Effects of resistance training on hepcidin levels and iron bioavailability in older individuals with end-stage renal disease: A randomized controlled trial.
tos Rosa T Abstract Anemia is an inherent complication of older individuals with end-stage renal disease (ESRD) that is associated with inflammation which in turn is an important factor in the activation of hepcidin that contributes to the decrease in serum iron. Athough resistance training (RT) seems to reduce inflammation in ESRD, its influence on hepcidin and iron availability in hemodialysis patients is unclear. Therefore, the aim of this study was to exemine the effects of RT in on inflammatory profile, hepcidin, and iron status in older individuals with ESRD. End-stage renal disease patients (N: 157, age: 66...
Source: Experimental Gerontology - July 4, 2020 Category: Geriatrics Authors: Moura SRG, Corrêa HL, Neves RVP, Santos CAR, Neto LSS, Silva VL, Souza MK, Deus LA, Reis AL, Simões HG, Beal FLR, Moraes MR, Navalta JW, Prestes J, Gadelha AB, Dos Santos Rosa T Tags: Exp Gerontol Source Type: research

Uncaria tomentosa improves cognition, memory and learning in middle-aged rats.
This study assessed the effects of U. tomentosa extract treatment on the aging process in the brain of Wistar rats. The spatial memory and learning, acetylcholinesterase (AChE) activity, and DNA damage were assessed. Animals of 14 months were tested with different doses of U. tomentosa (5 mg/kg, 15 mg/kg, and 30 mg/kg) and with different durations of treatment (one month and one year). In the Morris Water Maze (MWM), the escape latency was significantly (p 
Source: Experimental Gerontology - July 3, 2020 Category: Geriatrics Authors: Castilhos LG, Oliveira JS, Adefegha SA, Manzoni AG, Passos DF, Assmann CE, Silveira LL, Trelles KB, Kronbauer M, Doleski PH, Bremm JM, Braun J, Abdalla FH, Gonçalves JF, Andrade CM, Cruz IM, Burger ME, Leal DBR Tags: Exp Gerontol Source Type: research

Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis.
CONCLUSIONS: Based on a small number of studies of low methodological quality, this systematic review with meta-analysis suggests that RET is not effective at reducing molecular oxidation markers in healthy older people. More research is needed on the effects of RET on redox homeostasis in older people. PROSPERO REGISTRATION NUMBER: CRD42019121529. PMID: 32615210 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 29, 2020 Category: Geriatrics Authors: Iván CV, Lily BC, Stephanie SF, Hunter-Echeverría K, Nasri MG Tags: Exp Gerontol Source Type: research

Quadriceps echo intensity can be an index of muscle size regardless of age in 65 or more years old.
Abstract Although age-related deterioration of skeletal muscle strength and size has gained much attention, the age-related increase in adipose tissue within skeletal muscle has not received the same level of attention, especially in older individuals. It is not well known how echo intensity (EI), which is an index of intramuscular adipose tissue (IntraMAT) and connective tissue, is associated with demographic, functional, and morphological characteristics in older individuals. The purpose of this study was to assess the relationships between the EI of the quadriceps femoris (QF) and demographic, functional, and m...
Source: Experimental Gerontology - June 26, 2020 Category: Geriatrics Authors: Akima H, Yoshiko A, Ogawa M, Maeda H, Tomita A, Ando R, Tanaka NI Tags: Exp Gerontol Source Type: research

Circulating biomarkers characterizing physical frailty: CRP, hemoglobin, albumin, 25OHD and free testosterone as best biomarkers. Results of a meta-analysis.
CONCLUSION: We found 5 biomarkers that were associated with frailty (CRP, hemoglobin, albumin, 25OHD and free testosterone in men) belonging to multiple physiological systems. Further cohort studies are needed to verify their ability to screen for frailty. PMID: 32599147 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 26, 2020 Category: Geriatrics Authors: Mailliez A, Guilbaud A, Puisieux F, Dauchet L, Boulanger É Tags: Exp Gerontol Source Type: research

Antihypertensive medications and physical function in older persons.
CONCLUSION: Use of BB and three or more antiHTNs yielded 44% and 52% increased odds of accelerometry-defined high sedentary time, respectively. Notably, high sedentary time is a risk factor for adverse health outcomes. Thus, future work should evaluate whether high sedentary time mitigates benefits or increases risks, regarding antiHTN use in aging populations. PMID: 32593771 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 25, 2020 Category: Geriatrics Authors: Vaz Fragoso CA, McAvay GJ Tags: Exp Gerontol Source Type: research

Cluster-sets resistance training induce similar functional and strength improvements than the traditional method in postmenopausal and elderly women.
Abstract OBJECTIVE: The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS: Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7 ± 4.7 cm) were randomized to TRT (n = 35) or CS (n = 31). Anthropometric measures, muscle strength and power, gait speed, core stability, flexibility, and functional performance tests were performed before and after 12 weeks of traini...
Source: Experimental Gerontology - June 24, 2020 Category: Geriatrics Authors: Dias RKN, Penna EM, Noronha ASN, de Azevedo ABC, Barbalho M, Gentil PV, Coswig VS Tags: Exp Gerontol Source Type: research

Fisetin prevents the aging-associated decline in relative spectral power of α, β and linked MUA in the cortex and behavioral alterations.
Fisetin prevents the aging-associated decline in relative spectral power of α, β and linked MUA in the cortex and behavioral alterations. Exp Gerontol. 2020 Jun 24;:111006 Authors: Das J, Singh R, Ladol S, Nayak SK, Sharma D Abstract Mental health in old age is of great concern due to the increased incidence of neurological and psychiatric diseases. With age, probability of cognitive and behavioral deficits increase and the prognosis deteriorates. Although a few in vitro studies have reported that flavonoid fisetin is beneficial for healthy aging, its effect on deteriorating mental health w...
Source: Experimental Gerontology - June 24, 2020 Category: Geriatrics Authors: Das J, Singh R, Ladol S, Nayak SK, Sharma D Tags: Exp Gerontol Source Type: research

What is the impact of acute inflammation on muscle performance in geriatric patients?
In conclusion, a negative association between the presence of acute and persistent systemic markers of inflammation and various aspects of muscle function and its recovery after bedrest is observed in geriatric patients. PMID: 32592832 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 24, 2020 Category: Geriatrics Authors: Karlsen A, Mackey AL, Suetta C, Kjaer M Tags: Exp Gerontol Source Type: research

Swertiamarin, a secoiridoid glycoside modulates nAChR and AChE activity.
Abstract The ailments related to a malfunction in cholinergic functioning currently employ the use of inhibitors for acetylcholinesterase (AChE) and N-methyl-d-aspartate (NMDA) receptors. The present study was designed to elucidate the potential of swertiamarin (SW), a secoiridoidal glycoside isolated from Enicostemma littorale in curtailing the cholinergic dysfunction. Using Caenorhabditis elegans as a model, SW was found to enhance neurotransmission by modulating AChE and nicotinic acetylcholine receptor (nAChR) activity; being orchestrated through up-regulation of unc-17 and unc-50. SW exhibited AChE inhibition...
Source: Experimental Gerontology - June 23, 2020 Category: Geriatrics Authors: Pandey T, Smita SS, Mishra A, Sammi SR, Pandey R Tags: Exp Gerontol Source Type: research

Comparison of the value of malnutrition and sarcopenia for predicting mortality in hospitalized old adults over 80  years.
This study aimed to compare the prognostic value of malnutrition and sarcopenia for mortality in old adults over 80 years. METHODS: A prospective analysis was performed in 427 hospitalized old adults. Anthropometric measures and biochemical parameters were carried out for each patient. Sarcopenia was defined according to the revised consensus definition of the European Working Group on Sarcopenia in Older People (EWGSOP2). Malnutrition was defined according to the European Society of Clinical Nutrition and Metabolism (ESPEN) criteria. Mortality data were available for up to 32 months of follow-up. RESULTS: Th...
Source: Experimental Gerontology - June 23, 2020 Category: Geriatrics Authors: Tao J, Ke YY, Zhang Z, Zhang Y, Wang YY, Ren CX, Xu J, Zhu YX, Zhang XL, Zhang XY Tags: Exp Gerontol Source Type: research

Low free triiodothyronine levels are associated with risk of frailty in older adults with type 2 diabetes mellitus.
The objective of the study was to evaluate the relationship between thyroid hormone concentrations and frailty in older adults with T2DM. METHODS: A total of 240 older adults with T2DM were divided into three groups according to the frailty phenotype criteria: robust group (n = 94), pre-frail (n = 110) and frail group (n = 36). Concentrations of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH), 25-hydroxyvitamin D3 [25(OH) D3], highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were determined. Handgrip strength was measured using a Jamar hand dynam...
Source: Experimental Gerontology - June 23, 2020 Category: Geriatrics Authors: Xiu S, Mu Z, Zhao L, Sun L Tags: Exp Gerontol Source Type: research

Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial.
In conclusion, a resistance training program provided significant benefits in the stair climb test, unrelated to plantar flexor-derived muscle quality measures as previously demonstrated in quadriceps femoris. PMID: 32562747 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 17, 2020 Category: Geriatrics Authors: Lopez P, Crosby BJ, Robetti BP, Turella DJP, Weber TAS, de Oliveira ML, Rech A Tags: Exp Gerontol Source Type: research

C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer's disease dementia.
CONCLUSION: CRP may add information of risk of conversion in MCI patients. Patients with lower CRP levels appear to have a more rapid conversion to AD dementia. PMID: 32561398 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 16, 2020 Category: Geriatrics Authors: Fernandes A, Tábuas-Pereira M, Duro D, Lima M, Gens H, Santiago B, Durães J, Almeida MR, Leitão MJ, Baldeiras I, Santana I Tags: Exp Gerontol Source Type: research

Sex-moderated association between body composition and cognition in older adults.
CONCLUSION: Overall, higher lean mass and in particular trunk and arms lean mass was associated with higher cognitive abilities in older men. Longitudinal studies or intervention studies are needed to further identify physiological mechanisms that sustain the relationship between lean mass and cognition. PMID: 32561399 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 16, 2020 Category: Geriatrics Authors: Langeard A, Fakrahnak Z, Vrinceanu T, de la Colina AN, Pothier K, Berryman N, Vu TTM, Girouard H, Karelis AD, Bherer L Tags: Exp Gerontol Source Type: research

The crosstalk between cellular reprogramming and senescence in aging and regeneration.
Abstract Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue regeneration and rejuvenation. Here we review recent studies on the interplay between cellular senescence and reprogramming. We discuss how both strategies could impact aging process and the possibility of combine them for more efficient regeneration and rejuvenation. PMID: 32561400 [Pu...
Source: Experimental Gerontology - June 16, 2020 Category: Geriatrics Authors: Chiche A, Chen C, Li H Tags: Exp Gerontol Source Type: research

The feasibility of muscle mitochondrial respiratory chain phenotyping across the cognitive spectrum in Parkinson's disease.
CONCLUSIONS: Detailed phenotyping, muscle biopsy and imaging was feasible and acceptable across a spectrum of cognitive function in PD. Sarcopenia was relatively common and may be associated with lower mitochondrial mass and low levels of MRC deficiency. PMID: 32554091 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 15, 2020 Category: Geriatrics Authors: Yarnall AJ, Granic A, Waite S, Hollingsworth KG, Warren C, Vincent AE, Turnbull DM, Taylor RW, Dodds RM, Sayer AA Tags: Exp Gerontol Source Type: research

A 10-week yoga practice has no effect on cognition, but improves balance and motor learning by attenuating brain-derived neurotrophic factor levels in older adults.
Abstract Despite studies investigating the effect of yoga on cognitive and motor functioning in older adults, the effect on dual-task performance and motor learning and the specific mechanisms underlying the positive effect of yoga remain unclear. Thus, the aim of this study was to investigate the effects of yoga on cognition, balance under single- and dual-task conditions, and motor learning. The potential role of brain-derived neurotrophic factor (BDNF) in induced improvement was also explored. Participants aged 60-79 years were randomized to either a control group (n = 15) or a yoga group (n = 18) for...
Source: Experimental Gerontology - June 13, 2020 Category: Geriatrics Authors: Čekanauskaitė A, Skurvydas A, Žlibinaitė L, Mickevičienė D, Kilikevičienė S, Solianik R Tags: Exp Gerontol Source Type: research

Thyroid hormones and frailty in persons experiencing extreme longevity.
Abstract CONTEXT: The aging phenotype is quite heterogeneous, being the result of the capability of each individual to successfully or unsuccessfully response to stressors. The reduction of homeostatic reserve characterizing aging is accompanied by a remodeling of the endocrine system. Frailty has been indicated as a promising way for capturing the physiological decline as well as the biological aging of the individuals. In particular, the Frailty Index (FI), based on the assumption that health deficits tend to accumulate with aging, represents a quantitative measure of extreme interest. OBJECTIVE: The study ...
Source: Experimental Gerontology - June 7, 2020 Category: Geriatrics Authors: Arosio B, Monti D, Mari D, Passarino G, Ostan R, Ferri E, De Rango F, Franceschi C, Cesari M, Vitale G Tags: Exp Gerontol Source Type: research

D-galactose-induced aging does not cause further deterioration in brain pathologies and cognitive decline in the obese condition.
Abstract Largely as a consequence of changes in modern lifestyle, a significant proportion of global population have become obese. When obese people grow old, pathologies aggravate neurodegeneration. Several studies have demonstrated that both aging and obesity have deleterious impact on brain. However, the time course effects of combined aging-induced by d-galactose and obesity caused by high-fat diet on cognitive and brain function have not been explored. We hypothesize that D-galactose accelerates and aggravates brain pathologies and cognitive dysfunction in the state of obesity. Ninety-six Wistar rats were sep...
Source: Experimental Gerontology - June 6, 2020 Category: Geriatrics Authors: Shwe T, Bo-Htay C, Leech T, Ongnok B, Jaiwongkum T, Kerdphoo S, Palee S, Pratchayasakul W, Chattipakorn N, Chattipakorn SC Tags: Exp Gerontol Source Type: research

Normalized maximal rate of torque development during voluntary and stimulated static contraction in human tibialis anterior: Influence of age.
Abstract The risk of falling in older adults has been related, among other factors, to the reduction of the rate of torque development (RTD) with age. It is well known that both structural/peripheral and neural factors can influence the RTD. The purpose of this study was to compare the normalized RTD in young and older participants obtained during a) rapid voluntary tension production and b) neuromuscular electrical stimulation. The tibialis anterior of 19 young subjects (10 males and 9 females; age 21-33 years old) and 19 older participants (10 males and 9 females; age 65-80 years old) was studied. The subjec...
Source: Experimental Gerontology - June 5, 2020 Category: Geriatrics Authors: Cogliati M, Cudicio A, Toscani F, Gaffurini P, Bissolotti LM, Orizio C, Negro F Tags: Exp Gerontol Source Type: research

Cell signaling and the aging of B cells.
Abstract The uniqueness of each B cell lies in the structural diversity of the B-cell antigen receptor allowing the virtually limitless recognition of antigens, a necessity to protect individuals against a range of challenges. B-cell development and response to stimulation are exquisitely regulated by a group of cell surface receptors modulating various signaling cascades and their associated genetic programs. The effects of these signaling pathways in optimal antibody-mediated immunity or the aberrant promotion of immune pathologies have been intensely researched in the past in young individuals. In contrast, we ...
Source: Experimental Gerontology - June 3, 2020 Category: Geriatrics Authors: Labi V, Derudder E Tags: Exp Gerontol Source Type: research

Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia.
Abstract BACKGROUND: Low muscle strength (dynapenia) is a primary characteristic of sarcopenia, the age-related loss of muscle mass and strength or low walking speed. New evidence suggests that muscle strength positively affects blood pressure (BP) responses to exercise. As older adults with lowest handgrip strength also have lowest BP at rest, those with dynapenia may experience attenuated BP responses during physical activity. The purpose of this study was to test the hypothesis that dynapenic older adults would exhibit lower BP response to post-exercise muscle ischemia (PEMI). METHODS: Brachial and aortic ...
Source: Experimental Gerontology - June 2, 2020 Category: Geriatrics Authors: Wong A, Jaime SJ, Grubbs B, Panton LB, Fischer SM, Figueroa A Tags: Exp Gerontol Source Type: research

Sex-specific associations of inflammation markers with cognitive decline.
CONCLUSIONS: Circulating markers of CRP and IL-6 may be differential risk factors for men and women in relation to cognitive decline. A novel inflammation marker, sTNFR1, may be a useful predictor of memory decline in older adults. PMID: 32497552 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 1, 2020 Category: Geriatrics Authors: West NA, Kullo IJ, Morris C, Mosley TH Tags: Exp Gerontol Source Type: research

The effects of GAMotion (a giant exercising board game) on physical capacity, motivation and quality of life among nursing home residents: A pilot interventional study.
P, Mouton A Abstract BACKGROUND: In 2017, our team highlighted promising results of a giant exercising board game on physical activity level and a broader array of physical and psychological outcomes among nursing home residents. However, some improvements of this game were needed to make it more suitable for nursing homes and more challenging in terms of exercises. Therefore, we decided to develop a new version of a giant exercising board game: the GAMotion. OBJECTIVES: The primary objective of this pilot study was to assess the impact of the GAMotion on physical capacity among nursing home residents. The se...
Source: Experimental Gerontology - May 27, 2020 Category: Geriatrics Authors: Buckinx F, Bruyère O, Lengelé L, Reginster JY, Marchal Q, Hurtrez P, Mouton A Tags: Exp Gerontol Source Type: research

Prevalence of muscle dysfunction concomitant with osteoporosis in a home-dwelling Danish population aged 65-93  years - The Copenhagen Sarcopenia Study.
Prevalence of muscle dysfunction concomitant with osteoporosis in a home-dwelling Danish population aged 65-93 years - The Copenhagen Sarcopenia Study. Exp Gerontol. 2020 May 25;:110974 Authors: Nielsen BR, Andersen HE, Haddock B, Hovind P, Schwarz P, Suetta C Abstract INTRODUCTION: As life expectancy increases, a growing percentage of older individuals with age-related diseases such as osteoporosis and sarcopenia are expected. Patients with both conditions, i.e. patient with osteosarcopenia, are suggested to have a higher risk of fall and fracture compared to individuals with either condition. ...
Source: Experimental Gerontology - May 25, 2020 Category: Geriatrics Authors: Nielsen BR, Andersen HE, Haddock B, Hovind P, Schwarz P, Suetta C Tags: Exp Gerontol Source Type: research

The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouse.
Abstract Telomeres are repetitive DNA sequences localized at the ends of eukaryotic chromosomes, and shorten during ovarian aging. The molecular background of telomere shortening during ovarian aging is not fully understood. As the telomerase components (TERT and Terc) and telomere-associated proteins (TRF1, TRF2, and POT1a) play key roles in the elongation and maintenance of telomeres, we aimed to determine their spatial and temporal expression and cellular localization in the mouse ovaries at the different ages of postnatal life. For this purpose, five groups were generated based on the ovarian histological chan...
Source: Experimental Gerontology - May 25, 2020 Category: Geriatrics Authors: Kosebent EG, Uysal F, Ozturk S Tags: Exp Gerontol Source Type: research

High and low-load resistance training produce similar effects on bone mineral density of middle-aged and older people: A systematic review with meta-analysis of randomized clinical trials.
Abstract PURPOSE: To compare the effects of high-load (≥ 70 of 1RM) and low-load (
Source: Experimental Gerontology - May 23, 2020 Category: Geriatrics Authors: Souza D, Barbalho M, Ramirez-Campillo R, Martins W, Gentil P Tags: Exp Gerontol Source Type: research

Amelioration of age-related alterations in rat liver: Effects of curcumin C3 complex, Astragalus membranaceus and blueberry.
This study aimed to investigate the potential ameliorating effects of curcumin C3 complex, Astragalus membranaceus and blueberry on certain age-related biochemical alterations in rat liver. Four groups of rats, aged 12 months-old, were used. The first group; aged control group in which rats were left without any treatment until the age of 17 months. The other three groups received daily by oral gavage for 5 months the following supplements; curcumin C3 complex (110 mg/kg), Astragalus membranaceus (100 mg/kg) and blueberry (100 mg/kg) respectively. Additionally, a fifth group of rats, aged 5 months-old, was us...
Source: Experimental Gerontology - May 22, 2020 Category: Geriatrics Authors: Selim AM, Nooh Mohamed MM, El-Sawalhi MM, Ismail NA Tags: Exp Gerontol Source Type: research

Nicotinamide riboside-A missing piece in the puzzle of exercise therapy for older adults?
Abstract Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that a reason for the variability in exercise training responses may be the age-related dysregulation of the nicotinamide adenine dinucleotide (NAD+) metabolome. NAD+ is an essential enzymatic cofactor in energetic and signaling pathways. Endogenous NAD+ pool is lower in several chronic and degen...
Source: Experimental Gerontology - May 22, 2020 Category: Geriatrics Authors: Custodero C, Saini SK, Shin MJ, Jeon YK, Christou DD, McDermott MM, Leeuwenburgh C, Anton SD, Mankowski RT Tags: Exp Gerontol Source Type: research

Associations between the serum levels of selected bone turnover markers and biological traits in nursing home women aged 80+ without inflammation. A pilot study.
Abstract BACKGROUND: Bone turnover markers (BTM) reflect the status of bone remodeling processes responsible for bone mineral density. The existing body of evidence that osseous tissue can interact with many other body tissues and organs suggests that the cross-talks can lead to different relationships. The biological traits associated with BTMs have not been thoroughly studied in the elderly despite bone turnover being known to increase with age. OBJECTIVE: To determine whether the C-terminal crosslinking telopeptides of type I collagen (CTXI) and the serum levels of total (TAP) and bone-specific (BAP) alkal...
Source: Experimental Gerontology - May 16, 2020 Category: Geriatrics Authors: Zarzeczny R, Polak A, Nawrat-Szołtysik A, Manasar A Tags: Exp Gerontol Source Type: research

Long-term assessment of morphological, functional, and quantitative parameters of skeletal muscle in older patients after unilateral total hip arthroplasty.
Abstract Total hip arthroplasty (THA) is performed for pain relief in patients with osteoarthritis of the hip joint. After THA, patients may recover muscle mass and physical function. Muscle quality is the main parameter used to indicate intramuscular fat content, and it is related with muscle function in older individuals. However, how THA affects muscle quality, as determined by echo intensity (EI), is not well understood. The purpose of this study was to determine the long-term characteristics of EI, muscle quantity, muscle function, and physical functions in the patients with THA surgery. In order to achieve t...
Source: Experimental Gerontology - May 15, 2020 Category: Geriatrics Authors: Yoshiko A, Beppu M, Izumida R, Matsubara M, Otani T, Shiratsuchi H, Takahira N, Moritani T, Watanabe K Tags: Exp Gerontol Source Type: research

A molecular perspective on age-dependent changes to the heat shock axis.
Abstract Aging is a complex process associated with progressive damage that leads to cellular dysfunction often accompanied by frailty and age-related diseases. Coping with all types of physiologic stress declines with age. While representing a primordial, cross-species response in poikilo- and homeotherms, the age-dependent perturbation of the stress response is more complex than previously thought. This short review examines how age influences the stress axis at multiple levels that involve both activating and attenuating pathways. PMID: 32407864 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 11, 2020 Category: Geriatrics Authors: Trivedi R, Jurivich DA Tags: Exp Gerontol Source Type: research

Is inflammatory signaling involved in disease-related muscle wasting? Evidence from osteoarthritis, chronic obstructive pulmonary disease and type II diabetes.
Abstract Muscle loss is an important feature that occurs in multiple pathologies including osteoarthritis (OA), chronic obstructive pulmonary disease (COPD) and type II diabetes (T2D). Despite differences in pathogenesis and disease-related complications, there are reasons to believe that some fundamental underlying mechanisms are inherent to the muscle wasting process, irrespective of the pathology. Recent evidence shows that inflammation, either local or systemic, contributes to the modulation of muscle mass and/or muscle strength, via an altered molecular profile in muscle tissue. However, it remains ambiguous ...
Source: Experimental Gerontology - May 10, 2020 Category: Geriatrics Authors: Dalle S, Koppo K Tags: Exp Gerontol Source Type: research

Mitochondria as central characters in a complex narrative: Linking genomics, energetics, and pace-of-life in natural populations of garter snakes.
Abstract As a pacesetter for physiological processes, variation in metabolic rate can determine the shape of energetic trade-offs and thereby drive variation in life-history traits. In turn, such variation in metabolic performance and life-histories can have profound consequences for lifespan and lifetime fitness. Thus, the extent to which metabolic rate variation is due to phenotypic plasticity or fixed genetic differences among individuals or populations is likely to be shaped by natural selection. Here, we first present a generalized framework describing the central role of mitochondria in processes linking env...
Source: Experimental Gerontology - May 5, 2020 Category: Geriatrics Authors: Gangloff EJ, Schwartz TS, Klabacka R, Huebschman N, Liu AY, Bronikowski AM Tags: Exp Gerontol Source Type: research

Reduced mitophagy in the cochlea of aged C57BL/6J mice.
Abstract An increase in mitochondrial damage has been associated with a decline in the ability to mitigate damage through mitophagy in age-related pathologies. The present study aimed to investigate the changes of mitophagy in a mouse model with age-related hearing loss. C57BL/6J mice were divided into two groups: young (1 month) and aged (12 months). Hearing tests were conducted through the measurement of auditory brainstem response (ABR). Mitochondrial DNA copy number, the level of mitochondrial DNA damage, mitochondrial biogenesis, and mitophagy-related genes and proteins were investigated using real-time P...
Source: Experimental Gerontology - May 5, 2020 Category: Geriatrics Authors: Oh J, Youn CK, Jun Y, Jo ER, Cho SI Tags: Exp Gerontol Source Type: research

More than a quarter century of the most prescribed sleeping pill: Systematic review of zolpidem use by older adults.
ga OT Abstract Zolpidem is widely used to treat insomnia of older adults despite that few randomized controlled studies were conducted in this group. We systematically reviewed the relevant literature on efficacy/effectiveness and safety of zolpidem use by elderly individuals in relevant databases completed with a manual search of key journals. Studies were required to include individuals aged ≥60 years under intervention with zolpidem compared to placebo or other hypnosedatives. Outcomes were either objectively- or subjectively-assessed improvements in specific sleep parameters and safety for clinical use. T...
Source: Experimental Gerontology - April 30, 2020 Category: Geriatrics Authors: Machado FV, Louzada LL, Cross NE, Camargos EF, Dang-Vu TT, Nóbrega OT Tags: Exp Gerontol Source Type: research

Quadriceps muscle electromyography activity during physical activities and resistance exercise modes in younger and older adults.
Abstract BACKGROUND: Understanding the root cause of the age-related impairment in muscle adaptive remodelling with resistance exercise training (RET) and developing pragmatic and accessible resistance exercise for older adults, are essential research directives. METHODS: We sought to determine whether indices of quadriceps muscle EMG activity in response to different modes of resistance exercise training (RET) and activities of daily living (ADL), differed between 15 healthy younger (25 ± 3 years) and 15 older (70 ± 5 years) adults. On four separate days, participants completed a ma...
Source: Experimental Gerontology - April 30, 2020 Category: Geriatrics Authors: Marshall RN, Morgan PT, Martinez-Valdez E, Breen L Tags: Exp Gerontol Source Type: research

Achilles tendon loading is lower in older adults than young adults across a broad range of walking speeds.
Abstract The purpose of this study was to investigate age-related differences in Achilles tendon loading during gait. Fourteen young (7F/7M, 26 ± 5 years) and older (7F/7M, 67 ± 5 years) adults without current neurological or orthopaedic impairment participated. Shear wave tensiometry was used to measure tendon stress by tracking Achilles tendon wave speed. The wave speed-stress relationship was calibrated using simultaneous tensiometer and force plate measures during a standing sway task. Tendon stress was computed from the force plate measures using subject-specific ultrasound measures ...
Source: Experimental Gerontology - April 29, 2020 Category: Geriatrics Authors: Ebrahimi A, Loegering IF, Martin JA, Pomeroy RL, Roth JD, Thelen DG Tags: Exp Gerontol Source Type: research

Selenoprotein S attenuates endothelial dysfunction in a diabetic vascular chip.
Abstract Endothelial dysfunction (ED) is a critical and initiating factor in the genesis of diabetic vascular complications whose occurrence and development is closely related to the complex intravascular microenvironment. However, currently, there is no dynamic model simulating the diabetic vascular endothelial microenvironment that can be used to investigate the mechanism underlying multifactor-induced ED. Here, we developed an integrated microfluidic chip as a new methodological platform to study vascular ED. Selenoprotein S (SELENOS) was found to be involved in the defense against oxidative stress-induced vasc...
Source: Experimental Gerontology - April 27, 2020 Category: Geriatrics Authors: Zhong Y, Yu S, Yu H, Yao J, Men L, Li Y, Wang Q, Du J Tags: Exp Gerontol Source Type: research

The effects of environmental stressors on candidate aging associated genes.
CONCLUSION: Our results suggest that the model we used was a fitting model for the assessment of environmental stressors on candidate gene expression. In addition, we established a cellular response to the environment via changes in gene expression. PMID: 32344118 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 25, 2020 Category: Geriatrics Authors: Andrawus M, Sharvit L, Shekhidem HA, Roichman A, Cohen HY, Atzmon G Tags: Exp Gerontol Source Type: research

Novel approach for pathogenesis of osteoporosis in ovariectomized rats as a model of postmenopausal osteoporosis.
CONCLUSIONS: Visceral obesity played a crucial role in the development of osteoporosis in ovariectomized rats through effects that might involve both osteoblasts and osteoclasts. PMID: 32339647 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 24, 2020 Category: Geriatrics Authors: Saleh N, Nassef NA, Shawky MK, Elshishiny MI, Saleh HA Tags: Exp Gerontol Source Type: research

MitoTEMPO provides an antiarrhythmic effect in aged-rats through attenuation of mitochondrial reactive oxygen species.
Abstract The death prevalence from cardiovascular disease is significantly high in elderly-populations, while mitochondrial-aging plays an important in abnormal function of vital organs through high mitochondrial ROS production. Mitochondria have a unique mode of action by providing ATP production and modulating the cytosolic Ca2+-signaling and maintain the redox status of cardiomyocytes. There is an aging-associated impairment in oxidative phosphorylation which causes a marked dysregulation of mitochondrial biogenesis. Therefore, we aimed to examine whether a mitochondria-targeting antioxidant, MitoTEMPO, can dir...
Source: Experimental Gerontology - April 20, 2020 Category: Geriatrics Authors: Olgar Y, Billur D, Tuncay E, Turan B Tags: Exp Gerontol Source Type: research

Association between regional brain volume and masticatory performance differed in cognitively impaired and non-impaired older people.
This study tested the hypothesis that the association between the structural signature of the right premotor cortex (which relates to sensorimotor integration) and masticatory performance would differ between cognitively impaired (CI) and healthy older people. Thirty-one CI and 31 non-CI older participants (aged 60-84 years; male: female = 28: 34) were recruited and between-group matched for the average age and sex ratio. All the participants received T1-weighted magnetic resonance imaging (MRI) and assessments of MP and the number of missing teeth (NMT). Voxel-based morphometry (VBM) was performed to quantify the gr...
Source: Experimental Gerontology - April 20, 2020 Category: Geriatrics Authors: Lin CS, Lin HH, Wang SJ, Fuh JL Tags: Exp Gerontol Source Type: research

miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2.
miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2. Exp Gerontol. 2020 Apr 19;:110954 Authors: Kim YJ, Kim SH, Park Y, Park J, Lee JH, Kim BC, Song WK Abstract Alzheimer's disease (AD) is the most common form of dementia with irreversible neurodegeneration. Accumulation of amyloid beta (Aβ) in the brain is considered to be a major cause of neuronal cell death in AD, but the neurotoxic mechanism of Aβ is not yet fully understood. Here, we focused on the role of microRNAs (miR...
Source: Experimental Gerontology - April 19, 2020 Category: Geriatrics Authors: Kim YJ, Kim SH, Park Y, Park J, Lee JH, Kim BC, Song WK Tags: Exp Gerontol Source Type: research

Muscle fatigability measured with Pneumatic and Hydraulic handgrip systems are not interchangeable.
ans I Abstract BACKGROUND: Fatigue resistance (FR) was here defined as the time during which grip strength (GS) drops to 50% of its maximum during sustained contraction. Since different GS systems exist, we compared FR obtained with Pneumatic (Pneu) and Hydraulic (Hydr) handgrip systems. Hand pain induced by both systems was also investigated since this might influence FR-outcomes. METHODS: 618 young controls (Y: reference group), 426 middle-aged (MA) and 234 old community-dwelling adults (OLD), and 50 hospitalized patients (HOSP) participated. FR was recorded with Pneu and Hydr. Grip work corrected for body ...
Source: Experimental Gerontology - April 18, 2020 Category: Geriatrics Authors: De Dobbeleer L, Beckwée D, Arnold P, Baudry S, Beyer I, Demarteau J, Lieten S, Punie Y, Bautmans I Tags: Exp Gerontol Source Type: research

DNA methylation of the RE-1 silencing transcription factor in peripheral blood mononuclear cells and gene expression of antioxidant enzyme in patients with late-onset Alzheimer disease.
inez M, López AD, García AM Abstract Late-onset Alzheimer disease (LOAD) is the most frequent cause of dementia in elderly adults. However, the factors determining disease onset remain unclear. In the elderly, the activation and expression of the gene encoding RE-1 silencing transcription factor (REST) may be a determinant of neuroprotective mechanisms and good amyloidogenic pathway management. In the present study, the minimal promoter region of REST1 was genetically and epigenetically analyzed in blood samples from 21 subjects with LOAD and 20 cognitively healthy elderly subjects. Genomic DNA was i...
Source: Experimental Gerontology - April 16, 2020 Category: Geriatrics Authors: Mundo IG, Vielma NMP, López MG, Fleury A, Basurto JC, Rosales-Hernández MC, Sixto-López Y, de Los Ángeles Martínez Godinez M, López AD, García AM Tags: Exp Gerontol Source Type: research

Impact of dehydroepianrosterone (DHEA) supplementation on serum levels of insulin-like growth factor 1 (IGF-1): A dose-response meta-analysis of randomized controlled trials.
CONCLUSION: DHEA supplementation may increase serum IGF-I levels especially in women and older subjects. However, further studies are warranted before DHEA can be recommended for clinical use. PMID: 32304719 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 15, 2020 Category: Geriatrics Authors: Xie M, Zhong Y, Xue Q, Wu M, Deng X, Santos HO, Tan SC, Kord-Varkaneh H, Jiao P Tags: Exp Gerontol Source Type: research

Executive function predicts decline in mobility after a fall: The MYHAT study.
CONCLUSIONS: Higher executive function may offer resilience to mobility decline after a fall, especially among older adults with other risk factors for mobility decline. Future studies should assess whether executive function may be a helpful risk index of fall-related physical functional decline in geriatric settings. PMID: 32302664 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 14, 2020 Category: Geriatrics Authors: Hughes TF, Beer JC, Jacobsen E, Ganguli M, Chang CH, Rosano C Tags: Exp Gerontol Source Type: research

Cardiovascular risk factors from childhood and midlife physical function: The Bogalusa Heart Study.
CONCLUSION: Cumulative burden of CVRFs from childhood were associated with worse physical function in midlife independent of adulthood CVRFs. PMID: 32294512 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 12, 2020 Category: Geriatrics Authors: Du T, Fernandez C, Barshop R, Guralnik J, Bazzano LA Tags: Exp Gerontol Source Type: research