Visuospatial cognition predicts performance on an obstructed vision obstacle walking task in older adults
This study lays the groundwork for using the OBVIO task in future assessment and intervention studies.PMID:38490285 | DOI:10.1016/j.exger.2024.112403 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 15, 2024 Category: Geriatrics Authors: Steven P Winesett Sudeshna A Chatterjee Brianne Borgia Brigette A Cox Kelly A Hawkins Jon W Miles Clayton W Swanson Julia T Choi Rachael D Seidler Emily J Fox David J Clark Source Type: research

Endoplasmic reticulum stress-induced necroptosis promotes cochlear inflammation: Implications for age-related hearing loss
In this study, we found that the inflammation, endoplasmic reticulum (ER) stress and necroptosis signalings are activated in the cochlea of aged C57BL/6 mice. ER stress activator tunicamycin (TM) induced necroptosis in cochlear HEI-OC1 cells and cochlear explants, while necroptosis inhibitors protected cochlear cells from ER stress-induced cell death. The antioxidants inhibited necroptosis and protected HEI-OC1 cells from TM insults. Necroptotic HEI-OC1 cells promoted the activation of the co-cultured macrophages via Myd88 signaling. Moreover, necroptosis inhibitor protected from TM-induced hearing loss, and inhibited infl...
Source: Experimental Gerontology - March 15, 2024 Category: Geriatrics Authors: Zhongwu Su Yi Liu Weijian Zhang Wenhui Liang Yuyan Chen Jinyuan Cao Yu Liu Yiqing Zheng Qi Li Source Type: research

Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice
This study explored the effects of outer membrane vesicles (OMVs) from the gut microbiota of AD patients on learning and memory abilities and Tau protein phosphorylation in mice. In contrast to the OMVs from healthy controls and the PBS treatment group, mice treated with AD-OMVs exhibited notable declines in learning and memory capabilities, as evidenced by results from the Morris water maze, Y-maze, and novel object recognition tests. Immunohistochemistry and Western blot assessments unveiled elevated levels of hyperphosphorylated Tau in the cortex and hippocampus of mice treated with AD-OMVs. However, there were no alter...
Source: Experimental Gerontology - March 14, 2024 Category: Geriatrics Authors: Zhongying Shao Yanjun Lu Aihong Xing Xiying He Hongyan Xie Ming Hu Source Type: research

Impact of combined alpha-lipoic acid and mitoquinone supplementation on myocardial infarction in aged rats: Heart performance and molecular mechanisms
CONCLUSION: The study revealed that combined intervention synergistically mitigated cardiac dysfunction by suppressing inflammatory and apoptotic pathways in aged rats with MI. Further research is needed to validate the potential of ALA and Mito Q as therapeutic options for elderly people at risk of heart attacks.PMID:38484905 | DOI:10.1016/j.exger.2024.112402 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 14, 2024 Category: Geriatrics Authors: Samira Nemati Zohreh Zavvari-Oskuye Soleyman Bafadam Behnaz Mokhtari Reza Badalzadeh Abedin Vakili Source Type: research

The mediating role of lower body muscle strength and IGF-1 level in the relationship between age and cognition. A MIDUS substudy
CONCLUSIONS: Our study demonstrated the serial multiple mediation roles of muscle strength and IGF-1 levels on the relationship between age and specific cognitive functions. Further longitudinal research should be performed to confirm the serial mediation results.PMID:38484906 | DOI:10.1016/j.exger.2024.112399 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 14, 2024 Category: Geriatrics Authors: Evrim G ökçe Navin Kaushal Theo Fontanille Tudor Vrinceanu Kathia Saillant Wouter A J Vints Thomas Freret Antoine Gauthier Louis Bherer Antoine Langeard Source Type: research

Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice
This study explored the effects of outer membrane vesicles (OMVs) from the gut microbiota of AD patients on learning and memory abilities and Tau protein phosphorylation in mice. In contrast to the OMVs from healthy controls and the PBS treatment group, mice treated with AD-OMVs exhibited notable declines in learning and memory capabilities, as evidenced by results from the Morris water maze, Y-maze, and novel object recognition tests. Immunohistochemistry and Western blot assessments unveiled elevated levels of hyperphosphorylated Tau in the cortex and hippocampus of mice treated with AD-OMVs. However, there were no alter...
Source: Experimental Gerontology - March 14, 2024 Category: Geriatrics Authors: Zhongying Shao Yanjun Lu Aihong Xing Xiying He Hongyan Xie Ming Hu Source Type: research

Impact of combined alpha-lipoic acid and mitoquinone supplementation on myocardial infarction in aged rats: Heart performance and molecular mechanisms
CONCLUSION: The study revealed that combined intervention synergistically mitigated cardiac dysfunction by suppressing inflammatory and apoptotic pathways in aged rats with MI. Further research is needed to validate the potential of ALA and Mito Q as therapeutic options for elderly people at risk of heart attacks.PMID:38484905 | DOI:10.1016/j.exger.2024.112402 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 14, 2024 Category: Geriatrics Authors: Samira Nemati Zohreh Zavvari-Oskuye Soleyman Bafadam Behnaz Mokhtari Reza Badalzadeh Abedin Vakili Source Type: research

The mediating role of lower body muscle strength and IGF-1 levels in age related cognitive change. A MIDUS substudy
CONCLUSIONS: Our study demonstrated the serial multiple mediation roles of muscle strength and IGF-1 levels on the relationship between age and specific cognitive functions. Further longitudinal research should be performed to confirm the serial mediation results.PMID:38484906 | DOI:10.1016/j.exger.2024.112399 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 14, 2024 Category: Geriatrics Authors: Evrim G ökçe Navin Kaushal Theo Fontanille Tudor Vrinceanu Kathia Saillant Wouter Vints Thomas Freret Antoine Gauthier Louis Bherer Antoine Langeard Source Type: research

Parental age at death is associated with age at first birth in offspring
CONCLUSION: Our findings suggest that aging-related processes may be interrelated with the processes underlying the timing of reproduction and are in general agreement with evolutionary theories of aging.PMID:38479685 | DOI:10.1016/j.exger.2024.112396 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 13, 2024 Category: Geriatrics Authors: Anna Thal én Anders Ledberg Source Type: research

Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults
Exp Gerontol. 2024 Mar 12;188:112397. doi: 10.1016/j.exger.2024.112397. Online ahead of print.ABSTRACTAlthough sleep quality and physical activity (PA) may influence on arterial stiffness, the combined effects of these two factors on arterial stiffness remain unknown. A total of 103 healthy middle-aged and older men and women (aged 50-83 years) with no history of cardiovascular disease and depression were included in this study. Arterial stiffness was measured using carotid-femoral pulse wave velocity (cfPWV), brachial-ankle PWV (baPWV), and femoral-ankle PWV (faPWV). Poor sleepers were defined as those with a Pittsburgh S...
Source: Experimental Gerontology - March 10, 2024 Category: Geriatrics Authors: Youngju Choi Keisei Kosaki Nobuhiko Akazawa Koichiro Tanahashi Seiji Maeda Source Type: research

Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults
Exp Gerontol. 2024 Mar 8:112397. doi: 10.1016/j.exger.2024.112397. Online ahead of print.ABSTRACTAlthough sleep quality and physical activity (PA) may influence on arterial stiffness, the combined effects of these two factors on arterial stiffness remain unknown. A total of 103 healthy middle-aged and older men and women (aged 50-83 years) with no history of cardiovascular disease and depression were included in this study. Arterial stiffness was measured using carotid-femoral pulse wave velocity (cfPWV), brachial-ankle PWV (baPWV), and femoral-ankle PWV (faPWV). Poor sleepers were defined as those with a Pittsburgh Sleep ...
Source: Experimental Gerontology - March 10, 2024 Category: Geriatrics Authors: Youngju Choi Keisei Kosaki Nobuhiko Akazawa Koichiro Tanahashi Seiji Maeda Source Type: research

Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults
Exp Gerontol. 2024 Mar 8:112397. doi: 10.1016/j.exger.2024.112397. Online ahead of print.ABSTRACTAlthough sleep quality and physical activity (PA) may influence on arterial stiffness, the combined effects of these two factors on arterial stiffness remain unknown. A total of 103 healthy middle-aged and older men and women (aged 50-83 years) with no history of cardiovascular disease and depression were included in this study. Arterial stiffness was measured using carotid-femoral pulse wave velocity (cfPWV), brachial-ankle PWV (baPWV), and femoral-ankle PWV (faPWV). Poor sleepers were defined as those with a Pittsburgh Sleep ...
Source: Experimental Gerontology - March 10, 2024 Category: Geriatrics Authors: Youngju Choi Keisei Kosaki Nobuhiko Akazawa Koichiro Tanahashi Seiji Maeda Source Type: research

Tangshen Formula alleviates inflammatory injury against aged diabetic kidney disease through modulating gut microbiota composition and related amino acid metabolism
Exp Gerontol. 2024 Mar 9;188:112393. doi: 10.1016/j.exger.2024.112393. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is leading causes and one of the fastest growing causes of chronic kidney disease worldwide, and leads to high morbidity and mortality. Emerging evidences have revealed gut microbiota dysbiosis and related metabolism dysfunction play a dominant role in DKD progression and treatment through modulating inflammation. Our previous studies showed that Tangshen Formula (TSF), a Chinese herbal prescription, exhibited anti-inflammatory effect on DKD, but underlying mechanism that involved gut microbiot...
Source: Experimental Gerontology - March 8, 2024 Category: Geriatrics Authors: Dan-Qian Chen Hao-Jun Zhang Wen Zhang Kai Feng Hui Liu Hai-Ling Zhao Ping Li Source Type: research

Tangshen Formula alleviates inflammatory injury against aged diabetic kidney disease through modulating gut microbiota composition and related amino acid metabolism
Exp Gerontol. 2024 Mar 6:112393. doi: 10.1016/j.exger.2024.112393. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is leading causes and one of the fastest growing causes of chronic kidney disease worldwide, and leads to high morbidity and mortality. Emerging evidences have revealed gut microbiota dysbiosis and related metabolism dysfunction play a dominant role in DKD progression and treatment through modulating inflammation. Our previous studies showed that Tangshen Formula (TSF), a Chinese herbal prescription, exhibited anti-inflammatory effect on DKD, but underlying mechanism that involved gut microbiota an...
Source: Experimental Gerontology - March 8, 2024 Category: Geriatrics Authors: Dan-Qian Chen Hao-Jun Zhang Wen Zhang Kai Feng Hui Liu Hai-Ling Zhao Ping Li Source Type: research

Circulating cytokines and vascular dementia: A bi-directional Mendelian randomization study
Exp Gerontol. 2024 Mar 5:112394. doi: 10.1016/j.exger.2024.112394. Online ahead of print.ABSTRACTInflammatory responses are associated with the development of vascular dementia (VaD). Circulating cytokines modulate the inflammatory response and are important for the immune system. To further elucidate the role of the immune system in VaD, we used Mendelian randomization (MR) to comprehensively and bi-directionally assess the role of circulating cytokines in VaD. Using state-of-the-art genome-wide association studies, we primarily assessed whether different genetic levels of 41 circulating cytokines affect the risk of devel...
Source: Experimental Gerontology - March 7, 2024 Category: Geriatrics Authors: Yuge Xia Zhirui Xu Yicong Zhang Dongli Jiang Yunyi Zhu Xiaolun Liang Rui Sun Source Type: research