Intervention with a combined physical exercise training to reduce oxidative stress of women over 40  years of age.
Intervention with a combined physical exercise training to reduce oxidative stress of women over 40 years of age. Exp Gerontol. 2019 May 15;: Authors: Mota MP, Dos Santos ZA, Soares JFP, de Fátima Pereira A, João PV, O'Neil Gaivão I, Oliveira MM Abstract Exercise training has been shown to be one of the most important lifestyle factor for improving functional performance and health status. Nevertheless, and although some evidence exists about the effects of aerobic training on oxidative stress, there is scarce information concerning the effects of combined exercise training (aer...
Source: Experimental Gerontology - May 15, 2019 Category: Geriatrics Authors: Mota MP, Dos Santos ZA, Soares JFP, de Fátima Pereira A, João PV, O'Neil Gaivão I, Oliveira MM Tags: Exp Gerontol Source Type: research

Impact of housing conditions on social behavior, neuroimmune markers, and oxytocin receptor expression in aged male and female Fischer 344 rats.
Abstract Aging is associated with a substantial decline in social behavior, whereas positive social interaction can improve overall health in aged individuals. In laboratory rodents, manipulations of the social environment across the lifespan have been shown to affect social behavior. Therefore, we examined the effects of long-term (5-6 weeks) housing conditions (alone, with one adult, or with two adults) on social behavior and the expression of neuroinflammation-related genes as well as oxytocin receptor (OXTR) gene expression in brain areas associated with social behavior regulation in aged male and female Fis...
Source: Experimental Gerontology - May 14, 2019 Category: Geriatrics Authors: Perkins AE, Varlinskaya EI, Deak T Tags: Exp Gerontol Source Type: research

Plasma matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs and aging and lifelong exercise adaptations in ventricular and arterial stiffness.
In conclusion, there was not a clear or consistent difference in plasma MMPs and TIMPs with lifelong exercise dose despite exhibiting lower cardiovascular stiffness at the highest exercise levels. PMID: 31095969 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 13, 2019 Category: Geriatrics Authors: Carrick-Ranson G, Spinale FG, Bhella PS, Sarma S, Shibata S, Fujimoto N, Hastings JL, Levine BD Tags: Exp Gerontol Source Type: research

Physical performance, plasma S-klotho, and all-cause mortality in elderly dialysis patients: A prospective cohort study.
ntiago C, Ruiz MP Abstract The secreted protein form of the α-klotho gene, S-klotho, is gaining popularity as a predictor of overall morbimortality, and its role in dialysis patients has been recently highlighted. However, physical performance -which can be assessed through practical field-tests- might be a more practical prognostic marker. The present study aimed to analyze the relationship between physical performance, plasma S-klotho and all-cause mortality in this population. 30 male hemodialysis patients (71 ± 9 years) participated in this prospective, cohort study. Their plasma S-klotho le...
Source: Experimental Gerontology - May 8, 2019 Category: Geriatrics Authors: Valenzuela PL, Cobo F, Vega ID, Sánchez-Hernández R, Pedrero-Chamizo R, Verde-Rello Z, González-Gross M, Santiago C, Ruiz MP Tags: Exp Gerontol Source Type: research

Brain gray matter volume associations with gait speed and related structural covariance networks in cognitively healthy individuals and in patients with mild cognitive impairment: A cross-sectional study.
CONCLUSIONS: Two different patterns of brain GM volume association and covariance with gait speed were found and involving frontal cortex in CHI and the striatum in patients with MCI. PMID: 31075383 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 7, 2019 Category: Geriatrics Authors: Beauchet O, Montembeault M, Barden JM, Szturm T, Bherer L, Liu-Ambrose T, Chester VL, Li K, Helbostad JL, Allali G, Canadian Gait Consortium Tags: Exp Gerontol Source Type: research

Negative senescence in sea urchins.
Abstract Negative senescence, a decrease in size-specific mortality of large individuals, is shown by sea urchins. Sea urchins have indeterminate growth and size-specific gamete production increases throughout life. These characteristics are present in short-lived species, Lytechinus pictus and L. variegatus as well as ones that are long-lived: Mesocentrotus franciscanus, Strongylocentrotus purpuratus, Echinometra mathaei, and Stomopneustes variolaris. Both short and long-lived species have cellular mechanisms that counter senescence. Many groups of organisms have species that are short-lived as well species with ...
Source: Experimental Gerontology - May 4, 2019 Category: Geriatrics Authors: Ebert TA Tags: Exp Gerontol Source Type: research

Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty "cytokinome" at its core.
CONCLUSIONS: A core inflammatory profile was identified in people with PF&S with a gender-specific signature. The dissection of the PF&S "cytokinome" will provide novel insights into the role played by inflammation in the disabling cascade and allow designing personalized treatment strategies. PMID: 31054959 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 2, 2019 Category: Geriatrics Authors: Marzetti E, Picca A, Marini F, Biancolillo A, Coelho-Junior HJ, Gervasoni J, Bossola M, Cesari M, Onder G, Landi F, Bernabei R, Calvani R Tags: Exp Gerontol Source Type: research

Caffeine and neuropsychiatric symptoms in patients with dementia: A systematic review.
CONCLUSION: These findings suggest that caffeine can either induce or reduce neuropsychiatric symptoms in individual patients with dementia. Therefore, in these patients, caffeine consumption requires a prudent individualized approach and further research on the effects of caffeine on individual neuropsychiatric symptoms is required. PMID: 31051199 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 30, 2019 Category: Geriatrics Authors: Kromhout MA, Ottenheim NR, Giltay E, Numans ME, Achterberg WP Tags: Exp Gerontol Source Type: research

Moringa oleifera seed extract protects against brain damage in both the acute and delayed stages of ischemic stroke.
Abstract The extract of Moringa oleifera (M. oleifera) seeds exerts various pharmacological effects. Our previous study demonstrated that M. oleifera seed extract (MSE) alleviates scopolamine-induced learning and memory impairment in mice. In the present study, we investigate the neuropharmacological properties of 70% ethanolic MSE in the acute and delayed stages of ischemic stroke. MSE may be effective for the prevention and/or treatment of acute ischemic stroke. The most effective dose was 500 mg/kg, and the therapeutic window seemed to be within 4 h after reperfusion. Additionally, we found that MSE treatme...
Source: Experimental Gerontology - April 27, 2019 Category: Geriatrics Authors: Zeng K, Li Y, Yang W, Ge Y, Xu L, Ren T, Zhang H, Zhuo R, Peng L, Chen C, Zhou Y, Zhao Y, Li WJ, Jin X, Yang L Tags: Exp Gerontol Source Type: research

Older women take shorter steps during backwards walking and obstacle crossing.
CONCLUSION: The findings revealed that older adult women adapt walking in a way that might predispose them to tripping or falling (i.e. shorter steps and closer obstacle approach). Gender differences in adaptive walking are related to functional test performance and processing speed. Clinicians should consider targeting step length during adaptive walking tasks in women that may be at risk of mobility impairments. PMID: 31034865 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 26, 2019 Category: Geriatrics Authors: Raffegeau TE, Kellaher GK, Terza MJ, Roper JA, Altmann LJ, Hass CJ Tags: Exp Gerontol Source Type: research

Somatosensory perception sensitivity in voluntary postural sway movements: Age, gender and sway effect magnitudes.
Abstract OBJECTIVES: 1) to develop a reliable device for assessing somatosensory perception sensitivity in voluntary postural sway movement, specifically a sway discrimination apparatus (SwayDA) for testing voluntary lateral sway discrimination sensitivity (VLSDS); 2) to explore the relationship between mobility performance and VLSDS in older adults, and 3) to determine the effects of age, gender and sway magnitude on VLSDS. METHODS: First, eighteen healthy young adults (8 males, 10 females, age ranging from 22 to 70) were recruited for a test-retest reliability study. During the SwayDA test, the participants...
Source: Experimental Gerontology - April 25, 2019 Category: Geriatrics Authors: Chen Z, Han J, Waddington G, Adams R, Witchalls J Tags: Exp Gerontol Source Type: research

Phase angle and metabolic equivalents as predictors of frailty transitions in advanced age.
CONCLUSIONS: PhA and METs may be indirect measures of functional reserve, with lower values being potential biomarkers of evolving frailty. PMID: 31028839 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 24, 2019 Category: Geriatrics Authors: Zanforlini BM, Trevisan C, Bertocco A, Piovesan F, Dianin M, Mazzochin M, Alessi A, Zoccarato F, Manzato E, Sergi G Tags: Exp Gerontol Source Type: research

Repeated exposure to the threat of perturbation induces emotional, cognitive, and postural adaptations in young and older adults.
This study examined the effects of initial and repeated postural threat exposure on emotional, cognitive, and postural responses. Twenty-seven young and twenty-seven older adults stood on a force plate fixed to a translating platform. Threat was manipulated through expectation of a temporally and directionally (left or right) unpredictable platform perturbation. Participants completed one 60s stance trial with no expectation of perturbation (No Threat) followed by 24 trials with threat of perturbation (Threat). The stance period before each perturbation varied (5-60s) except on an early Threat trial and the last Threat tri...
Source: Experimental Gerontology - April 24, 2019 Category: Geriatrics Authors: Johnson KJ, Zaback M, Tokuno CD, Carpenter MG, Adkin AL Tags: Exp Gerontol Source Type: research

Bioimpedance analysis and physical functioning as mortality indicators among older sarcopenic people.
lvis RS Abstract OBJECTIVES: To assess the prognostic significance of various characteristics and measurements of sarcopenia and physical functioning on all-cause mortality among home-dwelling older people with or at-risk of sarcopenia. DESIGN: Cross-sectional and longitudinal analyses. SETTING: Porvoo sarcopenia trial in open care. PARTICIPANTS: Community-dwelling people aged 75 and older (N = 428, of which 182 were re-examined at one year) with four years of follow-up. MEASUREMENTS: Body mass index (BMI), physical functioning (physical component of the RAND-36) and physical performance te...
Source: Experimental Gerontology - April 23, 2019 Category: Geriatrics Authors: Björkman MP, Pitkala KH, Jyväkorpi S, Strandberg TE, Tilvis RS Tags: Exp Gerontol Source Type: research

Nutritional status and body fat mass: Determinants of sarcopenia in community-dwelling older adults.
CONCLUSION: The prevalence of sarcopenia is high among elderly individuals. This study underlined that sarcopenia might develop in older adults with impaired nutritional status and high body fat mass. Further studies could evaluate the effects of appropriate nutritional interventions on sarcopenia management and prevention. PMID: 31022445 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 22, 2019 Category: Geriatrics Authors: Nasimi N, Dabbaghmanesh MH, Sohrabi Z Tags: Exp Gerontol Source Type: research

Exercise preconditioning attenuates hind limb unloading-induced gastrocnemius muscle atrophy possibly via the HDAC4/Gadd45 axis in old rats.
Abstract The mechanisms involved in unloading-induced skeletal muscle loss may be age-specific, and the evidence for exercise preconditioning-induced protection against disuse muscle atrophy in aged rats is limited. Therefore, in this study, we investigated age-related differences in the activation of the HDAC4/Gadd45α pathway following hindlimb unloading (HU). We also assessed the protective effect of preconditioning exercise on this pathway in young and old rat gastrocnemius muscle. Three-month-old (young, n = 18) and 24-month-old (old, n = 18) male Wistar rats were assigned to the following groups...
Source: Experimental Gerontology - April 19, 2019 Category: Geriatrics Authors: Yoshihara T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Naito H Tags: Exp Gerontol Source Type: research

Effects of moderate mountain hiking and balneotherapy on community-dwelling older people: A randomized controlled trial.
CONCLUSIONS: A seven-day intervention with moderate mountain hiking in combination with balneotherapy is an effective training for highly functioning older persons, inducing short-term improvements in static balance and quality of life. PMID: 31004732 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 17, 2019 Category: Geriatrics Authors: Prossegger J, Huber D, Grafetstätter C, Pichler C, Weisböck-Erdheim R, Iglseder B, Wewerka G, Hartl A Tags: Exp Gerontol Source Type: research

Inhibition of TLR9 attenuates skeletal muscle fibrosis in aged sarcopenic mice via the p53/SIRT1 pathway.
In this study, we hypothesized that TLR9 modulated skeletal muscle fibrosis via Sirt1. We used TLR9 knockout (TLR9 KO) mice and C57 mice, and grip strength and body composition were compared at different ages. We found that TLR9 knockout significantly attenuated skeletal muscle fibrosis and improved muscle function in aged mice. Furthermore, silent information regulator 1 (Sirt1) activity in mice was inhibited by Ex527, which is a specific inhibitor of Sirt1. Negative Sirt1 regulation via the activation of TLR9-related signaling pathways participated in skeletal muscle fibrosis in the sarcopenic mice, and this process migh...
Source: Experimental Gerontology - April 16, 2019 Category: Geriatrics Authors: Lyu AK, Zhu SY, Chen JL, Zhao YX, Pu D, Luo C, Lyu Q, Fan Z, Sun Y, Wu J, Zhao KX, Xiao Q Tags: Exp Gerontol Source Type: research

Erythropoietin does not improve fracture healing in aged mice.
Conclusion: In fracture healing of aged mice EPO treatment increases callus TMD as well as OPG and RANKL expression, indicating an accelerated bone turnover when compared to controls. However, EPO does not improve fracture healing in aged mice. The process of fracture healing may be altered by EPO due to a deterioration of the microcirculation caused by the worsened rheological properties of the blood and due to an increased bone fragility caused by the accelerated bone turnover. Thus, EPO may not be used to improve fracture healing in the elderly. PMID: 30998964 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 15, 2019 Category: Geriatrics Authors: Orth M, Baudach J, Scheuer C, Osche D, Veith NT, Braun BJ, Rollmann MF, Herath SC, Pohlemann T, Menger MD, Histing T Tags: Exp Gerontol Source Type: research

Multicomponent exercise and the hallmarks of frailty: Considerations on cognitive impairment and acute hospitalization.
rdo M Abstract Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living. On the other hand, physical exercise interventions induce marked improvements in frailty physical hallmarks (e.g., gait ability, muscle strength, balance and falls). In addition, because cognitive impairment is closely related to frailty syndrome, exercise is an effective intervention to counteract the physical consequences of mild cognitive impairment and dementia. Moreover, exer...
Source: Experimental Gerontology - April 14, 2019 Category: Geriatrics Authors: Cadore EL, Sáez de Asteasu ML, Izquierdo M Tags: Exp Gerontol Source Type: research

Commentary: High-speed resistance training in elderly women: Effects of cluster training sets on functional performance and quality of life.
di RR PMID: 30980921 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 10, 2019 Category: Geriatrics Authors: Ferreira-Júnior JB, Martins-Costa HC, Dinardi RR Tags: Exp Gerontol Source Type: research

Effects of free weights and machine training on muscular strength in high-functioning older adults.
CONCLUSION: Our results demonstrate that especially free-weight training has benefits in improving leg and triceps strength as well as in the subjective perception in older adults. Nevertheless, our results do not overall indicate that free-weight training is superior to machine training for increasing strength. PMID: 30980922 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 10, 2019 Category: Geriatrics Authors: Schott N, Johnen B, Holfelder B Tags: Exp Gerontol Source Type: research

Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma.
CONCLUSION: Our findings indicate an effect of physical exercise on markers of neuroinflammation in CSF measured by an increase in sTREM2 in patients with AD. Further, there may be a small inflammatory systemic effect related to physical exercise in patients with AD. PMID: 30980923 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 10, 2019 Category: Geriatrics Authors: Jensen CS, Bahl JM, Østergaard LB, Høgh P, Wermuth L, Heslegrave A, Zetterberg H, Heegaard NHH, Hasselbalch SG, Simonsen AH Tags: Exp Gerontol Source Type: research

Association of health empowerment and handgrip strength with intention to participate in physical activity among community-dwelling older adults.
Abstract INTRODUCTION: Health empowerment is an individual's perceived control and competence related to health and health care. The projected increased growth of the older adult population calls for a health-related empowerment movement in health education that targets older adults. Using the theory of planned behavior, the purpose of this study was to investigate the association of health empowerment and handgrip strength with intention to participate in physical activity among older adults. METHODS: The Korean Health Empowerment Scale (K-HES) was used as a measure of health empowerment. Handgrip strength w...
Source: Experimental Gerontology - April 10, 2019 Category: Geriatrics Authors: Caillouet KA, Cosio-Lima L Tags: Exp Gerontol Source Type: research

Muscle mass and strength gains following 6  months of resistance type exercise training are only partly preserved within one year with autonomous exercise continuation in older adults.
Muscle mass and strength gains following 6 months of resistance type exercise training are only partly preserved within one year with autonomous exercise continuation in older adults. Exp Gerontol. 2019 Apr 09;: Authors: Snijders T, Leenders M, de Groot CPGM, van Loon LJC, Verdijk LB Abstract INTRODUCTION: Although resistance type exercise training (RT) effectively increases muscle mass and strength in older individuals, it remains unclear whether gains in muscle mass and strength are maintained without continued supervised training. We assessed the capacity of older individuals to maintain muscle m...
Source: Experimental Gerontology - April 9, 2019 Category: Geriatrics Authors: Snijders T, Leenders M, de Groot CPGM, van Loon LJC, Verdijk LB Tags: Exp Gerontol Source Type: research

Study of the association of DHEAS, testosterone and cortisol with S-Klotho plasma levels in healthy sedentary middle-aged adults.
CONCLUSIONS: DHEAS and testosterone were positively associated with S-Klotho in healthy sedentary middle-aged men while only testosterone was positively associated in women. PMID: 30928678 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 27, 2019 Category: Geriatrics Authors: Dote-Montero M, Amaro-Gahete FJ, De-la-O A, Jurado-Fasoli L, Gutierrez A, Castillo MJ Tags: Exp Gerontol Source Type: research

Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice.
CONCLUSION: We present evidence of altered mt-mRNA translation during cardiac hypertrophy in aged obesity. We build on these results by demonstrating the necessity of mtIF2 in maintaining oxidative characteristics of cardiac muscle cells. PMID: 30928679 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 27, 2019 Category: Geriatrics Authors: Lee DE, Perry RA, Brown JL, Rosa-Caldwell ME, Brown LA, Haynie WS, Rajaram N, Washington TA, Greene NP Tags: Exp Gerontol Source Type: research

In vitro model of chronological aging of adipocytes: Interrelationships with hypoxia and oxidation.
This study characterizes the progressive morphological and functional changes in aging adipocytes during prolonged cell cultures and explores the addictive effects of hypoxia and oxidation, given at different stages of cellular maturation and senescence. PMID: 30928680 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 27, 2019 Category: Geriatrics Authors: Zoico E, Rizzatti V, Policastro G, Tebon M, Darra E, Petronio RA, Mazzali G, Fantin F, Zamboni M Tags: Exp Gerontol Source Type: research

Ageing differently: Sex-dependent ageing rates in Daphnia magna.
In this study we provide evidence in support of establishing genetically identical female and male Daphnia as unique and valuable resources for research into mechanisms of ageing and begin to delineate the mechanisms involved in sex differences in lifespan. We identify significant differences between genders in physiological markers such as lifespan, growth rate, heart rate and swimming speed in addition to molecular markers such as lipid peroxidation product accumulation, thiol content decline and age-dependent decline in DNA damage repair efficiency. Overall, our data indicates that investigating sex differences in longe...
Source: Experimental Gerontology - March 25, 2019 Category: Geriatrics Authors: Constantinou J, Sullivan J, Mirbahai L Tags: Exp Gerontol Source Type: research

The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation.
Abstract AIM: Chronic inflammation increases with age and is correlated positively to visceral fat mass, but inversely to muscle mass. We investigated the hypothesis that resistance training would increase muscle mass and strength together with a concomitant drop in local and systemic inflammation level independent of any changes in visceral fat tissue in elderly. METHODS: 25 subjects (mean 67, range 62-70 years) were randomized to 1 year of heavy resistance training (HRT) or control (CON), and tested at 0, 4 and 12 months for physical performance, body composition (DXA), vastus lateralis muscle area (M...
Source: Experimental Gerontology - March 21, 2019 Category: Geriatrics Authors: Ziegler AK, Jensen SM, Schjerling P, Mackey AL, Andersen JL, Kjaer M Tags: Exp Gerontol Source Type: research

A longitudinal study of the stability, variability, and interdependencies among late-differentiated T and NK cell subsets in older adults.
We examined the variability and change over time in T and NK cell subsets in a longitudinal sample of older adults; the effects of sex, cytomegalovirus (CMV) serostatus, and chronic disease severity on immune levels and trajectories; and interdependencies among T and NK cell subsets. Older adults (N = 149, age 64-94 years, 42% male) provided blood every 6 months for 2.5 years (up to 5 waves) to evaluate late-differentiated CD8 T cells (CD28-, CD57+) and CD56dimNK cells (CD57+, NKG2C+, FcɛRIγ-). In multilevel models, most of the variance in immune subsets reflected stable differences between people. However...
Source: Experimental Gerontology - March 15, 2019 Category: Geriatrics Authors: Reed RG, Al-Attar A, Presnell SR, Lutz CT, Segerstrom SC Tags: Exp Gerontol Source Type: research

Serum adiponectin is associated with body composition and cognitive and psychological status in older adults living in long-term nursing homes.
Irazusta J Abstract Frailty is a geriatric syndrome characterized by decreasing functional reserves and increasing vulnerability to falls, injuries and declining health, leading to dependence upon caregivers. Frailty is associated not only with physical decline, but also with cognitive and psychological impairments in aging people. Higher serum adiponectin concentration has been linked to better performance on frailty measures but also to worse cognitive status. Nonetheless, several studies have proposed adiponectin as a frailty biomarker. To further delineate the relationship between adiponectin serum levels and...
Source: Experimental Gerontology - March 15, 2019 Category: Geriatrics Authors: Sanz B, Arrieta H, Hervás G, Rezola-Pardo C, Ruiz-Litago F, Iturburu M, Gil SM, Rodríguez-Larrad A, Irazusta J Tags: Exp Gerontol Source Type: research

Fall-related healthcare use and mortality among older adults in the Netherlands, 1997-2016.
CONCLUSION: Even though the standardized incidence rates of ED visits decreased in the past twenty years, the absolute number of fall-related ED visits increased. The number of hospital admissions has also increased, but the total number of admission days has almost halved during the same period. If the observed trends would continue, this may have implications for healthcare resource allocation, as the burden of care in EDs increases, and the admission duration reduces. PMID: 30878641 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 13, 2019 Category: Geriatrics Authors: Olij BF, Panneman MJM, van Beeck EF, Haagsma JA, Hartholt KA, Polinder S Tags: Exp Gerontol Source Type: research

Comorbid sensorimotor and emotional profiles in the forced swim test immobility and predictive value of a single assay in very old female mice.
nez-Llort L Abstract The increase of prevalence of mental health problems in the elderly due to the aging of the population becomes an outstanding issue since in most individuals it happens in an already complex multimorbid scenario that may include frailty and age-related medical conditions. Depression, soon the major cause of global disease burden, can be found as an age-related comorbidity and frailty, or as part of neurodegenerative diseases and where females are more vulnerable to it. Thought the multifactorial aetiology and heterogeneous nature of depression render it difficult to be modelled in animals, act...
Source: Experimental Gerontology - March 13, 2019 Category: Geriatrics Authors: Ramírez-Boix P, Giménez-Llort L Tags: Exp Gerontol Source Type: research

Mouse models in modeling aging and cancer.
Abstract Mouse models have been widely used in the research of human diseases. Aging, just as cancer, is influenced by the interaction of various genetic and environmental factors. Currently, aging could be induced by many mechanism, including telomere dysfunction, oxidase stress, DNA damage and epigenetic changes. Many of these genetic pathways are also shared by aging and cancer. The mouse models generated to study these pathways might manifest either aging or cancer phenotypes, sometimes both, which in deed has worked as a good model system in understanding the correlation between aging and cancer. Here, we rev...
Source: Experimental Gerontology - March 12, 2019 Category: Geriatrics Authors: Li H, Wei C, Zhou R, Wang B, Zhang Y, Shao C, Luo Y Tags: Exp Gerontol Source Type: research

Periodized and non-periodized resistance training programs on body composition and physical function of older women.
CONCLUSION: NP and DUP improved physical function in community-dwelling older women, with greater improvements in physical parameters only observed after NP. PMID: 30862526 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 9, 2019 Category: Geriatrics Authors: Coelho-Júnior HJ, de Oliveira Gonçalvez I, Sampaio RAC, Sampaio PYS, Cadore EL, Izquierdo M, Marzetti E, Uchida MC Tags: Exp Gerontol Source Type: research

Digital behavior change interventions to promote physical activity and/or reduce sedentary behavior in older adults: A systematic review and meta-analysis.
This study aims to assess the efficacy of DBCI interventions in older adults (≥50 years) on physical activity and sedentary behavior. METHODS: A systematic review of major databases from inception to 03/2018 was undertaken. Randomized controlled trials (RCT) or pre-post interventions assessing effects of DBCI on physical activity and/or sedentary behavior in older adults (≥50 years) were included. Random effects meta-analyses were carried out. RESULTS: Twenty-two studies were included, including 1757 older adults (mean age = 67 years, %male = 41), 68% showed moderate-high risk of bias. Meta-an...
Source: Experimental Gerontology - March 2, 2019 Category: Geriatrics Authors: Stockwell S, Schofield P, Fisher A, Firth J, Jackson SE, Stubbs B, Smith L Tags: Exp Gerontol Source Type: research

Corrigendum to "High-speed resistance training in elderly women: Effects of cluster training sets on functional performance and quality of life" [Exp. Gerontol. 110 (September 2018) 216-222].
Corrigendum to "High-speed resistance training in elderly women: Effects of cluster training sets on functional performance and quality of life" [Exp. Gerontol. 110 (September 2018) 216-222]. Exp Gerontol. 2019 Mar 01;: Authors: Ramirez-Campillo R, Alvarez C, García-Hermoso A, Celis-Morales C, Ramirez-Velez R, Gentil P, Izquierdo M PMID: 30831201 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 1, 2019 Category: Geriatrics Authors: Ramirez-Campillo R, Alvarez C, García-Hermoso A, Celis-Morales C, Ramirez-Velez R, Gentil P, Izquierdo M Tags: Exp Gerontol Source Type: research

The relationship between polypharmacy and trajectories of cognitive decline in people with dementia: A large representative cohort study.
In conclusion, polypharmacy defined by the number of drugs does not appear to predict cognitive decline in a naturalistic cohort of patients with dementia. More sophisticated tools, considering appropriateness of prescribing and the clinical picture, might be better placed to evaluate cognitive outcomes in dementia and to make practice and research recommendations. PMID: 30831202 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 1, 2019 Category: Geriatrics Authors: Soysal P, Perera G, Isik AT, Onder G, Petrovic M, Cherubini A, Maggi S, Shetty H, Molokhia M, Smith L, Stubbs B, Stewart R, Veronese N, Mueller C Tags: Exp Gerontol Source Type: research

Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans.
Abstract Ageing is a progressive deterioration in functional and structural well-being of the body, accompanied with age-associated neurological disorders such as Parkinson's disease (PD), Alzheimer's disease and Huntington's disease. PD is marked with motor function decline, progressive neurodegeneration due to aggregation of insoluble α-synuclein in the dopaminergic neuron. Here we investigated the effect of tambulin (3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl) chromen-4-one), a hydroxy substituted flavanol isolated from fruits of Zanthoxyllum armatum DC (Family-Rutaceae) for its longevity promoting an...
Source: Experimental Gerontology - February 27, 2019 Category: Geriatrics Authors: Pandey T, Sammi SR, Nooreen Z, Mishra A, Ahmad A, Bhatta RS, Pandey R Tags: Exp Gerontol Source Type: research

Dual task performance and history of falls in community-dwelling older adults.
CONCLUSIONS: Dual TUG including cognitive stops and cognitive errors may be more capable than the single TUG to detect differences and accurately classify fallers and non-fallers in the elderly. PMID: 30825548 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 27, 2019 Category: Geriatrics Authors: Tomas-Carus P, Biehl-Printes C, Pereira C, Vieiga G, Costa A, Collado-Mateo D Tags: Exp Gerontol Source Type: research

Orthostatic hypotension and cognition in older adults: A systematic review and meta-analysis.
CONCLUSIONS: OH is common in older populations and is associated with worse cognition expressed as lower MMSE scores. Use of MMSE alone as a cognitive assessment tool may underestimate the association. It is yet unclear whether the association between OH and worse cognitive performance is causative. PMID: 30825549 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 27, 2019 Category: Geriatrics Authors: Iseli R, Nguyen VTV, Sharmin S, Reijnierse EM, Lim WK, Maier AB Tags: Exp Gerontol Source Type: research

Nutrition-related parameters predict the health-related quality of life in home care patients.
k N Abstract INTRODUCTION: There is evidence that nutritional status is one of the major factors affecting quality of life. Low quality of life is an important reason that reflects the risk of malnutrition as well as dependency and frailty. OBJECTIVE: The present study aimed to examine nutritional risk factors and sociodemographic features affecting health-related quality of life in home care patients. MATERIALS AND METHODS: The data of 209 adult or elderly eligible subjects were evaluated in the study. A general questionnaire including sociodemographic and nutritional characteristics, 'Mini Nutritional ...
Source: Experimental Gerontology - February 26, 2019 Category: Geriatrics Authors: Adıgüzel E, Acar-Tek N Tags: Exp Gerontol Source Type: research

The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells.
Abstract Human aging is a physiological process characterized by a chronic low-grade inflammation. Senescence may affect endothelial cells, subsequently involved in the most common age-related diseases (ARDs), as well as mesenchymal stem cells (MSCs) with an impairment of their properties in tissues regeneration. Endothelial cells seem to be able to exert a paracrine effect on BM-MSCs through the secretion of pro-inflammatory factors. This work is aimed to evaluate if the senescent status of human umbilical vein endothelial cells (HUVECs) could affect bone marrow derived MSCs (BM-MSCs) proliferative ability and st...
Source: Experimental Gerontology - February 26, 2019 Category: Geriatrics Authors: Lazzarini R, Caffarini M, Tang H, Cerqueni G, Pellegrino P, Vladia M, Di Primio R, Orciani M Tags: Exp Gerontol Source Type: research

Lifestyle multidomain intervention, omega-3 supplementation, or both for reducing the risk of developing clinically relevant depressive symptoms in older adults with memory complaints? Secondary analysis from the MAPT trial.
CONCLUSIONS: To conclude, we did not find any association of a lifestyle multidomain intervention with the onset of clinically depressive symptoms in older adults with memory complaints. A study with a more intensive multidomain intervention might bring further insights on this topic. PMID: 30817982 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 25, 2019 Category: Geriatrics Authors: Maltais M, de Souto Barreto P, Pother K, Cantet C, Andrieu S, Rolland Y, Vellas B, MAPT/DSA Study Group Tags: Exp Gerontol Source Type: research

Bench stepping with incremental heights improves muscle volume, strength and functional performance in older women.
CONCLUSION: Our results indicate that bench step training with incremental step heights simultaneously improves functional ability, thigh muscle volume and force-velocity characteristics of the knee extensors in older women. PMID: 30797825 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 21, 2019 Category: Geriatrics Authors: Baggen RJ, Van Roie E, Verschueren SM, Van Driessche S, Coudyzer W, van Dieën JH, Delecluse C Tags: Exp Gerontol Source Type: research

Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.
In this study, we investigated whether brain exposure of Pg-LPS induced systemic organ dysfunction in a model of AD mouse. We employed 6 (young) and 13 (middle-aged) months-old 5XFAD mice and 6 months-old littermate (LT) mice, and treated with intracerebroventricular (ICV) injection of 2 μg Pg-LPS or saline (vehicle). The animals were monitored cognitive functions (Y maze, nest building, and Morris water maze tests), motor functions (wire hang and rotarod tests), physical condition (symptom score), and blood pressure (BP). Twenty-eight days later, their organs were weighted and the organ damages were examined. Conti...
Source: Experimental Gerontology - February 17, 2019 Category: Geriatrics Authors: Hayashi K, Hasegawa Y, Takemoto Y, Cao C, Takeya H, Komohara Y, Mukasa A, Kim-Mitsuyama S Tags: Exp Gerontol Source Type: research

Long-term stimulation of angiotensin II induced endothelial senescence and dysfunction.
This study aimed to clarify the effects of Ang II on endothelial senescence by establishing a replicative senescence model of human umbilical vein endothelial cells (HUVECs) in vitro. The population-doubling level (PDL) was calculated, PDL5 and PDL25 respectively referred to cells cultured for 2 days and 30 days. Compared with Ang II-treated young PDL5 cells, chronic stimulation of Ang II significantly promoted the senescence-associated β-galactosidase activity and expression of senescence-related genes p16 and p21, slowed down cell growth rate, and decreased expression of longevity-related genes sirtuin1 as well ...
Source: Experimental Gerontology - February 15, 2019 Category: Geriatrics Authors: Li R, Mi X, Yang S, Yang Y, Zhang S, Hui R, Chen Y, Zhang W Tags: Exp Gerontol Source Type: research

HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric restriction-induced neuroprotection after surgery in aged mice.
In this study, we evaluated whether CR improves impaired learning and memory after surgery by attenuating ER-stress in an SIRT1-dependent manner. Male 18-month-old C57BL/6J mice receiving a 12-week CR or an ad libitum (AL) diet pre-intervention were challenged with tibial open fracture surgery and anesthesia or no treatment. We found a significant protective effect of CR on memory in contextual fear conditioning test after surgery compared with the AL group. CR alleviated ER-stress and neuronal apoptosis in the hippocampus induced by surgery. CR increased HSP70 expression through the HSF1/HSP pathway in a SIRT1-mediated ma...
Source: Experimental Gerontology - February 14, 2019 Category: Geriatrics Authors: Yao M, Zhao Z, Wei L, Zhou D, Xue Z, Ge S Tags: Exp Gerontol Source Type: research

Objective physical activity and physical performance in middle-aged and older adults.
Abstract BACKGROUND: Older adults may have difficulty meeting the Physical Activity (PA) Guidelines. A favorable balance between PA and sedentary time (SED) is an important determinant of physical performance in older adults. Our objective was to explore associations of PA/SED with physical performance across mid-older age in adults without overt mobility disability. METHODS: Framingham Offspring Study participants free of mobility disability with accelerometry and physical performance data (gait speed, chair stand time, and handgrip strength), were studied in cross-sectional analysis (n = 1352). We regre...
Source: Experimental Gerontology - February 13, 2019 Category: Geriatrics Authors: Spartano NL, Lyass A, Larson MG, Tran T, Andersson C, Blease SJ, Esliger DW, Vasan RS, Murabito JM Tags: Exp Gerontol Source Type: research