USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis

In conclusion, this study highlights the critical role of the USP46/PTBP1/PKM2 axis in TAM resistance in BC. Targeted therapy against USP46 may represent a promising strategy to improve the prognosis of TAM-resistant patients.PMID:38176460 | DOI:10.1016/j.bbadis.2023.167011
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research