Deficient mitochondrial biogenesis in IL-2 activated NK cells correlates with impaired PGC1- α upregulation in elderly humans.
Deficient mitochondrial biogenesis in IL-2 activated NK cells correlates with impaired PGC1-α upregulation in elderly humans. Exp Gerontol. 2018 May 18;: Authors: Miranda D, Jara C, Mejias S, Ahumada V, Martin MC, Ibañez J, Hirsch S, Montoya M Abstract Immunosenescence has been described as age-associated changes in the immune function which are thought to be responsible for the increased morbidity with age. Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in immune defense against tumor and microbial diseases. Interestingly, aging-rela...
Source: Experimental Gerontology - May 18, 2018 Category: Geriatrics Authors: Miranda D, Jara C, Mejias S, Ahumada V, Martin MC, Ibañez J, Hirsch S, Montoya M Tags: Exp Gerontol Source Type: research

Benefits of a multicomponent Falls Unit-based exercise program in older adults with falls in real life.
te;n MI, Soler PA Abstract BACKGROUND/OBJECTIVES: Multicomponent exercise programs are the cornerstone in preventing gait and balance impairments and falls in older adults. However, the effects of these programs in usual clinical practice have been poorly analyzed. DESIGN: 4-Month, twice-a-week multicomponent exercise program cohort study in real-life. SETTING: Falls Unit, Complejo Hospitalario Universitario of Albacete, Spain. PARTICIPANTS: Sixty-seven participants who had experienced a fall in the previous year were included. MEASUREMENTS: Pre- and post-intervention measurements were collecte...
Source: Experimental Gerontology - May 17, 2018 Category: Geriatrics Authors: Molina RG, Grao MCR, García AN, Reig MM, Víctor ME, Redín MI, Soler PA Tags: Exp Gerontol Source Type: research

The shape of lives to come.
PMID: 29775744 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 15, 2018 Category: Geriatrics Authors: Ground I Tags: Exp Gerontol Source Type: research

Analysis of neurotrophic and antioxidant factors related to midbrain dopamine neuronal loss and brain inflammation in the cerebrospinal fluid of the elderly.
The objective was to analyze neurotrophic and oxidative parameters that could be related to midbrain dopamine neuronal loss or brain inflammation in the CSF of elderly subjects: 1) levels of the dopaminotrophic factors BDNF, GDNF, persephin, and neurturin, 2) levels of the proinflammatory factors TGFβ1 and TGFβ2; 3) activity of main antioxidant enzymes (catalases, glutathione-peroxidase, glutathione-reductase, glutathione-S-transferases, peroxirredoxins, and superoxide-dismutases), 4) ferritin content, antioxidant protein which reduces reactive free iron, and 5) antioxidant potential of the cerebrospinal fluid. E...
Source: Experimental Gerontology - May 15, 2018 Category: Geriatrics Authors: Martin-de-Pablos A, Córdoba-Fernández A, Fernández-Espejo E Tags: Exp Gerontol Source Type: research

Anthropometric measurements and mortality in frail older adults.
CONCLUSIONS: Anthropometric measurements have different significance in frail older adults, and these differences could have implications on adverse outcomes. Calf circumference has a potential value in predicting negative health outcomes or likewise. PMID: 29775746 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 15, 2018 Category: Geriatrics Authors: Easton JF, Stephens CR, Román-Sicilia H, Cesari M, Pérez-Zepeda MU Tags: Exp Gerontol Source Type: research

Mediterranean diet and depression among older individuals: The multinational medis study.
CONCLUSIONS: Greater adherence to the MedDiet and daily tea drinking seem to have a beneficial effect on depressive symptoms in older adults. PMID: 29775747 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 15, 2018 Category: Geriatrics Authors: Masana MF, Haro JM, Mariolis A, Piscopo S, Valacchi G, Bountziouka V, Anastasiou F, Zeimbekis A, Tyrovola D, Gotsis E, Metallinos G, Polystipioti A, Tur JA, Matalas AL, Lionis C, Polychronopoulos E, Sidossis LS, Tyrovolas S, Panagiotakos DB Tags: Exp Gerontol Source Type: research

Lifestyle determinants of healthy ageing in a Mediterranean population: The multinational MEDIS study.
MEDIS Study Group Abstract BACKGROUND: To evaluate modifiable, lifestyle risk factors of cardiovascular disease (CVD) among older adults, across ageing, in the Mediterranean area. METHODS: During 2005-2017, 3131 individuals from 26 Mediterranean islands of 5 countries, ≥65 years of age, were voluntarily enrolled. Anthropometrical, clinical and socio-demographic characteristics, dietary habits, lifestyle parameters were measured through standard procedures. Analyses were performed by year and across consecutive age groups of the participants. RESULTS: A decrease in the prevalence of current smoking (p 
Source: Experimental Gerontology - May 12, 2018 Category: Geriatrics Authors: Foscolou A, Magriplis E, Tyrovolas S, Soulis G, Bountziouka V, Mariolis A, Piscopo S, Valacchi G, Anastasiou F, Gotsis E, Metallinos G, Tyrovola D, Polystipioti A, Polychronopoulos E, Matalas AL, Lionis C, Zeimbekis A, Tur JA, Sidossis LS, Panagiotakos D, Tags: Exp Gerontol Source Type: research

Habitual aerobic exercise, gene APOA5 named rs662799 SNP and response of blood lipid and lipoprotein phenotypes among older Chinese adult.
CONCLUSIONS: Excess risk for low HDL-C and hyperlipidemia was associated with rs662799 genotype alleles of APOA5 SNPs in older Chinese adults. Interaction of gene-HAE and HAE levels may induce different responses of blood lipids and lipoprotein phenotypes. HAE levels have less influence on TG changes in the AA carriers; however, high HAE levels appeared to greatly impact TG responses in the AG + GG carriers. PMID: 29758349 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 11, 2018 Category: Geriatrics Authors: Liu X, Huang G, Niu Z, Wei Y, Wang R Tags: Exp Gerontol Source Type: research

Effect of protein intake beyond habitual intakes following resistance training on cardiometabolic risk disease parameters in pre-conditioned older women.
Abstract OBJECTIVE: The aim of this study was to analyze the effects of higher protein (HP) intake associated with resistance training (RT) on parameters of cardiometabolic risk disease (CMR). METHODS: A randomized, double-blind and placebo-controlled design was conducted. Thirty-two pre-conditioned older women were randomized in two groups to receive 35 g of protein (high protein group - HP) or 35 g of placebo (low protein group - LP) after training sessions. The RT program was carried out over 12 weeks, 3 days per week and 3 sets of 8-12 repetitions. Body composition (whole-body dual-energy X-ray ab...
Source: Experimental Gerontology - May 9, 2018 Category: Geriatrics Authors: Fernandes RR, Nabuco HCG, Junior PS, Cavalcanti EF, Tomeleri CM, Ribeiro AS, Barbosa DS, Venturini D, Schoenfeld BJ, Cyrino ES Tags: Exp Gerontol Source Type: research

Sex-dependent and sex-independent muscle activation patterns in adult gait as a function of age.
eacute; JN Abstract INTRODUCTION: Aging leads to poorer neuromuscular control that may impact mobility. However, the specific decades when these changes occur, and whether these time-based changes are sex-specific, are unclear. METHODS: Adults aged 20-82 years (N = 93, 51 females) walked six gait trials at their preferred speed over a 10-m platform. Electromyography (EMG) of the rectus femoris (RF), tibialis anterior (TA), and gastrocnemius lateralis (GL) were measured using wireless surface sensors. Root mean square (RMS) and within-cycle coefficient of variation (CV) values were calculated for several...
Source: Experimental Gerontology - May 8, 2018 Category: Geriatrics Authors: Bailey CA, Corona F, Pilloni G, Porta M, Fastame MC, Hitchcott PK, Penna MP, Pau M, Côté JN Tags: Exp Gerontol Source Type: research

Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis.
Abstract A gradual loss of skeletal muscle mass is a common feature of aging, leading to impaired insulin sensitivity and mobility. Sestrin1, 2, 3 are multifunctional proteins that regulate the mammalian target of rapamycin complex (mTORC1), autophagy and redox homeostasis. It is unclear how aging affects Sestrins and their downstream targets in human, therefore this study examined the basal expression of Sestrins in three age groups, young, middle-aged and older men and explored the mTORC1 pathway, autophagy markers and antioxidant regulation. Older men had less Sestrin1 and 3 protein and a different pattern of S...
Source: Experimental Gerontology - May 8, 2018 Category: Geriatrics Authors: Zeng N, D'Souza RF, Mitchell CJ, Cameron-Smith D Tags: Exp Gerontol Source Type: research

Overdosing of benzodiazepines/Z-drugs and falls in older adults: Costs for the health system.
CONCLUSIONS: Appropriate dosage of BZD/Z drugs in older adults could reduce both patient suffering and costs for the health system. PMID: 29751092 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 8, 2018 Category: Geriatrics Authors: Díaz-Gutiérrez MJ, Cengotitabengoa MM, Bermúdez-Ampudia C, García S, López P, Martínez-Cengotitabengoa M, González-Pinto A Tags: Exp Gerontol Source Type: research

Relationship between high sodium and low PUFA intake and carotid atherosclerosis in elderly women.
Abstract Several biologically active molecules including nutrients can affect the vascular endothelium which becomes dysfunctional and, as a consequence, predisposes to atherosclerosis. However, the impact of the intake of sodium and polyunsaturated fatty acids on carotid atherosclerosis in a population of elderly women has scarcely been studied. Our aim was to investigate the association between carotid intima-media thickness and atherosclerotic plaque and nutrient intake in asymptomatic elderly women. Carotid atherosclerosis was determined by duplex ultrasound in 108 elderly women. Dietary intake was assessed by...
Source: Experimental Gerontology - May 7, 2018 Category: Geriatrics Authors: Mazza E, Ferro Y, Lamprinoudi T, Gazzaruso C, Doldo P, Pujia A, Montalcini T Tags: Exp Gerontol Source Type: research

Neuromuscular electrical stimulation can improve mobility in older adults but the time course varies across tasks: Double-blind, randomized trial.
We examined the influence of two interventions that involved neuromuscular electrical stimulation (NMES) applied to the triceps surae muscles on the mobility and muscle function of older adults. Thirty healthy older adults (73.5 ± 4.8 yrs) participated in a 6-week intervention comprising 3 weekly sessions of either narrow- or wide-pulse NMES. Motor function was assessed at Weeks 0, 4, 7, and 10. There were no statistically significant differences in the changes in mobility for the two groups of participants, so the data for the two groups were combined to examine changes across time. Time to walk 400 m decre...
Source: Experimental Gerontology - May 5, 2018 Category: Geriatrics Authors: Mani D, Almuklass AM, Amiridis IG, Enoka RM Tags: Exp Gerontol Source Type: research

Altered gene expression pattern indicates the differential regulation of the immune response system as an important factor in cardiac aging.
In conclusion, myocardial aging is mainly associated with an altered expression pattern of molecules involved in the immune reaction. PMID: 29738791 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 5, 2018 Category: Geriatrics Authors: Bartling B, Niemann K, Pliquett RU, Treede H, Simm A Tags: Exp Gerontol Source Type: research

The relationship between different settings of medical service and incident frailty.
CONCLUSION: Participants receiving health care from sources other than private doctors are at increased risk of frailty, highlighting the need for screening for frailty in these health settings. PMID: 29730329 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 3, 2018 Category: Geriatrics Authors: Bolzetta F, Wetle T, Besdine R, Noale M, Cester A, Crepaldi G, Maggi S, Veronese N Tags: Exp Gerontol Source Type: research

Water-based aerobic training improves strength parameters and cardiorespiratory outcomes in elderly women.
, Kruel LFM Abstract The aim of the present study was to compare the effects of water-based aerobic training and water-based resistance training on muscular strength and cardiorespiratory fitness in older women. Sixty-nine individuals were randomized into the following three groups: the water-based aerobic training (WA, n = 23) group, the water-based resistance training (WR, n = 23) group, and the control group (CG, n = 23). Participants were trained two times per week for 10 weeks. The trainings presented a linear periodization with an increase in the volume-intensity relation. Maximal dynamic muscu...
Source: Experimental Gerontology - May 3, 2018 Category: Geriatrics Authors: Costa RR, Kanitz AC, Reichert T, Prado AKG, Coconcelli L, Buttelli ACK, Pereira LF, Masiero MPB, Meinerz AP, Conceição MO, Sbeghen IL, Kruel LFM Tags: Exp Gerontol Source Type: research

Higher muscle power training volume is not determinant for the magnitude of neuromuscular improvements in elderly women.
Abstract The aim of this study was to compare the effects of 12 weeks of muscle power training using one- and three-sets on neuromuscular adaptations in elderly women. Twenty six healthy elderly women were randomly assigned into two groups: one-set (n = 13) and three-sets (n = 13). Maximal dynamic and isometric strength, rapid force assessed as absolute and normalized rate of force development (RTD) and contractile impulse during unilateral leg knee extension at 0-50 and 0-200 ms, overall quadriceps muscle thickness, muscle power during a countermovement jump (CMJ), and functional performance using tim...
Source: Experimental Gerontology - May 3, 2018 Category: Geriatrics Authors: Radaelli R, Brusco CM, Lopez P, Rech A, Machado CL, Grazioli R, Muller DC, Cadore EL, Pinto RS Tags: Exp Gerontol Source Type: research

The relationship between selected body fatness indices and the level of blood interleukin-6 in female nursing home residents aged 80+  years without inflammation: A pilot study.
The relationship between selected body fatness indices and the level of blood interleukin-6 in female nursing home residents aged 80+ years without inflammation: A pilot study. Exp Gerontol. 2018 May 03;: Authors: Zarzeczny R, Nawrat-Szołtysik A, Polak A, Manasar A, Maliszewski J, Kiełtyka A, Matyja B, Dudek M, Zborowska J, Wajdman A Abstract BACKGROUND: Interleukin-6 (IL-6) production facilitates a shift from acute to chronic inflammation that may induce the development of some diseases and aging. Several studies have suggested that adiposity is closely related to serum IL-6 level, but their auth...
Source: Experimental Gerontology - May 3, 2018 Category: Geriatrics Authors: Zarzeczny R, Nawrat-Szołtysik A, Polak A, Manasar A, Maliszewski J, Kiełtyka A, Matyja B, Dudek M, Zborowska J, Wajdman A Tags: Exp Gerontol Source Type: research

Effect of metabolic syndrome and aging on Ca2+ dysfunction in coronary smooth muscle and coronary artery disease severity in Ossabaw miniature swine.
CONCLUSIONS: Ca2+ dysregulation, mainly the SR Ca2+ store, in CSM is more pronounced in lean old compared to both MetS groups, which is indicative of mild, proliferative CAD. MetS old and MetS young swine exhibit Ca2+ dysfunction that is typical of late, severe disease. The more advanced, complex plaques in MetS old swine suggest that the "aging milieu" potentiates effects of Ca2+ handling dysfunction in CAD. PMID: 29730333 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 3, 2018 Category: Geriatrics Authors: Badin JK, Bruning RS, Sturek M Tags: Exp Gerontol Source Type: research

Overexpression of Nmnat improves the adaption of health span in aging Drosophila.
In this study, our results showed Nmnat was a positive factor on lifespan and movement capacity, which was consistent on d-galactose induced aging acceleration. Further investigation showed that oxidative stress biomarkers, longevity gene, mitochondria related genes and ATP levels were significantly improved in the Nmnat overexpression Drosophila, which suggested that the underlying mechanism of Nmnat on aging process and movement capacity was partly due to its anti-oxidative stress and mitochondrial-protection function. In addition, on H2O2 challenge tests, Nmnat overexpression was sufficient to increase the survival time...
Source: Experimental Gerontology - May 1, 2018 Category: Geriatrics Authors: Liu X, Xiang Z, Li Q, Ruan X, Xiong K, Dengtai W, Zheng L Tags: Exp Gerontol Source Type: research

Effects of aging and insulin resistant states on protein anabolic responses in older adults.
Abstract Insulin is the principal postprandial anabolic hormone and resistance to its action could contribute to sarcopenia. We developed different types of hyperinsulinemic clamp protocols to measure glucose and protein metabolism in insulin resistant states (older adults, obesity, diabetes, etc.). To define effects of healthy aging in response to insulin, we employed the hyperinsulinemic, euglycemic and isoaminoacidemic (HYPER-1) clamp. The net whole-body anabolic (protein balance) response to hyperinsulinemia was lower in the elderly vs young (p = 0.007) and was highly correlated with the clamp glucose rate...
Source: Experimental Gerontology - April 30, 2018 Category: Geriatrics Authors: Morais JA, Jacob K, Chevalier S Tags: Exp Gerontol Source Type: research

5-Methoxyindole-2-carboxylic acid (MICA) suppresses A β-mediated pathology in C. elegans.
5-Methoxyindole-2-carboxylic acid (MICA) suppresses Aβ-mediated pathology in C. elegans. Exp Gerontol. 2018 Apr 27;: Authors: Ahmad W, Ebert PR Abstract Alzheimer's disease (AD) is an age-related disease characterized by loss of memory and disrupted thinking that is associated with altered energy metabolism. Variants of an important enzyme of energy metabolism, dihydrolipoamide dehydrogenase (dld), have been genetically linked to late-onset AD. Moreover, reduced activity of DLD-containing enzyme complexes is associated with AD progression. To understand how energy metabolism influences AD progres...
Source: Experimental Gerontology - April 27, 2018 Category: Geriatrics Authors: Ahmad W, Ebert PR Tags: Exp Gerontol Source Type: research

Low doses of DNA damaging agents extend Saccharomyces cerevisiae chronological lifespan by promoting entry into quiescence.
Abstract A variety of mild stresses have been shown to extend lifespan in diverse species through hormesis, which is a beneficial response to a stress or toxin that would cause a negative response at a higher exposure. Whether particular stresses induce hormesis can vary with genotype for a given species, and the underlying mechanisms of lifespan extension are only partly understood in most cases. We show that low doses of the DNA damaging or replication stress agents hydroxyurea, methyl methanesulfonate, 4-nitroquinoline 1-oxide, or Zeocin (a phleomycin derivative) lengthened chronological lifespan in Saccharomyc...
Source: Experimental Gerontology - April 26, 2018 Category: Geriatrics Authors: Ross EM, Maxwell PH Tags: Exp Gerontol Source Type: research

Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials.
CONCLUSIONS: Oral creatine administration may improve short-term memory and intelligence/reasoning of healthy individuals but its effect on other cognitive domains remains unclear. Findings suggest potential benefit for aging and stressed individuals. Since creatine is safe, future studies should include larger sample sizes. It is imperative that creatine should be tested on patients with dementias or cognitive impairment. PMID: 29704637 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 25, 2018 Category: Geriatrics Authors: Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D Tags: Exp Gerontol Source Type: research

Mild cognitive impairment and sedentary behavior: A multinational study.
This study assessed the association of SB with MCI in six low- and middle-income countries. METHODS: The Study on Global Ageing and Adult Health (SAGE) survey included 34,129 adults aged ≥50 years [mean (SD) age 62.1 (15.6) years; 51.7% females]. SB was self-reported and expressed as a categorical variable [
Source: Experimental Gerontology - April 25, 2018 Category: Geriatrics Authors: Vancampfort D, Stubbs B, Lara E, Vandenbulcke M, Swinnen N, Smith L, Firth J, Herring MP, Hallgren M, Koyanagi A Tags: Exp Gerontol Source Type: research

Proteomic analysis of age-related changes in ovine cerebrospinal fluid.
In this study, ovine CSF proteins from young (1-2 year old), middle aged (3-6 year old) and old (7-10 year old) sheep were systemically studied. CSF proteins were labelled with iTRAQ tagging reagents and fractionated by 2-dimensional high performance, liquid chromatography. Tryptic peptides were identified using MS/MS fragmentation ions for sequencing and quantified from iTRAQ reporter ion intensities at m/z 114, 115, 116 and 117. Two hundred thirty one peptides were detected, from which 143 proteins were identified. There were 52 proteins with>25% increase in concentrations in the old sheep compared to the young....
Source: Experimental Gerontology - April 25, 2018 Category: Geriatrics Authors: Chen CPC, Preston JE, Zhou S, Fuller HR, Morgan DGA, Chen R Tags: Exp Gerontol Source Type: research

Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: The Toledo Study for Healthy Aging.
CONCLUSIONS: This work highlights the important implication of frailty status in the association between Hcy and increased bone turnover in older women. PMID: 29704640 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 25, 2018 Category: Geriatrics Authors: Álvarez-Sánchez N, Álvarez-Ríos AI, Guerrero JM, García-García FJ, Rodríguez-Mañas L, Cruz-Chamorro I, Lardone PJ, Carrillo-Vico A Tags: Exp Gerontol Source Type: research

Chronically raised C-reactive protein is inversely associated with cortical β-amyloid in older adults at risk of dementia.
CONCLUSIONS: Our preliminary findings suggest that inflammation might be beneficial in the early stages of Alzheimer's disease as the immune systems attempts to combat Aβ pathology particularly in ApoE ε4 carriers. Investigating the temporal relationships between cerebral Aβ and a panel of inflammatory markers would provide further evidence as to whether chronic inflammation might modulate amyloidogenesis in vivo. PMID: 29704641 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 25, 2018 Category: Geriatrics Authors: Hooper C, De Souto Barreto P, Cantet C, Cesari M, Payoux P, Salabert AS, Vellas B, MAPT/DSA study group Tags: Exp Gerontol Source Type: research

Reduced body weight or increased muscle quality: Which is more important for improving physical function following exercise and weight loss in overweight and obese older women?
Abstract The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4 kg/m2) older (age = 69.3 ± 4.1 y) women completed 6 months of multicomponent exercise (cardiorespiratory, resistance, balance and flexibility training) and weight loss (hypocaloric diet that reduced energy intake by ~500 kcal/d). Body composition was mea...
Source: Experimental Gerontology - April 18, 2018 Category: Geriatrics Authors: Straight CR, Berg AC, Reed RA, Johnson MA, Evans EM Tags: Exp Gerontol Source Type: research

Both oophorectomy and obesity impaired solely hippocampal-dependent memory via increased hippocampal dysfunction.
Abstract Our previous study demonstrated that obesity aggravated peripheral insulin resistance and brain dysfunction in the ovariectomized condition. Conversely, the effect of obesity followed by oophorectomy on brain oxidative stress, brain apoptosis, synaptic function and cognitive function, particularly in hippocampal-dependent and hippocampal-independent memory, has not been investigated. Our hypothesis was that oophorectomy aggravated metabolic impairment, brain dysfunction and cognitive impairment in obese rats. Thirty-two female rats were fed with either a normal diet (ND, n = 16) or a high-fat diet (HF...
Source: Experimental Gerontology - April 17, 2018 Category: Geriatrics Authors: Mantor D, Pratchayasakul W, Minta W, Sutham W, Palee S, Sripetchwandee J, Kerdphoo S, Jaiwongkum T, Sriwichaiin S, Krintratun W, Chattipakorn N, Chattipakorn SC Tags: Exp Gerontol Source Type: research

Long-term inhibition of PDE5 ameliorates aging-induced changes in rat testis.
Abstract NO-cGMP signaling pathway has been implicated in reduction of testicular steroidogenesis during aging. Here we analyzed the effect of PDE5 inhibition on old testicular phenotype formation. The old phenotype exhibited low testosterone and increased nitrite levels in circulation, increased cGMP accumulation in testicular interstitial fluid (TIF), progressive atrophy of testicular seminiferous tubules and enlargement of interstitial area followed by rise in blood vessel density and slight increase in the number of Leydig cells and macrophages. Leydig cells have reduced steroidogenic capacity, increased MAP k...
Source: Experimental Gerontology - April 13, 2018 Category: Geriatrics Authors: Sokanovic SJ, Capo I, Medar MM, Andric SA, Kostic TS Tags: Exp Gerontol Source Type: research

Effects of 3-months sitting callisthenic balance and resistance exercise on aerobic capacity, aortic stiffness and body composition in healthy older participants. Randomized Controlled Trial.
CONCLUSIONS: Despite no significant changes in indicators of aerobic capacity (VO2max and 6MWT result) in both groups, significant improvement in all measures of AS, except SBPao were observed in the SCB group, while no AS improvement in the RET group was noted. There were some differences in pattern of body compositions improvement between two groups. PMID: 29655928 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 12, 2018 Category: Geriatrics Authors: Kujawski S, Kujawska A, Gajos M, Klawe JJ, Tafil-Klawe M, Mądra-Gackowska K, Stankiewicz B, Newton JL, Kędziora-Kornatowska K, Zalewski P Tags: Exp Gerontol Source Type: research

Aging impairs mitochondrial respiratory capacity in classical monocytes.
Abstract Aging is a critical healthcare concern, with age-related inflammation disposing individuals to a variety of diseases. Monocytes are affected by the aging process, with increased inflammation and impaired cellular functions such as phagocytosis. Mechanisms by which aging alters monocyte function are unknown, but recent research suggests that the balance of metabolic processes determine immune cell phenotype and function. Given the known association between aging and mitochondrial dysfunction in other tissues, we hypothesized that aging would impair mitochondrial function in monocytes. To test this, we isol...
Source: Experimental Gerontology - April 12, 2018 Category: Geriatrics Authors: Pence BD, Yarbro JR Tags: Exp Gerontol Source Type: research

Do depressive symptoms affect balance in older adults with mild cognitive impairment? Results from the "gait and brain study".
Do depressive symptoms affect balance in older adults with mild cognitive impairment? Results from the "gait and brain study". Exp Gerontol. 2018 Apr 10;: Authors: Pieruccini-Faria F, Muir-Hunter SW, Montero-Odasso M Abstract BACKGROUND: Mild cognitive impairment (MCI) and depression independently affect balance control in older adults. However, it is uncertain whether depressive symptoms would amplify balance problems in older adults with MCI. AIM: To evaluate if the presence of significant depressive symptoms affects postural sway under somatosensory challenges in a MCI population. ...
Source: Experimental Gerontology - April 10, 2018 Category: Geriatrics Authors: Pieruccini-Faria F, Muir-Hunter SW, Montero-Odasso M Tags: Exp Gerontol Source Type: research

Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro.
In this study, mouse neuroblastoma (N2a) cells were treated with d‑galactose (d‑Gal) to establish cell aging to investigate the antiaging effect and mechanisms of spermidine. Changes in the cell cycle and β-galactosidase activity were analyzed to evaluate the extent of cell aging. Stabilities of mitochondrial mRNA and mitochondrial membrane potential (MMP) were evaluated in the process of cell aging under different treatments. The mitochondrial function was also evaluated using the Seahorse Metabolic Analysis System combined with ATP production. The unfolded protein response (UPR) of the N2a cells was analyzed und...
Source: Experimental Gerontology - April 9, 2018 Category: Geriatrics Authors: Jing YH, Yan JL, Wang QJ, Chen HC, Ma XZ, Yin J, Gao LP Tags: Exp Gerontol Source Type: research

Associations of sarcopenic obesity with the metabolic syndrome and insulin resistance over five years in older men: The concord health and ageing in men project.
Abstract PURPOSE: Previous cross-sectional studies investigating associations of sarcopenic obesity with metabolic syndrome (MetS) and insulin resistance have not utilised consensus definitions of sarcopenia. We aimed to determine associations of sarcopenic obesity with MetS and insulin resistance over five years in community-dwelling older men. METHODS: 1231 men aged ≥70 years had appendicular lean mass (ALM) and body fat percentage assessed by dual-energy X-ray absorptiometry and hand grip strength and gait speed tests. Sarcopenia was defined as low ALM/height (m2) and low hand grip strength or gait sp...
Source: Experimental Gerontology - April 9, 2018 Category: Geriatrics Authors: Scott D, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Seibel M, Waite LM, Hirani V Tags: Exp Gerontol Source Type: research

Reaction time in healthy elderly is associated with chronic low-grade inflammation and advanced glycation end product.
Abstract Chronic inflammation and Advanced Glycation End products (AGE) are associated with sarcopenia. Decreased voluntary muscle activation and increased antagonist coactivation can contribute to age-related muscle weakness. The influence of chronic inflammation and AGE in these neuromuscular mechanisms is not clear. We studied whether a relation exists between circulating levels of inflammatory cytokines and AGEs as well as the interplay between agonist and antagonist muscle activation. We studied 64 community-dwelling old subjects, during a maximal isometric voluntary contraction (MVC) and a reaction-time (RT)...
Source: Experimental Gerontology - April 6, 2018 Category: Geriatrics Authors: Arnold P, Njemini R, Vantieghem S, Gorus E, Pool-Goudzwaard A, Buyl R, Bautmans I Tags: Exp Gerontol Source Type: research

Exercise training causes a partial improvement through increasing testosterone and eNOS for erectile function in middle-aged rats.
CONCLUSIONS: Exercise training has beneficial effects on erectile function in aged rats through increased testosterone production from the testis and strengthening of the cavernous endothelium with activation of eNOS. Therefore, exercise training may be a therapeutic modality for improving erectile dysfunction associated with aging. PMID: 29627420 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 5, 2018 Category: Geriatrics Authors: Seo DY, Lee SR, Kwak HB, Park H, Seo KW, Noh YH, Song KM, Ryu JK, Ko KS, Rhee BD, Han J Tags: Exp Gerontol Source Type: research

Depressive symptoms and muscle weakness: A two-way relation?
Abstract The potential association between depressive symptoms and dynapenia - i.e. muscle weakness - is limited to few, mainly cross-sectional, studies. We use SHARE (Survey on Health, Ageing and Retirement in Europe) panel data to investigate whether the onset of dynapenia at 4-year follow-up can be explained by pre-existing (either at baseline, or at 2-year follow-up) depressive symptoms, or vice versa. Depressive symptoms were identified as a score of 4 or more on the 12-item EURO-D scale. Individuals were classified as affected by dynapenia if they had handgrip strength of
Source: Experimental Gerontology - April 5, 2018 Category: Geriatrics Authors: Bertoni M, Maggi S, Manzato E, Veronese N, Weber G Tags: Exp Gerontol Source Type: research

Elevated expression of ageing and immunity genes in queens of the black garden ant.
Abstract Studies in model organisms have identified a variety of genes whose expression can be experimentally modulated to produce changes in longevity, but whether these genes are the same as those involved in natural variation in lifespan remains unclear. Social insects boast some of the largest lifespan differences known between plastic phenotypes, with queen and worker lifespans differing by an order of magnitude despite no systematic nucleotide sequence differences between them. The contrasting lifespans of queens and workers are thus the result of differences in gene expression. We used RNA sequencing of bra...
Source: Experimental Gerontology - April 3, 2018 Category: Geriatrics Authors: Lucas ER, Keller L Tags: Exp Gerontol Source Type: research

Limb muscle quality and quantity in elderly adults with dynapenia but not sarcopenia: An ultrasound imaging study.
Abstract BACKGROUND: Dynapenia is prevalent in people with reduced skeletal muscle mass, i.e. sarcopenia, but a certain population develops muscle strength loss despite having normal skeletal muscle volume. To date, studies investigating muscle quality and quantity in groups with dynapenia but not sarcopenia are limited. METHODS: Echogenicity and thickness of the biceps brachii, triceps brachii, rectus femoris, and medial gastrocnemius muscles were measured using high-resolution ultrasonography in 140 community-dwelling elderly adults. Participants with decreased handgrip strength but normal muscular volume w...
Source: Experimental Gerontology - March 28, 2018 Category: Geriatrics Authors: Chang KV, Wu WT, Huang KC, Jan WH, Han DS Tags: Exp Gerontol Source Type: research

Effects of aquatic and land-based exercises on amyloid beta, heat shock protein 27, and pulse wave velocity in elderly women.
Abstract BACKGROUND: Alzheimer's disease is a neurodegenerative brain disease resulting from the deterioration of neuronal cells and vascular dementia, the latter of which results from cerebrovascular disorders. Exercise is effective in preventing and treating degenerative brain diseases as it activates blood flow to the brain, increases nerve production in the hippocampus, and promotes the expression of synaptic plasticity-related proteins. Therefore, this study investigated the effects of 16-week aquatic and land-based exercise programs on amyloid beta (Aβ), heat shock protein (HSP) 27 levels, and pulse wav...
Source: Experimental Gerontology - March 28, 2018 Category: Geriatrics Authors: Kim JH, Jung YS, Kim JW, Ha MS, Ha SM, Kim DY Tags: Exp Gerontol Source Type: research

Slow loaded breathing training improves blood pressure, lung capacity and arm exercise endurance for older people with treated and stable isolated systolic hypertension.
CONCLUSION: Slow inspiratory muscle training is not only effective in reducing resting BP, even in older people with well controlled isolated systolic hypertension, and increases inspiratory muscle strength, lung capacity and arm exercise duration. PMID: 29604403 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2018 Category: Geriatrics Authors: Ublosakka-Jones C, Tongdee P, Pachirat O, Jones DA Tags: Exp Gerontol Source Type: research

Cardiovascular tissue engineering: From basic science to clinical application.
Abstract Valvular heart disease is an increasing population health problem and, especially in the elderly, a significant cause of morbidity and mortality. The current treatment options, such as mechanical and bioprosthetic heart valve replacements, have significant restrictions and limitations. Considering the increased life expectancy of our aging population, there is an urgent need for novel heart valve concepts that remain functional throughout life to prevent the need for reoperation. Heart valve tissue engineering aims to overcome these constraints by creating regenerative, self-repairing valve substitutes wi...
Source: Experimental Gerontology - March 28, 2018 Category: Geriatrics Authors: Fioretta ES, von Boehmer L, Motta SE, Lintas V, Hoerstrup SP, Emmert MY Tags: Exp Gerontol Source Type: research

Predictors of cognitive impairment assessed by Mini Mental State Examination in community-dwelling older adults: relevance of the step test.
Abstract BACKGROUND: Several predictors of cognitive impairment assessed by Mini Mental State Examination (MMSE) have previously been identified. However, which predictors are the most relevant and what is their effect on MMSE categories remains unclear. METHODS: Cross-sectional and longitudinal study using data from 1116 older adults (72.6 ± 5.6 years, 579 female), 350 of whom were followed for 7 years. At baseline, the following variables were collected: personal data, marital status, occupation, anthropometric measures, risk factors, previous cardiovascular events, self-rated health and phys...
Source: Experimental Gerontology - March 27, 2018 Category: Geriatrics Authors: Muscari A, Spiller I, Bianchi G, Fabbri E, Forti P, Magalotti D, Pandolfi P, Zoli M, Pianoro Study Group Tags: Exp Gerontol Source Type: research

Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs.
Abstract We recently reported that in addition to its classical cytoplasmic location, the fast skeletal muscle Troponin T3 (TnT3) shuttles to the nucleus, where it appears to perform nonclassical transcription regulatory functions. Importantly, changes in the composition of the nucleus-localized pool of TnT3 and its fragments contribute to age-dependent muscle damage and wasting. Here, using ChIP-Seq, we demonstrate that TnT3 associates with DNA consensus sequences including the TGCCT motif, which is required for p53 binding to the promoter area of p53-related genes. Gene set enrichment analysis further demonstrat...
Source: Experimental Gerontology - March 26, 2018 Category: Geriatrics Authors: Nunez Lopez YO, Messi ML, Pratley RE, Zhang T, Delbono O Tags: Exp Gerontol Source Type: research

Age dependent variations in the deep brain photoreceptors (DBPs), GnRH-GnIH system and testicular steroidogenesis in Japanese quail, Coturnix coturnix japonica.
Abstract The complex physiology of aging involves a number of molecular and biochemical events, manifested as signs of senescence. Japanese quail is a very unique and advantageous model to study the signs and symptoms of senescence in the central and peripheral modules of HPG axis. In the present study, we have investigated the age dependent variations in hypothalamic deep brain photoreceptors (DBPs), central GnRH-I/II-GnIH-Mel1cR system, testicular GnRH-GnIH system, testicular steroidogenic genes and proteins, androgen receptor (AR) and serum testosterone level in quail of different age groups [3-wk (sexually imm...
Source: Experimental Gerontology - March 23, 2018 Category: Geriatrics Authors: Banerjee S, Shahin S, Chaturvedi CM Tags: Exp Gerontol Source Type: research

Repetitions to failure versus not to failure during concurrent training in healthy elderly men: A randomized clinical trial.
Abstract This randomized clinical trial compared the neuromuscular adaptations induced by concurrent training (CT) performed with repetitions to concentric failure and not to failure in elderly men. Fifty-two individuals (66.2 ± 5.2 years) completed the pre- and post-measurements and were divided into three groups: repetitions to failure (RFG, n = 17); repetitions not to failure (NFG, n = 20); and repetitions not to failure with total volume equalized to RFG (ENFG, n = 15). Participants were assessed in isometric knee extension peak torque (PTiso), maximal strength (1RM) in the leg press (...
Source: Experimental Gerontology - March 22, 2018 Category: Geriatrics Authors: da Silva Neves LX, Teodoro JL, Menger E, Lopez P, Grazioli R, Farinha J, Moraes K, Bottaro M, Pinto RS, Izquierdo M, Cadore EL Tags: Exp Gerontol Source Type: research

Comparing the effects of a home-based exercise program using a gerontechnology to a community-based group exercise program on functional capacities in older adults after a minor injury.
-Leheudre M PMID: 29577975 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 22, 2018 Category: Geriatrics Authors: Martel D, Lauzé M, Agnoux A, de Laclos LF, Daoust R, Émond M, Sirois MJ, Aubertin-Leheudre M Tags: Exp Gerontol Source Type: research