Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model
In this study, both young and aged mice (male and female) underwent 72 h of hyperoxia exposure and were monitored at 24-hour intervals for cardiac electrophysiological and functional parameters using ECG and electrocardiogram data. Our analysis showed that young male mice experienced significant weight loss as well as significant lung edema by 48 h. Although young male mice were highly susceptible to physical changes, they were resistant to early cardiac functional and electrophysiological changes compared to the other groups. Both young and aged female and aged males developed functional impairments by 24 h of hyperoxia e...
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yashwant Ayalasomayajula Anagha Hesaraghatta Neha Dantuluri Jenna Yassine Faizan Saleem Hussein Mansour Chayapatou Chayawatto Nishank Rangarajan Sashank Rangarajan Smrithi Krishnan Siva Kumar Panguluri Source Type: research
LncRNA NEAT1 promotes MPP+ induced injury of PC12 cells and accelerates the progression of Parkinson's disease in mice through FUS mediated inhibition of PI3K/AKT/mTOR signalling pathway
In conclusion, NEAT1 is involved in PD progression through FUS-mediated inhibition of the PI3K/AKT/mTOR signalling pathway.PMID:38636570 | DOI:10.1016/j.exger.2024.112436 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yonghui Wang Zhuo Li Jiwen Li Chao Sun Source Type: research
Genetically determined type 1 diabetes mellitus and risk of osteoporosis
CONCLUSIONS: This study shows a causal relationship between T1DM and the risk of some sites of OP (FN-BMD, LS-BMD), allowing for continued research to discover the clinical and experimental mechanisms of T1DM and OP. It also contributes to the recommendation if patients with T1DM need targeted care to promote bone health and timely prevention of osteoporosis.PMID:38636571 | DOI:10.1016/j.exger.2024.112434 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Ting Cheng Jia-Lin Hou Zi-Yi Han Xin-Lei Geng Yao-Chen Zhang Ke-Yi Fan Liu Liu He-Yi Zhang Yue-Hong Huo Xiao-Feng Li Sheng-Xiao Zhang Source Type: research
Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model
In this study, both young and aged mice (male and female) underwent 72 h of hyperoxia exposure and were monitored at 24-hour intervals for cardiac electrophysiological and functional parameters using ECG and electrocardiogram data. Our analysis showed that young male mice experienced significant weight loss as well as significant lung edema by 48 h. Although young male mice were highly susceptible to physical changes, they were resistant to early cardiac functional and electrophysiological changes compared to the other groups. Both young and aged female and aged males developed functional impairments by 24 h of hyperoxia e...
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yashwant Ayalasomayajula Anagha Hesaraghatta Neha Dantuluri Jenna Yassine Faizan Saleem Hussein Mansour Chayapatou Chayawatto Nishank Rangarajan Sashank Rangarajan Smrithi Krishnan Siva Kumar Panguluri Source Type: research
LncRNA NEAT1 promotes MPP+ induced injury of PC12 cells and accelerates the progression of Parkinson's disease in mice through FUS mediated inhibition of PI3K/AKT/mTOR signalling pathway
In conclusion, NEAT1 is involved in PD progression through FUS-mediated inhibition of the PI3K/AKT/mTOR signalling pathway.PMID:38636570 | DOI:10.1016/j.exger.2024.112436 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Yonghui Wang Zhuo Li Jiwen Li Chao Sun Source Type: research
Genetically determined type 1 diabetes mellitus and risk of osteoporosis
CONCLUSIONS: This study shows a causal relationship between T1DM and the risk of some sites of OP (FN-BMD, LS-BMD), allowing for continued research to discover the clinical and experimental mechanisms of T1DM and OP. It also contributes to the recommendation if patients with T1DM need targeted care to promote bone health and timely prevention of osteoporosis.PMID:38636571 | DOI:10.1016/j.exger.2024.112434 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 18, 2024 Category: Geriatrics Authors: Ting Cheng Jia-Lin Hou Zi-Yi Han Xin-Lei Geng Yao-Chen Zhang Ke-Yi Fan Liu Liu He-Yi Zhang Yue-Hong Huo Xiao-Feng Li Sheng-Xiao Zhang Source Type: research
A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil
Exp Gerontol. 2024 Apr 18;191:112433. doi: 10.1016/j.exger.2024.112433. Online ahead of print.ABSTRACTImmunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as "Inflammaging." Inflammaging can be associated with many diseases related to older people. As the older population continues to grow, understanding changes in the immune system becomes essential. While prior studies assessing these alterations have been conducted in countries with Caucasian populations, this investigation marks a pioneering effor...
Source: Experimental Gerontology - April 15, 2024 Category: Geriatrics Authors: Maria Luiza Lima-Silva Karen Cec ília Lima Torres Juliana Vaz de Melo Mambrini Nathalia Coimbra Brot Sara Oliveira Santos Olindo Assis Martins-Filho Andr éa Teixeira-Carvalho Maria Fernanda Lima-Costa S érgio Viana Peixoto Source Type: research
A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil
Exp Gerontol. 2024 Apr 13:112433. doi: 10.1016/j.exger.2024.112433. Online ahead of print.ABSTRACTImmunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as "Inflammaging." Inflammaging can be associated with many diseases related to older people. As the older population continues to grow, understanding changes in the immune system becomes essential. While prior studies assessing these alterations have been conducted in countries with Caucasian populations, this investigation marks a pioneering effort. T...
Source: Experimental Gerontology - April 15, 2024 Category: Geriatrics Authors: Maria Luiza Lima-Silva Karen Cec ília Lima Torres Juliana Vaz de Melo Mambrini Nathalia Coimbra de Brot Sara de Oliveira Santos Olindo Assis Martins-Filho Andr éa Teixeira-Carvalho Maria Fernanda Lima-Costa S érgio Viana Peixoto Source Type: research
A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil
Exp Gerontol. 2024 Apr 13:112433. doi: 10.1016/j.exger.2024.112433. Online ahead of print.ABSTRACTImmunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as "Inflammaging." Inflammaging can be associated with many diseases related to older people. As the older population continues to grow, understanding changes in the immune system becomes essential. While prior studies assessing these alterations have been conducted in countries with Caucasian populations, this investigation marks a pioneering effort. T...
Source: Experimental Gerontology - April 15, 2024 Category: Geriatrics Authors: Maria Luiza Lima-Silva Karen Cec ília Lima Torres Juliana Vaz de Melo Mambrini Nathalia Coimbra de Brot Sara de Oliveira Santos Olindo Assis Martins-Filho Andr éa Teixeira-Carvalho Maria Fernanda Lima-Costa S érgio Viana Peixoto Source Type: research
The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice
In conclusion, pair housing protects against the development of PSD depending on OXT and OXTR in the brain, with no significant divergence based on sex. These findings provide valuable insights into the potential of social interaction and oxytocin as therapeutic targets for PSD. Further research into the underlying mechanisms of these effects may contribute to the development of novel treatments for PSD.PMID:38614224 | DOI:10.1016/j.exger.2024.112432 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Su-Ting Jiang Shu-Ying Lian Yao-Huan Sun Mei-Bo Pan Bin Wang Hui Wang Jun Hua Yi-Chen Wang Qiu-Ling Wang Yin-Feng Dong Source Type: research
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease
CONCLUSION: These findings suggested that LY96 might be a novel potential biomarker for PD, and offer insights into its immunoregulatory role.PMID:38614225 | DOI:10.1016/j.exger.2024.112415 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Haoran Peng Longyu Wu Siyuan Chen Shaopu Wu Xiaoxue Shi Jianjun Ma Hongqi Yang Xue Li Source Type: research
The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice
In conclusion, pair housing protects against the development of PSD depending on OXT and OXTR in the brain, with no significant divergence based on sex. These findings provide valuable insights into the potential of social interaction and oxytocin as therapeutic targets for PSD. Further research into the underlying mechanisms of these effects may contribute to the development of novel treatments for PSD.PMID:38614224 | DOI:10.1016/j.exger.2024.112432 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Su-Ting Jiang Shu-Ying Lian Yao-Huan Sun Mei-Bo Pan Bin Wang Hui Wang Jun Hua Yi-Chen Wang Qiu-Ling Wang Yin-Feng Dong Source Type: research
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease
CONCLUSION: These findings suggested that LY96 might be a novel potential biomarker for PD, and offer insights into its immunoregulatory role.PMID:38614225 | DOI:10.1016/j.exger.2024.112415 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Haoran Peng Longyu Wu Siyuan Chen Shaopu Wu Xiaoxue Shi Jianjun Ma Hongqi Yang Xue Li Source Type: research
The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice
In conclusion, pair housing protects against the development of PSD depending on OXT and OXTR in the brain, with no significant divergence based on sex. These findings provide valuable insights into the potential of social interaction and oxytocin as therapeutic targets for PSD. Further research into the underlying mechanisms of these effects may contribute to the development of novel treatments for PSD.PMID:38614224 | DOI:10.1016/j.exger.2024.112432 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Su-Ting Jiang Shu-Ying Lian Yao-Huan Sun Mei-Bo Pan Bin Wang Hui Wang Jun Hua Yi-Chen Wang Qiu-Ling Wang Yin-Feng Dong Source Type: research
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease
CONCLUSION: These findings suggested that LY96 might be a novel potential biomarker for PD, and offer insights into its immunoregulatory role.PMID:38614225 | DOI:10.1016/j.exger.2024.112415 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Haoran Peng Longyu Wu Siyuan Chen Shaopu Wu Xiaoxue Shi Jianjun Ma Hongqi Yang Xue Li Source Type: research
