493 Effects of chemotherapy agents on placental cells: implications for treating breast cancer during pregnancy

To examine anti-proliferative and cytotoxic effects of three breast cancer chemotherapeutics (5-fluorouracil (5-FU), doxorubicin (DXR), and cyclophosphamide (CP)) on human placental cell lines JAR and JEG-3. Tamoxifen (TAM) a hormone therapy contraindicated in pregnancy was also examined.

Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Nathan A. Keller, Xiangying Xue, Christine Metz Source Type: research