dose-dependent cardiotoxicity and toxicity to renal, hepatic, and neurological systems. Therefore, there is a pressing need for novel drug regimens which can provide increased efficacy and safety. BromAc is a novel drug combination developed as a mucolytic agent which has demonstrated anticancer activity both in vitro and in vivo in several cancers. Here, we investigated the efficacy of BromAc in combination with dox...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Lillian Dong Kevin Ke Samina Badar Ahmed H Mekkawy Javed Akhter Krishna Pillai Carly J Carter David L Morris Source Type: research

Empirical assessment of allele frequencies of genome wide association study variants associated with obstructive sleep apnea
CONCLUSION: The study highlights genetic heterogeneity among different population groups that gets diluted and results are biased when the samples are pooled irrespective of their endogamous groups. Our results provide insight to researchers to target specific endogamous groups for future studies on OSA.PMID:35702131 | PMC:PMC9185076 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: None Mohit Indu Sharma Varun Sharma Sachin Kumar Garima Rastogi Pranjali Dutt Ashutosh Shrivastava Niraj Rai Pooran Chand Source Type: research

BMP-2/CPC scaffold with dexamethasone-loaded blood clot embedment accelerates clinical bone regeneration
Am J Transl Res. 2022 May 15;14(5):2874-2893. eCollection 2022.ABSTRACTDelayed repair caused by prolonged inflammatory response might lead to clinical nonunion and failed bone regeneration. The design of desirable biomaterials requires precise regulation of the initial osteoimmune responses and efficient osteoinductive capacity to facilitate later bone regeneration. Herein, a Dex-loaded blood clot-embedded BMP-2/CPC scaffold (Dex/blood/BMP-2/CPC) was fabricated for clinical bone regeneration with the sequential release of dexamethasone (Dex), a clinical immunosuppression drug, and BMP-2, a potent osteogenic growth factor. ...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Yutong Liu Dan Lin Bo Li Hua Hong Chuan Jiang Yuan Yuan Jinwu Wang Ruyin Hu Bo Li Changsheng Liu Source Type: research