Three dimensional texture analysis of noncontrast chest CT in differentiating solitary solid lung squamous cell carcinoma from adenocarcinoma and correlation to immunohistochemical markers
The model created by five selected textural feature parameters can differentiate solid SCC from AC without contrast media. The selected five texture feature parameters are correlated to the immunohistochemical markers P63 and P40. BackgroundThe aim of the study was to investigate 3D texture analysis (3D ‐TA) in noncontrast enhanced computed tomography (CT) (NCECT) to differentiate squamous cell carcinoma (SCC) from adenocarcinoma (AC), and the correlation with immunohistochemical markers.MethodsA total of 70 patients confirmed with SCC (n = 29) and AC (n = 41) were enrolled in this retrospective study. 3D ‐TA was utili...
Source: Thoracic Cancer - September 18, 2020 Category: Cancer & Oncology Authors: Rui Han, Roshan Arjal, Jin Dong, Hong Jiang, Huan Liu, Dongyou Zhang, Lu Huang Tags: ORIGINAL ARTICLE Source Type: research

Unusual lung involvements of invasive mucinous adenocarcinoma with chylothorax
This case of invasive mucinous adenocarcinoma (IMA) showed subpleural micronodular opacities and chylothorax as unusual chest computed tomography (CT) patterns for IMA. IMA should be considered in the differential diagnosis of subpleural micronodular opacities accompanied by pleural effusion on chest CT. AbstractA 77 ‐year‐old man who had a persistent productive cough for one month was admitted to our hospital. Chest computed tomography (CT) revealed subpleural nodular opacities, irregular pleural thickening with bilateral basal predominance, and a small right pleural effusion. Aspirated fluid was exudative and had the...
Source: Thoracic Cancer - September 18, 2020 Category: Cancer & Oncology Authors: Ayako Aoki, Yu Hara, Koji Okudela, Yoshihiro Ishikawa, Kosei Doshita, Hisashi Hashimoto, Kentaro Nakashima, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko Tags: IMAGING IN THORACIC CANCERS Source Type: research

Expression and role of p16 and GLUT1 in malignant diseases and lung cancer: A review
This review highlights the role of p16 and GLUT ‐1 and GLUTs proteins in malignancies especially in lung cancer, focusing on the pathways activated leading to cell cycle dysregulation, cancer growth and migration. Since they have a clinical prognostic value, they may become targets for novel therapies. Non ‐small cell lung cancer (NSCLC) is the leading cause of cancer death and in most cases it is often diagnosed at an advanced stage. Many genetic and microenvironmental factors are able to modify the cell cycle inducing carcinogenesis and tumor growth. Among the metabolic and genetic factors that co me into play in car...
Source: Thoracic Cancer - September 18, 2020 Category: Cancer & Oncology Authors: Aldo Pezzuto, Michela D'Ascanio, Alberto Ricci, Alessandra Pagliuca, Elisabetta Carico Tags: MINI REVIEW Source Type: research

Primary tumor resection of non ‐small cell lung cancer patients with ipsilateral pleural dissemination (M1a) in the era of targeted therapy
ConclusionsThe results of this study indicated that PTR could prolong OS in stage IV NSCLC patients with ipsilateral pleural dissemination, especially in patients who are not candidates for targeted therapy.Key points Non ‐small cell lung cancer patients with ipsilateral pleural dissemination can benefit from primary tumor resection. Primary tumor resection could prolong overall survival (OS) in non‐small cell lung cancer patients with ipsilateral pleural dissemination who are not candidates for targeted therapy. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 18, 2020 Category: Cancer & Oncology Authors: Hao Li, Taorui Liu, Zewen Sun, Fan Yang Tags: ORIGINAL ARTICLE Source Type: research

Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7
ConclusionsHere, we demonstrated for the first time that E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7. Our findings provide new evidence to support the important role of KIF7 in the pathogenesis of lung cancer and suggests new therapeutic targets. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 18, 2020 Category: Cancer & Oncology Authors: Yue Hu, Ming ‐Zhe Wu, Na‐Jin Gu, Hong‐Tao Xu, Qing‐Chang Li, Guang‐Ping Wu Tags: ORIGINAL ARTICLE Source Type: research

Successful treatment with nivolumab in a patient with lung adenocarcinoma complicated by pulmonary aspergilloma
In conclusion, to safely treat patients with locally limited chronic pulmonary aspergillosis (CPA), surgical resection should be considered before ICI therapy. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 17, 2020 Category: Cancer & Oncology Authors: Naoki Furuya, Koji Kojma, Hideki Marushima, Kazutaka Kakinuma, Akihito Tsunoda, Eriko Koda, Hajime Tsuruoka, Kohei Nishida, Takeo Inoue, Hisashi Saji, Masamichi Mineshita Tags: CASE REPORT Source Type: research

Longitudinal analysis of complete blood count parameters in advanced ‐stage lung cancer patients
In our longitudinal analyses, we found significantly decreasing ALC, and significantly increasing ANC levels in advanced ‐stage lung cancer patients during disease progression. Interestingly, patients with brain metastases have descending‐ascending PLT trendlines, while patients with bone metastases exhibit ascending‐descending trendlines during disease progression. The current study might help to improve patien t selection and treatment strategies for brain and bone metastatic lung cancer patients. BackgroundMetastatic lung cancer is a debilitating disease, but with the advances in immunotherapy, therapeutic options...
Source: Thoracic Cancer - September 17, 2020 Category: Cancer & Oncology Authors: Livia Rojko, Zsolt Megyesfalvi, Eszter Czibula, Lilla Reiniger, Vanda Teglasi, Zsolt Szegedi, Zoltan Szallasi, Balazs Dome, Judit Moldvay Tags: ORIGINAL ARTICLE Source Type: research

Surgery at the frontline at the time of the COVID ‐19 outbreak
(Source: Thoracic Cancer)
Source: Thoracic Cancer - September 16, 2020 Category: Cancer & Oncology Authors: Alberto Testori, Ugo Cioffi, Michele M. Ciulla, Edoardo Bottoni, Umberto Cariboni, Gianluca Perroni, Marco Alloisio Tags: COMMENTARY Source Type: research

Matrix metalloproteinase ‐14 (MMP‐14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation
The results of this study indicate that MMP ‐14 upregulation commonly occurs in human ESCC and is correlated with to tumor T classification, N classification, degree of differentiation, and clinical stage of ESCC patients. MMP‐14 knockdown can additionally compromise the proliferative and invasive activity of these tumor cells, suggesting that MMP‐14 may be a viable therapeutic target for the treatment of ESCC, although further research will be needed to validate these findings. Furthermore, downregulation of the MMP‐14 expression level decreased cell proliferation and invasion ability. BackgroundMatrix metalloprot...
Source: Thoracic Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Nanzheng Chen, Guangjian Zhang, Junke Fu, Qifei Wu Tags: ORIGINAL ARTICLE Source Type: research

Male breast cancer: A closer look at patient and tumor characteristics and factors associated with survival
In our study we compared the similarities and differences between male and female breast cancer. The biological characteristics and prognostic factors of male breast cancer were analyzed. BackgroundThe prognostic effect of molecular subtypes on male breast cancer (MBC) remains unclear. The aim of this study was to evaluate the clinicopathological and prognostic factors of MBC patients.MethodsFrom 1 January 1990 to 31 December 2014, the data of 152 MBC and 304 female breast cancer (FBC) patients were identified and extensively compared.ResultsCompared with the FBC group, MBC patients were found to have a higher rate of canc...
Source: Thoracic Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Jing Zhao, Bin Wang, Jing Zhao, Yiran Mao, Jun Liu, Yanfang Yang Tags: ORIGINAL ARTICLE Source Type: research

Lung adenocarcinoma with tumor resolution and dystrophic calcification after salvage surgery following immune checkpoint inhibitor therapy: A case report
This study showed the efficacy of immune checkpoint inhibitors as neoadjuvant chemotherapy to be followed by salvage surgery for unresectable advanced lung adenocarcinoma. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Toshiyuki Sumi, Hirofumi Uehara, Toshiaki Masaoka, Makoto Tada, Yoshiko Keira, Koki Kamada, Naoki Shijubou, Yuichi Yamada, Hisashi Nakata, Yuji Mori, Hirofumi Chiba Tags: CASE REPORT Source Type: research

HAX1 enhances the survival and metastasis of non ‐small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway
ConclusionsThe present study provided a better understanding of HAX1 mechanism in NSCLC and potential therapeutic target for NSCLC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 14, 2020 Category: Cancer & Oncology Authors: Zhigang Liang, Yuan Zhong, Lifei Meng, Yi Chen, Yahui Liu, Aihua Wu, Xinjian Li, Mingsong Wang Tags: ORIGINAL ARTICLE Source Type: research

Prognostic and clinicopathological roles of programmed death ‐ligand 1 (PD‐L1) expression in thymic epithelial tumors: A meta‐analysis
In this study, we systematically evaluated the prognostic and clinicopathological roles of PD‐L1 expression in TETs.MethodsWe searched the literature through PubMed, Embase and Cochrane library and chose the eligible studies, and subsequently performed a meta ‐analysis to evaluate the prognostic and clinicopathological roles of PD‐L1 expression in TETs.ResultsSix of the 75 articles found in the literature were selected. PD ‐L1 expression was significantly related to unfavorable overall survival (hazard ratio 1.52, 95% confidence interval [CI]: 1.01–2.30,P =  0.046) in TETs. PD‐L1 expression was signi...
Source: Thoracic Cancer - September 14, 2020 Category: Cancer & Oncology Authors: Hyun Min Koh, Bo Gun Jang, Hyun Ju Lee, Chang Lim Hyun Tags: ORIGINAL ARTICLE Source Type: research

Serum immune modulators during the first cycle of anti ‐PD‐1 antibody therapy in non‐small cell lung cancer: Perforin as a biomarker
ConclusionsSerum baseline perforin levels may be used to predict the prognosis of NSCLC patients treated with anti ‐PD‐1 antibody therapy.Key points To identify a useful predictive marker for anti ‐PD‐1 antibody therapy, using blood samples might be helpful. Serum baseline perforin levels were closely associated with prognosis with anti‐PD‐1 antibody therapy in non‐small cell lung cancer. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 11, 2020 Category: Cancer & Oncology Authors: Takayo Ota, Tomoya Fukui, Yoshiro Nakahara, Takayuki Takeda, Junji Uchino, Takako Mouri, Keita Kudo, Saki Nakajima, Tomohiro Suzumura, Masahiro Fukuoka Tags: ORIGINAL ARTICLE Source Type: research

Metastatic large cell carcinoma of the lung: A rare cause of acute small bowel obstruction
We report a case of acute intestinal obstruction as the initial presentation of primary lung cancer in a male patient. The patient underwent emergency surgery for multiple luminal malignancy with mesenteric masses, and immunohistochemical staining of the specimen revealed metastatic large cell carcinoma originating from the lung. Here, we report a case of acute intestinal obstruction as the initial presentation of primary lung cancer in a male patient. Abdominal computed tomography (CT) showed multiple polypoid masses and regional lymphadenopathy with small bowel obstruction. The patient underwent emergency surgery for mul...
Source: Thoracic Cancer - September 11, 2020 Category: Cancer & Oncology Authors: Min Cheol Kim, Min Hye Jang, June Hong Ahn Tags: CASE REPORT Source Type: research

Correlation between CXCR4, CXCR5 and CCR7 expression and survival outcomes in patients with clinical T1N0M0 non ‐small cell lung cancer
Expression levels of CXCR4, CXCR5 and CCR7 were significantly higher in tumor tissues, and expression of CXCR5 and CCR7 were independent prognostic factors for survival. Moreover, all three chemokines were correlated to the survival outcomes of patients with clinical T1N0M0 NSCLC, providing potential prognosticators and therapy targets for lung cancer treatment. BackgroundLung cancer is the leading cause of cancer ‐related death. Even if early detection and treatment have proven to be effective, the survival outcomes are still poor.MethodsTissue samples and clinicopathological data of 244 patients with clinical T1N0M0 NS...
Source: Thoracic Cancer - September 8, 2020 Category: Cancer & Oncology Authors: Zhao Yue, Ding Ningning, Yang Lin, Ying Jianming, Zhang Hongtu, Yuan Ligong, Li Feng, Wang Shuaibo, Mao Yousheng Tags: ORIGINAL ARTICLE Source Type: research

Modified heptapeptide from tau binds both tubulin and microtubules
ConclusionsThese results suggest that using a peptide ‐based strategy for imaging microtubules might be plausible and attempts to improve its affinity is warranted in the future. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 7, 2020 Category: Cancer & Oncology Authors: Jingrui Li, Yuyang Li, Min Liu, Songbo Xie Tags: BRIEF REPORT Source Type: research

CXCR4 polymeric nanocomplex ‐mediated pulmonary delivery of siPD‐L1: A novel procedure to enhance immunotherapy
Thoracic Cancer, EarlyView. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 7, 2020 Category: Cancer & Oncology Authors: Xiayao Diao Tags: EDITORIAL Source Type: research

Quantitative multiplex immunofluorescence analysis identifies infiltrating PD1+CD8+ and CD8+ T cells as predictive of response to neoadjuvant chemotherapy in breast cancer
ConclusionsPD1+CD8+ rather than TIM3+CD8+ cells are main predictive components within tumor ‐infiltrating T cells in NAT breast cancer patients. Dynamically incremental levels of PD1+CD8+ cells occurred in non ‐pCR cases after NAT, suggesting the combination of chemotherapy with PD1 inhibition might benefit these patients.Key pointsSignificant findings of the study PD1+CD8+, rather than TIM3+CD8+, T cells are the main component to predict the response of neoadjuvant therapies in breast cancer.What this study adds Incremental levels of PD1+CD8+ T cells in non ‐pCR post‐NAT tumors suggest PD1 inhibition might benefit...
Source: Thoracic Cancer - September 7, 2020 Category: Cancer & Oncology Authors: Hongling Liang, Hongsheng Li, Zhi Xie, Tianen Jin, Yu Chen, Zhiyi Lv, Xiaojun Tan, Jia Li, Guodong Han, Weixing He, Ni Qiu, Ming Jiang, Jie Zhou, Haoming Xia, Yongtao Zhan, Lulu Cui, Weiling Guo, Jianqing Huang, Xuchao Zhang, Yi ‐long Tags: ORIGINAL ARTICLE Source Type: research

Glutaredoxin 1 regulates macrophage polarization through mediating glutathionylation of STAT1
ConclusionsGrx1 controlled deglutathionylation of STAT1, which in turn might regulate M1 ‐type polarization of macrophages. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 7, 2020 Category: Cancer & Oncology Authors: Lijuan Guo, Shanze Chen, Qingrong Liu, Hongyu Ren, Yuhao Li, Junyue Pan, Yuhan Luo, Tongzhou Cai, Ruofan Liu, Junli Chen, Yi Wang, Xiaoying Wang, Ning Huang, Jingyu Li Tags: ORIGINAL ARTICLE Source Type: research

Interleukin ‐5‐producing malignant pleural mesothelioma with eosinophilic pleural effusion
This is the first report of IL ‐5‐producing malignant pleural mesothelioma with eosinophilic pleural effusion. Malignant tumors are often associated with eosinophilic pleural effusion. Here, we encountered a case of interleukin ‐5 (IL‐5)‐producing malignant pleural mesothelioma with eosinophilic pleural effusion. The patient was a 50‐year‐old male. He had a history of a cough for several weeks and had visited a local doctor. Left pleural effusion was noted, and the patient was referred to our hospital. He was dia gnosed with malignant pleural mesothelioma by pleural biopsy, with eosinophilic pleural effusion....
Source: Thoracic Cancer - September 7, 2020 Category: Cancer & Oncology Authors: Eiji Takeuchi, Naoki Takahashi, Shun Morizumi, Hiroyuki Tamiya, Hisashi Matsuoka, Naoto Kuroda, Kenji Yorita Tags: CASE REPORT Source Type: research

MicroRNA ‐200b is a potential biomarker of the expression of PD‐L1 in patients with lung cancer
Relative to patients with a PD ‐L1 tumor proportion score of
Source: Thoracic Cancer - September 7, 2020 Category: Cancer & Oncology Authors: Seigo Katakura, Nobuaki Kobayashi, Hisashi Hashimoto, Chisato Kamimaki, Katsushi Tanaka, Sousuke Kubo, Kentaro Nakashima, Shuhei Teranishi, Saki Manabe, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Masaki Yamamoto, Makoto Kudo, Hongmei Piao, Tags: ORIGINAL ARTICLE Source Type: research

Use of glucocorticoids in the management of immunotherapy ‐related adverse effects
We described the mechanism, dosage forms, adverse effects and management of glucocorticoids. We aimed to provide references and suggestions for oncologists to use glucocorticoids in the proper treatment of irAEs. Immune checkpoint inhibitors (ICIs) activate host antitumor immunity to kill tumor cells. However, ICI therapy may be accompanied by a series of immunotherapy ‐related adverse effects (irAEs) caused by activated autoreactive T cells. Glucocorticoids are the mainstream therapy for irAEs. However, the usage, dosage and course of treatment of irAEs with glucocorticoids differs from those used in classic autoimmune ...
Source: Thoracic Cancer - September 6, 2020 Category: Cancer & Oncology Authors: Hanping Wang, Jiaxin Zhou, Xiaoxiao Guo, Yue Li, Lian Duan, Xiaoyan SI, Li Zhang Tags: CLINICAL GUIDELINE Source Type: research

Pulmonary metastasis of distal cholangiocarcinoma with multiple cavities in bilateral lungs: A case report
Cholangiocarcinoma can be transferred to the lung and the left supraclavicular lymph nodes through the lymphatic pathway and lymph node metastasis is characterized by jumping. Diffuse cystic change is a characteristic CT manifestation of lymphatic lung metastasis of cholangiocarcinoma. Cholangiocarcinoma is a type of malignant tumor derived from the epithelium of the bile duct. Cases of cholangiocarcinoma metastasis to the lung are rare, especially those with imaging features of multiple cavities in bilateral lungs. Here, we report a case of a patient who had previously undergone radical resection of primary distal cholang...
Source: Thoracic Cancer - September 4, 2020 Category: Cancer & Oncology Authors: Nailiang Zhai, Jinping Liu, Pan Xu, Bo Liu, Yichu Fan, Changjun Lv Tags: CASE REPORT Source Type: research

Issue Information
Thoracic Cancer, Volume 11, Issue 9, Page 2381-2382, September 2020. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 3, 2020 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

EEF1A2 and ERN2 could potentially discriminate metastatic status of mediastinal lymph node in lung adenocarcinomas harboring EGFR 19Del/L858R mutations
ConclusionsEEF1A2 and ERN2 were for the first time observed exhibiting distinct expression patterns in MLNM in lung adenocarcinomas harboring EGFR 19Del and EGFR L858R mutation by interindividual DEGs analysis.Key pointsSignificant findings of the studyIn our study, we focused on the mechanisms of metastasis and invasion that different EGFR mutations conferred and identified two critical genes separately involved in this process in EGFR 19Del and L858R mutation tumors.What this study addsOur findings not only reinforced theoretical foundations that the EGFR 19Del and L858R mutation tumors should be considered as two kinds ...
Source: Thoracic Cancer - September 3, 2020 Category: Cancer & Oncology Authors: Lei Xia, Hui Wang, He Xiao, Baohua Lan, Jie Liu, Zhenzhou Yang Tags: ORIGINAL ARTICLE Source Type: research

EGF+61 A > G polymorphism does not predict response to first ‐generation EGFR tyrosine kinase inhibitors in lung cancer patients
In conclusion, theEGF+61 polymorphism (AG and AG + GG) was independently associated with stable disease in lung cancer patients although it was not associated with the overall response rate to first ‐generation TKIs or patient outcome. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 3, 2020 Category: Cancer & Oncology Authors: Leticia F. Leal, Ana C. Laus, Rodrigo Cavagna, Flavia E. Paula, Marco A. Oliveira, Dayana M. Ribeiro, Fernanda M. Hassan, Jos é E. Miziara, Eduardo C. Albino Silva, Vinicius D. Silva, Pedro De Marchi, Rui M. Reis Tags: Leticia BRIEF REPORT Source Type: research

Potential monoamine oxidase A inhibitor suppressing paclitaxel ‐resistant non‐small cell lung cancer metastasis and growth
ConclusionsThese findings indicated G11 showed a moderate inhibitory effect on paclitaxel ‐resistant NSCLC metastasis and growth, and support further investigation on MAOA potentially as a promising therapeutic target for paclitaxel‐resistant NSCLC treatment.Key pointsSignificant findings of the study Inhibition of MAOA might contribute to the suppression of metastasis and growth in PTX ‐resistant NSCLC cells.What this study adds This study explored the potential function of MAOA in drug ‐resistant NSCLC and might consider MAOA as a promising target for the treatment of drug‐resistant NSCLC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 2, 2020 Category: Cancer & Oncology Authors: Xiaoguang Yang, Dongxue Zhao, Yanfeng Li, Yanyu Li, Wei Cui, Yuxin Li, Han Li, Xinyu Li, Dun Wang Tags: ORIGINAL ARTICLE Source Type: research

Long non ‐coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population
ConclusionsCASC8 rs1562430 A  >  G may cause susceptibility to ESCC andCASC8 SNPs may play a vital role in ESCC risk, thereby serving as a potential biomarker for diagnosing ESCC. A larger sample size and multifactor information are needed to confirm these results. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 2, 2020 Category: Cancer & Oncology Authors: Yonghua Sang, Haiyong Gu, Yongbing Chen, Yijun Shi, Chao Liu, Lu Lv, Yifeng Sun, Yongsheng Zhang Tags: ORIGINAL ARTICLE Source Type: research

Extended resections and other special cases in lung cancer surgery: Real ‐world population‐based outcomes
ConclusionsAfter guideline ‐based evaluation, a significant rate of these special cases can be resected with a low complication rate and good long‐term survival in real‐world practice.Key pointsSignificant findings of the study Extended resections for lung cancer include tumors spreading outside the lung The rate of extended resection was 14.9% in a population ‐based setting Major complications occurred in 7.5% and five‐year survival was 75.6%What this study adds Complication rate and long ‐term outcome were similar compared to normal patients Guideline‐based evaluation results with excellent outcome in real...
Source: Thoracic Cancer - September 1, 2020 Category: Cancer & Oncology Authors: Olli Helminen, Johanna Valo, Heidi Andersen, Johan S öderström, Eero Sihvo Tags: ORIGINAL ARTICLE Source Type: research

Tracheal fistula in a patient after esophageal surgery confirmed by lung ultrasound: A new bedside tool for thoracic surgeons
Tracheal fistula is a rare but severe complication of esophageal surgery. Here, we report the case of a tracheal fistula in a patient after esophageal surgery suggested by pneumothorax and confirmed by fiberoptic bronchoscopy, and introduce a new bedside tool ‐ lung ultrasound ‐ to sensitively detect pneumothorax. Tracheal fistula is a rare but severe complication following esophageal surgery. Here, we report the case of a tracheal fistula in a patient after esophageal surgery suggested by pneumothorax and confirmed by fiberoptic bronchoscopy, and introduce lung ultrasound as a new bedside tool to sensitively detect pn...
Source: Thoracic Cancer - September 1, 2020 Category: Cancer & Oncology Authors: Yi Li, Cheng Shen, Wanhong Yin Tags: CASE REPORT Source Type: research

Extensive calcification in adenocarcinoma of the lung: A case report
This study suggests the potential role of parathyroid hormone ‐related proteins in lung tumor calcification. The implications for clinicians are that calcified metastatic lymph nodes and tumors might be tightly fused to tissues. Therefore, surgery should be conducted with care. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 1, 2020 Category: Cancer & Oncology Authors: Fumiaki Watanabe, Katsutoshi Adachi, Kentaro Ito, Soichi Iwanaka, Ayaka Ohiwa, Yasumasa Sakakura, Tadashi Nishimura, Masahiro Naito Tags: CASE REPORT Source Type: research

Radiologic response of chemotherapy alone versus radiation and chemotherapy in the treatment of locally ‐advanced or advanced thymic epithelial tumors
ChemoRT was associated with a greater radiologic response than chemotherapy alone in patients with upfront unresectable TET BackgroundHere, we investigated radiological responses following chemotherapy alone as compared to both radiation/chemotherapy (chemoRT) in patients with thymic epithelial tumors (TETs) who did not receive upfront surgery.MethodsTETs treated at a tertiary academic cancer center between January 2007 and July 2018 were identified. Patients received chemotherapy or chemoRT as initial therapy and pre ‐ and post‐treatment scans were available. Student'st‐test, Wilcoxon rank‐sum tests, and Cox propo...
Source: Thoracic Cancer - September 1, 2020 Category: Cancer & Oncology Authors: Robert F. Chu, Amira Hussien, Q. Kay Li, Jiangxia Wang, Cole Friedes, Adam Ferro, Russell K. Hales, Richard Battafarano, David S. Ettinger, Khinh Ranh Voong Tags: ORIGINAL ARTICLE Source Type: research

Multivariate gene expression ‐based survival predictor model in esophageal adenocarcinoma
ConclusionsIn conclusion, we identified differences in the ceRNA regulatory networks and constructed a four –gene expression‐based survival predictor model, which could be referential for future clinical research. (Source: Thoracic Cancer)
Source: Thoracic Cancer - September 1, 2020 Category: Cancer & Oncology Authors: Maoyuan Zhao, Jingsong Wang, Meng Yuan, Zeliang Ma, Yongxin Bao, Zhouguang Hui Tags: ORIGINAL ARTICLE Source Type: research

Sorting and gene mutation verification of circulating tumor cells of lung cancer with epidermal growth factor receptor peptide lipid magnetic spheres
ConclusionsEG ‐P‐LMB can effectively capture CTCs in the peripheral blood of patients with lung cancer. CTC detection can accurately identify mutations in theEGFR gene and improve the ability to obtain tumor tissue in clinical practice.Key pointsSignificant findings of the studyEG ‐P‐LMB can effectively capture CTCs in the peripheral blood of patients with lung cancer. CTC detection can accurately identify mutations in theEGFR gene and improve the ability to obtain tumor tissue in clinical practice.What this study addsThis study added EGFR peptide lipid magnetic spheres to capture CTCs in the blood. Genetic testing...
Source: Thoracic Cancer - August 27, 2020 Category: Cancer & Oncology Authors: Sheng ‐guang Wang, Bin Zhang, Chen‐guang Li, Jian‐quan Zhu, Bing‐sheng Sun, Chang‐li Wang Tags: ORIGINAL ARTICLE Source Type: research

Prognostic study for survival outcome following the treatment of second primary lung cancer in patients with previously resected non ‐small cell lung cancer
ConclusionsRadiotherapy and sublobar resection can be considered reasonable alternative treatments for SPLC, especially when patients are unable to tolerate lobectomy. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 26, 2020 Category: Cancer & Oncology Authors: Yijun Wu, Chang Han, Yuming Chong, Jianghao Liu, Liang Gong, Zhile Wang, Naixin Liang Tags: ORIGINAL ARTICLE Source Type: research

Pericardial immunoglobulin G4 ‐related inflammatory pseudotumor after right upper lobectomy for lung cancer
We report a case of pericardial immunoglobulin G4 ‐related inflammatory pseudotumor that appeared after right upper lobectomy for lung cancer, and which naturally disappeared without any treatment. A 75 ‐year‐old woman underwent thoracoscopic right upper lobectomy for lung cancer. A histopathological examination showed adenocarcinoma, pT1aN0M0 stage IA1. At six months after surgery, chest computed tomography (CT) revealed pericardial nodules that had not been detected before pulmonary resection . Postoperative CT performed two months later revealed that the nodules were growing and F18 fluorodeoxyglucose ‐positron ...
Source: Thoracic Cancer - August 26, 2020 Category: Cancer & Oncology Authors: Risa Oda, Katsuhiro Okuda, Takayuki Murase, Tadashi Sakane, Tsutomu Tatematsu, Keisuke Yokota, Katsuhiko Endo, Ryoichi Nakanishi Tags: CASE REPORT Source Type: research

Long non ‐coding RNA HCG11 sponging miR‐522‐3p inhibits the tumorigenesis of non‐small cell lung cancer by upregulating SOCS5
ConclusionsLncRNA HCG11 inhibits cell viability, migration and invasion in NSCLC by functioning as a ceRNA of miR ‐522‐3p to upregulate SOCS5. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 26, 2020 Category: Cancer & Oncology Authors: Gang Fan, Jin Jiao, Feng Shen, Qingxia Ren, Qing Wang, Fulu Chu Tags: ORIGINAL ARTICLE Source Type: research

Efficacy and safety of S ‐1 monotherapy in previously treated elderly patients (aged ≥75 years) with non‐small cell lung cancer: A retrospective analysis
ConclusionsS ‐1 monotherapy is effective and feasible as a subsequent‐line treatment in elderly patients who were previously treated for NSCLC, and it produces results. S‐1 monotherapy could be one of the treatment choices for elderly patients with previously treated NSCLC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 26, 2020 Category: Cancer & Oncology Authors: Hisao Imai, Hiroyuki Minemura, Takayuki Kishikawa, Yutaka Yamada, Kensuke Suzuki, Yukihiro Umeda, Satoshi Wasamoto, Norimitsu Kasahara, Shinichi Ishihara, Ou Yamaguchi, Ichiro Naruse, Junji Uchino, Keita Mori, Kenya Kanazawa, Yoko Shibata, Tags: ORIGINAL ARTICLE Source Type: research

Successful use of extracorporeal membrane oxygenation for airway ‐obstructing lung adenocarcinoma
In this report, we describe the case of 39‐year‐old female who presented to our emergency department with severe respiratory distress. A computed tomography scan revealed a large mediastinal tumor invading the tracheal carina causing sev ere stenosis of the left main bronchus and right main pulmonary artery. ECMO support was required as the respiratory condition remained unstable despite high pressure ventilation. Under ECMO support, the patient underwent bronchial stent implantation and was successfully weaned off ECMO. The tumor w as histologically diagnosed as pulmonary adenocarcinoma with anaplastic lymphoma kinase...
Source: Thoracic Cancer - August 26, 2020 Category: Cancer & Oncology Authors: Shinsuke Kitazawa, Naohiro Kobayashi, Sho Ueda, Yuki Enomoto, Yoshiaki Inoue, Toshihiro Shiozawa, Ikuo Sekine, Hitomi Kawai, Masayuki Noguchi, Yukio Sato Tags: CASE REPORT Source Type: research

Clinical characteristics of resected solitary ground ‐glass opacities: Comparison between benign and malignant nodules
ConclusionsA higher smoking index, coughing, larger size, similar or increased size during follow ‐up, location in the upper and middle lobes, air bronchogram sign on CT, lesion margin to pleura distance over 1 cm, and malignant tendency on PET/CT reports were associated with malignant GGOs. Relatively active surgical interventions could be considered for GGOs highly suspected of malignancy. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 25, 2020 Category: Cancer & Oncology Authors: Yingzhi Qin, Yuan Xu, Dongjie Ma, Zhenhuan Tian, Cheng Huang, Xiaoyun Zhou, Jia He, Lei Liu, Chao Guo, Guige Wang, Jiaqi Zhang, Yanqing Wang, Hongsheng Liu Tags: ORIGINAL ARTICLE Source Type: research

Association of Mps one binder kinase activator 1 (MOB1) expression with poor disease ‐free survival in individuals with non‐small cell lung cancer
ConclusionsOur results suggest that MOB1 might promote early recurrence of NSCLC by increasing vascular invasion by tumor cells.Key pointsSignificant findings of the studyWe found that high MOB1 expression in surgical specimens of lung adenocarcinoma was associated with poor disease ‐free survival and with intratumoral vascular invasion. MOB1 expression also promoted the invasiveness of NSCLC cells in vitro.What this study addsOur results thus suggest that high MOB1 expression is a risk factor for early postoperative recurrence in lung adenocarcinoma. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 25, 2020 Category: Cancer & Oncology Authors: Nobuhisa Ando, Kentaro Tanaka, Kohei Otsubo, Gouji Toyokawa, Yuki Ikematsu, Maako Ide, Yasuto Yoneshima, Eiji Iwama, Hiroyuki Inoue, Kayo Ijichi, Tetsuzo Tagawa, Yoichi Nakanishi, Isamu Okamoto Tags: ORIGINAL ARTICLE Source Type: research

Long non ‐coding RNA TP73‐AS1 facilitates progression and radioresistance in lung cancer cells by the miR‐216a‐5p/CUL4B axis with exosome involvement
ConclusionsCollectively, TP73 ‐AS1 acted as a sponge of miR‐216a‐5p to regulate CUL4B in order to promote tumor progression and radioresistance in lung cancer cells with the implication of exosomes, which presents a novel mechanism of tumor action and radioresistance in lung cancer.Key pointsSignificant findings of the study TP73 ‐AS1 silence inhibits migration and invasion while elevates apoptosis and radiosensitivity in lung cancer cells TP73‐AS1 targets miR‐216a‐5p and miR‐216a‐5p targets CUL4BWhat this study adds Downregulation of TP73 ‐AS1 reduces tumor growth and radioresistance in vivo via the mi...
Source: Thoracic Cancer - August 25, 2020 Category: Cancer & Oncology Authors: Huibing Qiu, Lingyun Zhang, Tienan Yi, Kai Yang, Yan Gong, Conghua Xie Tags: ORIGINAL ARTICLE Source Type: research

Modified Collard versus end ‐to‐side hand‐sewn anastomosis for cervical anastomosis after McKeown esophagectomy
ConclusionsA modified Collard cervical esophagogastric anastomosis was associated with lower rates of anastomotic stricture and dysphagia, compared with ETS hand ‐sewn anastomosis. However, the modified Collard anastomosis is accompanied by an increased anastomotic leakage rate. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 24, 2020 Category: Cancer & Oncology Authors: Xiao ‐Kun Li, Yang Xu, Zhuang‐Zhuang Cong, Jing Luo, Hai Zhou, Sai‐Guang Ji, Yi‐Fei Diao, Wen‐Jie Wu, Yong Qiang, Jian‐Jun Qian, Yi Shen Tags: ORIGINAL ARTICLE Source Type: research

Incidental early diagnosis of biphasic pulmonary blastoma in a patient with history of stage IV lung adenocarcinoma
Here, we report a rare case of incidental early diagnosis of biphasic pulmonary blastoma while a patient was undergoing imaging surveillance for primary lung adenocarcinoma. Next ‐generation sequencing revealed distinct second primary cancer with a high mutation burden which might have therapeutic implications in further studies. Biphasic pulmonary blastoma is a rare but lethal type of lung malignancy with characteristic histology of both epithelial and mesenchymal components. Previously reported cases have been limited to presentation at advanced stages, suggesting that the clinical course of the disease is usually aggr...
Source: Thoracic Cancer - August 24, 2020 Category: Cancer & Oncology Authors: Kunhwa Kim, Sachin Gupta, Sorab Gupta, Priyanka Mittar, Corrado Minimo, William Tester Tags: CASE REPORT Source Type: research

Efficacy and safety of immune checkpoint inhibitor consolidation after chemoradiation in patients of Asian ethnicity with unresectable stage III non ‐small cell lung cancer: Chinese multicenter report and literature review
These data indicate that ICI consolidation therapy can achieve favorable short ‐term efficacy, while exhibiting good safety and acceptable toxicity profiles in Chinese patients with inoperable stage III NSCLC. BackgroundThe PACIFIC study has defined a new standard of care for patients with unresectable stage III non ‐small cell lung cancer (NSCLC) in the form of immune checkpoint inhibitor (ICI) consolidation therapy. However, there is little specific data pertaining to the safety and efficacy of this approach in Chinese NSCLC patients.MethodsThis was a prospective multicenter cohort study. Between September 2018 and J...
Source: Thoracic Cancer - August 24, 2020 Category: Cancer & Oncology Authors: Tao Zhang, Kunpeng Xu, Nan Bi, Li Zhang, Wei Jiang, Jun Liang, Lei Deng, Xin Wang, Jianyang Wang, Jie Wang, Luhua Wang Tags: ORIGINAL ARTICLE Source Type: research

Duration of immunotherapy in patients with advanced lung adenocarcinoma with negative driver genes: case report and literature review
In conclusion, whether the drug can be disco ntinued in advance after immune checkpoint inhibitor (ICI) therapy has been effective remains a concern, and at present there is no final conclusion in the medical profession. However, the results of this study indicate that early withdrawal of immunotherapy due to adverse reactions might also benef it patients with advanced lung adenocarcinoma with negative driver genes who achieve an early response to immunotherapy. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 24, 2020 Category: Cancer & Oncology Authors: Qinge Shan, Haiyong Wang, Xiao Han, Jun Guo, Zhehai Wang Tags: CASE REPORT Source Type: research

Primary signet ‐ring cell carcinoma of the lung: A report of seven cases
In this study, we described the clinicopathological and prognostic characteristics of, and the therapeutic strategies for seven patients with primary SRCC of the lung from Sichuan University West China Hospital to enhance our understanding of this kind of tumor. According to the information presented herein, it is believed that patients with primary pulmonary SRCC can live for a long time if the cancer is diagnosed early an d treated actively. However, more investigations are still needed due to the limited reports about primary SRCC of the lung.Key pointsSignificant findings of the study Primary signet ‐ring cell carcin...
Source: Thoracic Cancer - August 19, 2020 Category: Cancer & Oncology Authors: Yi Wang, Yan Wang, Jialong Li, Guowei Che Tags: CASE REPORT Source Type: research

High ‐grade myofibroblastic sarcoma of the pleura: A case report and literature review
High ‐grade myofibroblastic sarcoma (HGMS) is a rare disease. This is the first case diagnosed with HGMS originating from the pleura that was nonsurgically treated. High ‐grade myofibroblastic sarcoma (HGMS) is a rare cancer that has high recurrence and metastatic rates. Here, we report the first case of HGMS originating from the pleura. Based on the findings of pleural biopsy, pathological examination and immunohistochemical staining, grade III myofibroblastic sa rcoma (MS) was diagnosed. The patient underwent eight cycles of chemotherapy (epirubicin and ifosfamide), followed by radiotherapy. As of May 2020, the patie...
Source: Thoracic Cancer - August 19, 2020 Category: Cancer & Oncology Authors: Ruizhi Zhao, Jianyang Wang, Hongtu Zhang, Yihebali Chi, Nan Bi Tags: CASE REPORT Source Type: research

Effects of avitinib on the pharmacokinetics of osimertinib in vitro and in vivo in rats
We systematically investigated the effect of avitinib, one newly developed third ‐generation EGFR‐TKI, on the pharmacokinetics of osimertinib both in vitro and in vivo using rat model. BackgroundAvitinib is one type of the third ‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for the treatment of non‐small cell lung cancer (NSCLC) withEGFR mutations. The purpose of this study was to investigate the effect of avitinib on the pharmacokinetics of osimertinib, one FDA approved third ‐generation TIKI, both in vitro and in vivo.MethodsThe in vitro metabolic stability and inhibitory...
Source: Thoracic Cancer - August 19, 2020 Category: Cancer & Oncology Authors: Qingjun Wu, Hui Jiang, Shuanghu Wang, Dapeng Dai, Feifei Chen, Deru Meng, Peiwu Geng, Hongfeng Tong, Yunfang Zhou, Debiao Pan, Quan Zhou, Chunjie Wang Tags: ORIGINAL ARTICLE Source Type: research