Machine learning-based algorithm demonstrates differences in del19 and L858R EGFR subgroups in non-small cell lung cancer: a single center experience
CONCLUSION: This study used machine learning modeling with fair accuracy to demonstrate that ECOG PS, age at diagnosis, and smoking status are the three main predictive factors of PFS in these patients.PMID:35559374 | PMC:PMC9091123 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Ullas Batra Shrinidhi Nathany Mansi Sharma Anurag Mehta Surender Dhanda Joslia T Jose Source Type: research

Curable congestive heart failure in patients with primary aldosteronism: two cases reports
We report two male patients who were admitted because of severe cardiac systolic dysfunction induced by primary aldosteronism. Their cardiac function improved significantly after target therapy. Patient A was a 33 year old male with serum aldosterone concentration (PAC) 251.3 pg/ml, renin activity (PRA) 0.04 ng/ml/h, and aldosterone-to-renin ratio (ARR) 627.5. Computed tomography (CT) revealed a tumor in the left adrenal gland, while no dominant secretion function was found in the left side after the adrenal veins sampling (lateralization index 0.99). Bilateral adrenal hyperplasia was diagnosed and spironolactone was presc...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Zijun Chen Zhe Zhang Qianlan Xi Guimei Huang Liya Wang Source Type: research

Active Stat3 and Her-2 as combined survival predictors show superiority to TNM staging system for postoperative patients with gastric cancer
CONCLUSIONS: We conclude that area under the ROC curve (AUC) can be used to quantify SPP powers for biomarkers, making cross-comparisons possible among different survival predictors. This study has first established a multi-factor survival prediction model by which the p-Stat3+Her-2 combination has the best discriminative capability to differentiate low-risk patients from high-risk patients in terms of survival prognosis.PMID:35559376 | PMC:PMC9091078 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Ke Sun Meng Qing Xu Hai Jun Zhang Dan Dan Zhang Wen Yue Miao Miao Ma Lin Tao Wen Jie Zhang Source Type: research

Cranio-maxillofacial post-operative face prediction by deep spatial multiband VGG-NET CNN
Am J Transl Res. 2022 Apr 15;14(4):2527-2539. eCollection 2022.ABSTRACTCurrent plastic and reconstructive surgery computational techniques are not precise and take a long time to perform. Therefore, these limitations reduced the adoption of computational techniques. Although computer-aided surgical preparation systems may help to enhance clinical results, minimize operating time and costs, they are too complicated and require detailed manual information, which restricts their usage in doctor-patient communication and clinical decision-making. In order to obtain the optimal aesthetic and reconstruction treatment results, th...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Rizwan Ali Rui Lei Haifei Shi Jinghong Xu Source Type: research

Curcumin treats endometriosis in mice by the HIF signaling pathway
CONCLUSION: Curcumin played a role in the treatment of EM by modulating the HIF signaling pathway, improving the local hypoxia of the lesion, and reducing the inflammatory state of EM.PMID:35559378 | PMC:PMC9091111 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Jie Ding Shanshan Mei Wen Cheng Zhexin Ni Chaoqin Yu Source Type: research

LncRNA FER1L4 promotes differentiation and inhibits proliferation of NSCs via miR-874-3p/Ascl2
Am J Transl Res. 2022 Apr 15;14(4):2256-2266. eCollection 2022.ABSTRACTNeural stem cells (NSCs) may offer beneficeial and promising adjuncts for treatment of neurological diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and spinal cord injuries. Previous studies showed that LncRNA FER1L4 plays crucial roles in many biological procedures such as invasion, metabolism, apoptosis, and stem cell differentiation. However, the role of FER1L4 in differentiation and growth of NSCs remains unknown. In the present research, we noted that FER1L4 is upregulated in NSCs induced with TNF╬▒. Ectopic expression of FER1L4...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yanping Li Hui Wang Liping Zhan Qingyun Li Yang Li Gang Wu Huan Wei Xiaolin Dong Source Type: research

Epidemiologic characteristics and differential management strategies of seven case series with COVID-19 outbreaks caused by asymptomatic carriers from June 2020 to May 2021 in China
Am J Transl Res. 2022 Apr 15;14(4):2244-2255. eCollection 2022.ABSTRACTWith the COVID-19 epidemic quickly under control in China in the early stage of 2020, global cooperation/communications may pose great challenges to epidemic control and prevention in the country. Large-scale spread by asymptomatic carriers was a concern. We obtained data on new cluster outbreak regions with COVID-19 caused by asymptomatic carriers from June 2020 to May 2021 in China, and reported the epidemiological characteristics, the possible routes of viral transmission and infection, and different control strategies. These results show the importa...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Cheng Liu Hongbing Xiang Anne Manyande Weiguo Xu Li Fan Yunhua Zhang Boqi Xiang Source Type: research

Keap1-Nrf2/ARE signal pathway activated by butylphthalide in the treatment of ischemic stroke
CONCLUSION: The butylphthalide can effectively improve the clinical efficacy of acute ischemic stroke, and promote patients' neurological function and activities of daily living. The mechanism may be that butylphthalide improves the CVR of patients, enhances the establishment of collateral compensatory vessels, and changes the expression of the Keap1-Nrf2/ARE signaling pathway, thereby exerting the neuroprotective effect. Clinically, butylphthalide may have good safety in adjuvant therapy of acute ischemic stroke.PMID:35559381 | PMC:PMC9091106 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Xiaofeng Zhang Qiang Wu Zhihui Wang Haimei Li Jie Dai Source Type: research

Circ_MTM1 knockdown inhibits the progression of HBV-related liver fibrosis via regulating IL7R expression through targeting miR-122-5p
CONCLUSION: Circ_MTM1 could serve as a promoter in HBV-related LF through miR-122-5p/IL7R axis.PMID:35559382 | PMC:PMC9091097 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Bin Li Yonggang Li Shuhua Li Hongwei Li Ling Liu Haiying Yu Source Type: research

Biodistribution of mesenchymal stem cells (MSCs) in animal models and implied role of exosomes following systemic delivery of MSCs: a systematic review
Am J Transl Res. 2022 Apr 15;14(4):2147-2161. eCollection 2022.ABSTRACTMesenchymal stem cells (MSC) are promising candidates to combat the growing rates of chronic degenerative diseases. These cells provide regeneration and/or differentiation into other cell types, and secrete various trophic factors that participate in migration, proliferation, and immunomodulation. However, the novelty of MSC research has noticeably declined as common barriers and unresolved challenges prevent further progress. A common issue is the low survivability and migration of systemically infused MSC towards targeted regions. Nevertheless, succes...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Alvin Man Lung Chan Yashirdisai Sampasivam Yogeswaran Lokanathan Source Type: research

Meta-analysis of the prognosis after surgical treatment of osteosarcoma complicated by pathologic fracture
CONCLUSION: Complicated with pathologic fracture is a negative prognostic indicator of osteosarcoma, and its poor survival rates (both OS and DFS) may be associated with a higher DMR. For osteosarcoma patients with pathologic fractures treated with standard treatment, LRR and DMR exhibit no significant difference between amputation and limb-salvage surgery.PMID:35559384 | PMC:PMC9091088 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Wei Zhong Ziyi Wu Yuhao Yuan Wei Luo Source Type: research

CD24 is expressed on FoxP3 < sup > + < /sup > regulatory T cells and regulates their function
Am J Transl Res. 2022 Apr 15;14(4):2291-2300. eCollection 2022.ABSTRACTCD24 is a glycosyl-phosphatidylinositol (GPI) anchored cell surface glycoprotein with a variety of immunomodulatory functions such as inhibition of thymic generation of autoreactive T cells, regulation of antigen presenting cell functions, and mediation of autoimmunity. Given the autoimmune nature of FoxP3+ regulatory T cells and their importance in autoimmune diseases, we hypothesize that CD24 regulates the generation and functions of Treg cells. Through the analysis of the Treg repertoire in two strains of CD24-deficient mice, we found that CD24 does ...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yun Shi Jing Zhu Jin-Qing Liu Fatemeh Talebian Mingsong Li Xue-Feng Bai Source Type: research

Methods for identifying biomedical translation: a systematic review
In conclusion, there is still a lack of a gold-standard method for evaluating biomedical translational research.PMID:35559386 | PMC:PMC9091120 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Javier Padilla-Cabello Antonio Santisteban-Espejo Ruben Heradio Manuel J Cobo Miguel A Martin-Piedra Jose A Moral-Munoz Source Type: research

Effect of intravenous thrombolysis combined with mechanical thrombectomy on neurological function and short-term prognosis of patients with acute cerebral infarction
CONCLUSION: Intravenous thrombolysis combined with mechanical thrombectomy can accelerate the recovery of neurological function in patients with ACI, and yield a more promising outcome in terms of the patient's vascular recanalization rate compared with the monotherapy. It can also reduce the adverse reaction rate of patients to ensure a better short-term prognosis.PMID:35559387 | PMC:PMC9091080 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Yongchang Liu Zhen Hong Yan Li Shaoquan Li Qingran Liu Songwang Xie Junyong Wang Jian Wang Mingming Zheng Source Type: research

Awake fiberoptic intubation in a patient with a large thyroid tumor invading the trachea: a case report
We report a case of a patient with a large thyroid tumor invading the trachea, causing trachea narrowing and resulting in breathing difficulties, who required awake tracheal intubation (ATI). A 54-year-old woman underwent surgery for the removal of a thyroid tumor under general anesthesia. The tumor was invading and compressing the trachea, causing difficulty in breathing. To facilitate surgery, thyrocricocentesis and nerve block were considered, but they were difficult to implement. Extracorporeal membrane oxygenation (ECMO) is expensive and has risks of several complications, such as failure of the oxygenation membrane, ...
Source: American Journal of Translational Research - May 13, 2022 Category: Research Authors: Guo Ran Meng Ning Xu Zhang Source Type: research