Combination of nitrous oxide and the modified inflation ‐deflation method for identifying the intersegmental plane in segmentectomy: A randomized controlled trial
This study aimed to investigate the effect and safety of a nitrous oxide (N2O)/oxygen (O2) inspired mixture on the appearance time of the ISP (TISP) via the modified inflation ‐deflation method.MethodsA total of 65 participants who underwent segmentectomy were randomized into three groups: 75% N2O (n = 24), 50% N2O (n = 23) or 0% N2O (n = 18). The 75% N2O group received a gas mixture of N2O/O2 (Fio2 = 0.25), the 50% N2O group received N2O/O2 (Fio2 = 0.5), and the 0% N2O group received 100% oxygen during lung expansion. The appearance time of satisfactory and ideal planes was recorded. Furthermore, arterial blood gas at b...
Source: Thoracic Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Wenjing Yang, Zicheng Liu, Chun Yang, Shijiang Liu, Minna Guo, Wei Wen, Jun Wang, Cunming Liu, Quan Zhu Tags: ORIGINAL ARTICLE Source Type: research

Lung cancer metastasis to the pancreas mimicking autoimmune pancreatitis
The unique radiological manifestation mimicking autoimmune pancreatitis caused by lung cancer metastasis to the pancreas has not previously been reported. The incidence of pancreatic secondary tumors has previously been reported to be approximately 15% in autopsy cases of malignant tumors, and it is unusual for thoracic oncologists to find that the second common primary tumor site of metastatic pancreas tumor is the lung. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Naruhiko Ichiyama, Hiromichi Yamane, Nobuaki Ochi, Nozomu Nakagawa, Yasunari Nagasaki, Tatsuyuki Kawahara, Masataka Taoka, Ayaka Mimura, Hidekazu Nakanishi, Nagio Takigawa Tags: IMAGING IN THORACIC CANCER Source Type: research

Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma
Perineural invasion is an independent prognostic factor for shorter disease ‐free survival in patients treated surgically for esophageal squamous cell carcinoma. Documenting and closely following up with the perineural invasion status may significantly help physicians in devising therapeutic modalities to improve oncological outcome. AbstractBackgroundAlthough perineural invasion is a well known prognostic factor used in several cancers, its prognostic role in esophageal squamous cell carcinoma remains controversial. Here, we investigated the prognostic role of perineural invasion in surgically treated esophageal squamou...
Source: Thoracic Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Ha Eun Kim, Seong Yong Park, Hyunki Kim, Dae Joon Kim, Sun Ill Kim Tags: ORIGINAL ARTICLE Source Type: research

Mucinous adenocarcinoma caused by cancerization from a ciliated multinodular papilloma tumor: A case report
This report describes a case of mucinous adenocarcinoma caused by cancerization from CMPT. This indicates CMPT may be a neoplasm rather than a metaplastic process and provides histological evidence for the hypothesis that CMPT is a precancerous lesion of mucinous adenocarcinoma AbstractCiliated multinodular papilloma tumor (CMPT), a subtype of proximal bronchiolar adenoma (BA), is a rare mucin ‐producing papillary tumor arising in the peripheral lung. The nature of CMPT is so far controversial. The hypothesis that CMPT is a precancerous lesion that can lead to mucinous adenocarcinoma requires further research. A 61‐yea...
Source: Thoracic Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Feng Chen, Fan Ren, Honglin Zhao, Xiaoqian Xu, Jun Chen Tags: CASE REPORT Source Type: research

Primary pulmonary Hodgkin's lymphoma mimicking rheumatoid arthritis ‐associated organizing pneumonia: A case report
Primary pulmonary Hodgkin's lymphoma (PPHL) is an extremely rare disease. The nonspecific clinical and radiological features render the diagnosis a great challenge. Here, we present a case of PPHL mimicking rheumatoid arthritis ‐associated organizing pneumonia. AbstractPrimary pulmonary Hodgkin's lymphoma (PPHL) is an extremely rare disease. The nonspecific clinical and radiological features render the diagnosis a great challenge. Here, we present a case of PPHL mimicking rheumatoid arthritis ‐associated organizing pneumonia. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Kunyan Sun, Qing Yu, Jiaxin Zhou, Hong Zhang, Li Gao, Lin Nong, Mangju Wang, Chengli Que Tags: CASE REPORT Source Type: research

Handling benign interlobar lymphadenopathy during thoracoscopic lobectomy
Calcified or inflammatory lymph nodes between the target bronchus and pulmonary artery is a huge challenge when performing thoracoscopic lobectomy. Here, we report a strategy to handle this clinical situation. A needle was passed across the nodes and the target vessel was closed with a proximal and distal suture, and then gradually transected with scissors. After dissection of adenopathies, the target bronchus was stapled. AbstractThe presence of calcified or inflammatory lymph nodes between the target bronchus and pulmonary artery is a huge challenge when performing thoracoscopic lobectomy as it may frequently result in t...
Source: Thoracic Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Alfonso Fiorelli, Stefano Forte, Giovanni Natale, Mario Santini, Wentao Fang Tags: TECHNICAL NOTE Source Type: research

Efficacy and dose of afatinib in patients with non ‐small cell lung cancer after failure of prior gefitinib or erlotinib treatment
We report a subgroup analysis of afatinib with respect to its efficacy, safety, and the long ‐term survival of patients in a Named Patient Use program at a single institution.MethodsWe analyzed 60 patients with stage IV non ‐small cell lung cancer (NSCLC) who had been treated with ≥1 line of platinum‐based chemotherapy and had activating epidermal growth factor receptor (EGFR) mutations or disease control for ≥6 months with prior EGFR inhibitors. Afatinib was started on a daily dose of 50 mg, which was decrea sed according to the adverse events and tolerability.ResultsA total of 13 patients achieved part...
Source: Thoracic Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Hayoung Choi, Jae ‐Kyeong Lee, Hyung‐Joo Oh, Min‐Seok Kim, Bo Gun Kho, Cheol Kyu Park, In‐Jae Oh, Young‐Chul Kim Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Thoracic Cancer)
Source: Thoracic Cancer - April 2, 2021 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Prognostic significance of galectin ‐3 expression in patients with resected NSCLC treated with platinum‐based adjuvant chemotherapy
ConclusionsGAL3 expression is a reliable biomarker to predict the prognosis of completely resected NSCLC patients receiving platinum ‐based AC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 1, 2021 Category: Cancer & Oncology Authors: Seiichiro Kusuhara, Satoshi Igawa, Masaaki Ichinoe, Ryo Nagashio, Yuki Kuchitsu, Yasuhiro Hiyoshi, Kazu Shiomi, Yoshiki Murakumo, Makoto Saegusa, Yukitoshi Satoh, Yuichi Sato, Katsuhiko Naoki Tags: ORIGINAL ARTICLE Source Type: research

miR ‐493 by regulating of c‐Jun targets Wnt5a/PD‐L1‐inducing esophageal cancer cell development
ConclusionsThe miR ‐493/Wnt5A/c‐JUN loop is a molecular feedback loop that refers to the development of esophageal cancer cells and a potential target for the treatment of esophageal cancer. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 1, 2021 Category: Cancer & Oncology Authors: Wei Bian, Yishuai Li, Haiyong Zhu, Shaolin Gao, Ren Niu, Chuan Wang, Hao Zhang, Xuebo Qin, Shujun Li Tags: ORIGINAL ARTICLE Source Type: research

Clinical significance of intrapulmonary lymph node dissection in pathological stage IA non ‐small cell lung cancer: A propensity score matching analysis
ConclusionsThe prognostic impact of ILN dissection on patients with stage IA NSCLC appears to be significantly influenced by tumor size, and this should be taken into account when choosing the most appropriate therapeutic modality. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 1, 2021 Category: Cancer & Oncology Authors: Yungang Sun, Qiang Zhang, Zhao Wang, Feng Shao Tags: ORIGINAL ARTICLE Source Type: research

Clinical recommendations for perioperative immunotherapy ‐induced adverse events in patients with non‐small cell lung cancer
Perioperative irAE management is an important part of immune perioperative treatment of lung cancer. With the continuous development of immune perioperative treatment, more research is needed in the future to optimize the diagnosis and treatment of perioperative irAE. AbstractPerioperative adjuvant treatment has become an increasingly important aspect of the management of patients with non ‐small cell lung cancer (NSCLC). In particular, the success of immune checkpoint inhibitors, such as antibodies against PD‐1 and PD‐L1, in patients with lung cancer has increased our expectations for the success of these therapeuti...
Source: Thoracic Cancer - April 1, 2021 Category: Cancer & Oncology Authors: Jun Ni, Miao Huang, Li Zhang, Nan Wu, Chun ‐Xue Bai, Liang‐An Chen, Jun Liang, Qian Liu, Jie Wang, Yi‐Long Wu, Feng‐Chun Zhang, Shu‐Yang Zhang, Chun Chen, Jun Chen, Wen‐Tao Fang, Shu‐Geng Gao, Jian Hu, Tao Jiang, Shan‐Qin Tags: CLINICAL GUIDELINE Source Type: research

Genomic analysis between idiopathic pulmonary fibrosis and associated lung cancer using laser ‐assisted microdissection: A case report
Here, we report for the first time somatic mutations between the epithelium of IPF and LC sites detected by NGS using a laser ‐assisted microdissection technique. Almost all somatic mutations did not overlap between the IPF and LC regions. AbstractLung cancer (LC) is the most fatal complication of idiopathic pulmonary fibrosis (IPF). However, the molecular pathogenesis of the development of LC from IPF is still unclear. Here, we report a case of IPF ‐associated LC for which we investigated the genetic alterations between IPF and LC. We extracted formalin‐fixed paraffin‐embedded DNA from each part of the surgical lu...
Source: Thoracic Cancer - March 30, 2021 Category: Cancer & Oncology Authors: Yuko Iida, Yasuhiro Gon, Yoko Nakanishi, Yusuke Kurosawa, Yoshiko Nakagawa, Kenji Mizumura, Tetsuo Shimizu, Noriaki Takahashi, Shinobu Masuda Tags: CASE REPORT Source Type: research

Two cases of lung cancer with hemophagocytic lymphohistiocytosis caused by immune checkpoint inhibitors
We report the cases of two patients with secondary hemophagocytic lymphohistiocytosis caused by immune checkpoint inhibitors, who were diagnosed using the recently developed HScore. The first patient presented with fever, cytopenia, and elevated liver enzyme levels at 46  days post‐pembrolizumab administration. The HScore was 175. The second patient developed an immune‐related adverse event at 30 days after the final pembrolizumab dose. The HScore was 185. Hemophagocytic lymphohistiocytosis was confirmed in both patients, and corticotherapy improved their co ndition. It is challenging to diagnose hemophag...
Source: Thoracic Cancer - March 30, 2021 Category: Cancer & Oncology Authors: Atsumasa Kurozumi, Hidenori Takahashi, Takayasu Watanabe, Yoshinobu Iwasaki Tags: CASE REPORT Source Type: research

Management of chyle leakage after general thoracic surgery: Impact of thoracic duct embolization
ConclusionsTDE is an effective method for the management of chyle leakage and might help to avoid invasive surgery. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 30, 2021 Category: Cancer & Oncology Authors: Yeong Jeong Jeon, Jong Ho Cho, Dongho Hyun, Sumin Shin, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim Tags: ORIGINAL ARTICLE Source Type: research

Zinc ‐finger E‐box‐binding homeobox 1 (ZEB1) plays a crucial role in the maintenance of lung cancer stem cells resistant to gefitinib
ConclusionsZEB1 plays an important role in gefitinib ‐resistant lung CSCs with EMT features via regulation of miR‐200c and BMI1. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 29, 2021 Category: Cancer & Oncology Authors: Fariz Nurwidya, Fumiyuki Takahashi, Wira Winardi, Ken Tajima, Yoichiro Mitsuishi, Akiko Murakami, Isao Kobayashi, Takeshi Nara, Muneaki Hashimoto, Motoyasu Kato, Moulid Hidayat, Kentaro Suina, Daisuke Hayakawa, Tetsuhiko Asao, Ryo Ko, Takeh Tags: ORIGINAL ARTICLE Source Type: research

Recombinant human adenovirus type 5 (Oncorine) reverses resistance to immune checkpoint inhibitor in a patient with recurrent non ‐small cell lung cancer: A case report
Our patient with recurrent NSCLC experienced resistance to ICI (nivolumab), and was subsequently treated with nivolumab plus anlotinib with a transient response, followed by the combination of oncolytic virus (Oncorine) at the time of progression with obvious disease control. This was a successful exploration of oncolytic viruses reversing immune resistance. AbstractImmune checkpoint inhibitors (ICIs) have shown significant efficacy in various solid tumors, but only a small subgroup of patients benefit from them because of immune resistance. Oncorine (formerly H101), a recombinant human adenovirus type 5, has direct antica...
Source: Thoracic Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Qian ‐Ning Zhang, Yan Li, Qi Zhao, Mi Tian, Lu‐Lu Chen, Li‐Yun Miao, Yu‐Jie Zhou Tags: CASE REPORT Source Type: research

SHR ‐1316, an anti‐PD‐L1 antibody, plus chemotherapy as the first‐line treatment for advanced esophageal squamous cell carcinoma: A multicentre, phase 2 study
ConclusionsSHR ‐1316 plus liposomal irinotecan and 5‐fluorouracil has a promising efficacy and manageable safety profile, and could be a new first‐line treatment approach for patients with unresectable locally advanced or distant metastatic ESCC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Lan Mu, Yan Song, Kuaile Zhao, Ying Liu, Qingxia Fan, Xi Wang, Qun Li, Xiaopeng Wang, Jing Huang Tags: ORIGINAL ARTICLE Source Type: research

CITED4 enhances the metastatic potential of lung adenocarcinoma
ConclusionsThe CITED4 ‐CTNNB1‐CLDN3 axis plays a key role in the invasion and metastasis of ADC and provides a novel therapeutic target for lung cancer treatment. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Lianmin Zhang, Yuan Wang, Yongsheng Sha, Bin Zhang, Rui Zhang, Hua Zhang, Shilei Xu, Hailong Wang, Yue Xu, Yulong Chen, Xiaoliang Zhao, Jianquan Zhu, Zhenfa Zhang, Changli Wang Tags: ORIGINAL ARTICLE Source Type: research

miRNA ‐218‐5p increases cell sensitivity by inhibiting PRKDC activity in radiation‐resistant lung carcinoma cells
ConclusionsmiRNA ‐218‐5p could induce apoptosis and enhance the radiosensitivity of LC cells through regulatory activities, thus suggesting its application as a potential target for LC treatment. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Xiaoke Chen, Yuanyuan Xu, Long Jiang, Qiang Tan Tags: ORIGINAL ARTICLE Source Type: research

Diagnosis of miliary nodules as lung adenocarcinoma by cryobiopsy: A case report
This report provides important information regarding the role of TBLC in diagnosing metastatic cancer, such as diffuse small miliary nodules, and its genetic mutations. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 23, 2021 Category: Cancer & Oncology Authors: Momoko Morishita, Manabu Suzuki, Hiromu Watanabe, Chie Morita, Akane Ishida, Masao Hashimoto, Go Naka, Yuichiro Takeda, Masayuki Hojo, Haruhito Sugiyama Tags: CASE REPORT Source Type: research

GRP75 ‐mediated upregulation of HMGA1 stimulates stage I lung adenocarcinoma progression by activating JNK/c‐JUN signaling
ConclusionsThe activation of GRP75/HMGA1/JNK/c ‐JUN signaling is an important mechanism that promotes the progression of stage I LUAD, and a high level of HMGA1 is a novel biomarker for predicting recurrence and a poor prognosis in stage I LUAD patients. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 23, 2021 Category: Cancer & Oncology Authors: Guo ‐Bing Qiao, Ren‐Tao Wang, Shu‐Nan Wang, Shao‐Lin Tao, Qun‐You Tan, Hua Jin Tags: ORIGINAL ARTICLE Source Type: research

Diagnostic yield and safety of biopsy guided by electromagnetic navigation bronchoscopy for high ‐risk pulmonary nodules
ConclusionENB ‐guided biopsy for high‐risk pulmonary nodules demonstrated an acceptable diagnostic yield and good safety profile. Moreover, the diagnostic yield was associated with nodule size and procedure experience. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 22, 2021 Category: Cancer & Oncology Authors: Ju Hyun Oh, Chang ‐Min Choi, Seulgi Kim, Woo Sung Kim, Hee Sang Hwang, Se Jin Jang, Sang Young Oh, Mi Young Kim, Jae Cheol Lee, Wonjun Ji Tags: ORIGINAL ARTICLE Source Type: research

GPR12 inhibits migration and promotes apoptosis in esophageal cancer and hypopharyngeal cancer cells
ConclusionIn conclusion, GPR12 induced apoptosis by activating caspase ‐7 and inhibited migration through epithelial‐to‐mesenchymal transition (EMT) in EC and HC. Our findings demonstrated that GPR12 as a potential tumor suppressor mediated cell migration and apoptosis in EC and HC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 20, 2021 Category: Cancer & Oncology Authors: Minfa Zhang, Xiaoqi Yang, Shuai Chen, Wenming Jia, Xiaojie Ma, Juan Wang, Ye Qian, Dapeng Lei, Heng Liu, Xinliang Pan Tags: ORIGINAL ARTICLE Source Type: research

Remarkable response of non ‐small cell lung cancer to nintedanib treatment in a patient with idiopathic pulmonary fibrosis
This report indicates the possibility that nintedanib monotherapy could suppress lung cancer in patients with IPF. AbstractNintedanib is a multi ‐target receptor tyrosine kinase inhibitor that reduces the decline in forced vital capacity (FVC) and prevents acute exacerbations in idiopathic pulmonary fibrosis (IPF), which is a risk factor for lung cancer. However, it remains unclear whether nintedanib is an effective treatment for lung canc er in patients with IPF. Here, we describe an 82‐year‐old man with non‐small cell lung carcinoma complicated by IPF who was treated with nintedanib. High‐resolution computed to...
Source: Thoracic Cancer - March 20, 2021 Category: Cancer & Oncology Authors: Yoshiro Kai, Masayuki Matsuda, Atsuhiko Fukuoka, Shigeto Hontsu, Motoo Yamauchi, Masanori Yoshikawa, Shigeo Muro Tags: CASE REPORT Source Type: research

Characteristics and outcomes of thymomas in Latin America: Results from over 10 years of experience (CLICaP ‐LATimus)
ConclusionsOur data provides the largest insight into the clinical characteristics and outcomes of patients with thymomas in Latin America. Survival in patients with thymomas continues to be very favorable, especially when subjected to adequate local control. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 17, 2021 Category: Cancer & Oncology Authors: Claudio Mart ín, Diego Enrico, Luis Mas, Ana Karina Patane, Oscar Arrieta, Tannia Soria, Andrés F. Cardona, Alejandro Ruiz‐Patiño, Rossana Ruiz, Patricia Rioja, Sophia Lozano, Zyanya Lucia Zatarain‐Barrón, Feliciano Barrón, Carmen Pu Tags: ORIGINAL ARTICLE Source Type: research

Feasibility investigation of near ‐infrared fluorescence imaging with intravenous indocyanine green method in uniport video‐assisted thoracoscopic anatomical segmentectomy for identifying the intersegmental boundary line
AbstractObjectivesTo investigate the perioperative outcomes of patients who underwent uniport video ‐assisted thoracoscopic (VATS) segmentectomy for identifying the intersegmental boundary line (IBL) by the near‐infrared fluorescence imaging with the intravenous indocyanine green (ICG) method or the modified inflation‐deflation (MID) method and assess the feasibility and effectiveness of the ICG fluorescence (ICGF)‐based method.MethodsWe retrospectively analyzed the perioperative data in total 198 consecutive patients who underwent uniport VATS segmentectomy between February 2018 and August 2020. With the guidance ...
Source: Thoracic Cancer - March 17, 2021 Category: Cancer & Oncology Authors: Yungang Sun, Qiang Zhang, Zhao Wang, Feng Shao, Rusong Yang Tags: ORIGINAL ARTICLE Source Type: research

Risk of cardiac ‐related mortality in stage IIIA‐N2 non‐small cell lung cancer: Analysis of the Surveillance, Epidemiology, and End Results (SEER) database
ConclusionsWith a median follow ‐up of 25 months, no significant differences were found in cardiac‐related mortality between the PORT and Non‐PORT groups in stage IIIA‐N2 NSCLC patients. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 17, 2021 Category: Cancer & Oncology Authors: Xin Sun, Yu Men, Jianyang Wang, Yongxing Bao, Xu Yang, Maoyuan Zhao, Shuang Sun, Meng Yuan, Zeliang Ma, Zhouguang Hui Tags: ORIGINAL ARTICLE Source Type: research

Thoracoscopic intrapericardial lingular segmentectomy for advanced lung cancer following immunotherapy
We report the case of a 67 ‐year‐old female with a left lung squamous cell lung cancer revealed by computed tomography‐guided biopsy. Treatment started with chemotherapy followed by immunotherapy in which a partial response was recorded. Subsequent salvage lingulectomy with the thoracoscopic approach was performed. The patient fully recovered and shows no sign of recurrence at follow‐up 16 months on. Our case discusses the surgical tactics involved in the procedure, highlights similar findings encountered in the literature, and contributes to the few reports therein. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 16, 2021 Category: Cancer & Oncology Authors: Andre Chou, Shah Hwa Chou, Yu ‐Wei Liu Tags: CASE REPORT Source Type: research

CT ‐guided iodine‐125 brachytherapy as salvage therapy for recurrent mediastinal lymph node metastasis
ConclusionsCT ‐guided iodine‐125 brachytherapy provided a safe and effective choice for recurrent mediastinal lymph node metastasis with significant local therapeutic effects and minor complications, especially for patients who were not eligible for surgical resection and had failed to benefit from systemic t herapy. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 15, 2021 Category: Cancer & Oncology Authors: Hong Dong, Lin Li, Dianjin Xing, Yuliang Li, Wujie Wang Tags: ORIGINAL ARTICLE Source Type: research

Expanding TNM for lung cancer through machine learning
This study used machine learning to create prognostic systems that expand the TNM. On the basis of primary tumor, regional lymph nodes, metastasis, age, and histology type, a prognostic system for lung cancer was created to improve the patient stratification and survival prediction of the TNM. AbstractBackgroundExpanding the tumor, lymph node, metastasis (TNM) staging system by accommodating new prognostic and predictive factors for cancer will improve patient stratification and survival prediction. Here, we introduce machine learning for incorporating additional prognostic factors into the conventional TNM for stratifying...
Source: Thoracic Cancer - March 13, 2021 Category: Cancer & Oncology Authors: Matthew Hueman, Huan Wang, Zhenqiu Liu, Donald Henson, Cuong Nguyen, Dean Park, Li Sheng, Dechang Chen Tags: ORIGINAL ARTICLE Source Type: research

Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case report
This report widens the spectrum of differential diagnoses of primary tumors occurring in the PA. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 13, 2021 Category: Cancer & Oncology Authors: Shuji Mishima, Osamu Mishima, Koji Azuhata, Hisashi Shimojo, Nobuo Ito, Kenji Misawa, Kimihiro Shimizu Tags: CASE REPORT Source Type: research

Downregulation of long non ‐coding RNA LOC101928477 correlates with tumor progression by regulating the epithelial‐mesenchymal transition in esophageal squamous cell carcinoma
ConclusionsTogether, our results suggested that LOC101928477 could be a novel suppressor gene involved in ESCC progression. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 13, 2021 Category: Cancer & Oncology Authors: Demiao Kong, Dali Long, Bo Liu, Dengke Pei, Na Cao, Guihua Zhang, Zhenkun Xia, Meng Luo Tags: ORIGINAL ARTICLE Source Type: research

Prognostic value of the geriatric nutritional risk index among patients with previously treated advanced non ‐small cell lung cancer who subsequently underwent immunotherapy
This retrospective study evaluated the prognostic value of the geriatric nutritional risk index (GNRI) among patients with previously treated advanced non ‐small cell lung cancer (NSCLC) who subsequently underwent immunotherapy. A high GNRI was associated with good outcome among patients with NSCLC. These results can be applied in clinical practice to evaluate patient prognosis and response to therapy. AbstractBackgroundThe geriatric nutritional risk index (GNRI) is a simple and useful marker for predicting prognosis and treatment efficacy among patients with various cancers. However, to the best of our knowledge, there ...
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Kei Sonehara, Kazunari Tateishi, Taisuke Araki, Masamichi Komatsu, Hiroshi Yamamoto, Masayuki Hanaoka Tags: ORIGINAL ARTICLE Source Type: research

A retrospective analysis of pembrolizumab plus chemotherapy versus pembrolizumab monotherapy for advanced or recurrent non ‐small cell lung cancer
ConclusionThere was no significant difference in ORR and OS between the two groups, and treatment discontinuation was more frequent in the combination group. A randomized controlled trial is needed to evaluate the addition of chemotherapy to pembrolizumab for first ‐line treatment in patients with PD‐L1 TPS ≥50%. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Taisuke Isono, Naho Kagiyama, Shun Shibata, Hitomi Nakajima, Yuma Matsui, Kenji Takano, Takashi Nishida, Chiaki Hosoda, Eriko Kawate, Yoichi Kobayashi, Takashi Ishiguro, Yotaro Takaku, Kazuyoshi Kurashima, Tsutomu Yanagisawa, Noboru Takayana Tags: ORIGINAL ARTICLE Source Type: research

Activity of tarloxotinib ‐E in cells with EGFR exon‐20 insertion mutations and mechanisms of acquired resistance
ConclusionsThese findings indicate that tarloxotinib ‐E could be effective for NSCLC withEGFR exon 20 mutations. Our results also show that T790M or C797S mutations can confer acquired resistance to tarloxotinib ‐E; and suggest that resistance mechanisms are influenced by the baselineEGFR exon 20 mutations. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Masaya Nishino, Kenichi Suda, Takamasa Koga, Shuta Ohara, Toshio Fujino, Junichi Soh, Vijaya Tirunagaru, Avanish Vellanki, Robert C. Doebele, Tetsuya Mitsudomi Tags: ORIGINAL ARTICLE Source Type: research

Quercetin induces pro ‐apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro
ConclusionsQuercetin ‐induced autophagy contributes to apoptosis in A549 and H1299 lung cancer cells, which involved the SIRT1/AMPK signaling pathway. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Hengjuan Guo, Hui Ding, Xin Tang, Maoli Liang, Shuo Li, Jing Zhang, Jie Cao Tags: ORIGINAL ARTICLE Source Type: research

Learning curve of robotic portal lobectomy for pulmonary neoplasms: A prospective observational study
The learning curve of RPL ‐4 can be divided into three phases. Ten cases were required to pass the learning curve, but the mastery of RPL‐4 for satisfactory surgical outcomes requires experience from at least 56 cases. AbstractBackgroundWe aim to assess the learning curve of robotic portal lobectomy with four arms (RPL ‐4) in patients with pulmonary neoplasms using prospectively collected data.MethodsData from 100 consecutive cases with lung neoplasms undergoing RPL ‐4 were prospectively accumulated into a database between June 2018 and August 2019. The Da Vinci Si system was used to perform RPL‐4. Regression cur...
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Mu ‐Zi Yang, Ren‐Chun Lai, Abbas E. Abbas, Bernard J. Park, Ji‐Bin Li, Jie Yang, Jin‐Chun Wu, Gang Wang, Hao‐Xian Yang Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Thoracic Cancer)
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

A rare case of primary solitary endobronchial plasmacytoma
We present the case of an 86 ‐year‐old male ex‐smoker who visited our outpatient clinic for an endobronchial mass in the left upper lobe of the lung. Fiberoptic bronchoscopy revealed a protruding mass in the left upper lobar bronchus; based on the bronchoscopic biopsy findings, a primary solitary endobronchial plasmacytom a was diagnosed. AbstractExtramedullary plasmacytoma (EMP) is a rare plasma cell tumor involving the organs but without bone marrow involvement or the characteristics of multiple myeloma. Primary solitary endobronchial plasmacytoma is extremely rare. Here we present the case of an 86 ‐year‐old m...
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Jong Il Park, Yin Young Lee, Seok Soo Lee, June Hong Ahn Tags: CASE REPORT Source Type: research

ALK rearrangements as mechanisms of acquired resistance to osimertinib in EGFR mutant non ‐small cell lung cancer
In this study, we also summarized previously reported cases and concluded thatALK rearrangement is a rare but critical resistance mechanism to osimertinib. After failure of combined treatment with osimertinib plus crizotinib, comprehensive molecular profiling should be performed, and chemotherapy plus bevacizumab might be an optimal treatment especially for patients harboringVEGFA amplification. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Helei Hou, Dantong Sun, Chuantao Zhang, Dong Liu, Xiaochun Zhang Tags: CASE REPORT Source Type: research

Precise resection of multiple pulmonary nodules using a three ‐dimensional reconstruction model: A case report
In this case, there was a very special small pulmonary nodule in the anterior segment of the right upper lung. Using 3D reconstruction, as it was difficult to carry out a conventional pulmonary wedge resection, we determined that the nodule was located exactly between the roots of V3c and V3b+a. Therefore, we used electrocautery to strip the lung tissue along the boundary of V3c and V3b+a during the operation, and successfully removed the nodule. AbstractA 48 ‐year‐old woman presented to our department and chest computed tomography (CT) revealed five pulmonary nodules, two of which were in the left upper lobe of the lu...
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Xiang ‐Peng Chu, Zi‐Hao Chen, Shao‐Min Lin, Wen‐Fang Tang, Jia‐Tao Zhang, Yao‐Ming Lai, Rui Fu, Zhen‐Bin Qiu, Jun‐Tao Lin, Qiang Nie, Xue‐Ning Yang, Yi‐Long Wu, Wen‐Zhao Zhong Tags: CASE REPORT Source Type: research

Tofacitinib overcomes an IFN γ‐induced decrease in NK cell‐mediated cytotoxicity via the regulation of immune‐related molecules in LC‐2/ad
ConclusionsTaken together, our study shows that tofacitinib blocks the IFN γ‐induced transformation from an NK cell‐sensitive phenotype to an NK cell‐resistant one in IFNγ‐reacted LC‐2/ad cells, thereby implicating that tofacitinib may be a promising agent to overcome IFNγ‐induced tumor immune escape, although it may be adapted to the limited number of NSCLC patients. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Riki Okita, Katsuhiko Shimizu, Yuji Nojima, Shinsuke Saisho, Masao Nakata Tags: ORIGINAL ARTICLE Source Type: research

Propofol suppresses lung cancer tumorigenesis by modulating the circ ‐ERBB2/miR‐7‐5p/FOXM1 axis
ConclusionsPropofol inhibited lung cancer progression via mediating circ ‐ERBB2/miR‐7‐5p/FOXM1 axis, which might provide an effective therapeutic target for lung cancer therapy. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Jie Gao, Chengzhi Ding, Junhui Zhou, Gang Wu, Zongmao Han, Jianchao Li, Feilong Hei Tags: ORIGINAL ARTICLE Source Type: research

Patient prognostic scores and association with survival improvement offered by postoperative radiotherapy for resected IIIA/N2 non ‐small cell lung cancer: A population‐based study
The role of postoperative radiotherapy for IIIA/N2 non ‐small cell lung cancer is unclear. Treatments for IIIA/N2 non‐small cell lung cancer should be individualized. Patients who received postoperative radiotherapy had a lower CSM rate. The improved survival of patients receiving PORT was correlated with patient prognostic scores. Prognostic scores and clinical characteristics may be helpful in candidate selection for PORT. AbstractBackgroundCurrently, there is no consensus on the role of postoperative adjuvant radiotherapy (PORT) for resected stage IIIA/N2 non ‐small cell lung cancer (NSCLC). Our study sought to de...
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Lei Xu, Hou ‐nai Xie, Xian‐kai Chen, Nan Bi, Jian‐jun Qin, Yin Li Tags: ORIGINAL ARTICLE Source Type: research

Tumor ‐educated leukocytes mRNA as a diagnostic biomarker for non‐small cell lung cancer
This study aimed to investigate the diagnostic and prognostic role of tumor ‐educated leukocytes (TELs) mRNA in Chinese patients with non‐small cell lung cancer (NSCLC).MethodsThe TELs collected underwent total RNA isolation. RNA ‐sequencing (RNA‐seq) technology was used to analyze the transcriptome of the TELs. The mRNA expression levels of differential genes were analyzed by RT‐qPCR. Statistical analyses were performed using Prism and SPSS by Mann–Whitney nonparametric test, Kruskal‐Wallis test and one‐way ANOV A.ResultsWe used RNA ‐seq technology to screen 95 differential genes (DEGs) from seven NS...
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Limin Niu, Wei Guo, Xingguo Song, Xianrang Song, Li Xie Tags: ORIGINAL ARTICLE Source Type: research

Preoperative predictors of restoration in quality of life after surgery for lung cancer
ConclusionsThe EQ ‐5D VAS and EORTC GHS scores traced similar trajectories of QOL. In both QOL measures, preoperative pain was found as a common predictor. These predictors may help improve patient/survivor care in the future. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Hideo Ichimura, Keisuke Kobayashi, Masahiko Gosho, Kojiro Nakaoka, Takahiro Yanagihara, Sho Ueda, Yusuke Saeki, Naoki Maki, Naohiro Kobayashi, Shinji Kikuchi, Hisashi Suzuki, Yukinobu Goto, Yukio Sato Tags: ORIGINAL ARTICLE Source Type: research

Clinical outcomes and radiation pneumonitis after concurrent EGFR ‐tyrosine kinase inhibitors and radiotherapy for unresectable stage III non‐small cell lung cancer
ConclusionsCombined EGFR ‐TKI and radiotherapy showed favorable survival inEGFR‐mutant patients with inoperable stage III NSCLC, with a 6.7% incidence of grade 3 radiation pneumonitis/pneumonitis, despite a higher incidence of mild‐to‐moderate radiation pneumonitis.Key pointsSignificant findings of the studyWe evaluated the outcomes and radiation pneumonitis after EGFR ‐TKI during interval radiotherapy. EGFR‐TKI plus radiotherapy increased survival in patients withEGFR‐mutant inoperable stage III NSCLC. The mild‐to‐moderate radiation pneumonitis incidence increased but no grade 4–‐5 adverse events...
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Kunpeng Xu, Jun Liang, Tao Zhang, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Zefen Xiao, Zhouguang Hui, Jima Lu, Xin Wang, Lei Deng, Wenyang Liu, Jianyang Wang, Yirui Zhai, Jie Wang, Nan Bi, Luhua Wang Tags: ORIGINAL ARTICLE Source Type: research

Effects of periodontitis on postoperative pneumonia in patients with lung and esophageal cancer
Periodontal treatment is associated with a lower incidence of POP following lung and esophageal cancer surgery, and it is recommended that periodontal examination and therapy be carried out before surgical treatment of lung or esophageal cancer. AbstractBackgroundFew studies have been conducted on the relationship between chronic periodontitis and postoperative pneumonia (POP) in patients with lung and esophageal cancer. Furthermore, it remains controversial as to whether improving the periodontal condition of patients with lung and esophageal cancer before surgery reduces the incidence of POP. This retrospective study was...
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Chunling Jia, Yijun Luan, Xibo Li, Xiaoying Zhang, Cuirong Li Tags: ORIGINAL ARTICLE Source Type: research

A novel technique for preoperative localization of pulmonary nodules using a mixture of tissue adhesive and iohexol under computed tomography guidance: A 140 patient single ‐center study
In this study, a technique for preoperative localization of pulmonary nodules with tissue adhesive and iohexol mixture was established and proved to be safe, easy to operate and efficient in clinical practice based on our experience. It is a suitable technique for promotion in localization of pulmonary nodules including multiple pulmonary nodules. AbstractBackgroundThe increase in the incidence of pulmonary nodules has made computed tomography (CT) screening a requirement for diagnosis and treatment. Small pulmonary nodule detection during video ‐assisted thoracoscopic surgery (VATS) or thoracotomy is frequently challeng...
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Bingyu Zhang, Muyun Peng, Fenglei Yu, Xilong Mei, Jingqun Tang, Xiang Wang, Wenliang Liu, Chen Chen, Xiaofeng Chen Tags: ORIGINAL ARTICLE Source Type: research