Critical Appraisal of the Proposed Defenses for Planned Home Birth
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 14, 2019 Category: OBGYN Authors: Amos Gr ünebaum, Laurence B. McCullough, Birgit Arabin, Frank A. Chervenak Tags: Clinical Opinion Source Type: research

Expanding the indications for cell-free DNA in the maternal circulation: clinical considerations and implications
Non-invasive prenatal testing (NIPT) for fetal aneuploidy using cell-free DNA has been widely integrated into routine obstetrical care. The scope of cfDNA testing has expanded from trisomies 21, 18, and 13 to include sex chromosome conditions, panels of specific microdeletions, and more recently genome-wide copy number variants and rare autosomal trisomies. Because the technical ability to test for a condition does not necessarily correspond with a clinical benefit to a population or to individual pregnant women, the benefits and harms of screening programs must be carefully weighed before implementation. (Source: American...
Source: American Journal of Obstetrics and Gynecology - January 10, 2019 Category: OBGYN Authors: Gian Carlo di Renzo, Jose ’ Luis Bartha, Catia M. Bilardo Tags: Expert Review Source Type: research

Effect of postoperative partial bladder filling after minimally invasive hysterectomy on postanesthesia care unit discharge and cost: a  single-blinded, randomized controlled trial
Hysterectomy is one of the most common surgical procedures performed each year with substantial related health care costs. This trial studied the effect of postoperative bladder backfilling to submicturition level in the operating room and its effect on early postoperative patient care and related cost. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 9, 2019 Category: OBGYN Authors: Gaby Moawad, Paul Tyan, Cherie Marfori, Elias Abi Khalil, Daniel Park Tags: Original Research Source Type: research

Effect of Postoperative Partial Bladder Filling After Minimally Invasive Hysterectomy on Post Anesthesia Care Unit Discharge and Cost: A Single-Blinded Randomized Controlled Trial
Hysterectomy is one of the most common surgical procedures performed each year with substantial related healthcare costs. This trial studied the effect of postoperative bladder backfilling to sub-micturition level in the operating room and its effect on early postoperative patient care and related cost. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 9, 2019 Category: OBGYN Authors: Gaby Moawad, Paul Tyan, Cherie Marfori, Elias Abi Khalil, Daniel Park Tags: Original Research: Gynecology Source Type: research

Resolution of intra-amniotic sludge after antibiotic administration in a patient with short cervix and recurrent mid-trimester loss
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 9, 2019 Category: OBGYN Authors: Cheryl Dinglas, Martin Chavez, Anthony Vintzileos Tags: Images in Gynecology Source Type: research

Vaginal Assessment and Expedited Amniotomy in Oral Misoprostol Labor Induction in Nulliparas: A Randomized Trial
Labor is induced in 20-30% of maternities with an increasing trend of use. Labor induction with oral misoprostol is associated with reduced risk of Cesarean births and has a comparable safety and effectiveness profile to mechanical method like with the Foley catheter. Labor induction in nulliparous women continues to be challenging with the process often quite protracted and eventual Cesarean rate is high and particularly so when the cervix is unfavorable and ripening is required. Vaginal examination can cause discomfort and emotional distress particularly to nulliparous women, so plausibly affect patient satisfaction with...
Source: American Journal of Obstetrics and Gynecology - January 9, 2019 Category: OBGYN Authors: Sandar Tin Win, Peng Chiong Tan, Imelda Balchin, Su Yen Khong, Khaing Si Lay, Siti Zawiah Omar Tags: Original Research: Obstetrics Source Type: research

Association between gestational age and severe maternal morbidity and mortality of preterm cesarean delivery: a population-based cohort study
Cesarean delivery rates at extreme prematurity have regularly increased over the last years and few previous studies investigated severe maternal morbidity of extreme preterm cesarean. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 9, 2019 Category: OBGYN Authors: Julie Blanc, No émie Resseguier, François Goffinet, Elsa Lorthe, Gilles Kayem, Pierre Delorme, Christophe Vayssiere, Pascal Auquier, Claude D’ercole Tags: Original Research: Obstetrics Source Type: research

Time from neuraxial anesthesia placement to delivery is inversely proportional to umbilical arterial cord pH at scheduled cesarean delivery
Neuraxial block-related hypotension and maternal obesity contribute to uterine hypoperfusion and decreased umbilical arterial pH at cesarean delivery. Between the time of anesthesia placement and delivery, the fetus may be exposed to a hypo-perfused uterine environment without surgeon awareness of fetal compromise. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 9, 2019 Category: OBGYN Authors: Rebecca R. Rimsza, William M. Perez, Shilpa Babbar, Megan O ’Brien, Laura K. Vricella Tags: Original Research: Obstetrics Source Type: research

Diagnostic Performance of Third Trimester Ultrasound for the Prediction of Late-Onset Fetal Growth Restriction: A Systematic Review and Meta-Analysis
To establish the diagnostic performance of ultrasound screening for predicting late smallness for gestational age (SGA) and/or fetal growth restriction (FGR). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 9, 2019 Category: OBGYN Authors: Javier Caradeux, Raigam J. Martinez-Portilla, Anna Peguero, Alexandros Sotiriadis, Francesc Figueras Tags: Systematic Review Source Type: research

Academic Physicians as Factory Workers: Identifying and Preventing Alienation of Labor
Recent changes in the culture of academic obstetrics and gynecology have increased the potential for disconnect between physicians and their patients. These changes include increased emphasis on productivity, burgeoning bureaucracies for purposes of compliance, arbitrary clinical goals such as low cesarean delivery rates, the electronic medical record, and lack of respect. These changes are predatory on professionalism when they alienate obstetrician-gynecologists from their patients. The concepts of alienated labor and non-alienated labor in the political philosophy of Karl Marx can be used to explain this alienation. (So...
Source: American Journal of Obstetrics and Gynecology - January 7, 2019 Category: OBGYN Authors: Frank A. Chervenak, Laurence B. McCullough Tags: Clinical Opinion Source Type: research

Two Dose versus Single Dose of Methotrexate for Treatment of Ectopic Pregnancy: a Meta-Analysis
To compare the treatment success and failure rates, as well as side effects and surgery rates between methotrexate protocols. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 7, 2019 Category: OBGYN Authors: Snigdha Alur-Gupta, Laura G. Cooney, Suneeta Senapati, Mary D. Sammel, Kurt T. Barnhart Tags: Systematic Review Source Type: research

Alobar holoprosencephaly detected in a  9-week embryo
A 37-year-old woman with a spontaneous pregnancy presented for routine early ultrasound. Transvaginal scanning demonstrated a single live embryo with a crown −rump length of 25 mm, equivalent to 9 weeks’ gestation. In normal embryos, lateral cerebral ventricles are visible by 9 weeks (Figure 1). In this patient, a single anterior cerebral monoventricle (MV) was detected on 2-dimensional ultrasound (Figure 2). Three-dimensional ultrasound (Figure 3 ) with volume-rendered imaging of the ventricular system (Figure 4) confirmed alobar holoprosencephaly. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 6, 2019 Category: OBGYN Authors: Simon Meagher, Lisa Hui Tags: Images in Obstetrics Source Type: research

Alobar holoprosencephaly detected in a nine-week embryo
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 6, 2019 Category: OBGYN Authors: Simon Meagher, Lisa Hui Tags: Images in Obstetrics Source Type: research

The American Gynecological and Obstetrical Society - Reinvigorating for the 21st Century
This report reviews a strategic plan designed to reinvigorate AGOS to address, together with our partner organizations, the ever more pressing issues and challenges in women’s reproductive health. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 6, 2019 Category: OBGYN Authors: Laurel W. Rice, Charles J. Lockwood, Maureen Phipps, John O.L. Delancey, Ronald D. Alvarez, Marcelle I. Cedars Tags: Viewpoint Source Type: research

Clinical diagnosis of endometriosis: a call to action
Endometriosis can have a profound impact on women ’s lives, including associated pain, infertility, decreased quality of life, and interference with daily life, relationships, and livelihood. The first step in alleviating these adverse sequelae is to diagnose the underlying condition. For many women, the journey to endometriosis diagnosis is long and fraught with barriers and misdiagnoses. Inherent challenges include a gold standard based on an invasive surgical procedure (laparoscopy) and diverse symptomatology, contributing to the well-established delay of 4 to 11 years from first symptom onset to surgical diagnosi...
Source: American Journal of Obstetrics and Gynecology - January 6, 2019 Category: OBGYN Authors: Sanjay K. Agarwal, Charles Chapron, Linda C. Giudice, Marc R. Laufer, Nicholas Leyland, Stacey A. Missmer, Sukhbir S. Singh, Hugh S. Taylor Tags: Call to Action Source Type: research

Reply
We thank Walther-Antioni and Mariani for their interest and response to our study on the role of bleeding recognition and evaluation in the black-white disparities in endometrial cancer. They correctly emphasize the impact of our primary findings, which is that differences in health care delivery before diagnosis may influence the stage at diagnosis and thus mortality rates for women with this disease. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 27, 2018 Category: OBGYN Authors: Kemi M. Doll, Barbara A. Goff, Scott D. Ramsey Tags: Letter to the Editors Source Type: research

Are early screening biomarkers for endometrial cancer needed to reduce health disparities?
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 27, 2018 Category: OBGYN Authors: Marina R.S. Walther-Antonio, Andrea Mariani Tags: Letter to the Editors Source Type: research

In Reply: Are early screening biomarkers for endometrial cancer needed to reduce health disparities?
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 27, 2018 Category: OBGYN Authors: Kemi M. Doll, Barbara A. Goff, Scott D. Ramsey Tags: Letter to the Editors Source Type: research

Computerized analysis of cardiotocograms and ST signals is associated with significant reductions in hypoxic-ischemic encephalopathy and cesarean delivery: an observational study in 38 466 deliveries
Intrapartum cardiotocography (CTG) is widely used in high-resource countries and remains at the centre of fetal monitoring and the decision to intervene, but there is ample evidence of poor reliability in visual interpretation, as well as limited accuracy in identifying fetal hypoxia. Combined monitoring of CTG and ST segment signals was developed to increase specificity, but analysis relies heavily on CTG interpretation and is therefore also affected by the previously referred problems. Computerized analysis was developed to overcome these limitations, aiding in the quantification of parameters that are difficult to evalu...
Source: American Journal of Obstetrics and Gynecology - December 27, 2018 Category: OBGYN Authors: Joana Lopes-Pereira, Ant ónia Costa, Diogo Ayres-de-Campos, Cristina Costa-Santos, Joana Amaral, João Bernardes Tags: Original Research: Obstetrics Source Type: research

Red plaques and tumors on the vulva
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 26, 2018 Category: OBGYN Authors: Chao Wu Source Type: research

1: Subsequent pregnancy outcomes after open maternal-fetal surgery for fetal myelomeningocele closure
The objective of this study was to ascertain obstetric risk in subsequent pregnancies after open fetal surgery (OFS) for myelomeningocele (MMC) closure. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: William H. Goodnight, Ozan Bahtuyar, Kelly A. Bennett, Stephen Emery, Brad A. Feltis, Allan Fisher, Ruth Goldstein, Jillian Jatres, Foong-Yen Lim, Laurence McCullough, Ueli Moehrlen, Julie Moldenhauer, Anita Grady, Rodrigo Ruano, Daniel W. Skupski, Elizab Tags: Oral Plenary I Source Type: research

2: Resource utilization among low-risk nulliparas randomized to elective induction at 39 weeks or expectant management
To evaluate medical resource utilization for low –risk nulliparous women randomized to elective induction of labor (IOL) at 39 weeks compared to those randomized to expectant management (EM). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: William A. Grobman Tags: Oral Plenary I Source Type: research

3: Pregnancy high fructose diet: pathways involved in fetal programming of metabolic syndrome in adult offspring
We, as well as others, have shown that maternal intake of high fructose has been shown to lead to sex- specific fetal programming of adult obesity, hypertension and metabolic dysfunction in mice. Our objective was to test the hypothesis that these outcomes are related to altered fructose metabolism, lipid accumulation and inflammation in the liver of adult offspring. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Antonio Saad, Christian Thibodeaux, Talar Kechichian, Huaizhi Yin, Phyllis Orise, Ashley Salazar, George Saade Tags: Oral Plenary I Source Type: research

4: Have genomic screening advances gone far enough?
Advances in genomics have expanded the screening modalities available in pregnancy. Expanded carrier screening (ECS) is used to identify couples with reproductive risks for autosomal recessive (AR) and X-linked (XLR) disorders, and cell-free fetal DNA prenatal multigene screening (cffMGS) is available to detect de novo single base pair mutations noninvasively. We sought to determine the ability of ECS and cffMGS individually and in combination to detect genetic syndromes identified in a cohort of fetuses with congenital anomalies. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Jessica L. Giordano, Russell Miller, Brynn Levy, David Goldstein, Ronald J. Wapner Tags: Oral Plenary I Source Type: research

5: Maternal outcomes by race during postpartum readmissions
With efforts focusing on reducing differentials in adverse maternal outcomes, we sought to determine the association of race  with risk for serious complications during postpartum readmissions. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Aleha Aziz, Cynthia Gyamfi-Bannerman, Zainab Siddiq, Jason D. Wright, Dena Goffman, Jean-Ju Sheen, Mary E. D'Alton, Alexander M. Friedman Tags: Oral Plenary I Source Type: research

6: Early gestational diabetes screening in obese women: a randomized controlled trial
Although ACOG recommends screening obese women early for gestational diabetes (GDM), no studies demonstrate an improvement in perinatal outcomes. We sought to determine whether early GDM screening improves pregnancy outcomes in obese women. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Lorie M. Harper, Victoria C. Jauk, Sherri Longo, Joseph R. Biggio, Jeff M. Szychowski, Alan T. Tita Tags: Oral Plenary I Source Type: research

7: Text message remote blood pressure monitoring eliminated racial disparities in postpartum hypertension care
Significant racial disparities are observed in outcomes of women with pregnancy related hypertension (HTN). We evaluated whether text-based remote blood pressure (BP) monitoring could improve this disparity. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Adi Hirshberg, Diego J. Aviles, Sindhu Srinivas Tags: Oral Plenary I Source Type: research

8: Primary cytomegalovirus infection during pregnancy and subsequent congenital infection: maternal antibody screening involving 19,000 women
To identify the incidence rates of primary cytomegalovirus (CMV) infection during pregnancy and subsequent congenital CMV infection in Japan by conducting a maternal CMV antibody screening program in a large population of Mie Prefecture, Japan. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Kuniaki Toriyabe, Kyoko Shimada, Asa Kitamura, Toshio Minematsu, Makoto Ikejiri, Shigeru Suga, Fumi Furuhashi, Shoichi Magawa, Shintaro Maki, Michiko Kaneda, Masafumi Nii, Kayo Tanaka, Hiroaki Tanaka, Yuki Kamimoto, Tomoaki Ikeda Tags: Oral Plenary I Source Type: research

9: Randomized controlled trial of n-acetylcysteine to prevent adverse neonatal outcome in pregnancies with intra-amniotic infection/inflammation
Compelling animal data suggests restoration of maternal-fetal oxidative balance by N-acetylcysteine (NAC) may reduce risk of adverse neonatal outcome in pregnancies complicated by intra-uterine infection/inflammation. We aimed to evaluate if maternal administration of NAC lowers risk of morbidity or death in infants of women with intra- amniotic infection (IAI). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Catalin S. Buhimschi, Mert-Ozan Bahtiyar, Osama Abdelghany, Lydia Schneider, Sonya Abdel-Raqez, Antonette T. Dulay, Heather Lipkind, Elizabeth Lopez, Guomao Zhao, Lynette Rogers, Vineet Bhandari, Irina A. Buhimschi Tags: Oral Concurrent 1 Source Type: research

10: Stress, local immune responses, and spontaneous preterm birth risk in a majority African  American cohort
The role of host immunity and maternal psychosocial stress in the pathogenesis of spontaneous preterm birth (sPTB) remains unclear. Antimicrobial proteins in the cervicovaginal CV) space, such as beta-defensins ( βD), modulate immune responses to bacteria. While stress is known to induce immunological changes, no study has examined the interplay between stress and the CV immune response in association with sPTB. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Isabel C. Schmidt, Valerie Riis, Amy G. Brown, Michal A. Elovitz, Heather H. Burris Tags: Oral Concurrent 1 Source Type: research

11: Exosomal delivery of therapeutics to delay LPS induced preterm birth and decrease associated inflammatory response
In this study, we tested engineered extracellular vesicles, or exosomes, cargoing an inhibitor to pro-inflammatory transcription factor (NF-kB), called super repressor (SR) IkB, to prolong gestation in an infection (LPS) induced PTB mouse model. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Samantha Sheller-Miller, Chulhee Choi, George Saade, Ramkumar Menon Tags: Oral Concurrent 1 Source Type: research

12: Evidence for the crucial role of estrogen signaling with preterm labor and perinatal neuroinflammation
Female offspring are less susceptible to prematurity-related neuroinflammatory injury than males. We hypothesize such differences are attributed to sex-specific hormones, specifically estrogen. Using a murine prematurity model, we evaluated the role of estrogen signaling in the process of perinatal brain injury following exposure to intrauterine inflammation (IUI) by: 1) Characterizing the principle components of signaling (Esr1 and Esr2) and synthesis (Cyp19) and 2) Evaluating the phenotype with Esr1 deletion. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Stacey S. Schmiedecke, Sarah M. Estrada, Irina Burd, Peter G. Napolitano, Nicholas M. Ieronimakis Tags: Oral Concurrent 1 Source Type: research

13: Effect of prenatal tobacco use on perinatal outcomes and childhood neurodevelopment among infants born prematurely
Although it is well-known that nicotine is a neuroteratogen and prenatal tobacco exposure alters neurodevelopment, the effect on infants born prematurely is not yet well-described. We sought to examine the impact of prenatal tobacco exposure on childhood neurodevelopment until two years of age among infants born preterm. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Lindsay S. Robbins, Christina T. Blanchard, Rachel G. Sinkey, Stacy L. Harris, Alan T. Tita, Lorie M. Harper Tags: Oral Concurrent 1 Source Type: research

14: Relationship between human mtDNA variants, vaginal microbial species and strains, and frequency of preterm birth
Given the inability to consistently replicate or independently validate studies linking G. vaginalis and Lactobacillus spp. to preterm birth, differences in the ethnic or racial makeup of risk-disparate cohorts may be masking underlying true associations. As we and others have published on associations between genetic polymorphisms of the host mitochondrial genome and the microbiome, including the gut and vagina, we sought to evaluate the association of the vaginal microbiome with mitochondrial DNA (mtDNA) single nucleotide polymorphisms (SNPs) as risk-modifiers of preterm birth (PTB). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Ryan M. Pace, Derrick M. Chu, Kristen M. Meyer, Amanda L. Prince, Maxim Seferovic, Kjersti M. Aagaard Tags: Oral Concurrent 1 Source Type: research

15: Novel, sensor-based quantitative cervical elastography: objective quantification of cervical softness
Cervical ripening is a necessary physiologic phenomenon that precedes all labor, both term and preterm. Tissue elastography works by applying pressure to tissue and measuring tissue displacement. It is quantified by Young ’s modulus, a ratio of pressure to displacement. The harder the tissue, the less displacement and the higher the Young’s modulus. It is a promising technique for measuring cervical tissue stiffness to predict preterm birth, but to-date has been semi-quantitative because the exact force applied t o the cervix is difficult quantify. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Molly Stout, Peinan Zhao, Peng Hu, Yuan Qu, Jessica Chubiz, Konstantin Maslov, Julio Isla Garcia, Lihong Wang, George A. Macones, Methodius G. Tuuli Tags: Oral Concurrent 1 Source Type: research

16: Impact of severe stress after a major natural disaster on perinatal outcomes
Hurricane Harvey displaced over 60,000 of Houston ’s nearly 4.5 million residents. Natural disasters have been linked to posttraumatic stress disorders. Our objective was to evaluate the impact on perinatal outcomes of self-perceived stress among pregnant women in the weeks to months following Hurricane Harvey. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Hector Mendez-Figueroa, Mary Tolcher, Alireza Abdollah Shamshirsaz, Ryan M. Pace, Derrick M. Chu, Kjersti Aagaard Tags: Oral Concurrent 1 Source Type: research

17: Photoacoustic imaging of the uterine cervix: a novel method to characterize tissue composition
Mid-trimester sonographic cervical length is a powerful predictor of spontaneous preterm birth (NEJM 1996) and also identifies primiparous women at risk for cesarean delivery, due to poor progress in labor (NEJM 2008). Cervical remodeling is an important component of the common pathway of parturition. Therefore, assessing changes in cervical biochemistry could provide information about cervical status beyond that provided by cervical length and elastography. Photoacoustic imaging is a non-invasive ultrasound-based technology that captures acoustic signals emitted by the components of cervical tissue in response to laser pu...
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Aneesha Varrey, Mohammad Mehrmohammadi, Alpana Garg, Faisal Qureshi, Yan Yan, Maryam Basij, Adeel Siddiqui, Ali Alhousseini, Nardhy Gomez-Lopez, Roberto Romero, Sonia Hassan Tags: Oral Concurrent 1 Source Type: research

18: Influence of maternal body size on pharmacokinetics of weekly 17 alpha Hydroxyprogesterone Caproate (17OHPC)
Goal of the study is to estimate the pharmacokinetics (PK) of weekly 17OHPC in an obstetrical population and evaluate the effect of maternal body size on the PK parameters. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Micaela Della Torre, Christopher A. Enakpene, Samath Ravangard, Monique Sutherland, Laura DiGiovanni, Anna Whelan, James H. Fischer Tags: Oral Concurrent 1 Source Type: research

19: Increased concentration of 17-alpha hydroxyprogesterone caproate correlates with IL-10 to reduce spontaneous preterm birth
17-alpha hydroxyprogesterone caproate (17-OHPC) 250 mg reduces recurrent spontaneous preterm birth in women by 33%. We have previously demonstrated that women with the lowest quartile of plasma concentrations of 17- OHPC have elevated rates of preterm birth compared with women in the 2-4th quartiles. The mechanism of action of 17-OHPC is unknown but immune modulation is a possibility. We have previously reported elevated cytokines in the cervical fluid of women with a prior preterm birth. Additionally, circulating cytokines of immunoinhibitory IL-10 and pro-inflammatory TNF alpha have correlated with spontaneous preterm bi...
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Christina Megli, Alisse Hauspurg, Steve N. Caritis Tags: Oral Concurrent 1 Source Type: research

20: Induction of labor versus expectant management at 39 weeks: a cost-effectiveness analysis
A recent study found that induction of labor at 39 weeks for low-risk women was not associated with an increased risk of adverse neonatal outcomes. We sought to examine the cost-effectiveness and outcomes associated with induction of labor at 39 weeks versus expectant management. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Alyssa R. Hersh, Ashley E. Skeith, James A. Sargent, Aaron B. Caughey Tags: Oral Concurrent 2 Source Type: research

21: A randomized controlled trial of pre-induction cervical ripening comparing dilapan-s versus foley balloon (DILAFOL trial)
To test the hypothesis that Dilapan-S is not inferior to the Foley balloon for pre-induction cervical ripening at term. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Antonio Saad, Josephine Villareal, Joe Eid, Nicholas Spencer, Viviana Ellis, Gary D. Hankins, George Saade Tags: Oral Concurrent 2 Source Type: research

22: Transcervical ballon+vaginal misoprostol versus misoprostol for cervical ripening in nulliparous-obese women: a multicenter randomized trial
Nulliparous obese women are at increased risk for labor induction (IOL), unplanned cesarean delivery (CD) and adverse obstetric outcomes. Obesity has been associated with lower local prostaglandin sensitivity for cervical ripening. Our objective was to determine whether the combination of a transcervical Foley balloon and misoprostol (PGE1) is superior to PGE1 alone in decreasing the rate of CD in this population. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Oscar A. Viteri, Kareem K. Tabsh, Ximena C. Salazar, Mesk A. Alrais, Juan Lopez, Randolph Fok, Suneet P. Chauhan, Baha M. Sibai Tags: Oral Concurrent 2 Source Type: research

23: Factors associated with adverse outcomes in nulliparas at 39 weeks with induction or expectant management
To evaluate the association between baseline patient characteristics and adverse outcomes in low-risk nulliparous women randomized to planned induction of labor (IOL) at 39 weeks or expectant management (EM). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Yasser Y. El-Sayed Tags: Oral Concurrent 2 Source Type: research

24: Labor outcomes of immediate versus delayed oxytocin administration after amniotomy, a randomized controlled trial
To compare duration of labor, mode of delivery, maternal satisfaction and early neonatal outcomes following immediate (within 15-30 minutes) versus delayed (2 hours) oxytocin administration after amniotomy among low risk women in labour. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Osoti Alfred, Sule Kristina, Gachuno Onesmus Tags: Oral Concurrent 2 Source Type: research

25: Duration of latent phase of labor induction and maternal and neonatal outcomes in full-term nulliparas
The relationship of duration of latent phase (LP) in induced labor (IOL) to pregnancy outcomes remains controversial. We quantified the association between duration of LP of IOL and cesarean delivery (CD) and maternal and perinatal morbidity in healthy nulliparas at term. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Alan T. Tita Tags: Oral Concurrent 2 Source Type: research

26: Elective induction of labor at 39 weeks versus expectant management in low-risk multiparous women
The ARRIVE Trial demonstrated lower cesarean delivery rates, decreased hypertensive disorders of pregnancy and potentially improved perinatal outcomes in low-risk nulliparous women undergoing elective induction of labor (eIOL) at 39 weeks as compared to expectant management (EM). Our objective was to compare maternal and neonatal outcomes between eIOL and EM in low-risk multiparous women. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Rachel G. Sinkey, Christina T. Blanchard, Jeff M. Szychowski, Elizabeth Ausbeck, Akila Subramaniam, Alan T. Tita Tags: Oral Concurrent 2 Source Type: research

27: Externally validated induction score from a prospective population-based cohort study in 94 maternity units
The objective of our study was to build a score to predict the risk of cesarean section, from a population-based dataset especially designed for induction analysis purpose. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Floriane Jochum, Camille Le Ray, Pauline Blanc-Petitjean, Bruno Langer, Fran çois Severac, Nicolas Sananes Tags: Oral Concurrent 2 Source Type: research

28: Duration of 2nd stage of labor induction and maternal/perinatal outcomes in full-term low-risk nulliparas
Allowing a longer second stage (SS) increases the number of vaginal deliveries (VD) but women with longer SS are more likely to have a cesarean delivery (CD) and adverse maternal/perinatal outcomes than those with shorter SS. We sought to quantify the association of the duration of SS with CD and maternal/perinatal morbidity in a contemporary cohort of low-risk nulliparas who underwent induction of labor (IOL) at full term (FT). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Alan T. Tita Tags: Oral Concurrent 2 Source Type: research

29: The impact of elective induction of labor on cesareans and obstetric outcomes
A growing body of evidence supports improved or not worsened birth outcomes with induction of labor at 39 weeks compared to expectant management. Our goal was to compare outcomes for electively induced term pregnancies with those that were not electively induced in a population cohort. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Vivienne L. Souter, Ian Painter, Kristin Sitcov, Aaron B. Caughey Tags: Oral Concurrent 2 Source Type: research

30: Does mechanical induction of labor increase the risk of preterm birth in a subsequent pregnancy?
Mechanical induction with a Foley catheter is a frequent used method for induction of labor. Concerns have been raised on whether the mechanical aspect of this procedure can cause damage to the cervix and increase the risk of preterm birth (PTB) in a subsequent pregnancy. Here, we compare PTB rates (before 37 weeks of gestation) in subsequent pregnancies in women randomised to induction of labor with a Foley catheter versus Prostaglandins (PGE). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Marieke de Vaan, Dalila Blel, Kitty Bloemenkamp, Jan Willem de Leeuw, Martijn Oudijk, Jannet Bakker, Robbert Rijnders, Dimitri Papatsonis, Mallory Woiski, Ben Willem Mol, Roel de Heus Tags: Oral Concurrent 2 Source Type: research