Effects of resistance plus aerobic training on body composition and metabolic markers in older breast cancer survivors undergoing aromatase inhibitor therapy.
as IF Abstract OBJECTIVE: To evaluate the effects of combined aerobic + resistance training on body composition and metabolic markers in older breast cancer survivors undergoing aromatase inhibitor therapy. METHODS: Older breast cancer survivors were randomized to an exercise [resistance + aerobic training]: n = 18, or placebo control group: n = 18. Body composition (measured by DXA) and blood markers of lipid and glucose were measured at baseline, and at 12, 24, and 36 weeks. The exercise group performed 40 min of resistance exercises on machines followed by 30 min of aerobic training o...
Source: Experimental Gerontology - August 3, 2018 Category: Geriatrics Authors: de Paulo TRS, Winters-Stone KM, Viezel J, Rossi FE, Simões RR, Tosello G, Freitas IF Tags: Exp Gerontol Source Type: research

Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging.
ute;n M, Pamplona R, Ferrer I PMID: 30077575 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - August 2, 2018 Category: Geriatrics Authors: Domínguez-González M, Puigpinós M, Jové M, Naudi A, Portero-Otín M, Pamplona R, Ferrer I Tags: Exp Gerontol Source Type: research

Effect of resistance training on inflammatory markers of older adults: A meta-analysis.
CONCLUSIONS: Anti-inflammatory effects of RT were significant only for CRP with a tendency for a decrease in IL-6 as well. The exploratory analyses suggested the reduction in inflammatory markers could be dependent on increases in muscle mass and higher volume of RT protocols. These potential mediators of RT anti-inflammatory effects should be addressed in future meta-analyses to clarify the effects of RT on inflammatory markers of older adults with very specific conditions and larger numbers of studies. PMID: 30071283 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - July 30, 2018 Category: Geriatrics Authors: Sardeli AV, Tomeleri CM, Cyrino ES, Fernhall B, Cavaglieri CR, Chacon-Mikahil MPT Tags: Exp Gerontol Source Type: research

Association between serum activin A and metabolic syndrome in older adults: Potential of activin A as a biomarker of cardiometabolic disease.
Abstract Cardiovascular disease imposes substantial burdens of morbidity and mortality that increase with population aging. Estimating cardiometabolic risk accurately and expediently is challenging, and no single biomarker is satisfactory; hence, we investigated the potential of serum activin A for this purpose. Study data were collected from 433 community-dwelling adults age ≥53 years from Yilan County, Taiwan. Data included: demographics and medical history; physical measurements (blood pressure, body mass index, waist circumference); comprehensive functional assessments (frailty, cognitive function, depres...
Source: Experimental Gerontology - July 30, 2018 Category: Geriatrics Authors: Peng LN, Chou MY, Liang CK, Lee WJ, Kojima T, Lin MH, Loh CH, Chen LK Tags: Exp Gerontol Source Type: research

Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia.
Abstract Sirtuins have gained considerable attention as epigenetic regulators for slowing aging and age-related disorders. The growing association between neurodegeneration and inflammation has led researchers to investigate interactions of sirtuins with inflammatory markers in neurodegenerative diseases. We analyzed SIRT1's association with chronic inflammation in dementia as an age-related neurodegenerative condition through Toll-like receptor 4 (TLR4) and interleukin-7 (IL7) for the first time. In the present study, we observed a significant increase in the level of SIRT1 in patients with all types of dementia....
Source: Experimental Gerontology - July 30, 2018 Category: Geriatrics Authors: Kilic U, Elibol B, Uysal O, Kilic E, Yulug B, Sakul AS, Yildiz GB Tags: Exp Gerontol Source Type: research

Leucocyte telomere length is no molecular marker of physical frailty in late-life depression.
CONCLUSION: LTL is not associated with frailty; neither in non-depressed nor in depressed older persons. As LTL and physical frailty appear to represent different aspects of ageing, they may complement each other in future studies. PMID: 30071286 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - July 30, 2018 Category: Geriatrics Authors: Arts MHL, Collard RM, Comijs HC, de Jonge L, Penninx BWJH, Naarding P, Kok RM, Oude Voshaar RC Tags: Exp Gerontol Source Type: research

Effects of aging on the biomechanics of Coquerel's sifaka (Propithecus coquereli): Evidence of robustness to senescence.
This study examines a nonhuman primate model to evaluate its relevance to understanding human aging processes. To test the null hypothesis that age-related changes in joint function and gait do occur in primate models in a similar fashion to humans, a detailed gait analysis, including velocity, footfall timings, and vertical ground reaction forces, on bipedal locomotion was performed in Coquerel's sifaka (Propithecus coquereli), ranging in age from 5 years to 24 years. None of the spatiotemporal or kinetic gait variables measured was significantly correlated with age alone. There was a slight but significant reduction ...
Source: Experimental Gerontology - July 30, 2018 Category: Geriatrics Authors: Snyder ML, Schmitt D Tags: Exp Gerontol Source Type: research

The impact of age-related hearing loss and lateralized auditory attention on spatiotemporal parameters of gait during dual-tasking among community dwelling older adults.
nda C Abstract This investigation assessed the impact of hearing loss and lateralized auditory attention on spatiotemporal parameters of gait during overground dual-tasking by the use of the dichotic listening task. Seventy-eight right-handed, healthy older adults between 60 and 88 years were assigned to a Young-Old (71 years) group. Cognitive assessment and pure tone audiometry were conducted. Spatiotemporal parameters of gait quantified by mean (M), and coefficient of variations (CoV) were evaluated with the OptoGait system during 3 dichotic listening conditions: Non-Forced, Forced-Right and Forced-Left. Fac...
Source: Experimental Gerontology - July 26, 2018 Category: Geriatrics Authors: Gorecka MM, Vasylenko O, Espenes J, Waterloo K, Rodríguez-Aranda C Tags: Exp Gerontol Source Type: research

Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training.
In this study we compared HSR between healthy middle-aged adults, healthy elderly and type 2 diabetic (T2DM) elderly, and tested whether resistance training (RT) could improve the HSR in T2DM group. Thirty sedentary participants volunteered for this study. HSR (assessed as the capacity to export HSP72 during heat stress) was measured in the blood and compared between the groups. HSR was similar between healthy middle-aged and healthy elderly volunteers, but diminished in elderly T2DM (p 
Source: Experimental Gerontology - July 24, 2018 Category: Geriatrics Authors: de Lemos Muller CH, Rech A, Botton CE, Schroeder HT, Bock PM, Farinha JB, Lopez P, Schöler CM, Grigolo GB, Coelho J, Kowalewski LS, Rodrigues MIL, de Azevedo MA, Quincozes-Santos A, Rodrigues-Krause J, Reischak-Oliveira A, Pinto RS, De Vito G, de Bittenc Tags: Exp Gerontol Source Type: research

Resveratrol treatment reduces the appearance of tubular aggregates and improves the resistance to fatigue in aging mice skeletal muscles.
This study reports the effects of a 0,04% RES-supplemented diet for six months, on the skeletal muscle properties of C57/BL6 aging mice. The analysis of the morphology, protein expression, and functional-mechanical properties of selected skeletal muscles in treated compared to control mice, revealed that treated animals presented less tubular aggregates and a better resistance to fatigue in an ex-vivo contraction test, suggesting RES as a good candidate to reduce age-related alterations in muscle. PMID: 30036632 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - July 20, 2018 Category: Geriatrics Authors: Toniolo L, Fusco P, Formoso L, Mazzi A, Canato M, Reggiani C, Giacomello E Tags: Exp Gerontol Source Type: research

Maximal strength training increases muscle force generating capacity and the anaerobic ATP synthesis flux without altering the cost of contraction in elderly.
Abstract Aging is associated with a progressive decline in skeletal muscle function, then leading to impaired exercise tolerance. Maximal strength training (MST) appears to be a practical and effective intervention to increase both exercise capacity and efficiency. However, the underlying physiological mechanisms responsible for these functional improvements are still unclear. Accordingly, the purpose of this study was to examine the intramuscular and metabolic adaptations induced by 8 weeks of knee-extension MST in the quadriceps of 10 older individuals (75 ± 9 yrs) by employing a combination of mo...
Source: Experimental Gerontology - July 19, 2018 Category: Geriatrics Authors: Berg OK, Kwon OS, Hureau TJ, Clifton HL, Thurston T, Le Fur Y, Jeong EK, Amann M, Richardson RS, Trinity JD, Wang E, Layec G Tags: Exp Gerontol Source Type: research

A new marker for nutritional assessment in acute care geriatric units: The phase angle measured by bioelectrical impedance analysis.
PMID: 30031054 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - July 18, 2018 Category: Geriatrics Authors: Dadet S, Mulliez A, Ducher G, Bohatier J, Bonnefoy M, Lesourd B, Boirie Y Tags: Exp Gerontol Source Type: research

Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training.
In conclusion, there was a divergent regulation of autophagy and apoptosis in mouse muscle with aging and lifelong exercise training, whereas healthy aged human skeletal muscle seemed rather robust to changes in apoptosis, autophagy and mitophagy markers compared with mouse muscle at the investigated age. PMID: 30030137 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - July 17, 2018 Category: Geriatrics Authors: Dethlefsen MM, Halling JF, Møller HD, Plomgaard P, Regenberg B, Ringholm S, Pilegaard H Tags: Exp Gerontol Source Type: research

Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis.
Abstract Osteoarthritis (OA) is a degenerative chronic disease affecting>300,000 million people around the world as of 2016. Symptomatic measures exist, but there are hardly any curative treatments available. Disruption of the cartilage homeostasis in favor of catabolism leads to cartilage destruction. ROS-macromolecular-induced damage is significantly greater in OA cartilage and OA is described as low-grade chronic systemic inflammation. This review aimed to assess the critical role of cartilage ageing and oxidative stress in the OA process, focusing in particular on NADPH oxidase and especially Nox4 involveme...
Source: Experimental Gerontology - July 13, 2018 Category: Geriatrics Authors: Drevet S, Gavazzi G, Grange L, Dupuy C, Lardy B Tags: Exp Gerontol Source Type: research

Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice.
Abstract As the crucial etiological factor, aging-related microglia activation promotes the development of Parkinson's disease (PD). However, the molecular and functional changes of aged-microglia and their contribution to neurodegeneration in PD are only partially understood, which was investigated in our study. Female C57BL/6 mice were randomly divided into four groups, included young-control group, young-MPTP group, aged-control group and aged-MPTP group. Pole test and adhesive removal test were firstly performed. ELISA assay was used to detect the content of interleukin-1β (IL-1β) and tumor necrosis ...
Source: Experimental Gerontology - July 12, 2018 Category: Geriatrics Authors: Yao K, Zhao YF Tags: Exp Gerontol Source Type: research

ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats.
CS Abstract The obesity epidemic is multi-generational and is particularly debilitating in the aging population, necessitating the use of pharmaceutical interventions. Recent evidence suggests that increasing the activity of the angiotensin converting enzyme-2 [ACE2]/angiotensin-(1-7)[Ang-(1-7)]/Mas receptor (MasR) axis in obese animal models leads to significant reductions in body weight. It was hypothesized that activation of ACE2 via diminazene aceturate (DIZE) will significantly reduce body weight of rats fed a high fat diet. Young and old (4 and 23 months, respectively) male Fisher 344 × Brown No...
Source: Experimental Gerontology - July 11, 2018 Category: Geriatrics Authors: Bruce EB, Sakarya Y, Kirichenko N, Toklu HZ, Sumners C, Morgan D, Tümer N, Scarpace PJ, Carter CS Tags: Exp Gerontol Source Type: research

Vitamin D, homocysteine and n-3PUFA status according to physical and cognitive functions in older adults with subjective memory complaint: Results from cross-sectional study of the MAPT trial.
This study is a secondary analysis of the MAPT study. Subjects were classified into four groups: 1) Physical limitation with cognitive impairment (PLCI), 2) cognitive impairment (CI), 3) physical limitation (PL) and 4) no physical or cognitive deficits (NPCD). Baseline nutritional characteristics of the four groups according to Vitamin D (n = 732), Omega-3 polyunsaturated fatty acid (n-3PUFA) (n = 1537) and plasma total homocysteine (tHcy) (n = 729) status were investigated. Analysis was performed taking continuous and dichotomized value for Vitamin D insufficiency ([25(OH)D] 
Source: Experimental Gerontology - July 10, 2018 Category: Geriatrics Authors: Chhetri JK, de Souto Barreto P, Soriano G, Gennero I, Cantet C, Vellas B Tags: Exp Gerontol Source Type: research

Changes in regional cerebral blood flow associated with a 45  day course of the ketogenic agent, caprylidene, in patients with mild to moderate Alzheimer's disease: Results of a randomized, double-blinded, pilot study.
CONCLUSION: Daily ingestion of caprylidene over 45 days was associated with increased blood flow in specific brain regions in patients lacking an apolipoprotein ɛ4 allele. PMID: 30006299 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - July 10, 2018 Category: Geriatrics Authors: Torosyan N, Sethanandha C, Grill JD, Dilley ML, Lee J, Cummings JL, Ossinalde C, Silverman DH Tags: Exp Gerontol Source Type: research

Martin Vigorimeter assesses muscle fatigability in older adults better than the Jamar Dynamometer.
Abstract INTRODUCTION: Muscle fatigability can be measured based on sustained handgrip performance, but different grip strength devices exist and their relationship to frailty remains unclear. We aimed to compare muscle fatigability obtained by Martin Vigorimeter and Jamar Dynamometer in older women across levels of frailty. METHOD: 53 community-dwelling women living in Greece (63-100 y), categorized according to tertiles on the Frailty Index score (FI) as: low-frail (FI  0.36). Fatigue resistance (FR, time for maximal grip strength to decrease to 50% during sustained contraction) was measured with both...
Source: Experimental Gerontology - July 9, 2018 Category: Geriatrics Authors: De Dobbeleer L, Theou O, Beyer I, Jones GR, Jakobi JM, Bautmans I Tags: Exp Gerontol Source Type: research

Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans.
Abstract Oxidative damage is accrual of molecular deterioration from reactive oxygen species (ROS) while decrease in generation of ROS is related with free radical scavenging enzymes. Boerhaavia diffusa L. (Nyctaginaceae) derived novel molecule Boeravinone B (BOB) possesses a variety of pharmacological activities, yet their anti-aging potential has not been explored. The aim of the present study was to elucidate the mechanism of BOB mediated oxidative stress resistance and lifespan extension in Caenorhabditis elegans. The results showed that the BOB significantly extends the lifespan of C. elegans with its anti-ox...
Source: Experimental Gerontology - July 9, 2018 Category: Geriatrics Authors: Rathor L, Pandey R Tags: Exp Gerontol Source Type: research

Genetic predisposition score predicts the increases of knee strength and muscle mass after one-year exercise in healthy elderly.
This study aims to identify a genetic predisposition score from a set of candidate gene variants that predicts the response to a one-year exercise intervention. 200 participants (aged 60-83 years) were randomly assigned to a fitness (FIT), whole-body vibration (WBV) and control group. Participants in the exercise (FIT and WBV) groups performed a one-year intervention program. Whole-body skeletal muscle mass (SMM) and isometric knee extension strength (PTIM60) were measured before and after the intervention. A set of 170 muscle-related single nucleotide polymorphisms (SNPs) were genotyped. Stepwise regression analysis was...
Source: Experimental Gerontology - July 4, 2018 Category: Geriatrics Authors: He L, Van Roie E, Bogaerts A, Morse CI, Delecluse C, Verschueren S, Thomis M Tags: Exp Gerontol Source Type: research

Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat.
This study was conducted to identify proteome profiles in the hippocampus, mPFC, and striatum of 14-, 18-, 23-, and 27-month-old rats. Proteomics analysis using ultrahigh performance liquid chromatography coupled with Q Exactive HF Orbitrap mass spectrometry identified 1074 proteins in the hippocampus, 871 proteins in the mPFC, and 241 proteins in the striatum. Of these proteins, 97 in the hippocampus, 25 in mPFC, and 5 in striatum were differentially expressed with age. The altered proteins were classified into three ontologies (cellular component, molecular function, and biological process) containing 44, 38, and 35 func...
Source: Experimental Gerontology - July 4, 2018 Category: Geriatrics Authors: Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Bellier JP, Makpol S, Ngah WZW, Damanhuri HA, Tooyama I Tags: Exp Gerontol Source Type: research

Learning new gait patterns: Age-related differences in skill acquisition and interlimb transfer.
Abstract Evidence from upper-extremity literature suggests that the normal ageing process affects an individual's ability to learn and retain a motor skill, but spares their ability to transfer the skill to the untrained, opposite limb. While this phenomenon has been well-studied in the upper-extremity, evidence in the lower-extremity is limited. Further, it is unclear to what extent age-related differences in motor learning and transfer are dependent on visual feedback of the motor task. Therefore, the purpose of this study was to examine the effects of ageing on motor learning, retention, and interlimb transfer ...
Source: Experimental Gerontology - July 4, 2018 Category: Geriatrics Authors: Krishnan C, Washabaugh EP, Reid CE, Althoen MM, Ranganathan R Tags: Exp Gerontol Source Type: research

The association between decreased hand grip strength and hip fracture in older people: A systematic review.
Abstract Hip fractures are a global concern, resulting in poor outcomes and high health care costs. They mostly affect people>80 years. Hip fractures are influenced by various (modifiable) risk factors. Emerging evidence suggests hand grip strength (HGS) to be one of several useful tools to identify hip fracture risk. This is the first systematic review that aims to assess the evidence underlying the relationship between hip fracture incidence and HGS. Eleven studies were selected for this review (six case-control and five cohort studies), comprising 21,197 participants. Where reported, HGS was significantly ...
Source: Experimental Gerontology - June 30, 2018 Category: Geriatrics Authors: Denk K, Lennon S, Gordon S, Jaarsma RL Tags: Exp Gerontol Source Type: research

Long-term administration of pDC stimulative lactic acid bacteria, Lactococcus lactis strain Plasma, prevents immune-senescence and decelerates individual senescence.
In this study, we investigated the effect of long-term oral administration of LC-Plasma on IFN-α induction activity and individual senescence in the senescence-accelerated mice strains Prone 1 (SAMP1) and Prone 10 (SAMP10). LC-Plasma administration promoted IFN-α induction activity and increased the naïve T cell ratio in SAMP1 mice. In SAMP10 mice, in addition to preventing a decrease in the naïve T cell ratio, aging-associated skin thinning was suppressed histologically and the expression of representative tight junction genes, such as Claudin-1 and Zo-1, was increased. Furthermore, age-related muscl...
Source: Experimental Gerontology - June 29, 2018 Category: Geriatrics Authors: Tsuji R, Komano Y, Ohshio K, Ishii N, Kanauchi O Tags: Exp Gerontol Source Type: research

Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer's disease like pathology via maintaining oxidative balance through SIRT1 pathway.
This study explored the role of Syzygium aromaticum on SIRT1 and oxidative balance in amyloid beta induced toxicity. Anti-oxidative capacity of Syzygium aromaticum was performed in Aβ25-35 induced neurotoxicity in neuronal cells. Superoxide dismutase, Catalase and Glutathione enzyme activity were determined by the treatment of Syzygium aromaticum. Both recombinant and endogenous SIRT1 activity were performed in its presence. The expression of γ-secretase and SIRT1 were evaluated by western blot. Syzygium aromaticum was capable to scavenge ROS and elevate the percentage of anti-oxidant enzymes. It also activated ...
Source: Experimental Gerontology - June 27, 2018 Category: Geriatrics Authors: Shekhar S, Yadav Y, Singh AP, Pradhan R, Desai GR, Dey AB, Dey S Tags: Exp Gerontol Source Type: research

Hyperglycemia attenuates the association between telomere length and age in Ukrainian population.
Abstract Diabetes-related conditions such as chronic hyperglycemia and related oxidative stress and inflammation were repeatedly associated with accelerated telomere shortening in epidemiological studies, although some findings are inconsistent. In present study, we aimed to assess the impact of disturbances in glucose metabolism on association between age and leukocyte telomere length (LTL) in the Ukrainian population. The study was conducted on the 119 adult subjects aged between 43 and 87 years residing in the Kyiv region, Ukraine. LTL was determined by a quantitative PCR-based method. LTL was negatively corr...
Source: Experimental Gerontology - June 26, 2018 Category: Geriatrics Authors: Krasnienkov DS, Khalangot MD, Kravchenko VI, Kovtun VA, Guryanov VG, Chizhova VP, Korkushko OV, Shatilo VB, Kukharsky VM, Vaiserman AM Tags: Exp Gerontol Source Type: research

Cortical and hippocampal expression of inflammatory and intracellular signaling proteins in aged rats submitted to aerobic and resistance physical training.
va SG Abstract Aging is often accompanied by an increase in pro-inflammatory markers. This inflammatory process is directly related to cellular dysfunctions that induce events such as the exacerbated activation of cell death signaling pathways. In the aged brain, dysregulation of the normal activities of neuronal cells compromises brain functions, thereby favoring the onset of neurodegenerative diseases and cognitive deficits. Interactions between various stimuli, such as stress, are responsible for the modulation of cellular processes and activities. Physical exercise is a controllable model of stress, largely us...
Source: Experimental Gerontology - June 26, 2018 Category: Geriatrics Authors: Henrique JS, França EF, Dos Santos Cardoso F, Serra FT, de Almeida AA, Fernandes J, Arida RM, da Silva SG Tags: Exp Gerontol Source Type: research

Cardiac hypertrophy in sarcopenic obese C57BL/6J mice is independent of Akt/mTOR cellular signaling.
CONCLUSION: Cardiac hypertrophy in SO is likely pathogenic as evidenced by the alterations in MAPK and AMPK protein content and lack of activation in the Akt/mTOR pathway. PMID: 29958999 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 26, 2018 Category: Geriatrics Authors: Perry RA, Brown LA, Haynie WS, Brown JL, Rosa-Caldwell ME, Lee DE, Greene NP, Washington TA Tags: Exp Gerontol Source Type: research

Rate of power development of the knee extensors across the adult life span: A cross-sectional study in 1387 Flemish Caucasians.
Abstract A growing body of research in elderly populations suggests that the early phase of an explosive muscle contraction (i.e., ≤200 ms) may be more functionally relevant than peak values. However, age-related variation in early phase explosive strength have never been investigated across the full-adult life span. This cross-sectional study investigated the age-related changes in the rate of power development (RPD) and compared it to the changes in peak power (Ppeak), both in terms of magnitude and onset, across the adult life span. Age-related declines in power and determinants of muscle power were compar...
Source: Experimental Gerontology - June 25, 2018 Category: Geriatrics Authors: Van Roie E, Van Driessche S, Inglis AJ, Thomis M, Delecluse C Tags: Exp Gerontol Source Type: research

Effect of exercise order of combined aerobic and resistance training on arterial stiffness in older men.
Abstract Arterial stiffness increases with advancing age, and is as an emerging biomarker in the assessment of vascular health. Some studies suggest that high-intensity resistance training increases arterial stiffness, but low- to moderate-intensity resistance training does not effect on arterial stiffening. Current evidence suggests that performing aerobic exercise after resistance training improved arterial stiffness in the young men and women. However, few studies have been conducted on the effects of the order of combined training on arterial stiffness in the elderly. The purpose of this study was to examine t...
Source: Experimental Gerontology - June 25, 2018 Category: Geriatrics Authors: Shiotsu Y, Watanabe Y, Tujii S, Yanagita M Tags: Exp Gerontol Source Type: research

Cross-sectional and longitudinal associations between serum 25 ‑hydroxyvitamin D and anti-oxidative status in older adults.
CONCLUSION: The maintenance of an adequate vitamin D status may have a beneficial impact on the anti-oxidative defence system in older adults on a long-term perspective. PMID: 29953952 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 25, 2018 Category: Geriatrics Authors: Jungert A, Neuhäuser-Berthold M Tags: Exp Gerontol Source Type: research

The relationship between muscle quality and incidence of falls in older community-dwelling women: An 18-month follow-up study.
Abstract INTRODUCTION: Important components that might mediate the relationship between aging and falls are reduced muscle strength and mass. Although muscle-related phenotypes have been linked to falls in older people, the role of muscle quality has yet to be examined. AIM: To investigate the relationship between muscle quality and incidence of falls over an 18-month follow-up in older community-dwelling women. METHODS: A total of 167 women (68.1 ± 6.2 years) underwent quadriceps isometric peak torque and thigh-muscle thickness assessments using isokinetic dynamometer and ultrasound, respec...
Source: Experimental Gerontology - June 21, 2018 Category: Geriatrics Authors: Gadelha AB, Neri SGR, Bottaro M, Lima RM Tags: Exp Gerontol Source Type: research

Optimization of the APOP screener to predict functional decline or mortality in older emergency department patients: Cross-validation in four prospective cohorts.
CONCLUSION: In conclusion, optimization of the APOP screener resulted in a short and more simplified screener, which adequately identifies older ED patients at highest risk for functional decline or mortality. The findings of the pilot study were promising for clinical use. PMID: 29935293 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 20, 2018 Category: Geriatrics Authors: de Gelder J, Lucke JA, Blomaard LC, Booijen AM, Fogteloo AJ, Anten S, Steyerberg EW, Alsma J, Klein Nagelvoort Schuit SCE, Brink A, de Groot B, Blauw GJ, Mooijaart SP Tags: Exp Gerontol Source Type: research

The effects of donor age on organ transplants: A review and implications for aging research.
es JP Abstract Despite the considerable amount of data available on the effect of donor age upon the outcomes of organ transplantation, these still represent an underutilized resource in aging research. In this review, we have compiled relevant studies that analyze the effect of donor age in graft and patient survival following liver, kidney, pancreas, heart, lung and cornea transplantation, with the aim of deriving insights into possible differential aging rates between the different organs. Overall, older donor age is associated with worse outcomes for all the organs studied. Nonetheless, the donor age from whic...
Source: Experimental Gerontology - June 20, 2018 Category: Geriatrics Authors: Dayoub JC, Cortese F, Anžič A, Grum T, de Magalhães JP Tags: Exp Gerontol Source Type: research

Crowding of Drosophila larvae affects lifespan and other life-history traits via reduced availability of dietary yeast.
e;liková M Abstract Conditions experienced during development have often long-lasting effects persisting into adulthood. In Drosophila, it is well-documented that larval crowding influences fitness-related traits such as body size, starvation resistance and lifespan. However, the underlying mechanism of this phenomenon is not well understood. Here, we show that the effects of increased larval density on life-history traits can be explained by decreased yeast availability in the diet during development. Yeast-poor larval diet alters various life-history traits and mimics the effects of larval crowding. In pa...
Source: Experimental Gerontology - June 19, 2018 Category: Geriatrics Authors: Klepsatel P, Procházka E, Gáliková M Tags: Exp Gerontol Source Type: research

Time trends in the prevalence of cancer and non-cancer diseases among older U.S. adults: Medicare-based analysis.
Abstract Longer lifespan is accompanied by a larger number of chronic diseases among older adults. Because of a growing proportion of older adults in the U.S., this brings the problem of age-related morbidity to the forefront as a major contributor to rising medical expenditures. We evaluated 15-year time trends (from 1998 to 2013) in the prevalence of 48 acute and chronic non-cancer diseases and cancers in older U.S. adults aged 65+ and estimated the annual percentage changes of these prevalence trends using SEER-Medicare and HRS-Medicare data. We found that age-adjusted prevalence of cancers of kidney, pancreas,...
Source: Experimental Gerontology - June 19, 2018 Category: Geriatrics Authors: Akushevich I, Kravchenko J, Yashkin AP, Yashin AI Tags: Exp Gerontol Source Type: research

Is increased neutrophil lymphocyte ratio remarking the inflammation in sarcopenia?
A, Abiyev A Abstract OBJECTIVES: Increasing data suggests that chronic inflammation has an essential role on development of muscle dysfunction and progression of sarcopenia in aging population. The aim of the present study was to compare Neutrophil Lymphocyte Ratio (NLR) levels in sarcopenic and non-sarcopenic individuals and to present the correlation between NLR and other inflammatory markers. METHODS: A total of 105 subjects with sarcopenia (male/female: 54/51, mean age 72.8 ± 7.3) and 314 subjects as non-sarcopenic (male/female: 125/189, mean age 71.44 ± 5.4) were enrolled in this cr...
Source: Experimental Gerontology - June 18, 2018 Category: Geriatrics Authors: Öztürk ZA, Kul S, Türkbeyler İH, Sayıner ZA, Abiyev A Tags: Exp Gerontol Source Type: research

High-speed resistance training in elderly women: Effects of cluster training sets on functional performance and quality of life.
rdo M Abstract OBJECTIVE: To compare the effects of 12 weeks of high-speed resistance training on functional performance and quality of life in elderly women when using either a traditional-set (TS) or a cluster-set (CS) configuration for inter-set rest. METHODS: Three groups of subjects were formed by block-design randomization as follows: (i) control group (CG, n = 17; age, 66.5 ± 5.4 years); (ii) 12-week high-speed resistance training group under a CS configuration (CSG, n = 15; age, 67.6 ± 5.4 years); and (iii) 12-week high-speed resistance training group under a TS con...
Source: Experimental Gerontology - June 14, 2018 Category: Geriatrics Authors: Ramirez-Campillo R, Alvarez C, Garcìa-Hermoso A, Celis-Morales C, Ramirez-Velez R, Gentil P, Izquierdo M Tags: Exp Gerontol Source Type: research

Functional and physiological adaptations following concurrent training using sets with and without concentric failure in elderly men: A randomized clinical trial.
This study compared the functional and physiological adaptations induced by concurrent training (CT) performed with repetitions to concentric failure and not to failure in elderly men. Fifty-two individuals (66.2 ± 5.2 years) completed the pre- and post-measurements and were divided into three groups: repetitions to failure (RFG, n = 17); repetitions not to failure (NFG, n = 20); and repetitions not to failure with total volume equalized to that in the RFG (ENFG, n = 15). The participants' sit-to-stand ability, timed-up-and-go (TUG), muscle power output in squat jump (SJ) and countermovement jump (...
Source: Experimental Gerontology - June 13, 2018 Category: Geriatrics Authors: Cadore EL, Menger E, Teodoro JL, da Silva LXN, Boeno FP, Umpierre D, Botton CE, Ferrari R, Dos Santos Cunha G, Izquierdo M, Pinto RS Tags: Exp Gerontol Source Type: research

The effects of resveratrol and exercise on age and gender-dependent alterations of vascular functions and biomarkers.
Abstract The purpose of this study was to determine the effects of resveratrol and regular aerobic exercise on vascular functions and biomarkers related to vessel responsiveness in an age and gender-dependent manner. The study used young (3 months) and old (12 months) male and female Wistar albino rats. Resveratrol was given in the drinking water (0.05 mg/ml; approximately 7.5 mg/kg) for 6 weeks. In the exercise group, all rats performed treadmill running at 20 m/min on a 0° incline, 40 min/day, 3 times a week, for 6 weeks. Acetylcholine-induced, endothelium-dependent and sodium nitroprusside-m...
Source: Experimental Gerontology - June 13, 2018 Category: Geriatrics Authors: Han S, Bal NB, Sadi G, Usanmaz SE, Orhan Uludag M, Demirel-Yilmaz E Tags: Exp Gerontol Source Type: research

Aging related functional and structural changes in the heart and aorta: MitoTEMPO improves aged-cardiovascular performance.
Abstract Aging in humans represents declining in cardio-protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key mechanisms responsible for contractile dysfunction via comparing the improperly synchrony between electrical and mechanical activities in male aged-rats (24-month old) comparison to those of adult-rats (6-month old). We determined significantly increased systemic oxidative stress with decreased antioxidant capacity, clear insulin resistance and hypertrophy in aged-rats with normal fasting blood glucose. We also determined significantly high level of reactiv...
Source: Experimental Gerontology - June 13, 2018 Category: Geriatrics Authors: Olgar Y, Degirmenci S, Durak A, Billur D, Can B, Mutlu GK, Inan EA, Turan B Tags: Exp Gerontol Source Type: research

The influence of ageing on the extrapineal melatonin synthetic pathway.
Abstract Ageing affects various physiological and metabolic processes in a body and a progressive accumulation of oxidative damage stands out as often used explanation. One of the most powerful scavenger of reactive oxygen species (ROS) in all organs is melatonin. A majority of melatonin supplied to the body via blood originates from the pineal gland. However, we have been interested in a locally produced melatonin. We have used 2.5- and 36-months-old Wistar rats. Tissues were collected and gene expression of AA-NAT and ASMT, the two key enzymes in a synthesis of melatonin, was determined in brain, liver, kidney, ...
Source: Experimental Gerontology - June 12, 2018 Category: Geriatrics Authors: Popović B, Velimirović M, Stojković T, Brajović G, De Luka SR, Milovanović I, Stefanović S, Nikolić D, Ristić-Djurović JL, Petronijević ND, Trbovich AM Tags: Exp Gerontol Source Type: research

Holothuria scabra extracts possess anti-oxidant activity and promote stress resistance and lifespan extension in Caenorhabditis elegans.
In conclusion, this study strongly demonstrates anti-oxidant and anti-ageing properties of H. scabra extracts containing triterpene glycosides, which, in the C. elegans model, may be mediated via the insulin/IGF-1 signaling (IIS)-DAF-16 pathway. PMID: 29902502 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 11, 2018 Category: Geriatrics Authors: Jattujan P, Chalorak P, Siangcham T, Sangpairoj K, Nobsathian S, Poomtong T, Sobhon P, Meemon K Tags: Exp Gerontol Source Type: research

Molecular mechanisms and therapy of cardiovascular ageing.
PMID: 29898420 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 10, 2018 Category: Geriatrics Authors: Spyridopoulos I Tags: Exp Gerontol Source Type: research

Effect of the head extension swallowing exercise on suprahyoid muscle activity in elderly individuals.
This study showed that HESE can be a good option for improving the suprahyoid muscle and tongue strength in the elderly population. Additionally, this exercise does not require any additional equipment and has the advantage of being able to be performed anytime and anywhere. A variety of exercise options tailored according to individual characteristics may be helpful in choosing the most appropriate exercise. PMID: 29894751 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 9, 2018 Category: Geriatrics Authors: Jong-Chi OH Tags: Exp Gerontol Source Type: research

Associations of distinct levels of physical activity with mobility in independent healthy older women.
CONCLUSION: MVPA is associated with body composition and mobility parameters, while LPA is not related to any measured body composition nor mobility parameters. Accordingly, healthy older women could benefit from MVPA to maintain body composition and mobility parameters to preserve independence in later life. PMID: 29890269 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 8, 2018 Category: Geriatrics Authors: Rava A, Pihlak A, Kums T, Purge P, Pääsuke M, Jürimäe J Tags: Exp Gerontol Source Type: research

Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men.
Abstract BACKGROUND: Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to protein ingestion and resistance exercise in healthy older men. METHODS: Sixteen healthy older men were randomized to receive MCC (60 mL·d-1) or placebo (PLA) for two weeks, after baseline measures in week 1. During week 3, participants consumed 10 g whey protein·d-1 and completed three bouts of unilateral leg resistance exercise (4 &ti...
Source: Experimental Gerontology - June 8, 2018 Category: Geriatrics Authors: Jackman SR, Brook MS, Pulsford RM, Cockcroft EJ, Campbell MI, Rankin D, Atherton P, Smith K, Bowtell JL Tags: Exp Gerontol Source Type: research

Can measures of physical performance in mid-life improve the clinical prediction of disability in early old age? Findings from a British birth cohort study.
CONCLUSION: Measures of physical performance in midlife improve discrimination in clinical prediction models for disability over 16 years. Importantly, these and similar measures are also potential targets of future diet, exercise and pharmacological intervention in mid-life. PMID: 29885357 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 6, 2018 Category: Geriatrics Authors: Dodds RM, Kuh D, Sayer AA, Cooper R Tags: Exp Gerontol Source Type: research

Cardiorespiratory responses of a dance session designed for older women: A cross sectional study.
CONCLUSIONS: Cardiorespiratory demands of a dance class for older women are at low aerobic intensity. Show was similar to VT1, indicating that a dance class may be modulated to improve aerobic fitness, at least at initial stages of training. PMID: 29879448 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 4, 2018 Category: Geriatrics Authors: Rodrigues-Krause J, Farinha JB, Ramis TR, Boeno FP, Dos Santos GC, Krause M, Reischak-Oliveira A Tags: Exp Gerontol Source Type: research