Kynurenine Relaxes Arteries of Normotensive Women and Those with Preeclampsia
Conclusions: Kynurenine dilates systemic arteries from multiple territories via BKCa activation. Notably, the vasorelaxatory capacity of kynurenine is preserved in preeclampsia, suggesting this approach may have translational potential for the treatment of hypertension in pregnancy. The data warrants further investigation of the potential to exploit this endogenous vasorelaxant as a new treatment for hypertensive pathologies.PMID:33656370 | DOI:10.1161/CIRCRESAHA.120.317612 (Source: Circulation Research)
Source: Circulation Research - March 3, 2021 Category: Cardiology Authors: Stephanie A Worton Harry At Pritchard Susan L Greenwood Mariam Alakrawi Alexander Ep Heazell Mark Wareing Adam S Greenstein Jenny E Myers Source Type: research

Endothelial Pannexin 1 Regulates Cardiac Response to Myocardial Infarction
Circ Res. 2021 Mar 1. doi: 10.1161/CIRCRESAHA.120.317272. Online ahead of print.NO ABSTRACTPMID:33641341 | DOI:10.1161/CIRCRESAHA.120.317272 (Source: Circulation Research)
Source: Circulation Research - March 1, 2021 Category: Cardiology Authors: Miranda E Good Alexander Young Abigail G Wolpe Manxiu Ma Scott R Johnstone Philip J Hall Colleen K Duffy Mark Aronovitz Gregory Martin Robert M Blanton Norbert Leitinger Matthew J Wolf Brant E Isakson Source Type: research

Endothelial Pannexin 1 Regulates Cardiac Response to Myocardial Infarction
Circ Res. 2021 Mar 1. doi: 10.1161/CIRCRESAHA.120.317272. Online ahead of print.NO ABSTRACTPMID:33641341 | DOI:10.1161/CIRCRESAHA.120.317272 (Source: Circulation Research)
Source: Circulation Research - March 1, 2021 Category: Cardiology Authors: Miranda E Good Alexander Young Abigail G Wolpe Manxiu Ma Scott R Johnstone Philip J Hall Colleen K Duffy Mark Aronovitz Gregory Martin Robert M Blanton Norbert Leitinger Matthew J Wolf Brant E Isakson Source Type: research

Endothelial Pannexin 1 Regulates Cardiac Response to Myocardial Infarction
Circ Res. 2021 Mar 1. doi: 10.1161/CIRCRESAHA.120.317272. Online ahead of print.NO ABSTRACTPMID:33641341 | DOI:10.1161/CIRCRESAHA.120.317272 (Source: Circulation Research)
Source: Circulation Research - March 1, 2021 Category: Cardiology Authors: Miranda E Good Alexander Young Abigail G Wolpe Manxiu Ma Scott R Johnstone Philip J Hall Colleen K Duffy Mark Aronovitz Gregory Martin Robert M Blanton Norbert Leitinger Matthew J Wolf Brant E Isakson Source Type: research

Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia
Circ Res. 2021 Feb 25. doi: 10.1161/CIRCRESAHA.120.318216. Online ahead of print.NO ABSTRACTPMID:33626887 | DOI:10.1161/CIRCRESAHA.120.318216 (Source: Circulation Research)
Source: Circulation Research - February 25, 2021 Category: Cardiology Authors: Aline Jatho Anke Zieseniss Katja Brechtel-Curth Atsushi Yamamoto Mathew L Coleman Ana M Vergel Leon Daniel Biggs Benjamin Davies Chris W Pugh Peter J Ratcliffe D örthe M Katschinski Source Type: research

Innervation and Neuronal Control of the Mammalian Sinoatrial Node: A Comprehensive Atlas
Conclusions: This report provides an experimental demonstration of a discrete neuronal population controlling a specific geographic region of the heart (SAN) that can serve as a framework for further exploration of other parts of the intrinsic cardiac nervous system (ICNS) in mammalian hearts and for developing targeted therapies.PMID:33629877 | DOI:10.1161/CIRCRESAHA.120.318458 (Source: Circulation Research)
Source: Circulation Research - February 25, 2021 Category: Cardiology Authors: Peter Hanna Michael J Dacey Jaclyn Brennan Alison Moss Shaina Robbins Sirisha Achanta Natalia P Biscola Mohammed Amer Swid Pradeep Sundaram Rajendran Shumpei Mori Joseph E Hadaya Elizabeth H Smith Stanley G Peirce Jin Chen Leif Havton Zixi Jack Cheng Raja Source Type: research

Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia
Circ Res. 2021 Feb 25. doi: 10.1161/CIRCRESAHA.120.318216. Online ahead of print.NO ABSTRACTPMID:33626887 | DOI:10.1161/CIRCRESAHA.120.318216 (Source: Circulation Research)
Source: Circulation Research - February 25, 2021 Category: Cardiology Authors: Aline Jatho Anke Zieseniss Katja Brechtel-Curth Atsushi Yamamoto Mathew L Coleman Ana M Vergel Leon Daniel Biggs Benjamin Davies Chris W Pugh Peter J Ratcliffe D örthe M Katschinski Source Type: research

Innervation and Neuronal Control of the Mammalian Sinoatrial Node: A Comprehensive Atlas
Conclusions: This report provides an experimental demonstration of a discrete neuronal population controlling a specific geographic region of the heart (SAN) that can serve as a framework for further exploration of other parts of the intrinsic cardiac nervous system (ICNS) in mammalian hearts and for developing targeted therapies.PMID:33629877 | DOI:10.1161/CIRCRESAHA.120.318458 (Source: Circulation Research)
Source: Circulation Research - February 25, 2021 Category: Cardiology Authors: Peter Hanna Michael J Dacey Jaclyn Brennan Alison Moss Shaina Robbins Sirisha Achanta Natalia P Biscola Mohammed Amer Swid Pradeep Sundaram Rajendran Shumpei Mori Joseph E Hadaya Elizabeth H Smith Stanley G Peirce Jin Chen Leif Havton Zixi Jack Cheng Raja Source Type: research

Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia
Circ Res. 2021 Feb 25. doi: 10.1161/CIRCRESAHA.120.318216. Online ahead of print.NO ABSTRACTPMID:33626887 | DOI:10.1161/CIRCRESAHA.120.318216 (Source: Circulation Research)
Source: Circulation Research - February 25, 2021 Category: Cardiology Authors: Aline Jatho Anke Zieseniss Katja Brechtel-Curth Atsushi Yamamoto Mathew L Coleman Ana M Vergel Leon Daniel Biggs Benjamin Davies Chris W Pugh Peter J Ratcliffe D örthe M Katschinski Source Type: research

Innervation and Neuronal Control of the Mammalian Sinoatrial Node: A Comprehensive Atlas
Conclusions: This report provides an experimental demonstration of a discrete neuronal population controlling a specific geographic region of the heart (SAN) that can serve as a framework for further exploration of other parts of the intrinsic cardiac nervous system (ICNS) in mammalian hearts and for developing targeted therapies.PMID:33629877 | DOI:10.1161/CIRCRESAHA.120.318458 (Source: Circulation Research)
Source: Circulation Research - February 25, 2021 Category: Cardiology Authors: Peter Hanna Michael J Dacey Jaclyn Brennan Alison Moss Shaina Robbins Sirisha Achanta Natalia P Biscola Mohammed Amer Swid Pradeep Sundaram Rajendran Shumpei Mori Joseph E Hadaya Elizabeth H Smith Stanley G Peirce Jin Chen Leif Havton Zixi Jack Cheng Raja Source Type: research

CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice
Conclusions: We identified the early loss of CARMN lncRNA as critical event which primes vSMCs towards a pro-atherogenic phenotype in vitro and accelerates the development of atherosclerosis in vivo.PMID:33622045 | DOI:10.1161/CIRCRESAHA.120.318688 (Source: Circulation Research)
Source: Circulation Research - February 24, 2021 Category: Cardiology Authors: Francesca Vacante Julie Rodor Mukesh K Lalwani Amira D Mahmoud Matthew Bennett Azzura De Pace Eileen Miller Kim van Kuijk Jenny Bg de Bruijn Marion Gijbels Thomas Christie Williams Michael B Clark Jessica P Scanlon Amanda C Doran Rusty Montgomery David E Source Type: research

CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice
Conclusions: We identified the early loss of CARMN lncRNA as critical event which primes vSMCs towards a pro-atherogenic phenotype in vitro and accelerates the development of atherosclerosis in vivo.PMID:33622045 | DOI:10.1161/CIRCRESAHA.120.318688 (Source: Circulation Research)
Source: Circulation Research - February 24, 2021 Category: Cardiology Authors: Francesca Vacante Julie Rodor Mukesh K Lalwani Amira D Mahmoud Matthew Bennett Azzura De Pace Eileen Miller Kim van Kuijk Jenny Bg de Bruijn Marion Gijbels Thomas Christie Williams Michael B Clark Jessica P Scanlon Amanda C Doran Rusty Montgomery David E Source Type: research

KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBP β Signaling Pathway
Conclusions: Our findings have met a critical need to discover alterative, pharmacological-based therapies in the treatment of CAVD.PMID:33601919 | DOI:10.1161/CIRCRESAHA.120.318503 (Source: Circulation Research)
Source: Circulation Research - February 19, 2021 Category: Cardiology Authors: Punashi Dutta Madhav Karthik Kodigepalli Stephanie LaHaye J Will Thompson Sarah Rains Casey Nagel Kaitlyn Thatcher Robert B Hinton Joy Lincoln Source Type: research

Mechanical Load Regulates Excitation-Ca < sup > 2+ < /sup > Signaling-Contraction in Cardiomyocyte
Circ Res. 2021 Feb 19. doi: 10.1161/CIRCRESAHA.120.318570. Online ahead of print.NO ABSTRACTPMID:33601939 | DOI:10.1161/CIRCRESAHA.120.318570 (Source: Circulation Research)
Source: Circulation Research - February 19, 2021 Category: Cardiology Authors: Rafael Shimkunas Bence Hegyi Zhong Jian John A Shaw Mohammad A Kazemi-Lari Debika Mitra Kent Leach Xiaocen Li Mark Jaradeh Nicholas Balardi Yi-Je Chen Ariel L Escobar Anthony J Baker Julie Bossuyt Tamas Banyasz Nipavan Chiamvimonvat Kit S Lam Donald M Ber Source Type: research

KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBP β Signaling Pathway
Conclusions: Our findings have met a critical need to discover alterative, pharmacological-based therapies in the treatment of CAVD.PMID:33601919 | DOI:10.1161/CIRCRESAHA.120.318503 (Source: Circulation Research)
Source: Circulation Research - February 19, 2021 Category: Cardiology Authors: Punashi Dutta Madhav Karthik Kodigepalli Stephanie LaHaye J Will Thompson Sarah Rains Casey Nagel Kaitlyn Thatcher Robert B Hinton Joy Lincoln Source Type: research

Mechanical Load Regulates Excitation-Ca < sup > 2+ < /sup > Signaling-Contraction in Cardiomyocyte
Circ Res. 2021 Feb 19. doi: 10.1161/CIRCRESAHA.120.318570. Online ahead of print.NO ABSTRACTPMID:33601939 | DOI:10.1161/CIRCRESAHA.120.318570 (Source: Circulation Research)
Source: Circulation Research - February 19, 2021 Category: Cardiology Authors: Rafael Shimkunas Bence Hegyi Zhong Jian John A Shaw Mohammad A Kazemi-Lari Debika Mitra Kent Leach Xiaocen Li Mark Jaradeh Nicholas Balardi Yi-Je Chen Ariel L Escobar Anthony J Baker Julie Bossuyt Tamas Banyasz Nipavan Chiamvimonvat Kit S Lam Donald M Ber Source Type: research

KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBP β Signaling Pathway.
Conclusions: Our findings have met a critical need to discover alterative, pharmacological-based therapies in the treatment of CAVD. PMID: 33601919 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 19, 2021 Category: Cardiology Authors: Dutta P, Kodigepalli MK, LaHaye S, Thompson JW, Rains S, Nagel C, Thatcher K, Hinton RB, Lincoln J Tags: Circ Res Source Type: research

Mechanical Load Regulates Excitation-Ca2+ Signaling-Contraction in Cardiomyocyte.
PMID: 33601939 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 19, 2021 Category: Cardiology Authors: Shimkunas R, Hegyi B, Jian Z, Shaw JA, Kazemi-Lari MA, Mitra D, Leach K, Li X, Jaradeh M, Balardi N, Chen YJ, Escobar AL, Baker AJ, Bossuyt J, Banyasz T, Chiamvimonvat N, Lam KS, Bers DM, Izu L, Chen-Izu Y Tags: Circ Res Source Type: research

miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques.
Conclusions: Our results provide insight into the immune mechanisms and cellular players that execute anti-miR-33's atheroprotective actions in the plaque. PMID: 33593073 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 17, 2021 Category: Cardiology Authors: Afonso MS, Sharma M, Schlegel MP, van Solingen C, Koelwyn GJ, Shanley LC, Beckett L, Peled D, Rahman K, Giannarelli C, Li H, Brown EJ, Khodadadi-Jamayran A, Fisher EA, Moore KJ Tags: Circ Res Source Type: research

Loss of CASK Accelerates Heart Failure Development.
Conclusions: CASK associates with CaMKII in the human heart. CASK-KO in mice increases CaMKII activity, leading to contractile dysfunction and arrhythmias. Increasing CASK expression reduces CaMKII activity, improves Ca handling and contractile function. PMID: 33593074 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 17, 2021 Category: Cardiology Authors: Mustroph J, Sag CM, Bähr F, Schmidtmann AL, Gupta SN, Dietz A, Islam MT, Lücht CM, Beuthner BE, Pabel S, Baier MJ, El-Armouche A, Sossalla S, Anderson ME, Möllmann J, Lehrke M, Marx N, Mohler PJ, Bers DM, Unsöld B, He T, Dewenter M, Backs J, Maier LS, Tags: Circ Res Source Type: research

Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency.
Conclusions: These studies define a set of human proteins that requires a full NAA15 complement for normal synthesis and development. A 50% reduction in the amount of NAA15 alters levels of at least 562 proteins and Nt-acetylation of only 9 proteins. One or more modulated proteins are likely responsible for NAA15-haploinsufficiency mediated CHD. Additionally, genetically engineered iPS cells provide a platform for evaluating the consequences of amino acid sequence variants of unknown significance on NAA15 function. PMID: 33557580 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 9, 2021 Category: Cardiology Authors: Ward TL, Tai W, Morton SU, Impens F, VanDamme P, Van Haver D, Timmerman E, Venturini G, Zhang K, Jang MY, Willcox JA, Haghighi A, Gelb BD, Chung WK, Goldmuntz E, Porter GA, Lifton R, Brueckner M, Yost HJ, Bruneau BG, Gorham J, Kim Y, Pereira AC, Homsy J, Tags: Circ Res Source Type: research

LncRNA ZNF593-AS Alleviates Contractile Dysfunction in Dilated Cardiomyopathy.
Conclusions: Our findings suggested that lncRNA-based therapeutics may protect against DCM. PMID: 33550812 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 8, 2021 Category: Cardiology Authors: Fan J, Li H, Xie R, Zhang X, Nie X, Shi X, Zhan J, Yin Z, Zhao Y, Dai B, Yuan S, Wen Z, Chen C, Wang DW Tags: Circ Res Source Type: research

Meet the First Authors.
: 33539219 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 5, 2021 Category: Cardiology Authors: Authors. Tags: Circ Res Source Type: research

New Vistas in Stroke Treatment: Targeting the Endothelium to Restore Blood Flow.
PMID: 33539221 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 5, 2021 Category: Cardiology Authors: Reeson P, Brown CE Tags: Circ Res Source Type: research

Heart Failure in Diabetes: Still a Vexing Problem.
PMID: 33539222 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 5, 2021 Category: Cardiology Authors: Taegtmeyer H Tags: Circ Res Source Type: research

Integrating Matrix Signals During Arch Artery Morphogenesis.
PMID: 33539223 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 5, 2021 Category: Cardiology Authors: Kelly RG Tags: Circ Res Source Type: research

Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism.
Abstract Lipid uptake and metabolism are central to the function of organs such as heart, skeletal muscle, and adipose tissue. Although most heart energy derives from fatty acids (FAs), excess lipid accumulation can cause cardiomyopathy. Similarly, high delivery of cholesterol can initiate coronary artery atherosclerosis. Hearts and arteries-unlike liver and adrenals-have nonfenestrated capillaries and lipid accumulation in both health and disease requires lipid movement from the circulation across the endothelial barrier. This review summarizes recent in vitro and in vivo findings on the importance of endothelial...
Source: Circulation Research - February 5, 2021 Category: Cardiology Authors: Abumrad NA, Cabodevilla AG, Samovski D, Pietka T, Basu D, Goldberg IJ Tags: Circ Res Source Type: research

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy.
CONCLUSIONS: Diabetes-mediated activation of cardiomyocyte FOXO1 increases KLF5 expression, which stimulates NOX4 expression, ceramide accumulation, and causes DbCM. PMID: 33539225 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 5, 2021 Category: Cardiology Authors: Kyriazis ID, Hoffman M, Gaignebet L, Lucchese AM, Markopoulou E, Palioura D, Wang C, Bannister TD, Christofidou-Solomidou M, Oka SI, Sadoshima J, Koch WJ, Goldberg IJ, Yang VW, Bialkowska AB, Kararigas G, Drosatos K Tags: Circ Res Source Type: research

Is the Debate on the Flecainide Action on the RYR2 in CPVT Closed?
ez AM PMID: 33539226 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 5, 2021 Category: Cardiology Authors: Benitah JP, Gómez AM Tags: Circ Res Source Type: research

Retraction of: Dual Pathways for Nuclear Factor κB Activation by Angiotensin II in Vascular Smooth Muscle: Phosphorylation of p65 by IκB Kinase and Ribosomal Kinase.
Retraction of: Dual Pathways for Nuclear Factor κB Activation by Angiotensin II in Vascular Smooth Muscle: Phosphorylation of p65 by IκB Kinase and Ribosomal Kinase. Circ Res. 2021 Feb 05;128(3):e45 Authors: PMID: 33539227 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 5, 2021 Category: Cardiology Tags: Circ Res Source Type: research

Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling.
Conclusions: Altogether, our results demonstrate a critical paracrine role of MFAP4 in the development of cardiac hypertrophy and could inform future treatment options for heart failure patients. PMID: 33530700 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 3, 2021 Category: Cardiology Authors: Dorn LE, Lawrence WR, Petrosino J, Xu X, Hund TJ, Whitson BA, Stratton MS, Janssen PM, Mohler PJ, Schlosser A, Sørensen GL, Accornero F Tags: Circ Res Source Type: research

BCL11B Regulates Arterial Stiffness and Related Target Organ Damage.
Conclusions: We have identified VSM BCL11B as a crucial regulator of aortic smooth muscle function and a potential therapeutic target for vascular stiffness. PMID: 33530702 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 3, 2021 Category: Cardiology Authors: Valisno JAC, May J, Singh K, Helm EY, Venegas L, Budbazar E, Goodman JB, Nicholson CJ, Avram D, Cohen RA, Mitchell GF, Morgan KG, Seta F Tags: Circ Res Source Type: research

Atherosclerosis Regression and Cholesterol Efflux in Hypertriglyceridemic Mice.
Conclusions: Atherosclerosis regression in mice is driven by LDL-C reduction and is not affected by HyperTG and plasma HDL-C levels. PMID: 33530703 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 3, 2021 Category: Cardiology Authors: Josefs T, Basu D, Vaisar T, Arets B, Kanter JE, Huggins LA, Hu Y, Liu J, Clouet-Foraison N, Heinecke JW, Bornfeldt KE, Goldberg IJ, Fisher EA Tags: Circ Res Source Type: research

Molecular Mechanisms of Diaphragm Myopathy in Humans with Severe Heart Failure.
Conclusions: CHF patients demonstrate an obvious diaphragm myopathy independent of disuse or other confounding factors such as ageing, obesity, or hypertension. Diaphragm weakness in CHF was associated with intracellular abnormalities characterized by fiber atrophy, oxidative stress, mitochondrial dysfunction, impaired Ca2+ homeostasis, elevated proteasome dependent proteolysis, but inhibited autophagy/mitophagy, which we speculate offers a novel therapeutic molecular target regulated by a Nox-MuRF1/ubiquitin proteasome-mitochondria-RyR1/Ca2+ signaling axis. PMID: 33535772 [PubMed - as supplied by publisher] (Source: ...
Source: Circulation Research - February 1, 2021 Category: Cardiology Authors: Mangner N, Garbade J, Heyne E, van den Berg M, Winzer EB, Hommel J, Sandri M, Jozwiak-Nozdrzykowska J, Meyer A, Lehmann S, Schmitz C, Malfatti E, Schwarzer M, Ottenheijm C, Bowen TS, Linke A, Adams V Tags: Circ Res Source Type: research

MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca2+ Leak.
Conclusions: Moderate MCU overexpression in failing hearts enhances contractility and responses to β-adrenergic stimulation in isolated myocytes and perfused hearts by inhibiting mitochondrial oxidative stress-induced SR Ca2+ leak. MCU overexpression also reversed HF and inhibited ectopic ventricular arrhythmias. PMID: 33522833 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - February 1, 2021 Category: Cardiology Authors: Liu T, Yang N, Sidor A, O'Rourke B Tags: Circ Res Source Type: research

β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction.
Conclusions: Our findings indicate that elevated plasma β2M and TGFβ dichotomously polarize monocytes. Furthermore, these immune molecules share a common receptor, but induce SMAD-dependent canonical signaling (TGFβ) versus non-canonical SMAD-independent signaling (β2M) in a ubiquitin ligase dependent manner. This work has broad implications as β2M is increased in several inflammatory conditions, while TGFβ is increased in fibrotic diseases. PMID: 33508948 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - January 29, 2021 Category: Cardiology Authors: Hilt ZT, Maurya P, Tesoro L, Pariser DN, Ture SK, Cleary SJ, Looney MR, McGrath K, Morrell C Tags: Circ Res Source Type: research

Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci.
Abstract Rationale: Mitral valve prolapse (MVP) is a common valvopathy that leads to mitral insufficiency, heart failure and sudden death. Functional genomic studies in mitral valves are needed to better characterize MVP associated variants and target genes.Objective: To establish the chromatin accessibility profiles and assess functionality of variants and narrow down target genes at MVP loci.Methods and Results: We mapped the open chromatin regions in nuclei from 11 human pathogenic and 7 non-pathogenic mitral valves by an assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-Seq). Ope...
Source: Circulation Research - January 28, 2021 Category: Cardiology Authors: Kyryachenko S, Georges A, Yu M, Berrandou T, Guo L, Bruneval P, Rubio T, Gronwald J, Baraki H, Kutschka I, Aras K, Efimov IR, Norris RA, Voigt N, Bouatia-Naji N Tags: Circ Res Source Type: research

Myocardial Blood Flow Control by Oxygen Sensing Vascular Kv β Proteins.
Conclusions: The Kvβ proteins differentially regulate vascular tone and myocardial blood flow, whereby Kvβ2 promotes and Kvβ1.1 inhibits oxygen-dependent vasodilation and augments blood flow upon heightened metabolic demand. PMID: 33499656 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - January 27, 2021 Category: Cardiology Authors: Ohanyan V, Raph SM, Dwenger MM, Hu X, Pucci T, Mack GD, Moore Iv JB, Chilian WM, Bhatnagar A, Nystoriak MA Tags: Circ Res Source Type: research

Influenza Causes MLKL-Driven Cardiac Proteome Remodeling During Convalescence.
Conclusions: This study provides the first evidence that the cardiac proteome and phosphoproteome are significantly altered post pulmonary influenza infection. Moreover, viral particles can persist in the heart after lung clearance, altering mitochondrial function and promoting cell death without active replication and interferon responses. Finally, our findings show inhibition of necroptosis or prevention of mitochondrial damage as possible therapeutic interventions to reduce cardiac damage during influenza infections. PMID: 33501852 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - January 27, 2021 Category: Cardiology Authors: Lin YH, Platt M, Gilley RP, Brown D, Dube PH, Yu Y, Gonzalez-Juarbe N Tags: Circ Res Source Type: research

BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes.
Conclusions: We uncovered a novel mechanism whereby myocardial BH4 prevents and reverses LV diastolic and systolic dysfunction associated with diabetes via a nNOS-mediated increase in non-insulin dependent myocardial glucose uptake and utilization. These findings highlight the potential of GCH1/BH4-based therapeutics in human diabetic cardiomyopathy. PMID: 33494625 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - January 26, 2021 Category: Cardiology Authors: Carnicer Hijazo R, Duglan D, Ziberna K, Recalde A, Reilly S, Simon JN, Mafrici S, Arya R, Roselló-Lletí E, Chuaiphichai S, Tyler DJ, Lygate CA, Channon KM, Casadei B Tags: Circ Res Source Type: research

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes.
Conclusions: Combining the strengths of proximity and affinity proteomics, we identified isoform-specific Caveolin1 versus Caveolin3 binding partners in cardiomyocytes. McT1 represents a novel class of metabolically relevant Caveolin3-specific interactors close to mitochondria in cardiomyocyte transverse tubules. Caveolin3 knock-out uncovered a previously unknown role for functional stabilization of McT1 in the surface membrane of human cardiomyocytes. Strikingly, Caveolin3 deficient cardiomyocytes exhibit action potential prolongation and instability, reproducing human reentry arrhythmias in silico. Given that lactate is ...
Source: Circulation Research - January 25, 2021 Category: Cardiology Authors: Peper J, Kownatzki-Danger D, Weninger G, Seibertz F, Pronto JR, Sutanto H, Pacheu Grau D, Hindmarsh R, Brandenburg S, Kohl T, Hasenfuβ G, Gotthardt M, Rog-Zielinska EA, Wollnik B, Rehling P, Urlaub H, Wegener JW, Heijman J, Voigt N, Cyganek L, Lenz C, Le Tags: Circ Res Source Type: research

Cycling Cardiomyocytes: Scarce but Important in Recovery From Heart Infarction?
PMID: 33476201 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - January 22, 2021 Category: Cardiology Authors: Derks W, Bergmann O Tags: Circ Res Source Type: research

The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk.
Abstract Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), snapshots of each phase of atherosclerotic cardiovascular disease development can be captured. In this review, we will summarize emerging approaches for assessment of atherosclerotic cardiovascular disease risk in humans usin...
Source: Circulation Research - January 22, 2021 Category: Cardiology Authors: Nayor M, Brown KJ, Vasan RS Tags: Circ Res Source Type: research

Meet the First Authors.
: 33476203 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - January 22, 2021 Category: Cardiology Authors: Authors. Tags: Circ Res Source Type: research

A Single-Cell Analysis of DNMT3A-Mediated Clonal Hematopoiesis in Heart Failure.
PMID: 33476205 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - January 22, 2021 Category: Cardiology Authors: Evans MA, Walsh K Tags: Circ Res Source Type: research

Learning for Prevention of Sudden Cardiac Death.
PMID: 33476206 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - January 22, 2021 Category: Cardiology Authors: Trayanova NA Tags: Circ Res Source Type: research

Correction to: Coronary Neutrophil Extracellular Trap Burden and Deoxyribonuclease Activity in ST-Elevation Acute Coronary Syndrome Are Predictors of ST-Segment Resolution and Infarct Size.
Authors: PMID: 33476207 [PubMed] (Source: Circulation Research)
Source: Circulation Research - January 22, 2021 Category: Cardiology Tags: Circ Res Source Type: research

Aberrant Activation of Notch1 Signaling in Glomerular Endothelium Induces Albuminuria.
Conclusions: Our results reveal novel regulatory mechanisms whereby endothelial Notch1 signaling dictates the level of VE-cadherin through the transcription factors SNAI1 and ERG, leading to dysfunction of GFB and induction of albuminuria. PMID: 33435713 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - January 13, 2021 Category: Cardiology Authors: Li L, Liu Q, Shang T, Song W, Xu D, Allen TD, Wang X, Jeong J, Lobe CG, Liu J Tags: Circ Res Source Type: research

Meet the First Authors.
: 33411626 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - January 8, 2021 Category: Cardiology Authors: Authors. Tags: Circ Res Source Type: research

Lymphatics and the Brain: It's Time to Go Fishing.
PMID: 33411628 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - January 8, 2021 Category: Cardiology Authors: Hogan BM, Bower NI Tags: Circ Res Source Type: research