miR-135a-5p mediated down-regulation of STAT6 inhibits proliferation and induces apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis
CONCLUSION: miR-135a-5p/STAT6 is a potential novel therapeutic target for RA treatment.PMID:35702088 | PMC:PMC9185078 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Jiajia Liu Jianhua Xue Bo Xu Junbo Yu Yuxuan Zhang Lili Qin Aixian Zhang Yang Yang Source Type: research

Inflammation-mediated macrophage polarization induces TRPV1/TRPA1 heteromers in endometriosis
Am J Transl Res. 2022 May 15;14(5):3066-3078. eCollection 2022.ABSTRACTChronic pelvic pain (CPP) and infertility are the common characteristics of endometriosis. Macrophages and related inflammation play important roles in endometriosis pain. TRPV1 and TRPA1 form a heteromeric channel which is related to endometriosis pain. In the present study, the inflammation-mediated macrophage polarization along with TRPV1/TRPA1 heteromers in endometriosis was investigated in vivo and in vitro. Macrophage polarization and TRPV1/TRPA1 heteromers in endometriosis tissue of patients were assayed, and was further investigated in endometri...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Hai Zhu Yi Wang Yibo He Weifeng Yu Source Type: research

Expression and predictive value of NLRP3 in patients with atrial fibrillation and stroke
CONCLUSION: NLRP3 is highly expressed in peripheral blood of patients with NVAF complicated with IS, which is a potential indicator for predicting NVAF complicated with IS.PMID:35702090 | PMC:PMC9185086 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Jue Sun Jiayi Xu Qianhong Yang Source Type: research

The effects of combination therapy by solid lipid nanoparticle and dental stem cells on different degenerative diseases
Am J Transl Res. 2022 May 15;14(5):3327-3343. eCollection 2022.ABSTRACTStem cells have multiple therapeutic applications, as well as solid lipid nanoparticles. Solid lipid nanoparticle has appeared as a field of nano lipid technology with various potential applications in drug delivery, clinical medicine and research. Besides, the stem cells have a high proliferation rate and could differentiate into a variety of tissues. Stem cells derived from human dental pulp tissue differ from other sources of mesenchymal stem cells due to their embryonic neural crest source and neurotrophic potential. These consist of both dental pul...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Farideh Kamarehei Source Type: research

The repair effect and mechanism of continuous passive motion on osteoarthritis in a rabbit model
CONCLUSION: CPM can effectively improve the symptoms of knee osteoarthritis in rabbits and increase the mobility of the joints, and the mechanism may be related to the ability of CPM to reduce the overproduction of peroxide at the lesion site.PMID:35702092 | PMC:PMC9185065 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Bingguang Zuo Zhipei Wang Source Type: research

Meta-analysis of therapeutic efficacy and effects of integrated traditional Chinese and Western medicine on coagulation and fibrinolysis system in patients with threatened abortion and polycystic ovary syndrome
CONCLUSIONS: The effect of integrated traditional Chinese and Western medicine is better than that of Western medicine alone in the treatment of PCOS with threatened abortion, and it has certain advantages in improving the fibrinolytic status of patients. However, due to the limitation of the quality and quantity of the included literature, more rigorous and larger sample studies are needed to confirm these conclusions in the future.PMID:35702093 | PMC:PMC9185052 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Xueli Chen Chong Tao Jingyi Wang Baochang He Jinbang Xu Source Type: research

Prognosis of patients with early gastric carcinoma treated by endoscopic submucosal dissection and risk factors for additional postoperative surgery
CONCLUSION: ESD can accelerate the postoperative recovery of patients with EGC, and positive surgical margin is independently tied to additional postoperative surgery in patients after ESD.PMID:35702094 | PMC:PMC9185062 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Shuang Jiang Dahe Ge Kaijun Shou Source Type: research

Clinical effect of trans-areolar resection and minimally invasive mammotome biopsy in the treatment of breast fibroadenoma and its impact on the quality of life of patients
CONCLUSION: Compared with trans-areolar resection, minimally invasive mammotome biopsy has a better therapeutic effect on patients with breast fibroadenoma, and it can improve their quality of life more significantly.PMID:35702095 | PMC:PMC9185088 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Qi Wang Jianping Zheng Yufeng Ren Hui Xu Source Type: research

Clinical value of prophylactic transcatheter arterial chemoembolization treatment in patients with hepatocellular carcinoma
CONCLUSION: Prophylactic TACE significantly reduced the postoperative recurrence rate and improved the survival rate of patients with HCC. The optimal treatment efficacy was associated with interventional therapy within 1-2 months after surgery, while incomplete envelope, tumor diameter ≥5 cm, and combined cirrhosis were the high-risk factors for HCC recurrence.PMID:35702096 | PMC:PMC9185034 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Hui Li Zhihu Liu Cuiping Han Source Type: research

Expression and prognostic value of ratios of platelet lymphocyte, neutrophil lymphocyte and lymphocyte monocyte in breast cancer patients
CONCLUSION: Inflammatory markers based on NLR, PLR and LMR may become biological indicators to predict the pathological features and prognosis of invasive BC in the future.PMID:35702097 | PMC:PMC9185042 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Deba Song Xiaoxu Li Xiaojian Zhang Source Type: research

Correlation between salivary HBD-2 and LL-37 expression levels with blood glucose and periodontal status in patients with type 2 diabetes mellitus
CONCLUSION: There is a positively correlated relationship between blood glucose and periodontal status with salivary HBD-2 and LL-37 levels.PMID:35702098 | PMC:PMC9185056 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Zunsheng Xiao Wencui Ding Chao Wen Chao Ge Lu Liu Ke Xu Sumin Cao Source Type: research

The effectiveness of diet intervention in improving the metabolism of overweight and obese women: a systematic review and meta-analysis
CONCLUSIONS: Different dietary interventions benefit glucose and lipid metabolism of overweight or obese women. Further study is needed to determine which specific dietary effects have the greatest effect on improving metabolic indicators.PMID:35702099 | PMC:PMC9185074 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Mengkun Chen Qiuli Chen Wenjun Liu Hui Tong Yuedan Wu Source Type: research

Construction and validation of an eight pyroptosis-related lncRNA risk model for breast cancer
CONCLUSION: The potential role of pyroptosis-related lncRNAs in BRCA prognosis may be exploited as a treatment target for patients with BRCA.PMID:35702100 | PMC:PMC9185044 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Miduo Tan Guo Huang Jingjing Chen Jiansheng Yi Xi Liu Ni Liao Yi Hu Wei Zhou Qiong Guo Source Type: research

QRISK3-based analysis of cardiovascular risk factors in patients with long-term but well-controlled systemic lupus erythematosus
In this study, involving 180 patients, we compared the performance of the Framingham risk score, the recalibrated risk prediction SCORE, and QRISK3 for the assessment of CVD in patients with a long course of disease and low disease activity. Then, we used a more efficient algorithm, QRISK3 to identify the risk factors for CVD. This was a prospective and cross-sectional study involving 116 patients. All patients fulfilled the ACR criteria. The systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) is widely used to assess disease activity in SLE patients; patients with a SLEDAI-2K less than or equal to 4 are c...
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Shuo-Lin Wang Wei Li Tian-Fang Li Xu Liang Ye-Lan Yan Sheng-Yun Liu Source Type: research

Correlation of ApoE gene polymorphism with acute myocardial infarction and aspirin resistance after percutaneous coronary intervention
CONCLUSION: ApoE gene polymorphism is correlated with AMI and APC resistance after PCI, and ApoE ε4 genotype is probably the risk allele for AMI.PMID:35702102 | PMC:PMC9185036 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 15, 2022 Category: Research Authors: Luoqing Wang Chen Shao Cuimin Han Peng Li Feixiang Wang Yilian Wang Junping Li Source Type: research