Cellular senescence and the senescence-associated secretory phenotype: Potential therapeutic targets for renal fibrosis
Exp Gerontol. 2021 May 10:111403. doi: 10.1016/j.exger.2021.111403. Online ahead of print.ABSTRACTRenal fibrosis plays a crucial role in the progression of chronic kidney disease and end-stage renal disease. However, because the aetiology of this pathological process is complex and remains unclear, there is still no effective treatment. Cellular senescence and the senescence-associated secretory phenotype (SASP) have been reported to lead to renal fibrosis. This review first discusses the relationships among cellular senescence, the SASP and renal fibrosis. Then, the key role of the SASP in irreversible renal fibrosis, inc...
Source: Experimental Gerontology - May 13, 2021 Category: Geriatrics Authors: Wen-Juan Wang Xiang-Mei Chen Guang-Yan Cai Source Type: research

Sarcopenia is independently associated with parietal atrophy in older adults
CONCLUSIONS: This is the first study to explore associations between sarcopenia and global as well as regional brain atrophy in older adults. The sarcopenia group had higher rates of moderate to severe PA, GCA and MTA than the non-sarcopenia group. PA was significantly associated with sarcopenia in older adults. Further longitudinal studies are needed to address the mechanism and pathogenesis of brain atrophy and sarcopenia.PMID:33984449 | DOI:10.1016/j.exger.2021.111402 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 13, 2021 Category: Geriatrics Authors: Ying-Hsin Hsu Chih-Kuang Liang Ming-Yueh Chou Yu-Chun Wang Mei-Chen Liao Wei-Cheng Chang Chia-Chi Hsiao Ping-Hong Lai Yu-Te Lin Source Type: research

Load-velocity relationship in the horizontal leg-press exercise in older women and men
This study analyzed the predictive ability of movement velocity to estimate the relative load (i.e., % of one-repetition maximum [1RM]) during the horizontal leg-press exercise in older women and men. Twenty-four women and fourteen men living in community-dwelling centers volunteered to participate in this study. All participants performed a progressive loading test up to 1RM in the horizontal leg-press. The fastest peak velocity (PV) and mean velocity (MV) attained with each weight were collected for analysis. Linear regression equations were modeled for women and men. We observed very strong linear relationships between ...
Source: Experimental Gerontology - May 13, 2021 Category: Geriatrics Authors: Diogo Lu ís Marques Henrique Pereira Neiva Daniel Almeida Marinho C élia Nunes M ário Cardoso Marques Source Type: research

Cellular senescence and the senescence-associated secretory phenotype: Potential therapeutic targets for renal fibrosis
Exp Gerontol. 2021 May 10:111403. doi: 10.1016/j.exger.2021.111403. Online ahead of print.ABSTRACTRenal fibrosis plays a crucial role in the progression of chronic kidney disease and end-stage renal disease. However, because the aetiology of this pathological process is complex and remains unclear, there is still no effective treatment. Cellular senescence and the senescence-associated secretory phenotype (SASP) have been reported to lead to renal fibrosis. This review first discusses the relationships among cellular senescence, the SASP and renal fibrosis. Then, the key role of the SASP in irreversible renal fibrosis, inc...
Source: Experimental Gerontology - May 13, 2021 Category: Geriatrics Authors: Wen-Juan Wang Xiang-Mei Chen Guang-Yan Cai Source Type: research

Sarcopenia is independently associated with parietal atrophy in older adults
CONCLUSIONS: This is the first study to explore associations between sarcopenia and global as well as regional brain atrophy in older adults. The sarcopenia group had higher rates of moderate to severe PA, GCA and MTA than the non-sarcopenia group. PA was significantly associated with sarcopenia in older adults. Further longitudinal studies are needed to address the mechanism and pathogenesis of brain atrophy and sarcopenia.PMID:33984449 | DOI:10.1016/j.exger.2021.111402 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 13, 2021 Category: Geriatrics Authors: Ying-Hsin Hsu Chih-Kuang Liang Ming-Yueh Chou Yu-Chun Wang Mei-Chen Liao Wei-Cheng Chang Chia-Chi Hsiao Ping-Hong Lai Yu-Te Lin Source Type: research

Load-velocity relationship in the horizontal leg-press exercise in older women and men
This study analyzed the predictive ability of movement velocity to estimate the relative load (i.e., % of one-repetition maximum [1RM]) during the horizontal leg-press exercise in older women and men. Twenty-four women and fourteen men living in community-dwelling centers volunteered to participate in this study. All participants performed a progressive loading test up to 1RM in the horizontal leg-press. The fastest peak velocity (PV) and mean velocity (MV) attained with each weight were collected for analysis. Linear regression equations were modeled for women and men. We observed very strong linear relationships between ...
Source: Experimental Gerontology - May 13, 2021 Category: Geriatrics Authors: Diogo Lu ís Marques Henrique Pereira Neiva Daniel Almeida Marinho C élia Nunes M ário Cardoso Marques Source Type: research

Cellular senescence and the senescence-associated secretory phenotype: Potential therapeutic targets for renal fibrosis
Exp Gerontol. 2021 May 10:111403. doi: 10.1016/j.exger.2021.111403. Online ahead of print.ABSTRACTRenal fibrosis plays a crucial role in the progression of chronic kidney disease and end-stage renal disease. However, because the aetiology of this pathological process is complex and remains unclear, there is still no effective treatment. Cellular senescence and the senescence-associated secretory phenotype (SASP) have been reported to lead to renal fibrosis. This review first discusses the relationships among cellular senescence, the SASP and renal fibrosis. Then, the key role of the SASP in irreversible renal fibrosis, inc...
Source: Experimental Gerontology - May 13, 2021 Category: Geriatrics Authors: Wen-Juan Wang Xiang-Mei Chen Guang-Yan Cai Source Type: research

Sarcopenia is independently associated with parietal atrophy in older adults
CONCLUSIONS: This is the first study to explore associations between sarcopenia and global as well as regional brain atrophy in older adults. The sarcopenia group had higher rates of moderate to severe PA, GCA and MTA than the non-sarcopenia group. PA was significantly associated with sarcopenia in older adults. Further longitudinal studies are needed to address the mechanism and pathogenesis of brain atrophy and sarcopenia.PMID:33984449 | DOI:10.1016/j.exger.2021.111402 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 13, 2021 Category: Geriatrics Authors: Ying-Hsin Hsu Chih-Kuang Liang Ming-Yueh Chou Yu-Chun Wang Mei-Chen Liao Wei-Cheng Chang Chia-Chi Hsiao Ping-Hong Lai Yu-Te Lin Source Type: research

Load-velocity relationship in the horizontal leg-press exercise in older women and men
This study analyzed the predictive ability of movement velocity to estimate the relative load (i.e., % of one-repetition maximum [1RM]) during the horizontal leg-press exercise in older women and men. Twenty-four women and fourteen men living in community-dwelling centers volunteered to participate in this study. All participants performed a progressive loading test up to 1RM in the horizontal leg-press. The fastest peak velocity (PV) and mean velocity (MV) attained with each weight were collected for analysis. Linear regression equations were modeled for women and men. We observed very strong linear relationships between ...
Source: Experimental Gerontology - May 13, 2021 Category: Geriatrics Authors: Diogo Lu ís Marques Henrique Pereira Neiva Daniel Almeida Marinho C élia Nunes M ário Cardoso Marques Source Type: research

Shenqi Yizhi Granule attenuates A β < sub > 1-42 < /sub > induced cognitive dysfunction via inhibiting JAK2/STAT3 activated astrocyte reactivity
Exp Gerontol. 2021 May 8:111400. doi: 10.1016/j.exger.2021.111400. Online ahead of print.ABSTRACTShenqi Yizhi Granule (SYG), a modern preparation herbs based on the theory of traditional Chinese medicine, has been proved to be effective against Alzheimer's disease in clinical trials, APP/PS1 mice and 5XFAD transgenic mice. But the underlying mechanism remains ambiguous. Increasing evidence supports the crucial role of astrocyte reactivity in the pathogenesis of Alzheimer's disease (AD). In the present study, we attempt to explore the underlying mechanisms of SYG from astrocyte reactivity in Aβ1-42-induced rat model of...
Source: Experimental Gerontology - May 11, 2021 Category: Geriatrics Authors: Ping Li Qian Wu Xiaoqiong Li Bangyan Hu Wen Wen Shijun Xu Source Type: research

Leg press and chest press strength normative values by half-decades in older persons
This study developed age- and sex-specific normative strength values for older individuals. LP and CP 1-repetition maximum (1RM) values on Keiser A420 pneumatic machines were compiled from 445 older adults, ages 60-85y. Descriptive statistics and quartile rankings are reported, and two-way ANOVAs were conducted to determine differences between sex and age groups. There were significant sex x age group interactions for LP and CP. Men were significantly stronger than women across all age groups for both exercises (p
Source: Experimental Gerontology - May 11, 2021 Category: Geriatrics Authors: Rosalia L Parrino Keri L Strand Adam C Hockman Joseph F Signorile Source Type: research

Shenqi Yizhi Granule attenuates A β < sub > 1-42 < /sub > induced cognitive dysfunction via inhibiting JAK2/STAT3 activated astrocyte reactivity
Exp Gerontol. 2021 May 8:111400. doi: 10.1016/j.exger.2021.111400. Online ahead of print.ABSTRACTShenqi Yizhi Granule (SYG), a modern preparation herbs based on the theory of traditional Chinese medicine, has been proved to be effective against Alzheimer's disease in clinical trials, APP/PS1 mice and 5XFAD transgenic mice. But the underlying mechanism remains ambiguous. Increasing evidence supports the crucial role of astrocyte reactivity in the pathogenesis of Alzheimer's disease (AD). In the present study, we attempt to explore the underlying mechanisms of SYG from astrocyte reactivity in Aβ1-42-induced rat model of...
Source: Experimental Gerontology - May 11, 2021 Category: Geriatrics Authors: Ping Li Qian Wu Xiaoqiong Li Bangyan Hu Wen Wen Shijun Xu Source Type: research

Leg press and chest press strength normative values by half-decades in older persons
This study developed age- and sex-specific normative strength values for older individuals. LP and CP 1-repetition maximum (1RM) values on Keiser A420 pneumatic machines were compiled from 445 older adults, ages 60-85y. Descriptive statistics and quartile rankings are reported, and two-way ANOVAs were conducted to determine differences between sex and age groups. There were significant sex x age group interactions for LP and CP. Men were significantly stronger than women across all age groups for both exercises (p
Source: Experimental Gerontology - May 11, 2021 Category: Geriatrics Authors: Rosalia L Parrino Keri L Strand Adam C Hockman Joseph F Signorile Source Type: research

The effect of vitamin D supplementation on circulating osteoprogenitor cells, a pilot randomized controlled trial
Exp Gerontol. 2021 May 7:111399. doi: 10.1016/j.exger.2021.111399. Online ahead of print.ABSTRACTCirculating osteoprogenitor (COP) cells are a relatively newly discovered mesenchymal precursors population in the peripheral blood. While some aspects of their physiology have been documented in vitro, little is known about their behavior in vivo. To facilitate understanding regarding their potential role in the management of musculoskeletal disease, more research into how these cells respond to growth factors and hormones in vivo. To this end, we performed a randomized controlled pilot study investigating the effect of vitami...
Source: Experimental Gerontology - May 10, 2021 Category: Geriatrics Authors: Jack Feehan Elizabeth Degabrielle Nicholas Tripodi Ahmed Al Saedi Sara Vogrin Gustavo Duque Source Type: research

Inhibition of mTOR by rapamycin does not improve hypoxic pulmonary hypertension-induced right heart failure in old mice
Exp Gerontol. 2021 May 7:111395. doi: 10.1016/j.exger.2021.111395. Online ahead of print.ABSTRACTInhibition of the mammalian target of rapamycin (mTOR) by rapamycin attenuates heart failure (HF) and age-associated changes in left ventricular (LV) function. Rapamycin has also been suggested as a therapy for pulmonary hypertension (PH) and concomitant right heart failure (PH-RHF) based on reports of elevated mTOR signaling in young models with PH. However, rapamycin has yet to be tested in the setting of aging, PH, and right heart disease despite the fact that RV function predicts survival in both age-related HF as well as s...
Source: Experimental Gerontology - May 10, 2021 Category: Geriatrics Authors: Benjamin D McNair Jacob A Schlatter Ross F Cook Musharraf Yusifova Danielle R Bruns Source Type: research

The effect of vitamin D supplementation on circulating osteoprogenitor cells, a pilot randomized controlled trial
Exp Gerontol. 2021 May 7:111399. doi: 10.1016/j.exger.2021.111399. Online ahead of print.ABSTRACTCirculating osteoprogenitor (COP) cells are a relatively newly discovered mesenchymal precursors population in the peripheral blood. While some aspects of their physiology have been documented in vitro, little is known about their behavior in vivo. To facilitate understanding regarding their potential role in the management of musculoskeletal disease, more research into how these cells respond to growth factors and hormones in vivo. To this end, we performed a randomized controlled pilot study investigating the effect of vitami...
Source: Experimental Gerontology - May 10, 2021 Category: Geriatrics Authors: Jack Feehan Elizabeth Degabrielle Nicholas Tripodi Ahmed Al Saedi Sara Vogrin Gustavo Duque Source Type: research

Inhibition of mTOR by rapamycin does not improve hypoxic pulmonary hypertension-induced right heart failure in old mice
Exp Gerontol. 2021 May 7:111395. doi: 10.1016/j.exger.2021.111395. Online ahead of print.ABSTRACTInhibition of the mammalian target of rapamycin (mTOR) by rapamycin attenuates heart failure (HF) and age-associated changes in left ventricular (LV) function. Rapamycin has also been suggested as a therapy for pulmonary hypertension (PH) and concomitant right heart failure (PH-RHF) based on reports of elevated mTOR signaling in young models with PH. However, rapamycin has yet to be tested in the setting of aging, PH, and right heart disease despite the fact that RV function predicts survival in both age-related HF as well as s...
Source: Experimental Gerontology - May 10, 2021 Category: Geriatrics Authors: Benjamin D McNair Jacob A Schlatter Ross F Cook Musharraf Yusifova Danielle R Bruns Source Type: research

The impact of exercise training on inflammatory markers in postmenopausal women: A systemic review and meta-analysis
Exp Gerontol. 2021 May 7;150:111398. doi: 10.1016/j.exger.2021.111398. Online ahead of print.ABSTRACTBACKGROUND: The postmenopausal stage of life is associated with increased systemic inflammation that may be mitigated through exercise training. The effects of exercise training on inflammatory markers in postmenopausal women, however, require further elucidation. We therefore performed a systematic review and meta-analysis to investigate the available high-quality research on the effects of exercise training on inflammatory markers in postmenopausal women.METHOD: Electronic searches in PubMed, Scopus, Cochrane Central Regi...
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Mousa Khalafi Abbas Malandish Sara K Rosenkranz Source Type: research

Predictive equation for assessing appendicular lean soft tissue mass using bioelectric impedance analysis in older adults: Effect of body fat distribution
Exp Gerontol. 2021 May 6;150:111393. doi: 10.1016/j.exger.2021.111393. Online ahead of print.ABSTRACTBACKGROUND: Low muscle mass is associated with sarcopenia and increased mortality. Muscle mass, especially that of the limbs, is commonly estimated by dual-energy X-ray absorptiometry (DXA) or bioimpedance analysis (BIA). However, BIA-based predictive equations for estimating lean appendicular soft tissue mass (ALST) do not take into account body fat distribution, an important factor influencing DXA and BIA measurements.OBJECTIVES: To develop and cross-validate a BIA-based equation for estimating ALST with DXA as criterion,...
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: S Toselli F Campa C N Matias Bruna Spolador de Alencar Silva Vanessa Ribeiro Dos Santos P Maietta Latessa L A Gobbo Source Type: research

Red blood cell distribution width is associated with frailty in older inpatients in China: Sex differences in a cross-sectional study
This study aimed to determine whether there were sex-specific associations of RDW and frailty among older hospitalized patients.METHODS: A cross-sectional study was conducted in a comprehensive tertiary hospital in mainland China between February 2015 and November 2017. Hospitalized patients aged 60 years and above were included. Frailty was defined according to Fried's frailty phenotype. Data on patients' demographics, clinical characteristics, and inflammatory markers were collected. The association was evaluated by using the linear and logistic regression modeling.RESULTS: The frailty prevalence was 26.65% (89/334) in m...
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Qiuping Li Xi Chen Binru Han Source Type: research

Effects of task-oriented training combined with aerobic training on serum BDNF, GDNF, IGF-1, VEGF, TNF- α, and IL-1β levels in people with Parkinson's disease: A randomized controlled study
CONCLUSION: TOT-AT could not be an effective exercise method for changing serum concentrations of BDNF, GDNF, IGF-1, VEGF, TNF-α, and IL-1β in the rehabilitation of PD.PMID:33965556 | DOI:10.1016/j.exger.2021.111384 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Fatih Soke Bilge Kocer Isil Fidan Pembe Keskinoglu Arzu Guclu-Gunduz Source Type: research

SIRT1 suppresses cellular senescence and inflammatory cytokine release in human dermal fibroblasts by promoting the deacetylation of NF- κB and activating autophagy
Exp Gerontol. 2021 May 6;150:111394. doi: 10.1016/j.exger.2021.111394. Online ahead of print.ABSTRACTSkin aging is a complex process and involves extrinsic and intrinsic processes with distinct characteristics. Understanding skin aging requires knowledge of the senescence of human dermal fibroblasts (HDFs) and the biological mechanisms involved in this process. However, the molecular mechanism responsible for the aging of HDFs is still not clear. Therefore, we investigated mechanisms of autophagy, inflammation, and cellular senescence by Western blotting, immunofluorescence, real-time PCR, and senescence-associated β-...
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Jin Young Sung Seul Gi Kim Jae-Ryong Kim Hyoung Chul Choi Source Type: research

Echo intensity is more useful in predicting hospital-associated complications than conventional sarcopenia-related parameters in acute hospitalized older patients
CONCLUSIONS: Corrected echo intensity might be a useful parameter to help predict hospital-associated complication in acute hospitalized older patients and might contribute to establishing a strategy to prevent hospital-associated complication.PMID:33965558 | DOI:10.1016/j.exger.2021.111397 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Masaaki Nagae Hiroyuki Umegaki Akito Yoshiko Kosuke Fujita Hitoshi Komiya Kazuhisa Watanabe Yosuke Yamada Masafumi Kuzuya Source Type: research

The impact of exercise training on inflammatory markers in postmenopausal women: A systemic review and meta-analysis
Exp Gerontol. 2021 May 6:111398. doi: 10.1016/j.exger.2021.111398. Online ahead of print.ABSTRACTBACKGROUND: The postmenopausal stage of life is associated with increased systemic inflammation that may be mitigated through exercise training. The effects of exercise training on inflammatory markers in postmenopausal women, however, require further elucidation. We therefore performed a systematic review and meta-analysis to investigate the available high-quality research on the effects of exercise training on inflammatory markers in postmenopausal women.METHOD: Electronic searches in PubMed, Scopus, Cochrane Central Register...
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Mousa Khalafi Abbas Malandish Sara K Rosenkranz Source Type: research

Predictive equation for assessing appendicular lean soft tissue mass using bioelectric impedance analysis in older adults: Effect of body fat distribution
Exp Gerontol. 2021 May 6:111393. doi: 10.1016/j.exger.2021.111393. Online ahead of print.ABSTRACTBACKGROUND: Low muscle mass is associated with sarcopenia and increased mortality. Muscle mass, especially that of the limbs, is commonly estimated by dual-energy X-ray absorptiometry (DXA) or bioimpedance analysis (BIA). However, BIA-based predictive equations for estimating lean appendicular soft tissue mass (ALST) do not take into account body fat distribution, an important factor influencing DXA and BIA measurements.OBJECTIVES: To develop and cross-validate a BIA-based equation for estimating ALST with DXA as criterion, and...
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: S Toselli F Campa N C Matias Bruna Spolador de Alencar Silva Vanessa Ribeiro Dos Santos P Maietta Latessa L A Gobbo Source Type: research

Red blood cell distribution width is associated with frailty in older inpatients in China: Sex differences in a cross-sectional study
This study aimed to determine whether there were sex-specific associations of RDW and frailty among older hospitalized patients.METHODS: A cross-sectional study was conducted in a comprehensive tertiary hospital in mainland China between February 2015 and November 2017. Hospitalized patients aged 60 years and above were included. Frailty was defined according to Fried's frailty phenotype. Data on patients' demographics, clinical characteristics, and inflammatory markers were collected. The association was evaluated by using the linear and logistic regression modeling.RESULTS: The frailty prevalence was 26.65% (89/334) in m...
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Qiuping Li Xi Chen Binru Han Source Type: research

Effects of task-oriented training combined with aerobic training on serum BDNF, GDNF, IGF-1, VEGF, TNF- α, and IL-1β levels in people with Parkinson's disease: A randomized controlled study
CONCLUSION: TOT-AT could not be an effective exercise method for changing serum concentrations of BDNF, GDNF, IGF-1, VEGF, TNF-α, and IL-1β in the rehabilitation of PD.PMID:33965556 | DOI:10.1016/j.exger.2021.111384 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Fatih Soke Bilge Kocer Isil Fidan Pembe Keskinoglu Arzu Guclu-Gunduz Source Type: research

SIRT1 suppresses cellular senescence and inflammatory cytokine release in human dermal fibroblasts by promoting the deacetylation of NF- κB and activating autophagy
Exp Gerontol. 2021 May 6:111394. doi: 10.1016/j.exger.2021.111394. Online ahead of print.ABSTRACTSkin aging is a complex process and involves extrinsic and intrinsic processes with distinct characteristics. Understanding skin aging requires knowledge of the senescence of human dermal fibroblasts (HDFs) and the biological mechanisms involved in this process. However, the molecular mechanism responsible for the aging of HDFs is still not clear. Therefore, we investigated mechanisms of autophagy, inflammation, and cellular senescence by Western blotting, immunofluorescence, real-time PCR, and senescence-associated β-gala...
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Jin Young Sung Seul Gi Kim Jae-Ryong Kim Hyoung Chul Choi Source Type: research

Echo intensity is more useful in predicting hospital-associated complications than conventional sarcopenia-related parameters in acute hospitalized older patients
CONCLUSIONS: Corrected echo intensity might be a useful parameter to help predict hospital-associated complication in acute hospitalized older patients and might contribute to establishing a strategy to prevent hospital-associated complication.PMID:33965558 | DOI:10.1016/j.exger.2021.111397 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 9, 2021 Category: Geriatrics Authors: Masaaki Nagae Hiroyuki Umegaki Akito Yoshiko Kosuke Fujita Hitoshi Komiya Kazuhisa Watanabe Yosuke Yamada Masafumi Kuzuya Source Type: research

Effect of regular resistance training on memory in older adults: A systematic review
Exp Gerontol. 2021 May 5:111396. doi: 10.1016/j.exger.2021.111396. Online ahead of print.ABSTRACTThe purpose of this study was to evaluate the effect of regular resistance training on memory in older adults.METHODS: Eight databases (PubMed, Cochrane Library, EMBASE, Web of Science, SinoMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP) and Wanfang) were searched from their inception to March 24, 2021. The data included in the study were analysed according to the Cochrane handbook using Review Manager 5.3 software.RESULTS: Eighteen eligible randomized controlled trial...
Source: Experimental Gerontology - May 8, 2021 Category: Geriatrics Authors: Jiawei Wu Xiaoqian Wang Mingzhu Ye Lecong Wang Guohua Zheng Source Type: research

Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)
CONCLUSIONS AND IMPLICATIONS: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.PMID:33962026 | DOI:10.1016/j.exger.2021.111390 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 7, 2021 Category: Geriatrics Authors: Nat ália Oiring de Castro Cezar Ivan Aprahamian Juliana Hotta Ansai Marcos Paulo Braz de Oliveira Danielle Chagas Pereira da Silva Wildja de Lima Gomes Bruna Anzolin Barreiros Tamiris de C ássia Oliva Langelli Larissa Pires de Andrade Source Type: research

Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)
CONCLUSIONS AND IMPLICATIONS: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.PMID:33962026 | DOI:10.1016/j.exger.2021.111390 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 7, 2021 Category: Geriatrics Authors: Nat ália Oiring de Castro Cezar Ivan Aprahamian Juliana Hotta Ansai Marcos Paulo Braz de Oliveira Danielle Chagas Pereira da Silva Wildja de Lima Gomes Bruna Anzolin Barreiros Tamiris de C ássia Oliva Langelli Larissa Pires de Andrade Source Type: research

Immunomodulatory effect of pentagalloyl glucose in LPS-stimulated RAW264.7 macrophages and PAO1-induced Caenorhabditis elegans
In this study, to elucidate comprehensively the function of immunomodulation and its underlying mechanism of PGG in vitro and in vivo, two model systems were conducted, which including lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages cells and Pseudomonas aeruginosa (PAO1)-induced Caenorhabditis elegans (C. elegans). Current results showed that PGG significantly inhibited secretions of tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and mediator nitric oxide (NO) in LPS-stimulated RAW264.7 cells. In addition, the expression of genes nitric oxide synthase (iNOS), TN...
Source: Experimental Gerontology - May 6, 2021 Category: Geriatrics Authors: Xiaoying Zhang Wei Li Konglong Feng Jie Xiao Jie Du Yong Cao Yunjiao Chen Source Type: research

Comparative evaluation of inflammatory parameters and substitute insulin resistance indices in elderly women with and without type 2 diabetes mellitus
Exp Gerontol. 2021 May 3:111389. doi: 10.1016/j.exger.2021.111389. Online ahead of print.ABSTRACTPURPOSE: To analyze the influence of inflammatory parameters and substitute insulin resistance indices on the risk of type 2 diabetes mellitus (DM) development in elderly women, as well as to compare anthropometric measures and metabolic parameters according to the presence of type 2 DM and HbA1c levels.PATIENTS AND METHODS: One hundred and twenty elderly women (67.9 ± 6.0 years) were submitted to anthropometric analysis, determination of inflammatory and metabolic parameters. They also underwent indices of lipid accumul...
Source: Experimental Gerontology - May 6, 2021 Category: Geriatrics Authors: Mateus Medeiros Leite Maur ílio Tiradentes Dutra Manoela Vieira Gomes da Costa Silvana Schwerz Funghetto Alessandro de Oliveira Silva Luciano Ramos de Lima Izabel Cristina Rodrigues da Silva M árcio Rabelo Mota Marina Morato Stival Source Type: research

Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism
Exp Gerontol. 2021 May 3;150:111387. doi: 10.1016/j.exger.2021.111387. Online ahead of print.ABSTRACTResearchers studying the effect of folate restriction on rodents have resorted to the use of the antibiotic succinylsulfathiazole (SST) in the folate depleted diet to induce a folate deficient status. SST has been used extensively in rodent studies since the 1940s. Its localized effect on the gut bacteria as well as its effectiveness in reducing folate producing species is well documented. The possible overlap between the pathways affected by folate depletion and SST could potentially produce a confounding variable in such ...
Source: Experimental Gerontology - May 6, 2021 Category: Geriatrics Authors: Safa Beydoun Ali M Fardous Michael M Saruna Ali G Beydoun Johnathan A Sorge Hongzhi Ma Ghada Aoun Archana Unnikrishnan Diane C Cabelof Ahmad R Heydari Source Type: research

Performance during reactive handrail grasping during forward walking by young and older adults with and without prior knowledge of the direction of movement is correlated with grip strength
The objective of this study was to evaluate balance responses to weight shifting during walking and to investigate age-related changes in movement and strength. Thirty-two participants (16 young, 16 older) completed 12 straight walking trials and 6 trials in each condition where a weight shift was required to grasp a handrail. Instructions were to walk down the pathway and, if cued, grasp the handrail as quickly as possible. Conditions included left and right grasping trials, with and without prior knowledge about the movement direction. Kinematic data were recorded and center of mass (COM) was calculated to examine whole ...
Source: Experimental Gerontology - May 6, 2021 Category: Geriatrics Authors: Emily I McIntosh Lori Ann Vallis Source Type: research

Immunomodulatory effect of pentagalloyl glucose in LPS-stimulated RAW264.7 macrophages and PAO1-induced Caenorhabditis elegans
In this study, to elucidate comprehensively the function of immunomodulation and its underlying mechanism of PGG in vitro and in vivo, two model systems were conducted, which including lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages cells and Pseudomonas aeruginosa (PAO1)-induced Caenorhabditis elegans (C. elegans). Current results showed that PGG significantly inhibited secretions of tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and mediator nitric oxide (NO) in LPS-stimulated RAW264.7 cells. In addition, the expression of genes nitric oxide synthase (iNOS), TN...
Source: Experimental Gerontology - May 6, 2021 Category: Geriatrics Authors: Xiaoying Zhang Wei Li Konglong Feng Jie Xiao Jie Du Yong Cao Yunjiao Chen Source Type: research

Comparative evaluation of inflammatory parameters and substitute insulin resistance indices in elderly women with and without type 2 diabetes mellitus
Exp Gerontol. 2021 May 3:111389. doi: 10.1016/j.exger.2021.111389. Online ahead of print.ABSTRACTPURPOSE: To analyze the influence of inflammatory parameters and substitute insulin resistance indices on the risk of type 2 diabetes mellitus (DM) development in elderly women, as well as to compare anthropometric measures and metabolic parameters according to the presence of type 2 DM and HbA1c levels.PATIENTS AND METHODS: One hundred and twenty elderly women (67.9 ± 6.0 years) were submitted to anthropometric analysis, determination of inflammatory and metabolic parameters. They also underwent indices of lipid accumul...
Source: Experimental Gerontology - May 6, 2021 Category: Geriatrics Authors: Mateus Medeiros Leite Maur ílio Tiradentes Dutra Manoela Vieira Gomes da Costa Silvana Schwerz Funghetto Alessandro de Oliveira Silva Luciano Ramos de Lima Izabel Cristina Rodrigues da Silva M árcio Rabelo Mota Marina Morato Stival Source Type: research

Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism
Exp Gerontol. 2021 May 3:111387. doi: 10.1016/j.exger.2021.111387. Online ahead of print.ABSTRACTResearchers studying the effect of folate restriction on rodents have resorted to the use of the antibiotic succinylsulfathiazole (SST) in the folate depleted diet to induce a folate deficient status. SST has been used extensively in rodent studies since the 1940s. Its localized effect on the gut bacteria as well as its effectiveness in reducing folate producing species is well documented. The possible overlap between the pathways affected by folate depletion and SST could potentially produce a confounding variable in such stud...
Source: Experimental Gerontology - May 6, 2021 Category: Geriatrics Authors: Safa Beydoun Ali M Fardous Michael M Saruna Ali G Beydoun Johnathan A Sorge Hongzhi Ma Ghada Aoun Archana Unnikrishnan Diane C Cabelof Ahmad R Heydari Source Type: research

Performance during reactive handrail grasping during forward walking by young and older adults with and without prior knowledge of the direction of movement is correlated with grip strength
The objective of this study was to evaluate balance responses to weight shifting during walking and to investigate age-related changes in movement and strength. Thirty-two participants (16 young, 16 older) completed 12 straight walking trials and 6 trials in each condition where a weight shift was required to grasp a handrail. Instructions were to walk down the pathway and, if cued, grasp the handrail as quickly as possible. Conditions included left and right grasping trials, with and without prior knowledge about the movement direction. Kinematic data were recorded and center of mass (COM) was calculated to examine whole ...
Source: Experimental Gerontology - May 6, 2021 Category: Geriatrics Authors: Emily I McIntosh Lori Ann Vallis Source Type: research

The comparison of age- and sex-specific alteration in pubic bone microstructure: A cross-sectional cadaveric study
Exp Gerontol. 2021 Apr 30:111375. doi: 10.1016/j.exger.2021.111375. Online ahead of print.ABSTRACTBACKGROUND: The burden of age-associated fragility fracture of the pelvis has gradually amplified over the years. Commonly used clinical tools cannot fully explain age-associated fracture risk increase, and microstructural analysis could be required to elucidate pubic bone strength decline in elderly.MATERIAL AND METHODS: The study sample encompassed 46 pubic bones obtained from cadaveric donors divided into a young women (60 years, n = 11), young men (60 years, n = 12). Micro-computed tomography was used to evaluate the corti...
Source: Experimental Gerontology - May 3, 2021 Category: Geriatrics Authors: Jelena Jadzic Jovana Mijucic Slobodan Nikolic Marija Djuric Danijela Djonic Source Type: research

The comparison of age- and sex-specific alteration in pubic bone microstructure: A cross-sectional cadaveric study
Exp Gerontol. 2021 Apr 30:111375. doi: 10.1016/j.exger.2021.111375. Online ahead of print.ABSTRACTBACKGROUND: The burden of age-associated fragility fracture of the pelvis has gradually amplified over the years. Commonly used clinical tools cannot fully explain age-associated fracture risk increase, and microstructural analysis could be required to elucidate pubic bone strength decline in elderly.MATERIAL AND METHODS: The study sample encompassed 46 pubic bones obtained from cadaveric donors divided into a young women (60 years, n = 11), young men (60 years, n = 12). Micro-computed tomography was used to evaluate the corti...
Source: Experimental Gerontology - May 3, 2021 Category: Geriatrics Authors: Jelena Jadzic Jovana Mijucic Slobodan Nikolic Marija Djuric Danijela Djonic Source Type: research

The comparison of age- and sex-specific alteration in pubic bone microstructure: A cross-sectional cadaveric study
Exp Gerontol. 2021 Apr 30:111375. doi: 10.1016/j.exger.2021.111375. Online ahead of print.ABSTRACTBACKGROUND: The burden of age-associated fragility fracture of the pelvis has gradually amplified over the years. Commonly used clinical tools cannot fully explain age-associated fracture risk increase, and microstructural analysis could be required to elucidate pubic bone strength decline in elderly.MATERIAL AND METHODS: The study sample encompassed 46 pubic bones obtained from cadaveric donors divided into a young women (60 years, n = 11), young men (60 years, n = 12). Micro-computed tomography was used to evaluate the corti...
Source: Experimental Gerontology - May 3, 2021 Category: Geriatrics Authors: Jelena Jadzic Jovana Mijucic Slobodan Nikolic Marija Djuric Danijela Djonic Source Type: research

Association between knee extensor and ankle plantarflexor muscle thickness and echo intensity with postural sway, mobility and physical function in older adults
Exp Gerontol. 2021 Apr 28;150:111385. doi: 10.1016/j.exger.2021.111385. Online ahead of print.ABSTRACTThe purpose of this study was to assess the association between muscle thickness and echo intensity of the knee extensors and ankle plantarflexors with postural sway, mobility and physical function in older adults. Twenty-one older men and women (age; 69.9 ± 4.3 years) were assessed for postural sway (centre of pressure movement), mobility (i.e. Timed-Up and-Go-test [TUG]), physical function (i.e. 5 times sit-to-stand [STS]), and ultrasound derived measures of muscle thickness and echo intensity of the vastus latera...
Source: Experimental Gerontology - May 1, 2021 Category: Geriatrics Authors: Mathew William Hill Matthew Roberts Michael James Price Anthony David Kay Source Type: research

Association between knee extensor and ankle plantarflexor muscle thickness and echo intensity with postural sway, mobility and physical function in older adults
Exp Gerontol. 2021 Apr 28:111385. doi: 10.1016/j.exger.2021.111385. Online ahead of print.ABSTRACTThe purpose of this study was to assess the association between muscle thickness and echo intensity of the knee extensors and ankle plantarflexors with postural sway, mobility and physical function in older adults. Twenty-one older men and women (age; 69.9 ± 4.3 years) were assessed for postural sway (centre of pressure movement), mobility (i.e. Timed-Up and-Go-test [TUG]), physical function (i.e. 5 times sit-to-stand [STS]), and ultrasound derived measures of muscle thickness and echo intensity of the vastus lateralis ...
Source: Experimental Gerontology - May 1, 2021 Category: Geriatrics Authors: Matthew Roberts Michael James Price Anthony David Kay Mathew William Hill Source Type: research

Association between knee extensor and ankle plantarflexor muscle thickness and echo intensity with postural sway, mobility and physical function in older adults
Exp Gerontol. 2021 Apr 28:111385. doi: 10.1016/j.exger.2021.111385. Online ahead of print.ABSTRACTThe purpose of this study was to assess the association between muscle thickness and echo intensity of the knee extensors and ankle plantarflexors with postural sway, mobility and physical function in older adults. Twenty-one older men and women (age; 69.9 ± 4.3 years) were assessed for postural sway (centre of pressure movement), mobility (i.e. Timed-Up and-Go-test [TUG]), physical function (i.e. 5 times sit-to-stand [STS]), and ultrasound derived measures of muscle thickness and echo intensity of the vastus lateralis ...
Source: Experimental Gerontology - May 1, 2021 Category: Geriatrics Authors: Matthew Roberts Michael James Price Anthony David Kay Mathew William Hill Source Type: research

Associations between hemoglobin levels and sarcopenia and its components: Results from the I-Lan longitudinal study
Exp Gerontol. 2021 Apr 27:111379. doi: 10.1016/j.exger.2021.111379. Online ahead of print.ABSTRACTBACKGROUND: As a biomarker for anemia and nutritional status, hemoglobin may play various roles in the development of sarcopenia, but studies evaluating these roles are scarce. Hence, this study aimed to explore the associations between hemoglobin levels and sarcopenia and its components and to determine optimal cutoffs of hemoglobin for identifying sarcopenia.METHODS: Data from 730 participants identified from the I-Lan Longitudinal Aging Study were retrieved. Anemia was defined by the World Health Organization criteria as a hemoglobin level
Source: Experimental Gerontology - April 30, 2021 Category: Geriatrics Authors: Sung-Hua Tseng Wei-Ju Lee Li-Ning Peng Ming-Hsien Lin Liang-Kung Chen Source Type: research

Risk of non-vertebral fractures in men with type 2 diabetes: A systematic review and meta-analysis of cohort studies
CONCLUSION: Male patients with T2DM have a slightly increased risk of non-vertebral fractures. Due to the differences in bone strength, sex steroid hormone levels, bone quality and muscle strength and balance, men with type 2 diabetes have a lower risk of non-vertebral fractures than women.PMID:33905874 | DOI:10.1016/j.exger.2021.111378 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 27, 2021 Category: Geriatrics Authors: Yang Gao Fang Chai Source Type: research

Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson's disease
In this study we evaluate the effects of three dominant SCFAs (acetate, propionate and butyrate) on motor damage, dopaminergic neuronal degeneration and underlying neuroinflammation related mechanisms in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD mice. High (2.0 g/kg) or low doses (0.2 g/kg) of sodium acetate (NaA), sodium propionate (NaP) or sodium butyrate (NaB) were gavaged into PD mice for 6 weeks. High doses of NaA reduced the turning time of PD mice. NaB significantly reduced the turning and total time in pole test, and increased the average velocity in open field test when compared with PD mic...
Source: Experimental Gerontology - April 27, 2021 Category: Geriatrics Authors: Yichao Hou Xingqi Li Chang Liu Ming Zhang Xiaoying Zhang Shaoyang Ge Liang Zhao Source Type: research

Beta 2 microglobulin correlates with oxidative stress in elderly
Exp Gerontol. 2021 Apr 24:111359. doi: 10.1016/j.exger.2021.111359. Online ahead of print.ABSTRACTBeta 2 microglobulin (Β2M) is expressed in all nucleated cells, it interplays with mediators to regulate and modulate cellular functions. Its role in aging associated disorders has been documented recently. Oxidative stress has been known to play a direct implication on these disorders. Therefore, there is a rationality to explore the function of Β2M in oxidative stress in elderly people. The aim of the study was to assess the Β2M levels in different group of age, and to study the correlation between Β2M an...
Source: Experimental Gerontology - April 27, 2021 Category: Geriatrics Authors: Mohammad Althubiti Mohamed Elzubier Ghazzi Sallih Alotaibi Mohammed Abdullah Althubaiti Hazim Hamed Alsadi Ziyad Abdulaziz Alhazmi Fares Alghamdi Mahmoud Zaki El-Readi Riyad Almaimani Abdullatif Babakr Source Type: research