Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension
CONCLUSIONS: These data support the pathogenic role of CypD acetylation in endothelial dysfunction and hypertension. We suggest that targeting cytotoxic mitochondrial isolevuglandins and GCN5L1 reduces CypD acetylation, which may be beneficial in cardiovascular disease.PMID:38639088 | DOI:10.1161/CIRCRESAHA.123.323596 (Source: Circulation Research)
Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Anna Dikalova Daniel Fehrenbach Vladimir Mayorov Alexander Panov Mingfang Ao Louise Lantier Venkataraman Amarnath Marcos G Lopez Frederic T Billings Iv Michael N Sack Sergey Dikalov Source Type: research
Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
CONCLUSIONS: By identifying and integrating the most gene-rich single-cell subclusters of atherosclerosis to date with a coronary artery disease framework of GRNs, GRN39 was identified and independently validated as being critical for the transformation of contractile SMCs into an osteogenic phenotype promoting advanced-stage, symptomatic atherosclerosis.PMID:38639096 | DOI:10.1161/CIRCRESAHA.123.323184 (Source: Circulation Research)
Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Giuseppe Mocci Katyayani Sukhavasi Tiit Örd Sean Bankier Prosanta Singha Uma Thanigai Arasu Olayinka Oluwasegun Agbabiaje Petri M äkinen Lijiang Ma Chani J Hodonsky Redouane Aherrahrou Lars Muhl Jianping Liu Sonja Gustafsson Byambajav Byandelger Ying Wa Source Type: research
GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension
CONCLUSIONS: Our data highlight GLI1+ cells as an alternative cellular source of VSMCs in pulmonary hypertension and suggest that these cells and the associated signaling pathways represent an important therapeutic target for further studies.PMID:38639105 | DOI:10.1161/CIRCRESAHA.123.323736 (Source: Circulation Research)
Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Xuran Chu Vahid Kheirollahi Arun Lingampally Prakash Chelladurai Chanil Valasarajan Ana Ivonne Vazquez-Armendariz Stefan Hadzic Ali Khadim Oleg Pak Stefano Rivetti Jochen Wilhelm Marek Bartkuhn Slaven Crnkovic Alena Moiseenko Monika Heiner Simone Kraut Le Source Type: research
Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699 (Source: Circulation Research)
Source: Circulation Research - April 17, 2024 Category: Cardiology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research
Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699 (Source: Circulation Research)
Source: Circulation Research - April 17, 2024 Category: Cardiology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research
Immunoproteasomal Processing of IsoLG-Adducted Proteins Is Essential for Hypertension
CONCLUSIONS: These studies define a previously unknown role of the immunoproteasome in DCs and ECs in CD8+ T cell activation. The immunoproteasome in DCs and ECs is critical for isoLG-adduct presentation to CD8+ T cells, and in the endothelium, this guides homing and infiltration of T cells to specific tissues.PMID:38623763 | DOI:10.1161/CIRCRESAHA.124.324068 (Source: Circulation Research)
Source: Circulation Research - April 16, 2024 Category: Cardiology Authors: N éstor de la Visitación Wei Chen Jaya Krishnan Justin P Van Beusecum Venkataraman Amarnath Elizabeth M Hennen Shilin Zhao Mohammad Saleem Mingfang Ao Sergey I Dikalov Anna E Dikalova David G Harrison David M Patrick Source Type: research
Immunoproteasomal Processing of IsoLG-Adducted Proteins Is Essential for Hypertension
CONCLUSIONS: These studies define a previously unknown role of the immunoproteasome in DCs and ECs in CD8+ T cell activation. The immunoproteasome in DCs and ECs is critical for isoLG-adduct presentation to CD8+ T cells, and in the endothelium, this guides homing and infiltration of T cells to specific tissues.PMID:38623763 | DOI:10.1161/CIRCRESAHA.124.324068 (Source: Circulation Research)
Source: Circulation Research - April 16, 2024 Category: Cardiology Authors: N éstor de la Visitación Wei Chen Jaya Krishnan Justin P Van Beusecum Venkataraman Amarnath Elizabeth M Hennen Shilin Zhao Mohammad Saleem Mingfang Ao Sergey I Dikalov Anna E Dikalova David G Harrison David M Patrick Source Type: research
Inhibition of the mPTP and Lipid Peroxidation Is Additively Protective Against I/R Injury
CONCLUSIONS: In the present study, we have investigated the relationship between Ca2+ and ROS, and how they individually or synergistically induce mitochondrial swelling. Our findings suggest that Ca2+ mediates mitochondrial damage through the opening of the mPTP, although ROS mediates its damaging effects through lipid peroxidation. However, subtoxic levels both Ca2+ and ROS can induce mPTP-mediated mitochondrial damage. Targeting both of these triggers to preserve mitochondria viability unveils a highly effective therapeutic approach for mitigating I/R injury.PMID:38618716 | DOI:10.1161/CIRCRESAHA.123.323882 (Source: Circulation Research)
Source: Circulation Research - April 15, 2024 Category: Cardiology Authors: Arielys Mendoza Pooja Patel Dexter Robichaux Daniel Ramirez Jason Karch Source Type: research
Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease
CONCLUSIONS: Our studies uncover a novel buffering mechanism underlying the resiliency of PAA development and remodeling.PMID:38618720 | DOI:10.1161/CIRCRESAHA.123.322767 (Source: Circulation Research)
Source: Circulation Research - April 15, 2024 Category: Cardiology Authors: AnnJosette Ramirez Christina A Vyzas Huaning Zhao Kevin Eng Karl Degenhardt Sophie Astrof Source Type: research
Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions
Circ Res. 2024 Apr 12;134(8):1029-1045. doi: 10.1161/CIRCRESAHA.123.323477. Epub 2024 Apr 11.ABSTRACTThere has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparativ...
Source: Circulation Research - April 11, 2024 Category: Cardiology Authors: Sojin Youn Wass Omar Hahad Zain Asad Shuo Li Mina K Chung Emelia J Benjamin Khurram Nasir Sanjay Rajagopalan Sadeer G Al-Kindi Source Type: research
Meet the First Authors
Circ Res. 2024 Apr 12;134(8):952-953. doi: 10.1161/RES.0000000000000670. Epub 2024 Apr 11.NO ABSTRACTPMID:38603474 | DOI:10.1161/RES.0000000000000670 (Source: Circulation Research)
Source: Circulation Research - April 11, 2024 Category: Cardiology Source Type: research
Correction to: Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery
Circ Res. 2024 Apr 12;134(8):e92. doi: 10.1161/RES.0000000000000668. Epub 2024 Apr 11.NO ABSTRACTPMID:38603475 | DOI:10.1161/RES.0000000000000668 (Source: Circulation Research)
Source: Circulation Research - April 11, 2024 Category: Cardiology Source Type: research
AKAP12 Overexpression Affects Cardiac Function via PDE8
Circ Res. 2024 Apr 12;134(8):1023-1025. doi: 10.1161/CIRCRESAHA.124.324475. Epub 2024 Apr 11.NO ABSTRACTPMID:38603476 | DOI:10.1161/CIRCRESAHA.124.324475 (Source: Circulation Research)
Source: Circulation Research - April 11, 2024 Category: Cardiology Authors: Hariharan Subramanian Viacheslav O Nikolaev Source Type: research
Unveiling Platelets as Immune Regulatory Cells
Circ Res. 2024 Apr 12;134(8):987-989. doi: 10.1161/CIRCRESAHA.124.324167. Epub 2024 Apr 11.NO ABSTRACTPMID:38603477 | DOI:10.1161/CIRCRESAHA.124.324167 (Source: Circulation Research)
Source: Circulation Research - April 11, 2024 Category: Cardiology Authors: Danielle Karakas Heyu Ni Source Type: research
Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions
Circ Res. 2024 Apr 12;134(8):1029-1045. doi: 10.1161/CIRCRESAHA.123.323477. Epub 2024 Apr 11.ABSTRACTThere has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparativ...
Source: Circulation Research - April 11, 2024 Category: Cardiology Authors: Sojin Youn Wass Omar Hahad Zain Asad Shuo Li Mina K Chung Emelia J Benjamin Khurram Nasir Sanjay Rajagopalan Sadeer G Al-Kindi Source Type: research
