Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.
In this study, we investigated whether brain exposure of Pg-LPS induced systemic organ dysfunction in a model of AD mouse. We employed 6 (young) and 13 (middle-aged) months-old 5XFAD mice and 6 months-old littermate (LT) mice, and treated with intracerebroventricular (ICV) injection of 2 μg Pg-LPS or saline (vehicle). The animals were monitored cognitive functions (Y maze, nest building, and Morris water maze tests), motor functions (wire hang and rotarod tests), physical condition (symptom score), and blood pressure (BP). Twenty-eight days later, their organs were weighted and the organ damages were examined. Conti...
Source: Experimental Gerontology - February 17, 2019 Category: Geriatrics Authors: Hayashi K, Hasegawa Y, Takemoto Y, Cao C, Takeya H, Komohara Y, Mukasa A, Kim-Mitsuyama S Tags: Exp Gerontol Source Type: research

Long-term stimulation of angiotensin II induced endothelial senescence and dysfunction.
This study aimed to clarify the effects of Ang II on endothelial senescence by establishing a replicative senescence model of human umbilical vein endothelial cells (HUVECs) in vitro. The population-doubling level (PDL) was calculated, PDL5 and PDL25 respectively referred to cells cultured for 2 days and 30 days. Compared with Ang II-treated young PDL5 cells, chronic stimulation of Ang II significantly promoted the senescence-associated β-galactosidase activity and expression of senescence-related genes p16 and p21, slowed down cell growth rate, and decreased expression of longevity-related genes sirtuin1 as well ...
Source: Experimental Gerontology - February 15, 2019 Category: Geriatrics Authors: Li R, Mi X, Yang S, Yang Y, Zhang S, Hui R, Chen Y, Zhang W Tags: Exp Gerontol Source Type: research

HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric restriction-induced neuroprotection after surgery in aged mice.
In this study, we evaluated whether CR improves impaired learning and memory after surgery by attenuating ER-stress in an SIRT1-dependent manner. Male 18-month-old C57BL/6J mice receiving a 12-week CR or an ad libitum (AL) diet pre-intervention were challenged with tibial open fracture surgery and anesthesia or no treatment. We found a significant protective effect of CR on memory in contextual fear conditioning test after surgery compared with the AL group. CR alleviated ER-stress and neuronal apoptosis in the hippocampus induced by surgery. CR increased HSP70 expression through the HSF1/HSP pathway in a SIRT1-mediated ma...
Source: Experimental Gerontology - February 14, 2019 Category: Geriatrics Authors: Yao M, Zhao Z, Wei L, Zhou D, Xue Z, Ge S Tags: Exp Gerontol Source Type: research

Objective physical activity and physical performance in middle-aged and older adults.
Abstract BACKGROUND: Older adults may have difficulty meeting the Physical Activity (PA) Guidelines. A favorable balance between PA and sedentary time (SED) is an important determinant of physical performance in older adults. Our objective was to explore associations of PA/SED with physical performance across mid-older age in adults without overt mobility disability. METHODS: Framingham Offspring Study participants free of mobility disability with accelerometry and physical performance data (gait speed, chair stand time, and handgrip strength), were studied in cross-sectional analysis (n = 1352). We regre...
Source: Experimental Gerontology - February 13, 2019 Category: Geriatrics Authors: Spartano NL, Lyass A, Larson MG, Tran T, Andersson C, Blease SJ, Esliger DW, Vasan RS, Murabito JM Tags: Exp Gerontol Source Type: research

Activity and intracellular localization of senescence-associated β-galactosidase in aging Xenopus oocytes and eggs.
Activity and intracellular localization of senescence-associated β-galactosidase in aging Xenopus oocytes and eggs. Exp Gerontol. 2019 Feb 12;: Authors: Tokmakov AA, Sato KI Abstract Senescence-associated β-galactosidase (SA-β-gal) serves as a marker of senescence in aging somatic cells. However, little is known about SA-β-gal dynamics in aging gamete cells. To address this issue, here we investigated activity and intracellular localization of SA-β-gal in freshly obtained and aging oocytes and eggs of the African clawed frog Xenopus laevis. Data base mining revealed the presen...
Source: Experimental Gerontology - February 12, 2019 Category: Geriatrics Authors: Tokmakov AA, Sato KI Tags: Exp Gerontol Source Type: research

The impact of age on cardiac function and extracellular matrix component expression in adverse post-infarction remodeling in mice.
ss A, Podesser BK Abstract The aim of this study was to describe the potential associations of the expression of matricellular components in adverse post-infarction remodeling of the geriatric heart. In male geriatric (OM, age: 18 months) and young (YM, age: 11 weeks) OF1 mice myocardial infarction (MI) was induced by permanent ligation of the left anterior descending coronary artery. Cardiac function was evaluated by MRI. Plasma and myocardial tissue samples were collected 3d, 7d, and 32d post-MI. Age and MI were associated with impaired cardiac function accompanied by left-ventricular (LV) dilatation. mRNA e...
Source: Experimental Gerontology - February 11, 2019 Category: Geriatrics Authors: Nagel F, Santer D, Stojkovic S, Kaun C, Schaefer AK, Kššák M, Abraham D, Bencsik P, Ferdinandy P, Kenyeres E, Szabados T, Wojta J, Trescher K, Kiss A, Podesser BK Tags: Exp Gerontol Source Type: research

Potassium restriction boosts vacuolar acidity and extends lifespan in yeast.
Abstract Lysosome function is compromised during aging and in many disease states. Interventions that promote lysosomal activity and acidification are thus of prime interest as treatments for longevity and health. Intracellular pH can be controlled by the exchange of protons for inorganic ions, and in cells from microbes to man, when potassium is restricted in the growth medium, the cytoplasm becomes acidified. Here we use a yeast model to show that potassium limited-cells exhibit hallmarks of increased acidity in the vacuole, the analog of the lysosome, and live long by a mechanism that requires the vacuolar mach...
Source: Experimental Gerontology - February 8, 2019 Category: Geriatrics Authors: Sasikumar AN, Killilea DW, Kennedy BK, Brem RB Tags: Exp Gerontol Source Type: research

Immunosenescence in honey bees (Apis mellifera L.) is caused by intrinsic senescence and behavioral physiology.
ilde;es ZLP Abstract Young honey bee workers (0 to 2-3 weeks old) perform tasks inside the colony, including brood care (nursing), whereas older workers undergo foraging tasks during the next 3-4 weeks, when an intrinsic senescence program culminates in worker death. We hypothesized that foragers are less able to react to immune system stimulation than nurse bees and that this difference is due to an inefficient immune response in foragers. To test this hypothesis, we used an experimental design that allowed us to uncouple chronological age and behavior status (nursing/foraging). Worker bees from a normal age ...
Source: Experimental Gerontology - February 8, 2019 Category: Geriatrics Authors: Lourenço AP, Martins JR, Torres FAS, Mackert A, Roberto Aguiar L, Hartfelder K, Bitondi MMG, Simões ZLP Tags: Exp Gerontol Source Type: research

Diabetic neuropathies influence recovery from hip-fracture surgery in older persons with diabetes.
Abstract BACKGROUND/OBJECTIVES: To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS: Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 older persons (age ≥ 60) with DM over 2 years following hip-fracture surgery at a medical center in Taiwan. In the original trial, the experimental group (n = 88) received DM-specific care comprising diabetes care plus subacute care, and the control group (n = 88) receiv...
Source: Experimental Gerontology - February 7, 2019 Category: Geriatrics Authors: Tseng MY, Huang YF, Liang J, Wang JS, Yang CT, Wu CC, Cheng HS, Chen CY, Lin YE, Wang WS, Shyu YL Tags: Exp Gerontol Source Type: research

Sex-specific stress tolerance, proteolysis, and lifespan in the invertebrate Tigriopus californicus.
Abstract Because stress tolerance and longevity are mechanistically and phenotypically linked, the sex with higher acute stress tolerance might be expected to also live longer. On the other hand, the association between stress tolerance and lifespan may be complicated by tradeoffs between acute tolerance and long-term survival. Here we use the copepod Tigriopus californicus to test for sex differences in stress resistance, proteolytic activity and longevity. Unlike many model organisms, this species does not have sex chromosomes. However, substantial sex differences were still observed. Females were found to have ...
Source: Experimental Gerontology - February 7, 2019 Category: Geriatrics Authors: Foley HB, Sun PY, Ramirez R, So BK, Venkataraman YR, Nixon EN, Davies KJA, Edmands S Tags: Exp Gerontol Source Type: research

Elite athletes have longer telomeres than sedentary subjects: A meta-analysis.
Abstract The aim of this meta-analysis was to investigate the effects of high levels of physical activity (in elite athletes) and sedentary lifestyle on telomere length. Our meta-analysis was carried out using the following electronic databases: PubMed, Cochrane Library, LILACS, Science Direct and EBSCO. After study selection, nine articles were included in our meta-analysis. All of the included subjects were elite athletes (with experience in national or international competitions) or sedentary subjects, which served as the control group. The analysis showed that elite athletes (n = 306) had longer telomeres ...
Source: Experimental Gerontology - February 6, 2019 Category: Geriatrics Authors: Abrahin O, Cortinhas-Alves EA, Vieira RP, Guerreiro JF Tags: Exp Gerontol Source Type: research

Coupling lifespan and aging? The age at onset of body mass decline associates positively with sex-specific lifespan but negatively with environment-specific lifespan.
Abstract Whether lifespan scales to age-associated changes in health and disease is an urgent question in societies with increasing lifespan. Body mass is associated with organismal functioning in many species, and often changes with age. We here tested in zebra finches whether two factors that decreased lifespan, sex and poor environmental quality, accelerated the onset of body mass declines. We subjected 597 birds for nine years to experimentally manipulated foraging costs (harsh = H, benign = B) during development (small vs large brood size) and in adulthood (easy vs hard foraging conditions) in a 2 &...
Source: Experimental Gerontology - January 31, 2019 Category: Geriatrics Authors: Briga M, Jimeno B, Verhulst S Tags: Exp Gerontol Source Type: research

Autophagy in Alzheimer's disease and promising modulatory effects of herbal medicine.
Abstract Alzheimer's disease (AD) is a progressive and unremitting neurodegenerative disorder characterized by memory loss and cognitive impairment. It affects the quality of life of victims severely. The prevalence of AD has been increasing in recent years. Therefore, it is of great importance to elucidate the pathogenesis of AD and find out effective therapeutic approaches. Autophagy, a primary intracellular way of degrading aggregated proteins and damaged organelles, has been discovered to be involved in the pathological changes of AD. In the last few years, much progress has been made in finding autophagy regu...
Source: Experimental Gerontology - January 30, 2019 Category: Geriatrics Authors: Zeng Q, Siu W, Li L, Jin Y, Liang S, Cao M, Ma M, Wu Z Tags: Exp Gerontol Source Type: research

Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice.
CONCLUSIONS: These data indicated that testosterone replacement therapy (TRT) alleviates cardiac fibrosis and apoptosis, at least in part by enhancing Gas6 expression. Moreover, deletion of Axl disables testosterone, which indicated that Axl is an important downstream regulator of testosterone. TRT would improve aging-related cardiac remolding via Gas6/Axl signaling pathway, implicating its therapeutic potential to treat aging-related heart disease. PMID: 30710682 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 30, 2019 Category: Geriatrics Authors: Chen FF, Song FQ, Chen YQ, Wang ZH, Li YH, Liu MH, Li Y, Song M, Zhang W, Zhao J, Zhong M Tags: Exp Gerontol Source Type: research

Sarcopenia-related parameters in adults with Down syndrome: A cross-sectional exploratory study.
CONCLUSION: Findings from this exploratory study indicate that adults with DS show muscle mass indexes and physical performance levels similar to or lower than older adults with sarcopenia. The assessment of muscle mass and functional status should therefore be included in the routine evaluation of this population starting at young age. PMID: 30710683 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 30, 2019 Category: Geriatrics Authors: Coelho-Junior HJ, Villani ER, Calvani R, Carfì A, Picca A, Landi F, Bernabei R, Onder G, Marzetti E Tags: Exp Gerontol Source Type: research

Effect of pre-exercise and post-exercise creatine supplementation on bone mineral content and density in healthy aging adults.
Abstract Creatine supplementation, immediately before and immediately following resistance training, has been shown to increase muscle mass and strength. However, the effects of pre- exercise and post-exercise creatine supplementation on aging bone mineral content (BMC) and density (BMD) is unknown. Using a double-blind, repeated measures design, aging adults were randomized to one of three groups: creatine before (CR-B: n = 15; 53 ± 3 years, 170.1 ± 9.9 cm, 77.1 ± 15.6 kg; 0.1 g·kg-1 creatine immediately before resistance training and 0.1 g·kg-1 cornsta...
Source: Experimental Gerontology - January 29, 2019 Category: Geriatrics Authors: Candow DG, Forbes SC, Vogt E Tags: Exp Gerontol Source Type: research

Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice.
CONCLUSIONS: In conclusion, in the left ventricles of aged mice the growth of capillaries and arterioles supplying cardiomyocytes were in proportion to whole organ hypertrophy. Spermidine had no effect on quantitative characteristics of capillaries or arterioles, suggesting that the beneficial effects of spermidine on the ageing heart do not depend on the quantitative structural characteristics of the microcirculation which does not exclude potential functional differences between the groups. PMID: 30703435 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 28, 2019 Category: Geriatrics Authors: Wierich MC, Schipke J, Brandenberger C, Abdellatif M, Eisenberg T, Madeo F, Sedej S, Mühlfeld C Tags: Exp Gerontol Source Type: research

Influence of aging and visual feedback on the stability of hand grip control in elderly adults.
Abstract Aging causes a gradual decrease in maximal grip strength and leads many elderly people to have to rely on visual feedback to compensate for poorer muscle strength in performing daily activities and preventing accidents. Previous studies have investigated age and visual feedback-related changes in grip strength. However, little is known about methods of determining the quality and stability of hand grip strength control in the elderly, which is important for understanding their ability to generate grip force when handling objects with and without visual feedback in daily living. Therefore, the purpose of t...
Source: Experimental Gerontology - January 26, 2019 Category: Geriatrics Authors: Lin CH, Sung WH, Chiang SL, Lu LH, Wang PC, Wang XM Tags: Exp Gerontol Source Type: research

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner.
CONCLUSION: Nrf2 deficiency exacerbated frailty and sarcopenia during aging, at least partially by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner. PMID: 30690066 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 25, 2019 Category: Geriatrics Authors: Huang DD, Fan SD, Chen XY, Yan XL, Zhang XZ, Ma BW, Yu DY, Xiao WY, Zhuang CL, Yu Z Tags: Exp Gerontol Source Type: research

Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.
CONCLUSIONS: Shorter LTLs in CAD patients with previously suffered MI may indicate telomere attrition as part of its pathophysiology in men. The inverse association between LTLs and age exclusively in women underpins the previously reported decline in attrition rate in men with increasing age. As elevated GDF11 and SIRT1 along with attenuated pro-inflammatory cytokines seem to positively affect LTL in women, we hypothesize a potential sex-dimorphism in LTL regulation, which may implicate sex- adjusted health-preventive therapies. PMID: 30684534 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 23, 2019 Category: Geriatrics Authors: Opstad TB, Kalstad AA, Pettersen AÅ, Arnesen H, Seljeflot I Tags: Exp Gerontol Source Type: research

Transcriptomic analysis of the life-extending effect exerted by black rice anthocyanin extract in D. melanogaster through regulation of aging pathways.
This study examined the beneficial effects of black rice anthocyanin extract (BRAE), which provides as an excellent source of dietary antioxidants, on the lifespan of fruit flies and the underlying molecular mechanisms. Results showed that supplementation of BRAE extended the lifespan of fruit flies by 20% and retarded the loss of locomotor function. Comparison of mRNA transcriptome profile between fruit flies of 20 days and 50 days after the start of normal diet and normal diet supplemented with BRAE (5 mg/mL) identified 6687 differentially expressed coding genes. A large number of these differentially expressed mRN...
Source: Experimental Gerontology - January 22, 2019 Category: Geriatrics Authors: Li X, Zhang Z, Zhang X, Cheng J, Liu D, Yan Y, Wang H Tags: Exp Gerontol Source Type: research

Standardization of the Fried frailty phenotype improves cardiovascular disease risk discrimination.
The objective of this cross-sectional analysis was to compare the ability of the Fried frailty phenotype criteria (FC) to discriminate between individuals at higher risk for CVD according to the Framingham Risk Score and Rasmussen Disease Score in comparison to the S-FC. SETTING: Asper Clinical Research Institute, St. Boniface Hospital Research Centre. PARTICIPANTS: 985 women 55 years of age or older with no previous history of CVD. MEASUREMENTS: Discrimination of individuals with high CVD risk according to the Framingham and Rasmussen Disease scores was assessed using receiver operating characteristic (RO...
Source: Experimental Gerontology - January 22, 2019 Category: Geriatrics Authors: Boreskie KF, Kehler DS, Costa EC, Hiebert BM, Hamm NC, Moffatt TL, Hay JL, Stammers AN, Kimber DE, Kent DE, Cornish DE, Arora RC, Strachan SM, Semenchuk BN, Duhamel TA Tags: Exp Gerontol Source Type: research

Orthostatic blood pressure variability is associated with lower visual contrast sensitivity function: Findings from the Irish Longitudinal Study on Aging.
CONCLUSIONS: Orthostatic BP variability is associated with worse contrast sensitivity, independent of hypertension and retinal pathology and may be a cardiovascular biomarker of early ocular pathology. PMID: 30677467 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 21, 2019 Category: Geriatrics Authors: Bhuachalla BN, McGarrigle CA, O'Leary N, Akuffo KO, Peto T, Beatty S, Kenny RA Tags: Exp Gerontol Source Type: research

Injecting autologous platelet rich plasma solely into the knee joint is not adequate in treating geriatric patients with moderate to severe knee osteoarthritis.
This study aimed to evaluate the effectiveness of aPRP in treating patients with at least grade 2 on the Kellgren and Lawrence system for the classification of knee OA using a proteomic approach and clinical evaluation tool of Lequesne index. Musculoskeletal ultrasound was used for accurate needle placement into the knee joint, and to the perimeniscal soft tissue for the injection of aPRP. Three monthly aPRP injections were performed. Group 1 patients received intra-articular (IA) injection only, while group 2 received simultaneous IA and pes anserine aPRP injections. After two monthly aPRP injections, both groups revealed...
Source: Experimental Gerontology - January 18, 2019 Category: Geriatrics Authors: Chen CPC, Chen JL, Hsu CC, Pei YC, Chang WH, Lu HC Tags: Exp Gerontol Source Type: research

p38 MAPK-dependent alphaB-crystallin phosphorylation in Alzheimer's disease-like pathology in OXYS rats.
Abstract Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Development of AD is closely related to alterations of proteostasis including the deposition of amyloid beta (Aβ) and hyperphosphorylated tau in the brain. Molecular chaperones such as αB-crystallin (CryaB) can prevent aggregation of proteins and enable their correct refolding. The p38 mitogen-activated protein kinase signaling (MAPK) pathway regulates CryaB activity through phosphorylation of CryaB. Here, we examined CryaB and phospho-(p-)Ser59-CryaB protein amounts in the prefrontal cortex of the senescence-accelerated OXY...
Source: Experimental Gerontology - January 18, 2019 Category: Geriatrics Authors: Muraleva NA, Stefanova NA, Kolosova NG Tags: Exp Gerontol Source Type: research

Adherence to the Mediterranean diet, dietary factors, and S-Klotho plasma levels in sedentary middle-aged adults.
CONCLUSION: Our study suggests that, although dietary factors could be related to S-Klotho plasma levels in middle-aged sedentary adults, LMI is the main determinant in this regard. PMID: 30660660 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 17, 2019 Category: Geriatrics Authors: Jurado-Fasoli L, Amaro-Gahete FJ, De-la-O A, Martinez-Tellez B, Ruiz JR, Gutiérrez Á, Castillo MJ Tags: Exp Gerontol Source Type: research

Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke.
This study was aimed to assess the effects of BUD, ACL and FO in bronchial epithelial cells exposed to cigarette smoke extract (CSE) by evaluating: a) Expression of TLR4 and survivin and LPS binding by flow cytometry; b) expression of HDAC2, HDAC3, SIRT1 and FoxO3 and activation of the ERK 1/2 pathway by western blot; c) IL-8 mRNA levels and release by Real Time-PCR and ELISA, respectively. Reported results show that CSE increased TLR4 and survivin, LPS binding, ERK 1/2 activation, IL-8 release and mRNA levels but decreased SIRT1, HDAC2, HDAC3 and FoxO3 nuclear expression. Combined therapy with BUD, ACL and FO counteracted...
Source: Experimental Gerontology - January 16, 2019 Category: Geriatrics Authors: Ferraro M, Di Vincenzo S, Dino P, Bucchieri S, Cipollina C, Gjomarkaj M, Pace E Tags: Exp Gerontol Source Type: research

Effects of aerobic fitness on cognitive performance as a function of dual-task demands in older adults.
The objective of this study was to examine the effects of aerobic fitness on cognitive performance under varying dual-task demands in older adults. Thirty-four participants (mean ± SD age: 68.6 ± 10.1 years, 24 females) were included in this study. VO2 max was assessed with the Rockport 1-mile walk test (range = 6.68-45.57). Participants engaged in a cognitive task, the Modified Stroop Color Word Test (MSCWT) on a self-paced treadmill while simultaneously standing or walking. Performance on the Stroop Test was measured as interference of the accuracy score. Participants demonstrated over a 4-fol...
Source: Experimental Gerontology - January 16, 2019 Category: Geriatrics Authors: Chaparro GN, Stine-Morrow EAL, Hernandez ME Tags: Exp Gerontol Source Type: research

Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPAR α signaling pathway in cultured hepatocytes.
In this study, a cell model of NASH was induced with oleic acid (OA)/lipopolysaccharide (LPS) and treated for 36 h with different osthole concentrations. Results showed that intracellular lipid and inflammatory cytokine levels gradually decreased after osthole treatment. These effects, however, were abolished or attenuated after PPARα gene silencing. Accordingly, PPARα gene silencing reversed the osthole-mediated expressions of proteins involved in lipid synthesis and fatty acid oxidation. PPARα gene silencing also abrogated the inhibitory effect of osthole on nuclear factor kappa B p65 protein expressi...
Source: Experimental Gerontology - January 16, 2019 Category: Geriatrics Authors: Zhao X, Xue J, Xie M Tags: Exp Gerontol Source Type: research

Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice.
In this study, 3 and 17 months old male Swiss mice were used. Aged mice exhibited a significant reduction in motor performance and walking footprint pattern. Synaptosomes and mitochondrial fractions were isolated from mouse brain cortex. Active oxygen species and cardiolipin content were measured in both subcellular fractions. Synaptosomal acetylcholinesterase activity was measured in both animal age groups. Results showed that superoxide levels were 42.9% lower in synaptosomes from old mice as compared with young animals, while no changes were observed in non-synaptic mitochondria. Succinate-glutamate dependent H2O2 pro...
Source: Experimental Gerontology - January 15, 2019 Category: Geriatrics Authors: Lores-Arnaiz S, Lombardi P, Karadayian AG, Cutrera R, Bustamante J Tags: Exp Gerontol Source Type: research

A novel neurocognitive approach for placebo analgesia in neurocognitive disorders.
Abstract Neural correlates of placebo analgesia (PA) in patients with neurocognitive disorders have not yet been elucidated. The present study aimed to evaluate how and to what extent executive (dys)functions of the medial prefrontal cortex (MPFC) may be related to PA. To this end, twenty-three subjects complaining of different cognitive deficits (from mild cognitive impairment likely due to Alzheimer's Disease to mild AD) were recruited. PA was investigated by a well-known experimental venipuncture pain paradigm (open versus hidden, O-H, application of lidocaine). Patients also underwent a comprehensive neuropsyc...
Source: Experimental Gerontology - January 15, 2019 Category: Geriatrics Authors: Palermo S, Rainero I, Stanziano M, Vase L, D'Agata F, Rubino E, Valentini MC, Fonio P, Sardanelli F, Amanzio M Tags: Exp Gerontol Source Type: research

Superoxide dismutase activity and risk of cognitive decline in older adults: Findings from the Chinese Longitudinal Healthy Longevity Survey.
CONCLUSIONS: Higher SOD activity was associated with elevated risk of cognitive decline among Chinese older adults. PMID: 30654151 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 14, 2019 Category: Geriatrics Authors: Sun D, Sun X, Xu Y, Wu T, Tao L Tags: Exp Gerontol Source Type: research

Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults.
CONCLUSIONS: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL. PMID: 30641106 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 11, 2019 Category: Geriatrics Authors: Balogun S, Winzenberg T, Wills K, Scott D, Jones G, Callisaya ML, Aitken D Tags: Exp Gerontol Source Type: research

Prospective association of white matter hyperintensity volume and frailty in older adults.
CONCLUSION: WMH were associated with frailty severity over time. Why the progression of WMH was not associated with changes in frailty severity requires further investigation. PMID: 30639444 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 10, 2019 Category: Geriatrics Authors: Maltais M, de Souto Barreto P, Moon SY, Rolland Y, Vellas B, MAPT/DSA Study Group Tags: Exp Gerontol Source Type: research

Trimetazidine and l ‑carnitine prevent heart aging and cardiac metabolic impairment in rats via regulating cardiac metabolic substrates.
CONCLUSIONS: Trimetazidine and l‑carnitine may partially improve the age-related changes of rat myocardial metabolisms and heart function via regulating cardiac metabolic substrates, with trimetazidine being superior. Interestingly, they may also reduce cardiac energy generation and impair mitochondrial structures in young rats. These findings suggest that age should be taken as an independent factor during the use of metabolic modulatory drugs in the patients with cardiovascular diseases because it may completely change the effects of drugs. PMID: 30639303 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 8, 2019 Category: Geriatrics Authors: Zhang X, Liu C, Liu C, Wang Y, Zhang W, Xing Y Tags: Exp Gerontol Source Type: research

Age-related alterations in swallowing biomechanics.
CONCLUSION: Geometric morphometric analysis of rodent swallows suggests that swallow biomechanics are altered with age. When used in combination with biological assays of age-related adaptations in neuromuscular systems, this multivariate analysis may increase our understanding of underlying musculoskeletal dysfunction that contributes to swallowing disorders with aging. PMID: 30633957 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 8, 2019 Category: Geriatrics Authors: Kletzien H, Cullins MJ, Connor NP Tags: Exp Gerontol Source Type: research

Neural control of postural sway: Relationship to strength measures in young and elderly adults.
Abstract Age-related changes in postural sway are well-established, and studied from a control perspective using an inverted pendulum model. The purpose of the present work was to expand previous research in this area by investigating relationships between sway-related control parameters and musculoskeletal measures of muscle function and health. Eleven female older adults and eight female young adults completed blood draw, grip, leg extension, and balance tests. Serum levels of skeletal muscle-specific troponin T (sTnT), a biomarker for muscle health, were obtained from blood samples. Maximal grip force and leg e...
Source: Experimental Gerontology - January 7, 2019 Category: Geriatrics Authors: King GW, Abreu EL, Kelly PJ, Brotto M Tags: Exp Gerontol Source Type: research

Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.
Abstract Caloric restriction (CR) suppresses age-related pathophysiology and extends lifespan. We recently reported that metabolic remodeling of white adipose tissue (WAT) plays an important role in the beneficial actions of CR; however, the detailed molecular mechanisms of this remodeling remain to be established. In the present study, we aimed to identify CR-induced alterations in the expression of fibroblast growth factor 21 (FGF21), a regulator of lipid and glucose metabolism, and of its downstream signaling mediators in liver and WAT, across the lifespan of rats. We evaluated groups of rats that had been eith...
Source: Experimental Gerontology - January 5, 2019 Category: Geriatrics Authors: Fujii N, Uta S, Kobayashi M, Sato T, Okita N, Higami Y Tags: Exp Gerontol Source Type: research

Association between naturally occurring spine osteoarthritis in geriatric rats and neurogenic inflammation within neurosegmentally linked skeletal muscle.
CONCLUSION: These observations provide novel insight into the potential role of neurogenic inflammation in the pathophysiology of myofascial pain syndrome in the naturally occurring spinal OA in elderly population. PMID: 30615897 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 4, 2019 Category: Geriatrics Authors: Duarte FCK, Hurtig M, Clark A, Simpson J, Srbely JZ Tags: Exp Gerontol Source Type: research

Longitudinal association between brain volume change and gait speed in a general population.
Abstract OBJECTIVE: To determine the association between brain structural changes and gait speed in a four-year longitudinal prospective cohort study. MEASUREMENTS: A total of 767 well-functioning community-dwelling participants, free of arthritis, silent infarct, stroke, dementia, head injury, and cancer, completed baseline brain magnetic resonance imaging scan and gait speed tests between 2011 and 2014, and follow-up tests between 2015 and 2017. The gait test consisted of measuring the elapsed time to walk four meters at usual speed. To estimate whether brain volume changes predict gait speed decline at fol...
Source: Experimental Gerontology - January 3, 2019 Category: Geriatrics Authors: Lee S, Kim EY, Shin C Tags: Exp Gerontol Source Type: research

Effects of short-term resistance training on endothelial function and inflammation markers in elderly patients with type 2 diabetes: A randomized controlled trial.
CONCLUSIONS: No significant changes were found between the RT and AC groups, regarding inflammatory profile and endothelial function, which does not prove the superiority of this intervention model in the studied period. PMID: 30611727 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 3, 2019 Category: Geriatrics Authors: Rech A, Botton CE, Lopez P, Quincozes-Santos A, Umpierre D, Pinto RS Tags: Exp Gerontol Source Type: research

Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis.
CONCLUSION: Bmal1 deficiency affected the biphasic rhythm of coagulation and fibrinolysis factors predominantly in the liver. In the brain, Bmal1-dependent control of t-PA gene expression was documented for the first time. PMID: 30610898 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 2, 2019 Category: Geriatrics Authors: Hemmeryckx B, Frederix L, Roger Lijnen H Tags: Exp Gerontol Source Type: research

The age-related changes and differences in energy metabolism and glutamate-glutamine recycling in the d-gal-induced and naturally occurring senescent astrocytes in vitro.
Abstract Previously, we successfully established a d-galactose (d-gal)-induced astrocyte aging model in vitro. However, whether the changes in the aged astrocytes induced by d-gal are similar to those occurred in naturally are unknown. Therefore, in current study, we simultaneously established d-gal-induced and naturally aged astrocyte aging models in vitro to explore the age-related changes and to compare the differences in these two astrocyte aging models. The Seahorse Extracellular Flux Analyzer was used to examine the mitochondrial metabolism and glycolysis activities of the young and senescent astrocytes. The...
Source: Experimental Gerontology - January 2, 2019 Category: Geriatrics Authors: Cao P, Zhang J, Huang Y, Fang Y, Lyu J, Shen Y Tags: Exp Gerontol Source Type: research

Repeated sit-to-stand exercise enhances muscle strength and reduces lower body muscular demands in physically frail elders.
Abstract PURPOSE: To examine the effect of a conditioning program consisting of repeated sit-to-stand exercise on knee extensor strength and muscular activities during body mass-based squat movement in physically frail elders. METHODS: Fourteen men and women aged 75 to 88 years who used the long-term care insurance system participated in the 12-week training program (48 reps/session, 3 sessions/week). Isometric knee extension torque (KET) during a maximum voluntary contraction (MVC) and electromyogram (EMG) activities of the rectus femoris and vastus lateralis muscles during the MVC and a body mass-base...
Source: Experimental Gerontology - December 26, 2018 Category: Geriatrics Authors: Fujita E, Taaffe DR, Yoshitake Y, Kanehisa H Tags: Exp Gerontol Source Type: research

Sex differences in healthy life expectancy among nonagenarians: A multistate survival model using data from the Vitality 90+ study.
CONCLUSIONS: This study showed that the male-female health-survival paradox remains at very old age. Women aged 90+ live longer than men, and spend more time in poor health. PMID: 30590122 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 24, 2018 Category: Geriatrics Authors: Hoogendijk EO, van der Noordt M, Onwuteaka-Philipsen BD, Deeg DJH, Huisman M, Enroth L, Jylhä M Tags: Exp Gerontol Source Type: research

Healthy aging: A bibliometric analysis of the literature.
This study reported the network of healthy aging research using bibliometric approaches. Based on the results, aging of the brain and muscle is a primary research focus which is a critical part of the multiscale network regulating the aging process. Among aging-associated diseases, Alzheimer's disease and frailty are among the main research focuses, and emerging work has focused on developing diagnostic tools for these diseases. For research on anti-aging interventions, calorie restriction, physical activity, and anti-aging pharmacology are the main interventions, of which the underlying mechanisms have been comprehensivel...
Source: Experimental Gerontology - December 24, 2018 Category: Geriatrics Authors: Gu YH, Bai JB, Chen XL, Wu WW, Liu XX, Tan XD Tags: Exp Gerontol Source Type: research

Cardiac function is not associated with glucose control in older women.
Abstract The present study evaluated the effect of age on glucose tolerance and cardiac function and assessed the relationship between metabolic control and cardiac function and performance. Thirty-four healthy women aged 40 to 81 years were divided into two age groups: younger (≤50 years of age, N = 19) and older (≥60 years of age, N = 15). Participants performed an oral glucose tolerance test and a graded cardiopulmonary exercise test with non-invasive haemodynamic measurements. Compared to younger, older women demonstrated significantly higher 2-hour glucose (4.67 ± 1.01 vs 6.08...
Source: Experimental Gerontology - December 20, 2018 Category: Geriatrics Authors: Jones C, Markovic M, Charman S, Okwose N, Ivkovic S, Ropret R, Markovic B, Mandaric S, Grbovic M, MacGowan GA, Jakovljevic DG Tags: Exp Gerontol Source Type: research

The role of arginase in aging: A systematic review.
Abstract Aging is a normal, progressive and multi-step degeneration in the physiological functions and metabolic processes of living organisms until death. It represents the main risk factor for many diseases (e.g.: cancer, cardiovascular and neurodegenerative diseases) and contributes to increase in mortality. Aging results, at least partially, from an accumulation of cell and tissue damage related to inherited and environmental factors, leading to biological and biochemical dysregulations. Arginase is a ubiquitous L-arginine-metabolizing enzyme involved in some fundamental mechanisms such as the urea cycle or po...
Source: Experimental Gerontology - December 19, 2018 Category: Geriatrics Authors: Moretto J, Girard C, Demougeot C Tags: Exp Gerontol Source Type: research

Effect of all-extremity high-intensity interval training vs. moderate-intensity continuous training on aerobic fitness in middle-aged and older adults with type 2 diabetes: A randomized controlled trial.
In conclusion, all-extremity HIIT and MICT are feasible, well-tolerated and safe and result in similar improvements in aerobic fitness in middle-aged/older individuals with type 2 diabetes. These findings have important implications for exercise prescription for diabetic patients; they indicate that all-extremity exercise is a feasible alternative to weight-bearing exercise and those who are unable or unwilling to engage in HIIT may receive similar benefits from MICT. PMID: 30576716 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 18, 2018 Category: Geriatrics Authors: Hwang CL, Lim J, Yoo JK, Kim HK, Hwang MH, Handberg EM, Petersen JW, Holmer BJ, Leey Casella JA, Cusi K, Christou DD Tags: Exp Gerontol Source Type: research

Longitudinal study of sleep and diurnal rhythms in Drosophila ananassae.
Abstract Mistiming of circadian rhythms impairs quality of life. The sleep fragmentation that results can lead to fatigue, mood alteration, and short-term memory problems. Unfortunately, this suite occurs in humans as we age. In the current study, we used high-resolution monitors to track how circadian patterns of locomotor activity change in female Drosophila ananassae as they enter mid-to-late life. This equipment is a more recent addition to the fly circadian field and has not been previously used for long-term activity tracking. At 2-3 days post-eclosion, D. ananassae were placed into climate-controlled viva...
Source: Experimental Gerontology - December 17, 2018 Category: Geriatrics Authors: Kaladchibachi S, Secor MA, Negelspach DC, Fernandez F Tags: Exp Gerontol Source Type: research