Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart.
Conclusions: These findings uncover a novel mechanism for diabetes-triggered cardiac dysfunction, provide an endogenous case for saRNA that has been demonstrated so far only with synthetic RNAs in transfected cells, and suggest a potential strategy to develop a miRNA-based therapy to treat diabetes-associated cardiovascular complications. PMID: 31638474 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 22, 2019 Category: Cardiology Authors: Li H, Fan J, Zhao Y, Zhang X, Dai B, Zhan J, Yin Z, Nie X, Fu XD, Chen C, Wang DW Tags: Circ Res Source Type: research

A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T Cell Activation.
Conclusions: Following stimulation of the renin angiotensin system, A20 suppresses DC activation and thereby mitigates T cell-dependent blood pressure elevation. PMID: 31630621 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 21, 2019 Category: Cardiology Authors: Lu X, Rudemiller NP, Wen Y, Ren J, Hammer G, Griffiths R, Privratsky JR, Yang B, Sparks MA, Crowley SD Tags: Circ Res Source Type: research

The Triglyceride Paradox Is Related to Lipoprotein Size, Visceral Adiposity and Stearoyl-CoA Desaturase Activity in Black Versus White Women.
Conclusions: Lower visceral fat and SCD-1 activity may contribute to the paradoxical association of lower fasting and postprandial TRLP subfractions despite insulin resistance in black compared to white pre- and post-menopausal women. Similar concentrations of very small TRLPs are related to insulin resistance and could be important mediators of cardiometabolic disease risk in women. ClinicalTrial.gov: NCT01809288. PMID: 31623522 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 18, 2019 Category: Cardiology Authors: Chung ST, Cravalho CK, Meyers AG, Courville AB, Yang S, Matthan NR, Mabundo L, Sampson M, Ouwerkerk R, Gharib AM, Lichtenstein AH, Remaley AT, Sumner AE Tags: Circ Res Source Type: research

Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.
Conclusions: These findings reveal that oxLDL/CD36 signaling in macrophages links dys-regulated FA metabolism to oxidative stress from the mitochondria, which drives chronic inflammation. Thus, targeting to CD36 and its downstream effectors may serve as potential new strategies against chronic inflammatory diseases such as atherosclerosis. PMID: 31625810 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 18, 2019 Category: Cardiology Authors: Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding PJ, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL Tags: Circ Res Source Type: research

Impaired Autophagy in CD11b+ Dendritic Cells Expands CD4+ Regulatory T Cells And Limits Atherosclerosis in Mice.
Conclusions: In contrast to its pro-atherogenic role in macrophages, autophagy disruption in DCs induces a counter-regulatory response that maintains immune homeostasis in Ldlr-/- mice under high fat diet and limits atherogenesis. Selective modulation of autophagy in DCs could constitute an interesting therapeutic target in atherosclerosis. PMID: 31610723 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 15, 2019 Category: Cardiology Authors: Clément M, Raffort J, Lareyre F, Tsiantoulas D, Newland SA, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MK, Ozsvar-Kozma M, Lam B, Yeo GS, Binder CJ, Kaser A, Mallat Z Tags: Circ Res Source Type: research

Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency.
Conclusions: We demonstrate for the first time that the defect in gut barrier function and dysbiosis in CE2-/y-Akita mice can be favorably impacted by exogenous administration of MACs. PMID: 31610731 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 15, 2019 Category: Cardiology Authors: Duan Y, Prasad R, Feng D, Beli E, Li Calzi S, Longhini ALF, Lamendella R, Floyd JL, Dupont M, Noothi S, Sreejit G, Athmanathan B, Wright J, Jensen AR, Oudit GY, Markel TA, Nagareddy PR, Obukhov AG, Grant MB Tags: Circ Res Source Type: research

Workshop Report: FDA Workshop on Improving Cardiotoxicity Assessment With Human-Relevant Platforms.
Abstract Given that cardiovascular safety concerns remain the leading cause of drug attrition at the preclinical drug development stage, the National Center for Toxicological Research of the US Food and Drug Administration hosted a workshop to discuss current gaps and challenges in translating preclinical cardiovascular safety data to humans. This white paper summarizes the topics presented by speakers from academia, industry, and government intended to address the theme of improving cardiotoxicity assessment in drug development. The main conclusion is that to reduce cardiovascular safety liabilities of new therap...
Source: Circulation Research - October 11, 2019 Category: Cardiology Authors: Pang L, Sager P, Yang X, Shi H, Sannajust F, Brock M, Wu JC, Abi-Gerges N, Lyn-Cook B, Berridge BR, Stockbridge N Tags: Circ Res Source Type: research

Response by Riley et al to Letter Regarding Article, "More Data Than Options for the 'No-Option' Refractory Angina Patient in the United States".
Response by Riley et al to Letter Regarding Article, "More Data Than Options for the 'No-Option' Refractory Angina Patient in the United States". Circ Res. 2019 Oct 11;125(9):e42 Authors: Riley RF, Kereiakes DJ, Henry TD PMID: 31600126 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - October 11, 2019 Category: Cardiology Authors: Riley RF, Kereiakes DJ, Henry TD Tags: Circ Res Source Type: research

Meet the First Authors.
: 31600128 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - October 11, 2019 Category: Cardiology Authors: Authors. Tags: Circ Res Source Type: research

Letter by Picich è and Versaci Regarding Article, "More Data Than Options for the 'No-Option' Refractory Angina Patient in the United States".
Letter by Picichè and Versaci Regarding Article, "More Data Than Options for the 'No-Option' Refractory Angina Patient in the United States". Circ Res. 2019 Oct 11;125(9):e40-e41 Authors: Picichè M, Versaci F PMID: 31600129 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - October 11, 2019 Category: Cardiology Authors: Picichè M, Versaci F Tags: Circ Res Source Type: research

Targeting the Extracellular Matrix Promotes Healing Following Myocardial Infarction.
PMID: 31600130 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - October 11, 2019 Category: Cardiology Authors: Wight TN, Vernon RB Tags: Circ Res Source Type: research

Of Vesicles and Viruses: Why Statins Are Good for HIV Patients.
PMID: 31600131 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - October 11, 2019 Category: Cardiology Authors: Goody PR, Jansen F, Nickenig G Tags: Circ Res Source Type: research

Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions.
Conclusions: The combination of quantitative intravital imaging with deep transcriptomes identified four subsets of vascular macrophages in atherosclerosis that have unique transcriptomic profiles. Our data are the first to link vascular macrophage transcriptomes to their in vivo migratory function. Future work on the functional significance of the change in gene expression and motility characteristics will be needed to fully understand how these subsets contribute to disease progression. PMID: 31594470 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 9, 2019 Category: Cardiology Authors: McArdle S, Buscher K, Ghosheh Y, Pramod AB, Miller J, Winkels H, Wolf D, Ley K Tags: Circ Res Source Type: research

Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle.
Abstract A continuous supply of oxygen is essential for the survival of multi-cellular organisms. The understanding of how this supply is regulated in the microvasculature has evolved from viewing erythrocytes (red blood cells, RBCs) as passive carriers of oxygen to recognizing the complex interplay between hemoglobin and oxygen, carbon dioxide, and nitric oxide - the three-gas respiratory cycle - that insures adequate oxygen and nutrient delivery to meet local metabolic demand. In this context, it is blood flow not blood oxygen content that is the main driver of tissue oxygenation by RBCs. Herein we review the li...
Source: Circulation Research - October 8, 2019 Category: Cardiology Authors: Premont RT, Reynolds JD, Zhang R, Stamler JS Tags: Circ Res Source Type: research

Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development.
Conclusions: Combined with lineage-specific fate mapping systems, our knockout results document an unexpected heterogeneity in vascular cells that produce the elastic laminae. SMCs and ECs can independently form an IEL in most elastic arteries, whereas ECs are the major source of elastin for the IEL in muscular and resistance arteries. Neointimal formation at IEL disruptions in the ascending aorta confirms that the IEL is a critical physical barrier between SMCs and ECs in the large, elastic arteries. Our studies provide new information about how SMCs and ECs contribute elastin to the arterial wall and how local elastic la...
Source: Circulation Research - October 8, 2019 Category: Cardiology Authors: Lin CJ, Staiculescu MC, Hawes JZ, Cocciolone AJ, Hunkins BM, Roth RA, Lin CY, Mecham R, Wagenseil JE Tags: Circ Res Source Type: research

Race, Natriuretic Peptides, and High-Carbohydrate Challenge: A Clinical Trial.
Abstract Rationale: Lower natriuretic peptide (NP) levels may contribute to the development of cardiometabolic diseases. Blacks have lower NP levels than middle-aged and older white adults. A high-carbohydrate challenge causes an upregulation of a negative ANP regulator microRNA-425 (miR-425) which reduces atrial-NP (ANP) levels in whites. Objective: We designed a prospective trial to study racial differences in 1) NP levels among young adults, 2) NP response to a high-carbohydrate challenge, and 3) explore underlying mechanisms for race-based differences. Methods and Results: Healthy self-identified blacks and wh...
Source: Circulation Research - October 6, 2019 Category: Cardiology Authors: Patel N, Russell GK, Musunuru K, Gutierrez OM, Halade GV, Kain V, Lv W, Prabhu SD, Margulies KB, Cappola TP, Arora G, Wang TJ, Arora P Tags: Circ Res Source Type: research

Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes.
Conclusions: We established an unbiased proteomics method that can provide accurate and specific assessment of the maturity of hPSC-CMs, and identified new markers of maturation. Furthermore, this integrated proteomics strategy laid a strong foundation for uncovering the molecular pathways involved in cardiac development and disease using hPSC-CMs. PMID: 31573406 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 1, 2019 Category: Cardiology Authors: Cai W, Zhang J, De Lange WJ, Gregorich ZR, Karp H, Farrell ET, Mitchell ST, Tucholski T, Lin Z, Biermann M, McIlwain S, Ralphe JC, Kamp TJ, Ge Y Tags: Circ Res Source Type: research

Letter by Sterpetti Regarding Article, "G-CSF for Extensive STEMI: Results From the STEM-AMI OUTCOME CMR Substudy".
Letter by Sterpetti Regarding Article, "G-CSF for Extensive STEMI: Results From the STEM-AMI OUTCOME CMR Substudy". Circ Res. 2019 Sep 27;125(8):e37 Authors: Sterpetti AV PMID: 31557119 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 27, 2019 Category: Cardiology Authors: Sterpetti AV Tags: Circ Res Source Type: research

Response by Pompilio et al to Letter Regarding Article, "G-CSF for Extensive STEMI: Results From the STEM-AMI OUTCOME CMR Substudy".
Response by Pompilio et al to Letter Regarding Article, "G-CSF for Extensive STEMI: Results From the STEM-AMI OUTCOME CMR Substudy". Circ Res. 2019 Sep 27;125(8):e38-e39 Authors: Pompilio G, Colombo GI, Bassetti B, Pontone G, Achilli F PMID: 31557120 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 27, 2019 Category: Cardiology Authors: Pompilio G, Colombo GI, Bassetti B, Pontone G, Achilli F Tags: Circ Res Source Type: research

Meet the First Authors.
: 31557121 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 27, 2019 Category: Cardiology Authors: Authors. Tags: Circ Res Source Type: research

Letter by H üttemann et al Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction".
Letter by Hüttemann et al Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction". Circ Res. 2019 Sep 27;125(8):e33-e34 Authors: Hüttemann M, Sommer N, Weissmann N, Grossman LI PMID: 31557122 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 27, 2019 Category: Cardiology Authors: Hüttemann M, Sommer N, Weissmann N, Grossman LI Tags: Circ Res Source Type: research

Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction".
Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction". Circ Res. 2019 Sep 27;125(8):e35-e36 Authors: Dunham-Snary KJ, Archer SL PMID: 31557123 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 27, 2019 Category: Cardiology Authors: Dunham-Snary KJ, Archer SL Tags: Circ Res Source Type: research

ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure -A Possible Novel Therapeutic Target.
Conclusions: These results indicate that ADAMTS8 is a novel therapeutic target in PAH. PMID: 31556812 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 26, 2019 Category: Cardiology Authors: Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Ohtsuki T, Al-Mamun ME, Siddique MAH, Yaoita N, Sunamura S, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H Tags: Circ Res Source Type: research

Peripheral Vasoconstriction During Mental Stress and Adverse Cardiovascular Outcomes in Patients with Coronary Artery Disease.
Conclusions: Greater peripheral vasoconstriction with mental stress, denoted by a low sPAT ratio, is associated with a higher risk of adverse cardiovascular outcomes in patients with CAD. PMID: 31550998 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 25, 2019 Category: Cardiology Authors: Kim JH, Almuwaqqat Z, Hammadah M, Liu C, Ko YA, Lima BB, Sullivan S, Alkhoder A, Abdulbaki R, Ward L, Bremner JD, Sheps D, Raggi P, Sun Y, Shah AJ, Vaccarino V, Quyyumi AA Tags: Circ Res Source Type: research

Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked To Human Coronary Atherosclerosis.
Conclusions: These data provide the first report of a unique BM B-1a cell IgM repertoire and identifies CXCR4 expression as a critical factor selectively governing BM B-1a localization and anti-OSE IgM production. That CXCR4 expression on human B-1 cells was greater in humans with low coronary artery plaque burden suggests a potential targeted approach for immune modulation to limit atherosclerosis. PMID: 31549940 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 24, 2019 Category: Cardiology Authors: Upadhye A, Srikakulapu P, Gonen A, Hendrikx S, Perry HM, Nguyen AT, McSkimming C, Marshall M, Garmey J, Taylor A, Bender TP, Tsimikas S, Holodick NE, Rothstein TL, Witztum JL, McNamara CA Tags: Circ Res Source Type: research

Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body.
Conclusions: We conclude that leptin induces hypertension acting on Trmp7 in CB, which opens horizons for new therapy. PMID: 31545149 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 23, 2019 Category: Cardiology Authors: Shin MK, Caballero-Eraso C, Mu YP, Gu C, Hyeung BH, Kim LJ, Liu XR, Wu ZJ, Paudel O, Pichard LE, Shirahata M, Tang WY, Sham JSK, Polotsky VY Tags: Circ Res Source Type: research

Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association.
This article briefly reviews the challenges of cardio-oncology, the strengths and limitations of using human induced pluripotent stem cell-derived cardiomyocytes to represent clinical findings in the nonclinical research space, and future directions for their further use. PMID: 31533542 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 19, 2019 Category: Cardiology Authors: Gintant G, Burridge P, Gepstein L, Harding S, Herron T, Hong C, Jalife J, Wu JC, American Heart Association Council on Basic Cardiovascular Sciences Tags: Circ Res Source Type: research

Correction to: Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells.
Authors: PMID: 31513486 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 13, 2019 Category: Cardiology Tags: Circ Res Source Type: research

KCNK3 Channel: A New Player in the Field of Pulmonary Vascular Disease.
PMID: 31513487 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 13, 2019 Category: Cardiology Authors: Babicheva A, Zhao T, Yuan JX Tags: Circ Res Source Type: research

Meet the First Authors.
: 31513488 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 13, 2019 Category: Cardiology Authors: Authors. Tags: Circ Res Source Type: research

Leducq Transatlantic Network of Excellence to Cure Phospholamban-Induced Cardiomyopathy (CURE-PLaN).
Abstract The deletion of Arginine 14 of the phosholamban gene (PLN p.R14del) is associated with the pathogenesis of an inherited form of cardiomyopathy with prominent arrhythmias. Patients carrying the PLN R14del mutation are at risk of developing dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy. Although the genetic etiology is well defined, the molecular mechanism underlying the pathogenesis of PLN R14del-cardiomyopathy is unknown. Our CURE PLaN network, funded by the Foundation Leducq, will bring together leading scientists, clinicians, and patients to elucidate the genotype-phenotype r...
Source: Circulation Research - September 13, 2019 Category: Cardiology Authors: Doevendans PA, Glijnis PC, Kranias EG Tags: Circ Res Source Type: research

Body Mass Index Drives Changes in DNA Methylation: A Longitudinal Study.
Abstract Rationale: Previous epigenome-wide association studies (EWASs) suggest that obesity may be the cause, not a consequence, of changes in DNA methylation (DNAm). However, longitudinal observations are lacking. Objective: To identify CpG sites associated with body mass index (BMI) and examine the temporal relationship between dynamic changes in DNAm and BMI in a longitudinal cohort. Methods and Results: Race-specific EWASs were performed in 995 Whites and 490 Blacks from the Bogalusa Heart Study. Suggestive CpG sites were further replicated in 252 Whites and 228 Blacks from the Georgia Stress and Heart Study....
Source: Circulation Research - September 12, 2019 Category: Cardiology Authors: Sun D, Zhang T, Su S, Hao G, Chen T, Li QZ, Bazzano LA, He J, Wang X, Li S, Chen W Tags: Circ Res Source Type: research

Cell-Specific Gene Deletion Reveals the Anti-Thrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox.
Conclusions:These data demonstrate for the first time that, in healthy animals, endothelial COX1 provides an essential anti-thrombotic tone, which is masked when COX1 activity is lost in both endothelial cells and platelets. These results help us define a new two-component paradigm wherein thrombotic tone is regulated by both COX1 and COX2 through complementary but mechanistically distinct pathways. PMID: 31510878 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 12, 2019 Category: Cardiology Authors: Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR, Kirkby NS Tags: Circ Res Source Type: research

Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations.
CONCLUSIONS: This study identifies blood flow as an important physiological factor that is protective in the etiology of this devastating vascular pathology. PMID: 31495257 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 9, 2019 Category: Cardiology Authors: Rödel CJ, Otten C, Donat S, Lourenco M, Fischer D, Kuropka B, Paolini A, Freund C, Abdelilah-Seyfried S Tags: Circ Res Source Type: research

Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7 and Ctgf.
CONCLUSIONS: Our findings demonstrate that upregulation of Yy1 or co-modulation of Bmp7 and Ctgf offer novel therapeutic strategies for the treatment of DCM caused by LMNA insufficiency. PMID: 31495264 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 9, 2019 Category: Cardiology Authors: Tan CY, Wong JX, Chan PS, Tan H, Liao D, Chen W, Tan LW, Ackers-Johnson M, Wakimoto H, Seidman JG, Seidman CE, Lunde IG, Zhu F, Hu Q, Bian JS, Wang JW, Foo RS, Jiang J Tags: Circ Res Source Type: research

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: A Meta-Analysis of Population-Based Studies Involving 17,180 Individuals.
CONCLUSIONS: Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1-signaling might represent a therapeutic target to lower stroke risk. PMID: 31476962 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 3, 2019 Category: Cardiology Authors: Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt MS, Engström G, Herder C, Hoogeveen RC, Koenig W, Melander O, Orho-Melander M, Schiopu A, Söderholm M, Wareham N, Ballantyne CM, Tags: Circ Res Source Type: research

Response by Montone et al to Letter Regarding Article, "Optimized Treatment of ST-Elevation Myocardial Infarction".
Response by Montone et al to Letter Regarding Article, "Optimized Treatment of ST-Elevation Myocardial Infarction". Circ Res. 2019 Aug 30;125(6):e30 Authors: Montone RA, Stiermaier T, Niccoli G, Eitel I PMID: 31465265 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - August 30, 2019 Category: Cardiology Authors: Montone RA, Stiermaier T, Niccoli G, Eitel I Tags: Circ Res Source Type: research

FOXP1: A Gatekeeper of Endothelial Cell Inflammation.
PMID: 31465266 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - August 30, 2019 Category: Cardiology Authors: Kanter JE Tags: Circ Res Source Type: research

Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies.
Abstract Long-QT syndrome, a frequently fatal inherited arrhythmia syndrome caused by genetic variants (congenital) or drugs (acquired), affects 1 in 2000 people worldwide. Its sentinel event is often sudden cardiac death, which makes preclinical diagnosis by genetic testing potentially life-saving. Unfortunately, clinical experience with genetic testing has shown that it is difficult to correctly identify genetic variants as disease causing. These current deficiencies in accurately assigning pathogenicity led to the discovery of increasing numbers of rare variants classified as variant of uncertain significance. ...
Source: Circulation Research - August 30, 2019 Category: Cardiology Authors: Wu JC, Garg P, Yoshida Y, Yamanaka S, Gepstein L, Hulot JS, Knollmann BC, Schwartz PJ Tags: Circ Res Source Type: research

Correction to: G-CSF's Last Stand in STEMI.
Authors: PMID: 31465268 [PubMed] (Source: Circulation Research)
Source: Circulation Research - August 30, 2019 Category: Cardiology Tags: Circ Res Source Type: research

Letter by Jones et al Regarding Article, "Optimized Treatment of ST-Elevation Myocardial Infarction".
Letter by Jones et al Regarding Article, "Optimized Treatment of ST-Elevation Myocardial Infarction". Circ Res. 2019 Aug 30;125(6):e29 Authors: Jones DA, Mathur A, Ahluwalia A PMID: 31465270 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - August 30, 2019 Category: Cardiology Authors: Jones DA, Mathur A, Ahluwalia A Tags: Circ Res Source Type: research

Meet the First Authors.
: 31465271 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - August 30, 2019 Category: Cardiology Authors: Authors. Tags: Circ Res Source Type: research

Transplantation of Human Umbilical Cord Blood-Derived Cellular Fraction Improves LV Function and Remodeling after Myocardial Ischemia/Reperfusion.
CONCLUSIONS: Transplantation of hUCB-derived CD45- Lin- nonhematopoietic cellular subfraction after a reperfused MI in nonimmunosuppressed rats ameliorates LV dysfunction and improves remodeling via favorable paracrine modulation of molecular pathways. These findings with human cells in a clinically relevant model of myocardial ischemia/reperfusion in immunocompetent animals may have significant translational implications. PMID: 31462157 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - August 29, 2019 Category: Cardiology Authors: Zhao L, Cheng G, Choksi K, Samanta A, Girgis M, Soder RP, Vincent RJ, Wulser M, De Ruyter M, McEnulty P, Hauptman J, Yang Y, Weiner CP, Dawn B Tags: Circ Res Source Type: research

Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction.
CONCLUSIONS: Mitochondrial Miro2 expression levels regulate inter-mitochondrial communication along microtubules in adult cardiomyocytes, and degradation of Miro2 through Parkin-mediated ubiquitination contributes to impaired inter-mitochondrial communication and cardiac dysfunction during hypertrophic heart diseases. PMID: 31455181 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - August 28, 2019 Category: Cardiology Authors: Cao Y, Xu C, Ye J, He Q, Zhang X, Jia S, Qiao X, Zhang CL, Liu R, Weng L, Liu Y, Liu LM, Zheng M Tags: Circ Res Source Type: research

HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction: Implications for Statin Treatment in HIV Patients.
Conclusions: These studies establish a mechanism by which HIV-Nef persistence despite ART could contribute to ongoing HIV related vascular dysfunction which may then be ameliorated by statin treatment. PMID: 31451038 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - August 27, 2019 Category: Cardiology Authors: Chelvanambi S, Gupta SK, Chen X, Ellis BW, Maier BF, Colbert TM, Kuriakose J, Zorlutuna P, Jolicoeur P, Obukhov AG, Clauss M Tags: Circ Res Source Type: research

Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses.
CONCLUSIONS: Together, these data are consistent with a model wherein activation of ASIC1A, particularly in neurons, is critical for CO2CO2-induced NO production and vasodilation. With these findings, ASIC1A emerges as major regulator of microvascular tone. PMID: 31451088 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - August 27, 2019 Category: Cardiology Authors: Faraci FM, Taugher RJ, Lynch CM, Fan R, Gupta S, Wemmie J Tags: Circ Res Source Type: research

Heparan Sulfate-Editing Extracellular Sulfatases Enhance Vascular Endothelial Growth Factor Bioavailability for Ischemic Heart Repair.
CONCLUSIONS: These findings establish HS-editing Sulfs as critical inducers of postinfarction angiogenesis and identify HS sulfation as a therapeutic target for ischemic tissue repair. PMID: 31434553 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - August 22, 2019 Category: Cardiology Authors: Korf-Klingebiel M, Reboll MR, Grote K, Schleiner H, Wang Y, Wu X, Klede S, Mikhed Y, Bauersachs J, Klintschar M, Rudat C, Kispert A, Niessen HW, Lübke T, Dierks T, Wollert KC Tags: Circ Res Source Type: research

Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist.
CONCLUSIONS: Gq coupling is required for cardioprotection by an alpha-1A-AR agonist. Gq signaling can be adaptive. PMID: 31426700 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - August 20, 2019 Category: Cardiology Authors: Myagmar BE, Ismaili T, Swigart P, Raghunathan A, Baker AJ, Sahdeo S, Blevitt JM, Milla ME, Simpson PC Tags: Circ Res Source Type: research

Correction to: Phase 3 DREAM-HF Trial of Mesenchymal Precursor Cells in Chronic Heart Failure: A Review of Biological Plausibility and Implementation of Flexible Clinical Trial Design.
Authors: PMID: 31415229 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - August 16, 2019 Category: Cardiology Tags: Circ Res Source Type: research

PAD4 and von Willebrand Factor Link Inflammation and Thrombosis.
PMID: 31415230 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - August 16, 2019 Category: Cardiology Authors: Morrell CN, Hilt ZT, Pariser DN, Maurya P Tags: Circ Res Source Type: research