Use of free modified jejunal flaps to reconstruct pharyngoesophageal defects with preservation of the larynx in three cases
The larynx is often sacrificed in patients with hypopharyngoesophageal cancer before reconstruction using the jejunum to restore the continuity of the digestive tract and allow oral alimentation. We retrospectively collected and analyzed data from three patients who underwent hypopharyngoesophageal reconstruction by partial patch and partial tube free jejunal flap with preservation of laryngeal function. All three flaps survived in patients who underwent the modified jejunal flaps. The larynx was preserved in all three patients. Partial patch and partial tube jejunal flap is a possible option for reconstruction of large an...
Source: Thoracic Cancer - May 15, 2022 Category: Cancer & Oncology Authors: Jifeng Liu, Rong Yu, Ji Wang, Di Deng, Linke Li, Bo Li, Jun Liu, Fei Chen Tags: CASE REPORT Source Type: research

Circ_0001273 downregulation inhibits the growth, migration and glutamine metabolism of esophageal cancer cells via targeting the miR ‐622/SLC1A5 signaling axis
ConclusionCirc_0001273 high expression contributed to EC progression via modulating the miR-622/SLC1A5 signaling axis. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 14, 2022 Category: Cancer & Oncology Authors: Bomeng Wu, Ying Chen, Ying Chen, Xihao Xie, Hanping Liang, Fengyuan Peng, Weibi Che Tags: ORIGINAL ARTICLE Source Type: research

A large intrathoracic goiter with tracheal stenosis: Complete resection using a robot ‐assisted thoracoscopic approach
Chest computed tomography shows the trachea stenosed by the goiter (a). Coronal (b) and axial (c) sections show the tumor extending beyond the level of the carina. AbstractGrowing intrathoracic goiters may compress surrounding organs and deteriorate the cardiopulmonary function. Treating such cases requires carefully considering how to maintain oxygenation and resect the tumor with minimal invasiveness without complications. We herein report a surgically resected case of a large intrathoracic goiter-compressed trachea extending from the right lower pole of the thyroid gland to the carina. We secured the airway by intubatio...
Source: Thoracic Cancer - May 14, 2022 Category: Cancer & Oncology Authors: Ryuji Nakamura, Katsuhiro Okuda, Kensuke Chiba, Takuya Matsui, Risa Oda, Tsutomu Tatematsu, Keisuke Yokota, Ryoichi Nakanishi Tags: CASE REPORT Source Type: research

PRKCB is relevant to prognosis of lung adenocarcinoma through methylation and immune infiltration
ConclusionsPRKCB is relevant to prognosis of LUAD through methylation and immune infiltration. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 14, 2022 Category: Cancer & Oncology Authors: Jinjie Wang, Muqi Shi, Haijian Zhang, Hao Zhou, Zhanghao Huang, Youlang Zhou, Jiahai Shi Tags: ORIGINAL ARTICLE Source Type: research

Conditional catheter ‐related thrombosis free probability and risk‐adapted choices of catheter for lung cancer
ConclusionsCCFP increased, and the hazards of CRT decreased over time in a risk-dependent manner in patients with lung cancer. These valuable dynamic data may help optimize risk-adjusted choices of VADs and risk-adjusted prophylactic anticoagulation strategies for patients. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 14, 2022 Category: Cancer & Oncology Authors: Yanfeng Wang, Chanjuan Cui, Xin Liu, Lei Deng, Ke Yang, Bin Li, Jie Xue, Junying Xie, Wei Cui Tags: ORIGINAL ARTICLE Source Type: research

A randomized phase II study of docetaxel or pemetrexed with or without the continuation of gefitinib after disease progression in elderly patients with non ‐small cell lung cancer harboring EGFR mutations (JMTO LC12‐01)
ConclusionsPatients on G and Pem or Doc beyond PD showed a longer PFS than those on single-agent chemotherapy; however, it was associated with increased toxicity. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 14, 2022 Category: Cancer & Oncology Authors: Kazuhiro Asami, Masahiko Ando, Takashi Nishimura, Takashi Yokoi, Atsuhisa Tamura, Koichi Minato, Masahide Mori, Fumitaka Ogushi, Akiyoshi Yamamoto, Hiroshige Yoshioka, Masaaki Kawahara, Shinji Atagi Tags: ORIGINAL ARTICLE Source Type: research

Efficacy of different sequential patterns after crizotinib progression in advanced anaplastic lymphoma kinase ‐positive non–small cell lung cancer
ConclusionsThe application of next-generation ALK-TKIs after crizotinib progression significantly prolonged survival, whereas direct sequencing lorlatinib seemed advantageous. Similarly, lorlatinib also prolonged survival in patients with first- and second-generation ALK-TKIs failure. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 13, 2022 Category: Cancer & Oncology Authors: Xiya Ma, Shaoxing Yang, Kun Zhang, Jing Xu, Panpan Lv, Hongjun Gao, Haifeng Qin, Hong Wang, Xiaoqing Liu Tags: ORIGINAL ARTICLE Source Type: research

Use of a highly sensitive lung cancer compact panel to detect KRAS G12D in the wash fluid from a lung tumor: A case report
A highly sensitive lung cancer compact panel AbstractHere, we report a case of a pulmonary invasive mucinous adenocarcinoma harboringKRAS G12D, diagnosed from tumor samples containing a very small amount of tumor cells using next-generation sequencing (NGS) and the recently developed Lung Cancer Compact Panel. A 79-year-old woman without any respiratory symptoms underwent chest computed tomography, which revealed a tumor in the left lower lobe. During endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB) using a guide sheath (GS), a sufficient specimen for pathological diagnosis could not be obtained because t...
Source: Thoracic Cancer - May 12, 2022 Category: Cancer & Oncology Authors: Daisuke Minami, Nagio Takigawa, Yasuhiro Nakajima, Nobuaki Miyahara, Yasuyuki Mizumori, Mitsuhiro Ueda, Seiji Nakamura, Fumihiko Suzuki, Yoshiharu Sato, Kei Morikawa, Arihiko Kanehiro Tags: CASE REPORT Source Type: research

A targeted siRNA ‐loaded PDL1‐exosome and functional evaluation against lung cancer
ConclusionThe PD-L1 targeting exosome can be used as an efficient siRNA delivery carrier, which is an efficient and safe nanocarrier for tumor targeted gene therapy. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 12, 2022 Category: Cancer & Oncology Authors: Xianbin Lin, Liangan Lin, Jingyang Wu, Wentan Jiang, Jiayun Wu, Jianshen Yang, Chun Chen Tags: ORIGINAL ARTICLE Source Type: research

Lung cancer as a predominant feature in a patient with Peutz –Jeghers syndrome: Case report
Peutz –Jeghers syndrome is a rare syndrome associated with loss-of-functionSTK11 variants and is one of the few reasons for hereditary predisposition to lung cancer. Prompt identification ofSTK11 carriers can provide options for targeted therapies. AbstractPeutz –Jeghers syndrome (PJS) is characterized by mucocutaneous pigmentation and gastrointestinal hamartomatous polyposis, which can lead to intussusception. PJS patients face high lifetime risks for various cancer types, with the majority of patients being diagnosed with tumors along the gastrointestin al tract. Herein, we present the case of a 34-year-old man who c...
Source: Thoracic Cancer - May 11, 2022 Category: Cancer & Oncology Authors: Florentia Fostira, Elena Fountzilas, Kyriaki Papadopoulou, Theodoros Karaiskos, Ourania Mpatsi, Nikoleta Pastelli, Giannis Mountzios, Irene Konstantopoulou, George Fountzilas Tags: CASE REPORT Source Type: research

Chemoradiation followed by adjuvant durvalumab in stage III non –small cell lung cancer: Real‐world comparison of treatment outcomes to historical controls treated with chemoradiation alone
ConclusionTreatment with adjuvant durvalumab following chemoradiation was associated with improved PFS and OS compared to chemoradiation alone. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 11, 2022 Category: Cancer & Oncology Authors: Akram Saad, Jeffrey Goldstein, Sarit Appel, Sameh Daher, Damien Urban, Amir Onn, Hadas Gantz ‐Sorotsky, Anastasiya Lobachov, Teodor Gottfried, Benjamin Spieler, Jair Bar Tags: ORIGINAL ARTICLE Source Type: research

Different CT slice thickness and contrast ‐enhancement phase in radiomics models on the differential performance of lung adenocarcinoma
ConclusionsThe radiomic analysis of contrast-enhanced CT can be used for the differential diagnosis of lung adenocarcinoma. Moreover, different slice thickness and contrast-enhanced scan phase did not affect the discriminating ability in the radiomics models. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 11, 2022 Category: Cancer & Oncology Authors: Yang Wang, Fang Liu, Yan Mo, Chencui Huang, Yingxin Chen, Fuliang Chen, Xiangwei Zhang, Yunxin Yin, Qiang Liu, Lin Zhang Tags: ORIGINAL ARTICLE Source Type: research

ACT001 inhibits the proliferation of non ‐small cell lung cancer cells by upregulating NKTR expression
ConclusionOur results suggested NKTR may be the target of ACT001 in NSCLC. ACT001 holds promise as a novel method for the treatment of NSCLC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 11, 2022 Category: Cancer & Oncology Authors: Min Zhao, Tingting Qin, Dingzhi Huang Tags: ORIGINAL ARTICLE Source Type: research

Circ_0005231 promotes the progression of esophageal squamous cell carcinoma via sponging miR ‐383‐5p and regulating KIAA0101
ConclusionCirc_0005231 acted as a sponge of miR-383-5p to promote ESCC progression by upregulating KIAA0101, which provided a potential therapeutic strategy for ESCC treatment. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 7, 2022 Category: Cancer & Oncology Authors: Zhiguang Sun, Shaowei Zhang, Nan Zhang, Jianxin Wang, Jindong Wang, Junfeng Liu Tags: ORIGINAL ARTICLE Source Type: research

Safety and efficacy of endobronchial ultrasound ‐guided transbronchial needle aspiration (EBUS‐TBNA) for patients aged 80 years and older
ConclusionEBUS-TBNA can be considered safe and effective even in patients aged 80  years and older. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 7, 2022 Category: Cancer & Oncology Authors: Hideyuki Niwa, Masahide Oki, Yurika Ishii, Atsushi Torii, Arisa Yamada, Yuka Shinohara, Yoshihito Kogure, Hideo Saka Tags: ORIGINAL ARTICLE Source Type: research