Tamoxifen-Activated Cre Impairs Retinal Angiogenesis Independently of Gene Deletion.
PMID: 32635822 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - July 8, 2020 Category: Cardiology Authors: Brash JT, Bolton RL, Rashbrook VS, Denti L, Kubota Y, Ruhrberg C Tags: Circ Res Source Type: research

Correction to: Treatment of Obesity in Mitigating Metabolic Risk.
Authors: PMID: 32614711 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Tags: Circ Res Source Type: research

Circulation Research "In This Issue" Anthology.
Circulation Research "In This Issue" Anthology. Circ Res. 2020 Jul 03;127(2):e48-e76 Authors: Williams R, Editors PMID: 32614712 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Authors: Williams R, Editors Tags: Circ Res Source Type: research

Correction to: Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy.
Authors: PMID: 32614713 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Tags: Circ Res Source Type: research

Correction to: Rapamycin-Loaded Biomimetic Nanoparticles Reverse Vascular Inflammation.
Authors: PMID: 32614714 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Tags: Circ Res Source Type: research

If You Build It, They Will Come: Towards Self-Assembly of Functional Cardiovascular Tissues.
PMID: 32614715 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Authors: Lowenthal J, Gerecht S Tags: Circ Res Source Type: research

Zippering Up a Role for ZO-1 in Atrioventricular Node Conduction and Disease.
PMID: 32614716 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Authors: Liang Y, Sheikh F Tags: Circ Res Source Type: research

Letter by Weir Regarding Article, "Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2".
Letter by Weir Regarding Article, "Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2". Circ Res. 2020 Jul 03;127(2):e44-e45 Authors: Weir RAP PMID: 32614717 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Authors: Weir RAP Tags: Circ Res Source Type: research

Dynamic Protein Palmitoylation Cycling: A New Pathway Impacting Peripheral Arterial Disease?
PMID: 32614718 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Authors: Boutagy NE, Sessa WC Tags: Circ Res Source Type: research

Response by Gheblawi et al to Letter Regarding Article, "Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2".
Response by Gheblawi et al to Letter Regarding Article, "Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2". Circ Res. 2020 Jul 03;127(2):e46-e47 Authors: Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong JC, Turner AJ, Raizada MK, Grant MB, Oudit GY PMID: 32614719 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Authors: Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong JC, Turner AJ, Raizada MK, Grant MB, Oudit GY Tags: Circ Res Source Type: research

Atrial Fibrillation Is a Complex Trait: Very Complex.
PMID: 32614720 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Authors: Shoemaker MB, Roden DM Tags: Circ Res Source Type: research

Sympathetic Nervous System Activation and Vascular Endothelial Function With Chronic Hypoxia.
PMID: 32614721 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - July 3, 2020 Category: Cardiology Authors: Swenson ER Tags: Circ Res Source Type: research

Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1 (ATF1).
Conclusions: Taken together, these data demonstrate that both AMPK and ATF1 are required for normal hematoma resolution. PMID: 32611235 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - July 1, 2020 Category: Cardiology Authors: Seneviratne AN, Han Y, Wong E, Walter ER, Jiang L, Cave L, Long NJ, Carling D, Mason JC, Haskard DO, Boyle JJ Tags: Circ Res Source Type: research

Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-fibrotic Protein Synthesis During Cardiac Fibrosis.
Conclusions: Our results indicate that EPRS preferentially controls translational activation of proline codon rich pro-fibrotic genes in cardiac fibroblasts and augments pathological cardiac remodeling. PMID: 32611237 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - July 1, 2020 Category: Cardiology Authors: Wu J, Subbaiah KCV, Xie LH, Jiang F, Khor ES, Mickelsen DM, Myers JR, Tang WW, Yao P Tags: Circ Res Source Type: research

Reduced Platelet miR-223 Induction in Kawasaki Disease Leads To Severe Coronary Artery Pathology Through a miR-223/PDGFR β Vascular Smooth Muscle Cell Axis.
Conclusions: Platelet-derived miR-223 (through PDGFRβ inhibition) promotes VSMC differentia-tion and resolution of KD induced vascular injury. Lack of miR-223 induction leads to severe coro-nary pathology characterized by VSMC dedifferentiation and medial damage. Detection of platelet-derived miR-223 in KD patients (at the time of diagnosis) may identify patients at greatest risk of coronary artery pathology. Moreover, targeting platelet miR-223 or VSMC PDGFRβ represents po-tential therapeutic strategies to alleviate coronary pathology in KD. PMID: 32597702 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 29, 2020 Category: Cardiology Authors: Zhang Y, Wang Y, Zhang L, Xia L, Zheng MH, Zeng Z, Liu YY, Yarovinsky TO, Ostriker AC, Fan X, Weng K, Su M, Huang P, Martin KA, Hwa J, Tang WH Tags: Circ Res Source Type: research

The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
Abstract The recent emergence of SARS-CoV-2 and the ensuing global pandemic has presented a health emergency of unprecedented magnitude. Recent clinical data has highlighted that COVID-19 is associated with a significant risk of thrombotic complications ranging from microvascular thrombosis, venous thromboembolic disease and stroke. Importantly, thrombotic complications are markers of severe COVID-19 and are associated with multi-organ failure and increased mortality. The evidence to date supports the concept that the thrombotic manifestations of severe COVID-19 is due to the ability of SARS-CoV-2 to invade endo&n...
Source: Circulation Research - June 26, 2020 Category: Cardiology Authors: McFadyen JD, Stevens H, Peter K Tags: Circ Res Source Type: research

NAADP/SERCA3-Dependent Ca2+ Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation.
Conclusions: Upon activation a NAADP/SERCA3 Ca2+ mobilization pathway initiates an early ADP secretion, potentiating platelet activation, and a secondary wave of ADP secretion driven by both an IP3/SERCA2b-dependent Ca2+ stores pathway and the NAADP/SERCA3 pathway. This does not exclude that Ca2+ mobilized from SERCA3 stores may also enhance platelet global reactivity to agonists. Because of its modulating effect on platelet activation, this NAADP-SERCA3 pathway may be a relevant target for anti-thrombotic therapy. PMID: 32588751 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 26, 2020 Category: Cardiology Authors: Feng M, Elaïb Z, Borgel D, Denis CV, Adam F, Bryckaert M, Rosa JP, Bobe R Tags: Circ Res Source Type: research

Circulating Th17 and Th22 Cells Are Associated with CMR Imaging Biosignatures of Diffuse Myocardial Interstitial Remodeling in Chronic Coronary Artery Disease.
PMID: 32576092 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 24, 2020 Category: Cardiology Authors: Hoffmann J, Puntmann VO, Fiser K, Rasper T, Berkowitsch A, Carerj ML, Nagel E, Dimmeler S, Zeiher AM Tags: Circ Res Source Type: research

Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification.
Conclusions: We show here that contractile VSMCs are resistant to calcification and identify Nox5 as a key regulator of VSMC phenotypic switching. Additionally, we describe a new mechanism of Ca2+ uptake via EVs and show that Ca2+ induces ROS production in VSMCs via Nox5. ROS production is required for release of EVs, which promote calcification. Identifying molecular pathways that control Nox5 and VSMC-derived EVs provides potential targets to modulate vascular remodelling and calcification in the context of mineral imbalance. PMID: 32564697 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 22, 2020 Category: Cardiology Authors: Furmanik M, Chatrou M, van Gorp RH, Akbulut A, Willems B, Schmidt HH, van Eys G, Bochaton-Piallat ML, Proudfoot D, Biessen EA, Hedin U, Matic L, Mees B, Shanahan CM, Reutelingsperger C, Schurgers LJ Tags: Circ Res Source Type: research

Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis.
Conclusions: Together, these data provide a mechanism as to how TIH, prevalent in people with impaired glucose metabolism, contributes to CVD. These findings provide a rationale for continual glucose control in these patients and may also suggest that strategies aimed at targeting the S100A8/A9-RAGE axis could represent a viable approach to protect the vulnerable blood vessels in diabetes. PMID: 32564710 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 22, 2020 Category: Cardiology Authors: Flynn MC, Kraakman MJ, Tikellis C, Lee MK, Hanssen NM, Kammoun HL, Pickering R, Dragoljevic D, Al-Sharea A, Barrett TJ, Hortle F, Byrne FL, Olzomer E, McCarthy DA, Schalkwijk CG, Forbes JM, Hoehn K, Makowski L, Lancaster GI, El-Osta A, Fisher EA, Goldberg Tags: Circ Res Source Type: research

Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix.
Conclusions: We identified the postnatal cardiac ECM as a non-permissive environment for CM cytokinesis and uncovered novel functions for the embryonic ECM proteins SLIT2 and NPNT in promoting postnatal CM cytokinesis. PMID: 32564729 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 21, 2020 Category: Cardiology Authors: Wu CC, Jeratsch S, Graumann J, Stainier D Tags: Circ Res Source Type: research

Somatic Gain of KRAS Function in the Endothelium is Sufficient to Cause Vascular Malformations that Require MEK but not PI3K Signaling.
Conclusions: We demonstrate that active KRAS expression in the endothelium is sufficient for bAVM formation, even in the setting of uninjured adult vasculature. Furthermore, the finding that KRAS-dependent lesions are reversible in zebrafish suggests that MEK inhibition may represent a promising therapeutic treatment for AVM patients. PMID: 32552404 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 17, 2020 Category: Cardiology Authors: Fish JE, Flores-Suarez CP, Boudreau E, Herman AM, Gutierrez MC, Gustafson D, DiStefano PV, Cui M, Chen Z, Berman De Ruiz K, Schexnayder TS, Ward CS, Radovanovic I, Wythe JD Tags: Circ Res Source Type: research

Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
Conclusions: Our findings identify HDAC9 as a regulator of atherosclerotic plaque stability and IKK activation thus providing a mechanistic explanation for the prominence of HDAC9 as a vascular risk locus in genome-wide association studies. Its therapeutic inhibition may provide a potent lever to alleviate vascular inflammation. PMID: 32546048 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 17, 2020 Category: Cardiology Authors: Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RT, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, D Tags: Circ Res Source Type: research

Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates with Vascular Risks and Is Involved in Atherosclerosis.
Conclusions: These data demonstrate that Rap1 carried by MetS-lEVs participates in the enhanced SMC proliferation, migration, pro-inflammatory profile and activation of ERK5/p38 pathways leading to vascular inflammation and remodeling, and atherosclerosis. These results highlight that Rap1 carried by MetS-lEVs may be a novel determinant of diagnostic value for cardiometabolic risk factors and suggest Rap1 as a promising therapeutic target against the development of atherosclerosis. PMID: 32539601 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 16, 2020 Category: Cardiology Authors: Perdomo L, Vidal-Gomez X, Soleti R, Vergori L, Duluc L, Chwastyniak M, Bisserier M, Le Lay S, Villard A, Simard G, Meilhac O, Lezoualc'h F, Khantalin I, Veerapen R, Dubois S, Boursier J, Henni S, Gagnadoux F, Pinet F, Andriantsitohaina R, Martinez MC Tags: Circ Res Source Type: research

B55 α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Kill Pathological Vessels?
Conclusions: Our data underline a unique role of the B55α/PP2A phosphatase complex in vessel remodeling and suggest the use of PP2A-inhibitors as potent anti-angiogenic drugs targeting specifically nascent blood vessels with a mode-of-action complementary to VEGF(R)-targeted therapies. PMID: 32527198 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 12, 2020 Category: Cardiology Authors: Ehling M, Celus W, Martín-Pérez R, Alba R, Willox S, Di Conza G, Ponti D, Cid MC, Jones EA, Mazzone M Tags: Circ Res Source Type: research

Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype.
Conclusions: Disease and phenotype-association for 62 unique loci are now implicated. These loci may indeed mediated their effect through modification of enhancer H3K27-acetylation enrichment and their corresponding gene expression differences. PMID: 32529949 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 12, 2020 Category: Cardiology Authors: Tan WLW, Anene-Nzelu CG, Wong E, Lee M, Tan HS, Tang SJ, Perrin AMY, Wu KX, Zheng WH, Ashburn RJ, Pan B, Lee MY, Autio MI, Morley M, Tam WL, Cheung C, Margulies KB, Chen L, Cappola TP, Loh M, Chambers J, Prabhakar S, Foo RS Tags: Circ Res Source Type: research

GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failureβ.
Conclusions: These data reveal a critical role of SAP97 in maintaining the integrity of cardiac β1AR signaling and a detrimental cardiac GRK5-CaMKII axis that can be potentially targeted in heart failure therapy. PMID: 32507058 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 8, 2020 Category: Cardiology Authors: Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Raghavender Reddy G, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintrón M, Xiang YK Tags: Circ Res Source Type: research

Hypoalbuminemia, Coagulopathy and Vascular Disease in Covid-19.
PMID: 32508261 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 8, 2020 Category: Cardiology Authors: Violi F, Ceccarelli G, Cangemi R, Alessandri F, d'Ettorre G, Oliva A, Pastori D, Loffredo L, Pignatelli P, Ruberto F, Venditti M, Pugliese F, Mastroianni CM Tags: Circ Res Source Type: research

Systems Genetics for Mechanistic Discovery in Heart Diseases.
Abstract Cardiovascular diseases are the leading cause of death worldwide. Complex diseases with highly heterogenous disease progression among patient populations, cardiovascular diseases feature multifactorial contributions from both genetic and environmental stressors. Despite significant effort utilizing multiple approaches from molecular biology to genome-wide association studies, the genetic landscape of cardiovascular diseases, particularly for the nonfamilial forms of heart failure, is still poorly understood. In the past decade, systems-level approaches based on omics technologies have become an important ...
Source: Circulation Research - June 5, 2020 Category: Cardiology Authors: Rau CD, Lusis AJ, Wang Y Tags: Circ Res Source Type: research

Meet the First Authors.
: 32496910 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - June 5, 2020 Category: Cardiology Authors: Authors. Tags: Circ Res Source Type: research

microRNA-128: A New Tool in the Smooth Muscle Cell Plasticity Toolbox.
PMID: 32496911 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - June 5, 2020 Category: Cardiology Authors: Rayner KJ Tags: Circ Res Source Type: research

Response by Ma et al to Letter Regarding Article, "miRNA-Mediated Suppression of a Cardioprotective Cardiokine As a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders".
Response by Ma et al to Letter Regarding Article, "miRNA-Mediated Suppression of a Cardioprotective Cardiokine As a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders". Circ Res. 2020 Jun 05;126(12):e138-e139 Authors: Ma XL, Du Y, Wang Y, Bond Lau W, Wang X, Nie S, Wei Y PMID: 32496913 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - June 5, 2020 Category: Cardiology Authors: Ma XL, Du Y, Wang Y, Bond Lau W, Wang X, Nie S, Wei Y Tags: Circ Res Source Type: research

Response by Zhang et al to Letter Regarding Article, "Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19".
Response by Zhang et al to Letter Regarding Article, "Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19". Circ Res. 2020 Jun 05;126(12):e142-e143 Authors: Zhang P, Zhu L, Cai J, Lei F, Qin JJ, Wang Y, Yuan Y, Rohit L, Liu PP, Li H PMID: 32496914 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - June 5, 2020 Category: Cardiology Authors: Zhang P, Zhu L, Cai J, Lei F, Qin JJ, Wang Y, Yuan Y, Rohit L, Liu PP, Li H Tags: Circ Res Source Type: research

ERRing on the Side of a Mature Heart.
PMID: 32496915 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - June 5, 2020 Category: Cardiology Authors: Major JL, Bagchi RA, McKinsey TA Tags: Circ Res Source Type: research

Letter by Wang et al Regarding Article, "miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders".
Letter by Wang et al Regarding Article, "miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders". Circ Res. 2020 Jun 05;126(12):e136-e137 Authors: Wang D, Wang T, Yang X PMID: 32496916 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - June 5, 2020 Category: Cardiology Authors: Wang D, Wang T, Yang X Tags: Circ Res Source Type: research

Response by Cohen et al to Letter Regarding Article, "Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19".
Response by Cohen et al to Letter Regarding Article, "Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19". Circ Res. 2020 Jun 05;126(12):e140-e141 Authors: Cohen JB, Hanff TC, South AM, Sparks MA, Hiremath S, Bress AP, Byrd JB, Chirinos JA PMID: 32496917 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - June 5, 2020 Category: Cardiology Authors: Cohen JB, Hanff TC, South AM, Sparks MA, Hiremath S, Bress AP, Byrd JB, Chirinos JA Tags: Circ Res Source Type: research

Importance of Genetic Studies of Cardiometabolic Disease in Diverse Populations.
th KE Abstract Genome-wide association studies have revolutionized our understanding of the genetic underpinnings of cardiometabolic disease. Yet, the inadequate representation of individuals of diverse ancestral backgrounds in these studies may undercut their ultimate potential for both public health and precision medicine. The goal of this review is to describe the imperativeness of studying the populations who are most affected by cardiometabolic disease, to the aim of better understanding the genetic underpinnings of the disease. We support this premise by describing the current variation in the global burden ...
Source: Circulation Research - June 5, 2020 Category: Cardiology Authors: Fernández-Rhodes L, Young KL, Lilly AG, Raffield LM, Highland HM, Wojcik GL, Agler C, Love SM, Okello S, Petty LE, Graff M, Below JE, Divaris K, North KE Tags: Circ Res Source Type: research

Long Range Endocrine Delivery of Circulating miR-210 to Endothelium Promotes Pulmonary Hypertension.
Conclusions: Endogenous blood-borne transport of miR-210 into pulmonary vascular endothelial cells promotes PH, offering fundamental insight into the systemic physiology of miRNA activity. These results also describe a platform for RNA-mediated crosstalk in PH, providing an impetus for developing blood-based miR-210 technologies for diagnosis and therapy in this disease. PMID: 32493166 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 4, 2020 Category: Cardiology Authors: Zhao J, Florentin J, Tai YY, Torrino S, Ohayon L, Brzoska T, Tang Y, Yang J, Negi V, Woodcock CC, Risbano MG, Nouraie M, Sundd P, Bertero T, Dutta P, Chan SY Tags: Circ Res Source Type: research

LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight from Mouse Models.
Conclusions: Hepatic LDLr plays a critical role in the flow of macrophage-derived UC to feces, while the plasma increase of APOB-containing lipoproteins is unable to stimulate m-RCT. The results indicate that, besides the major HDL-dependent m-RCT pathway via SR-BI to the liver, a CETP-independent m-RCT path exists, in which LDL mediates the transfer of cholesterol from macrophages to feces. PMID: 32495699 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 4, 2020 Category: Cardiology Authors: Cedo L, Metso J, Santos D, García-León A, Plana N, Sabate-Soler S, Rotllan N, Rivas-Urbina A, Mendez-Lara KA, Tondo M, Girona J, Julve J, Pallarès V, Benitez-Amado A, Llorente Cortes V, Pérez A, Gómez-Coronado D, Ruotsalainen AK, Levonen AL, Sanchez- Tags: Circ Res Source Type: research

Deep Learning Identifies Cardiomyocyte Nuclei With High Precision.
PMID: 32486999 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - June 3, 2020 Category: Cardiology Authors: Ali SR, Nguyen D, Wang B, Jiang S, Sadek HA Tags: Circ Res Source Type: research

Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-induced Cardiomyopathy Through the SR-A1-c-Myc Axis.
Conclusions: The SR-A1-c-Myc axis may represent a promising target to treat DiCM through augmentation of cardiac resident reparative macrophage proliferation. PMID: 32466726 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - May 29, 2020 Category: Cardiology Authors: Zhang H, Xu A, Sun X, Yang Y, Zhang L, Bai H, Ben J, Zhu X, Li X, Yang Q, Wang Z, Wu W, Yang D, Zhang Y, Xu Y, Chen Q Tags: Circ Res Source Type: research

Novel Methods for Quantification of Vasodepression and Cardioinhibition During Tilt-Induced Vasovagal Syncope.
Abstract Rationale: Assessing the relative contributions of cardioinhibition and vasodepression to the blood pressure (BP) decrease in tilt-induced vasovagal syncope (T-VVS) requires methods that reflect BP physiology accurately. Objective: To assess the relative contributions of cardioinhibition and vasodepression to T-VVS using novel methods. Methods and Results: We studied the parameters determining BP, i.e. stroke volume (SV), heart rate (HR) and total peripheral resistance (TPR), in 163 patients with T-VVS documented by continuous ECG and video EEG monitoring. We defined the beginning of cardioinhibition as t...
Source: Circulation Research - May 28, 2020 Category: Cardiology Authors: van Dijk JG, Ghariq M, Kerkhof FI, Reijntjes RH, van Houwelingen MJ, van Rossum IA, Saal DP, van Zwet EW, van Lieshout JJ, Thijs RD, Benditt DG Tags: Circ Res Source Type: research

Iron-Deficiency and Estrogen Are Associated with Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability.
Conclusions: Our findings revealed that certain factors (i.e., ID and CC) up-regulating transferrin are risk factors of thromboembolic diseases decipher a previously unrecognized mechanistic association among ID, CC and IS and provide a novel strategy for the development of anti-IS medicine by interfering with transferrin-thrombin/FXIIa interactions. PMID: 32450779 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - May 26, 2020 Category: Cardiology Authors: Tang X, Fang M, Cheng R, Zhang Z, Wang Y, Shen C, Han Y, Lu Q, Du Y, Liu Y, Sun Z, Zhu L, Mwangi J, Xue M, Long C, Lai R Tags: Circ Res Source Type: research

Metabolic Inflammation and Insulin Resistance in Obesity.
Abstract Obesity is becoming an epidemic in the United States and worldwide and increases risk for many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. The mechanisms linking obesity with these diseases remain incompletely understood. Over the past 2 to 3 decades, it has been recognized that in obesity, inflammation, with increased accumulation and inflammatory polarization of immune cells, takes place in various tissues, including adipose tissue, skeletal muscle, liver, gut, pancreatic islet, and brain and may contribute to obesity-linked metabolic dysfunctions, le...
Source: Circulation Research - May 22, 2020 Category: Cardiology Authors: Wu H, Ballantyne CM Tags: Circ Res Source Type: research

Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity.
Abstract Adipose tissue (AT) plays a central role in both metabolic health and pathophysiology. Its expansion in obesity results in increased mortality and morbidity, with contributions to cardiovascular disease, diabetes mellitus, fatty liver disease, and cancer. Obesity prevalence is at an all-time high and is projected to be 50% in the United States by 2030. AT is home to a large variety of immune cells, which are critical to maintain normal tissue functions. For example, γδ T cells are fundamental for AT innervation and thermogenesis, and macrophages are required for recycling of lipids released by...
Source: Circulation Research - May 22, 2020 Category: Cardiology Authors: Weinstock A, Moura Silva H, Moore KJ, Schmidt AM, Fisher EA Tags: Circ Res Source Type: research

Metabolomics and Proteomics in Type 2 Diabetes.
Abstract The persistent increase in the worldwide burden of type 2 diabetes mellitus (T2D) and the accompanying rise of its complications, including cardiovascular disease, necessitates our understanding of the metabolic disturbances that cause diabetes mellitus. Metabolomics and proteomics, facilitated by recent advances in high-throughput technologies, have given us unprecedented insight into circulating biomarkers of T2D even over a decade before overt disease. These markers may be effective tools for diabetes mellitus screening, diagnosis, and prognosis. As participants of metabolic pathways, metabolite and pr...
Source: Circulation Research - May 22, 2020 Category: Cardiology Authors: Chen ZZ, Gerszten RE Tags: Circ Res Source Type: research

Obesity Phenotypes, Diabetes, and Cardiovascular Diseases.
eacute;s JP Abstract This review addresses the interplay between obesity, type 2 diabetes mellitus, and cardiovascular diseases. It is proposed that obesity, generally defined by an excess of body fat causing prejudice to health, can no longer be evaluated solely by the body mass index (expressed in kg/m2) because it represents a heterogeneous entity. For instance, several cardiometabolic imaging studies have shown that some individuals who have a normal weight or who are overweight are at high risk if they have an excess of visceral adipose tissue-a condition often accompanied by accumulation of fat in normally l...
Source: Circulation Research - May 22, 2020 Category: Cardiology Authors: Piché ME, Tchernof A, Després JP Tags: Circ Res Source Type: research

Treatment of Obesity in Mitigating Metabolic Risk.
;n JO Abstract Through diverse mechanisms, obesity contributes to worsened cardiometabolic health and increases rates of cardiovascular events. Effective treatment of obesity is necessary to reduce the associated burdens of diabetes mellitus, cardiovascular disease, and death. Despite increasing cardiovascular outcome data on obesity interventions, only a small fraction of the population with obesity are optimally treated. This is a primary impetus for this article in which we describe the typical weight loss, as well as the associated impact on both traditional and novel cardiovascular disease risk factors, provi...
Source: Circulation Research - May 22, 2020 Category: Cardiology Authors: Heffron SP, Parham JS, Pendse J, Alemán JO Tags: Circ Res Source Type: research

Introduction to the Obesity, Metabolic Syndrome, and CVD Compendium.
PMID: 32437304 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - May 22, 2020 Category: Cardiology Authors: Moore KJ, Shah R Tags: Circ Res Source Type: research

Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy.
Abstract The term diabetic cardiomyopathy is defined as the presence of abnormalities in myocardial structure and function that occur in the absence of, or in addition to, well-established cardiovascular risk factors. A key contributor to this abnormal structural-functional relation is the complex interplay of myocardial metabolic remodeling, defined as the loss the flexibility in myocardial substrate metabolism and its downstream detrimental effects, such as mitochondrial dysfunction, inflammation, and fibrosis. In parallel with the growth in understanding of these biological underpinnings has been developmental ...
Source: Circulation Research - May 22, 2020 Category: Cardiology Authors: Peterson LR, Gropler RJ Tags: Circ Res Source Type: research