Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice.
In conclusion, E+B reduced mortality, had no effect on cognitive function and variable effects on muscle function. PMID: 28818411 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - August 14, 2017 Category: Geriatrics Authors: Pence BD, Bhattacharya TK, Park P, Rytych JL, Allen JM, Sun Y, McCusker RH, Kelley KW, Johnson RW, Rhodes JS, Woods JA Tags: Exp Gerontol Source Type: research

Metabonomics approach to assessing the metabolism variation and gender gap of Drosophila melanogaster in aging process.
This study demonstrate that metabolomics is promising as a valuable method not only to reveal metabolites that related to senescence, but also to help us understand differences between male and female flies in aging process. PMID: 28811139 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - August 12, 2017 Category: Geriatrics Authors: Zhou YZ, Yan ML, Gao L, Zhang JQ, Qin XM, Zhang X, Du GH Tags: Exp Gerontol Source Type: research

Divergent effects of resistance training and anabolic steroid on the postsynaptic region of different skeletal muscles of aged rats.
This study aimed to analyze the effects of resistance training associated with testosterone administration in the neuromuscular junction (NMJ) postsynaptic region of different skeletal muscle types of aged rats. Wistar rats were divided into: SEI - 20-months-old control, SEF - 24-months-old control, T - 20-months-old with testosterone, S - 20-months-old resistance trained and ST - 20-months-old with resistance training associated with testosterone propionate. All groups were submitted to familiarization and maximum load carrying testing (MLCT). The MLCT was applied before and after the resistance training (RT) period. RT (...
Source: Experimental Gerontology - August 12, 2017 Category: Geriatrics Authors: Neto WK, de Assis Silva W, Ciena AP, Anaruma CA, Gama EF Tags: Exp Gerontol Source Type: research

Does long-term androgen deficiency lead to metabolic syndrome in middle-aged rats?
te; M, Uličná O, Ostatníková D, Hodosy J, Celec P Abstract Evidence from clinical observational studies and animal experiments suggests that hypogonadism is associated with the metabolic syndrome. In most of the experiments, androgen deficiency is induced by gonadectomy in the adulthood and relatively short-term effects of hypogonadism on metabolic parameters are usually observed. The purpose of this study was to evaluate the metabolic effects of long-term androgen deficiency starting before puberty in middle-aged male rats. The components of the metabolic syndrome were examined in male, fema...
Source: Experimental Gerontology - August 11, 2017 Category: Geriatrics Authors: Borbélyová V, Domonkos E, Bábíčková J, Tóthová Ľ, Kačmárová M, Uličná O, Ostatníková D, Hodosy J, Celec P Tags: Exp Gerontol Source Type: research

Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats.
Abstract We previously reported the ability of dietary supplementation with acetyl-l-carnitine (ALCAR) to prevent age-related decreases of mitochondrial biogenesis in skeletal muscle and liver of old rats. Here, we investigate the effects of ALCAR supplementation in cerebral hemispheres and cerebellum of old rats by analyzing several parameters linked to mitochondrial biogenesis, mitochondrial dynamics and antioxidant defenses. We measured the level of the coactivators PGC-1α and PGC-1β and of the factors regulating mitochondrial biogenesis, finding an age-related decrease of PGC-1β, whereas PGC-1&...
Source: Experimental Gerontology - August 11, 2017 Category: Geriatrics Authors: Nicassio L, Fracasso F, Sirago G, Musicco C, Picca A, Marzetti E, Calvani R, Cantatore P, Gadaleta MN, Pesce V Tags: Exp Gerontol Source Type: research

Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice.
Abstract Periods of skeletal muscle disuse, for example due to a sedentary lifestyle or bed rest, are associated with aging and can lead to muscle atrophy. We previously found that the flavan 3-ol fraction derived from cocoa (FL) enhanced energy expenditure with metabolic changes in skeletal muscle. In the present study, we examined the effect of FL on disuse muscle atrophy induced by hindlimb suspension in mice. Male C57BL/6J mice were assigned to four groups as follows: unsuspended-vehicle, unsuspended-FL, suspended-vehicle, and suspended-FL. Mice in the vehicle treatment groups were administered distilled water...
Source: Experimental Gerontology - August 11, 2017 Category: Geriatrics Authors: Ito M, Kudo N, Miyake Y, Imai T, Unno T, Yamashita Y, Hirota Y, Ashida H, Osakabe N Tags: Exp Gerontol Source Type: research

Power training using pneumatic machines vs. plate-loaded machines to improve muscle power in older adults.
CONCLUSIONS: Pneumatic and plate-loaded machines were effective in improving lower body power and physical function in older adults. The results suggest that power training can be safely and effectively performed by older adults using either pneumatic or plate-loaded machines. PMID: 28804046 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - August 10, 2017 Category: Geriatrics Authors: Balachandran AT, Gandia K, Jacobs KA, Streiner DL, Eltoukhy M, Signorile JF Tags: Exp Gerontol Source Type: research

Effect of resistance training volume on walking speed performance in postmenopausal women: A randomized controlled trial.
CONCLUSION: Our results suggest that high-volume RT (six sets) at 70% of 1RM is necessary to promote an improved fast walking speed performance and abdominal fatness in PW. PMID: 28804047 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - August 10, 2017 Category: Geriatrics Authors: Nunes PRP, Oliveira AA, Martins FM, Souza AP, Orsatti FL Tags: Exp Gerontol Source Type: research

Effects of concurrent and aerobic exercises on postexercise hypotension in elderly hypertensive men.
CONCLUSION: Concurrent exercise produced acute PEH similar to aerobic exercise but such effect did not last as long as aerobic exercise in elderly patients with essential hypertension. PMID: 28804048 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - August 10, 2017 Category: Geriatrics Authors: Ferrari R, Umpierre D, Vogel G, Vieira PJC, Santos LP, de Mello RB, Tanaka H, Fuchs SC Tags: Exp Gerontol Source Type: research

Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging.
We examined associations between baseline serum levels of Interleukin-6 (IL-6) and other cytokines (IL1-2, TNF, IL-10, and IL1β) and chemokines (CCL2, CCL5, CXCL8, CXCL9 and CXCL10) with 15-year mortality in 1,191 admixed Brazilians aged 60years and over. Elevated IL6 level (but not other biomarkers) was associated with increased risk of deaths with fully adjusted hazard ratios of 1.51 (95% CI=1.15, 1.97), 1.54 (95% CI=1.20, 1.96) and 1.79 (95% CI=1.40, 2.29) for the 2nd, 3rd and the highest quartiles, respectively. Genomic African and Native American proportions did not modify the association (p>0.05). The discrim...
Source: Experimental Gerontology - August 9, 2017 Category: Geriatrics Authors: Lima-Costa MF, de Melo Mambrini JV, de Lima Torres KC, Peixoto SV, de Oliveira C, Tarazona-Santos E, Teixeira-Carvalho A, Martins-Filho OA Tags: Exp Gerontol Source Type: research

Age-related changes of physiological performance and survivorship of bank voles selected for high aerobic capacity.
Abstract Variation in lifespans is an intriguing phenomenon, but how metabolic rate influence this variation remains unclear. High aerobic capacity can result in health benefits, but also in increased oxidative damage and accelerated ageing. We tested these contradictory predictions using bank voles (Myodes=Clethrionomys glareolus) from lines selected for high swim-induced aerobic metabolism (A), which had about 50% higher maximum metabolic rate and a higher basal and routine metabolic rates, than those from unselected control lines (C). We measured sprint speed (VSmax), forced-running maximum metabolic rate (VO2r...
Source: Experimental Gerontology - August 9, 2017 Category: Geriatrics Authors: Rudolf AM, Dańko MJ, Sadowska ET, Dheyongera G, Koteja P Tags: Exp Gerontol Source Type: research

Effects of aging on basement membrane of the soleus muscle during recovery following disuse atrophy in rats.
Abstract Aging is known to lead to the impaired recovery of muscle after disuse as well as the increased susceptibility of the muscle to damage. Here, we show that, in the older rats, reloading after disuse atrophy, causes the damage of the muscle fibers and the basement membrane (BM) that structurally support the muscle fibers. Male Wistar rats of 3-(young) and 20-(older) months of age were subjected to hindlimb-unloading for 2weeks followed by reloading for a week. In the older rats, the soleus muscles showed necrosis and central nuclei fiber indicating the regeneration of muscle fibers. Furthermore, ectopic imm...
Source: Experimental Gerontology - August 9, 2017 Category: Geriatrics Authors: Kanazawa Y, Ikegami K, Sujino M, Koinuma S, Nagano M, Oi Y, Onishi T, Sugiyo S, Takeda I, Kaji H, Shigeyoshi Y Tags: Exp Gerontol Source Type: research

A single high dose of dexamethasone increases GAP-43 and synaptophysin in the hippocampus of aged rats.
Abstract The administration of dexamethasone, a synthetic glucocorticoid receptor agonist, has been reported to modulate cognitive performance in both animals and humans. In the present study, we demonstrate the effects of a single high dose of dexamethasone on the expression and distribution of synaptic plasticity-related proteins, growth-associated protein-43 (GAP-43) and synaptophysin, in the hippocampus of 6-, 12-, 18- and 24-month-old rats. Acute dexamethasone treatment significantly altered the expression of GAP-43 at the posttranslational level by modulating the levels of phosphorylated GAP-43 and proteolyt...
Source: Experimental Gerontology - August 8, 2017 Category: Geriatrics Authors: Tesic V, Perovic M, Zaletel I, Jovanovic M, Puskas N, Ruzdijic S, Kanazir S Tags: Exp Gerontol Source Type: research

PGC-1 α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver.
PGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver. Exp Gerontol. 2017 Aug 08;: Authors: Kristensen CM, Brandt CT, Ringholm S, Pilegaard H Abstract Aging is associated with changes in several metabolic pathways affecting liver function including the adaptive unfolded protein response (UPR). On the other hand, exercise training has been shown to exert beneficial effects on metabolism including the liver and exercise training has been reported to affect hepatic UPR. PGC-1α is a transcriptional coactivator involved in exercise training-induced adaptations...
Source: Experimental Gerontology - August 8, 2017 Category: Geriatrics Authors: Kristensen CM, Brandt CT, Ringholm S, Pilegaard H Tags: Exp Gerontol Source Type: research

Mechanisms underlying longevity: A genetic switch model of aging.
Abstract While the questions of "What causes aging?" and "Why do we age?" and "How can we stop it?" remain unanswered, recent advances in aging research have continued to increase our understanding of the aging process. Until the last couple of decades, aging was viewed as an inevitable process of damage accumulation and not a subject for scientific pursuit. This view changed when it was demonstrated that the aging process is in fact malleable and genetically determined: mutations in single genes can have dramatic effects on longevity. Despite the rapid advancement of our knowledge ab...
Source: Experimental Gerontology - August 7, 2017 Category: Geriatrics Authors: Van Raamsdonk JM Tags: Exp Gerontol Source Type: research

Knee extensor power asymmetry is unrelated to functional mobility of older adults.
Abstract PURPOSE: To determine whether knee extensor power asymmetry limits functional mobility of older adults who possess muscle weakness. METHODS: Knee extensor power was measured in 36 older men and women (76.0±7.6yr), for each leg, on an isokinetic dynamometer at 60, 180, and 300degs(-1) and power asymmetry was calculated as the percent difference in power between strong and weak legs, at each isokinetic velocity. 400-m walk, stair ascent, and five-repetition chair rise tests were performed to assess functional mobility. Pearson correlations were used to examine the relationship between weak leg p...
Source: Experimental Gerontology - August 7, 2017 Category: Geriatrics Authors: LaRoche DP, Villa MR, Bond CW, Cook SB Tags: Exp Gerontol Source Type: research

Interaction between mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53/p21/p16.
Abstract Cellular senescence is related to aging and extremely stable proliferative arrest with active metabolism. Senescent cells can activate mammalian target of rapamycin (mTOR) pathway, which plays a crucial role in the regulation of cell metabolism, cellular growth, and autophagy in senescence-associated cardiovascular diseases. Therefore, we examined whether mTOR pathway could induce cellular senescence by inhibition of autophagy in vascular smooth muscle cells (VSMCs). We found that adriamycin-induced VSMC senescence is accompanied by increased activity of mTOR, a major controller of cell growth and a negat...
Source: Experimental Gerontology - August 7, 2017 Category: Geriatrics Authors: Sung JY, Lee KY, Kim JR, Choi HC Tags: Exp Gerontol Source Type: research

The subsequent course of disability in older persons discharged to a skilled nursing facility after an acute hospitalization.
CONCLUSION: Among older persons discharged to a SNF after an acute hospitalization, the functional course over 6months was generally poor, with recovery to pre-hospital function observed in only one out of every four cases. Relative to elective major surgery, functional outcomes were worse for non-elective major surgery, critical illness, and other hospitalizations. PMID: 28782593 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - August 3, 2017 Category: Geriatrics Authors: Liu Z, Han L, Leo-Summers L, Gahbauer EA, Allore HG, Gill TM Tags: Exp Gerontol Source Type: research

Hesperidin reverses perivascular adipose-mediated aortic stiffness with aging.
Abstract We tested the hypothesis that hesperidin would reverse age-related aortic stiffness, perivascular adipose (PVAT) mediated-arterial stiffening and PVAT advanced glycation end-products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures of arterial stiffness, were assessed in C57BL/6 mice that were young (6months), old (27-29months), or old treated with hesperidin for 4weeks. Old compared with young mice had increased aPWV (444±10 vs. 358±8cm/s, P
Source: Experimental Gerontology - August 2, 2017 Category: Geriatrics Authors: Ouyang A, Garner TB, Fleenor BS Tags: Exp Gerontol Source Type: research

Training load does not affect detraining's effect on muscle volume, muscle strength and functional capacity among older adults.
Abstract Research underlines the potential of low-load resistance exercise in older adults. However, while the effects of detraining from high-load protocols have been established, it is not known whether gains from low-load training would be better/worse maintained. The current study evaluated the effects of 24weeks of detraining that followed 12weeks of high- and low-load resistance exercise in older adults. Fifty-six older adults (68.0±5.0years) were randomly assigned to leg press and leg extension training at either HIGH load (2×10-15 repetitions at 80% of one-repetition maximum (1-RM)), LOW load ...
Source: Experimental Gerontology - August 1, 2017 Category: Geriatrics Authors: Van Roie E, Walker S, Van Driessche S, Baggen R, Coudyzer W, Bautmans I, Delecluse C Tags: Exp Gerontol Source Type: research

The clinical value of inflammatory biomarkers in coronary artery disease: PTX3 as a new inflammatory marker.
This study aims to compare the associations between plasma levels of these biomarkers and CAD, identifying the best biomarker that has the most powerful association with CAD. METHODS: Blood samples were collected from 64 patients admitted to the Department of Cardiology, 31 of whom had CAD and 33 of whom were CAD-free. Plasma levels of PTX3, MMP9, and IL-6 were measured via ELISA. The coronary Gensini score was used to evaluate the severity of coronary artery lesions. RESULTS: PTX3 levels and NLR levels between the CAD group and the CAD-free group were statistically significant (P
Source: Experimental Gerontology - August 1, 2017 Category: Geriatrics Authors: Guo T, Huang L, Liu C, Shan S, Li Q, Ke L, Cheng B Tags: Exp Gerontol Source Type: research

Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence.
A, Hurme M Abstract Ageing of the human immune system, or immunosenescence, is characterised by distinct changes in the proportion of the various cell types, e.g., increase of the CD14+ monocytic cells, decrease of CD19+ B lymphocytes, and changes in T cell subpopulations, namely increase of CD4+ and CD8+ cells which have lost the costimulatory CD28 antigen. Currently, it is believed that the lifelong antigenic burden may be one of the inducers of immunosenescence. Thus far, only one exogenous stimulus, cytomegalovirus infection, has shown to be a major factor in this respect. To find other possible candidates, w...
Source: Experimental Gerontology - July 31, 2017 Category: Geriatrics Authors: Marttila S, Nevalainen T, Jylhävä J, Kananen L, Jylhä M, Hervonen A, Hurme M Tags: Exp Gerontol Source Type: research

Adaptation to metabolic dysfunction during aging: Making the best of a bad situation.
This article reviews another form of communication between the mitochondria and the nucleus, in which the dysfunction of the former triggers changes in the expression of nuclear genes to compensate for it. The most extensively studied of these signaling pathways is the retrograde response whose effectors and downstream targets have been characterized. This response extends yeast replicative lifespan by adapting the organism to the mitochondrial dysfunction. Similar responses have been found in several other organisms, including mammals. Declining health and function during human aging incurs energetic costs. This compensat...
Source: Experimental Gerontology - July 28, 2017 Category: Geriatrics Authors: Michal Jazwinski S, Jiang JC, Kim S Tags: Exp Gerontol Source Type: research

Cardiovascular risk and the effect of nitric oxide synthase inhibition in female rats: The role of estrogen.
This study aimed to investigate cardiovascular, autonomic and oxidative parameters after selective NOS inhibition. A spectral analysis of systolic arterial pressure (SAP) and heart rate variability (HRV) was performed. NO levels, total antioxidant capacity (TRAP), lipid hydroperoxides (LOOH) and paraoxonase 1 (PON1) activity were measured in the plasma of rats treated with L-NG-nitroarginine methyl ester (L-NAME), S-methylisothiourea (SMT) or saline. Wistar rats, ovariectomized (OVX) with or without estradiol treatment (1mg/kg/day) or with a false ovariectomy (SHAM), were submitted to artery and vein catheterization. Cardi...
Source: Experimental Gerontology - July 28, 2017 Category: Geriatrics Authors: Castardo-de-Paula JC, de Campos BH, Amorim EDT, da Silva RV, de Farias CC, Higachi L, Pinge-Filho P, Barbosa DS, Martins-Pinge MC Tags: Exp Gerontol Source Type: research

The anti-aging and anti-oxidation effects of tea water extract in Caenorhabditis elegans.
Abstract Tea includes puer tea, black tea, green tea and many others. By using model organism Caenorhabditis elegans, the anti-aging and anti-oxidation effects of tea water extract were systemically examined in this study. We found that water extract of puer tea, black tea and green tea all increased the lifespan of worms, postponed Aβ-induced progressive paralysis in Alzheimer's disease transgenic worms, and improved the tolerance of worms to the oxidative stress induced by heavy metal Cr(6+). Moreover, the anti-oxidation effects of tea water extract at low concentration were different among 4 kinds of brand...
Source: Experimental Gerontology - July 24, 2017 Category: Geriatrics Authors: Fei T, Fei J, Huang F, Xie T, Xu J, Zhou Y, Yang P Tags: Exp Gerontol Source Type: research

Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster.
Abstract Alcohol abuse is a rising problem in middle-aged and older individuals resulting in serious health, family and economic consequences. Effective treatment necessitates the identification of factors influencing alcohol toxicity with aging. We investigated the interaction between aging, alcohol toxicity and circadian function using Drosophila as a model system. We found as wild type flies age, sensitivity to alcohol increases and circadian regulation of alcohol-induced behaviors weakens. Decreased circadian modulation is correlated with significantly greater alcohol sensitivity during the subjective day. The...
Source: Experimental Gerontology - July 24, 2017 Category: Geriatrics Authors: De Nobrega AK, Mellers AP, Lyons LC Tags: Exp Gerontol Source Type: research

llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause.
akamune AC Abstract During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic marker...
Source: Experimental Gerontology - July 21, 2017 Category: Geriatrics Authors: Pereira CS, Stringhetta-Garcia CT, da Silva Xavier L, Tirapeli KG, Pereira AAF, Kayahara GM, Tramarim JM, Crivelini MM, Padovani KS, Leopoldino AM, Louzada MJQ, Belló-Klein A, Llesuy SF, Ervolino E, Dornelles RCM, Chaves-Neto AH, de Melo Stevanato Nakamu Tags: Exp Gerontol Source Type: research

Physical exercise increases Sestrin 2 protein levels and induces autophagy in the skeletal muscle of old mice.
Abstract Sestrins and autophagy deficiencies are associated with several aging-related organic dysfunctions and metabolic disorders. Here we evaluate the effects of acute exercise on Sestrin 2 (Sesn2) protein content and autophagy markers in the skeletal muscle of experimental models of aging. Twenty-four months-old C57BL/6J male mice were submitted to a single bout of swimming exercise and the gastrocnemius muscle was evaluated by Western blot. Transcriptomic and phenotypic analysis were also performed by using strains of genetically-diverse BXD mice. The bioinformatics analysis showed a negative correlation betw...
Source: Experimental Gerontology - July 17, 2017 Category: Geriatrics Authors: Lenhare L, Crisol BM, Silva VRR, Katashima CK, Cordeiro AV, Pereira KD, Luchessi AD, da Silva ASR, Cintra DE, Moura LP, Pauli JR, Ropelle ER Tags: Exp Gerontol Source Type: research

Milk fat globule membrane supplementation with voluntary running exercise attenuates age-related motor dysfunction by suppressing neuromuscular junction abnormalities in mice.
In this study, we evaluated the effect of MFGM intake combined with voluntary running (MFGM-VR) on morphological changes of NMJ and motor function in aging mice. Seven months following the intervention, the MFGM-VR group showed a significantly improved motor coordination in the rotarod test and muscle force in the grip strength test compared with the control group at 13 and 14months of age, respectively. In 14-month old control mice, the extensor digitorum longus muscle showed increased abnormal NMJs, such as fragmentation and denervation, compared with 6-month old young mice. However, such age-related deteriorations of NM...
Source: Experimental Gerontology - July 17, 2017 Category: Geriatrics Authors: Yano M, Minegishi Y, Sugita S, Ota N Tags: Exp Gerontol Source Type: research

The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations.
rucci L Abstract Recent studies have shown contradictory associations between calcium levels and health outcomes. We suspected these conflicting results were the consequence of more general issues with how biomarkers are analyzed in epidemiological studies, particularly in the context of aging. To demonstrate the risks of typical analyses, we used three longitudinal aging cohort studies and their demographic subsets to analyze how calcium levels change with age and predict risk of mortality and frailty. We show that calcium levels either increase or decrease with age depending on the population, and positively or ...
Source: Experimental Gerontology - July 16, 2017 Category: Geriatrics Authors: Cohen AA, Legault V, Fuellen G, Fülöp T, Fried LP, Ferrucci L Tags: Exp Gerontol Source Type: research

The effects of strength exercise on hippocampus volume and functional fitness of elderly women.
This study aimed to identify the effects of 24weeks of the Growing Stronger program on hippocampus volume and functional fitness of elderly women. METHODS: Twenty elderly women aged over 65 participated in this study. Growing Stronger, which is a strength exercise program that is safe and effective for women and men of all ages, was conducted in 11 strength exercise group three times a week for 50-80min for 24weeks. The control group maintained their lifestyles without any special intervention. Subjects were given a pre-test (before applying for the program) and post-test (after 24weeks) to identify effects of the pro...
Source: Experimental Gerontology - July 14, 2017 Category: Geriatrics Authors: Kim YS, Shin SK, Hong SB, Kim HJ Tags: Exp Gerontol Source Type: research

An animal model of co-existing sarcopenia and osteoporotic fracture in senescence accelerated mouse prone 8 (SAMP8).
This study validated an animal model of co-existing sarcopenia and osteoporotic fracture, where a delayed fracture healing might be resulted in the presence of sarcopenia. PMID: 28711604 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - July 12, 2017 Category: Geriatrics Authors: Zhang N, Chow SKH, Leung KS, Lee HH, Cheung WH Tags: Exp Gerontol Source Type: research

A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease.
Abstract INTRODUCTION: Deteriorating brain glucose metabolism precedes the clinical onset of Alzheimer's disease (AD) and appears to contribute to its etiology. Ketone bodies, mainly β-hydroxybutyrate and acetoacetate, are the primary alternative brain fuel to glucose. Some reports suggest that brain ketone metabolism is unchanged in AD but, to our knowledge, no such data are available for MCI. OBJECTIVE: To compare brain energy metabolism (glucose and acetoacetate) and some brain morphological characteristics in cognitively healthy older adult controls (CTL), mild cognitive impairment (MCI) and early AD...
Source: Experimental Gerontology - July 11, 2017 Category: Geriatrics Authors: Croteau E, Castellano CA, Fortier M, Bocti C, Fulop T, Paquet N, Cunnane SC Tags: Exp Gerontol Source Type: research

Aging-related effects of bed rest followed by eccentric exercise rehabilitation on skeletal muscle macrophages and insulin sensitivity.
Abstract The pro- and anti-inflammatory macrophages are associated with insulin sensitivity and skeletal muscle regeneration. Infiltrating macrophages in skeletal muscle during a period of physical inactivity and subsequent reloading/rehabilitation in older adults is unknown, but may provide insight into mechanisms related to the development of metabolic disease and changes in muscle cell size. The purpose of this study was to determine if skeletal muscle macrophage infiltration is modulated differently between young and older adults after bed rest and exercise rehabilitation and if these responses are related to ...
Source: Experimental Gerontology - July 10, 2017 Category: Geriatrics Authors: Reidy PT, Lindsay CC, McKenzie AI, Fry CS, Supiano MA, Marcus RL, LaStayo PC, Drummond MJ Tags: Exp Gerontol Source Type: research

A framework for identifying the adaptations responsible for differences in pegboard times between middle-aged and older adults.
Abstract Time to complete two tests of manual dexterity, the 9-hole Peg Test and Grooved Pegboard Test, increases with advancing age. However, the adaptations responsible for the differences in pegboard times between middle-aged and older adults are largely unknown. Potential mechanisms include neuromuscular characteristics, cognitive function, and cutaneous sensation. To provide a tractable framework to address these gaps in knowledge, the purpose of the current study was to identify the latent variables underlying age-associated differences in time to complete the 9-hole and grooved pegboard tests. The approach ...
Source: Experimental Gerontology - July 5, 2017 Category: Geriatrics Authors: Hamilton LD, Thomas E, Almuklass AM, Enoka RM Tags: Exp Gerontol Source Type: research

Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses.
Abstract Immune cells with a senescence-associated secretory phenotype increase in the blood of elderly individuals or individuals with age-associated diseases or with infections. Although senescent immune cells do not proliferate, they are transcriptionally and metabolically active and affect the microenvironment through the secretion of pro-inflammatory mediators. An age-driven increase in senescent B, T and NK cells has been reported and the function of these cells has been characterized. Results published by different groups have demonstrated that cell senescence induces the accumulation of terminally-differen...
Source: Experimental Gerontology - July 4, 2017 Category: Geriatrics Authors: Frasca D Tags: Exp Gerontol Source Type: research

Middle age exacerbates acute respiratory distress syndrome in a double hit murine model.
CONCLUSION: Middle-old mice were more susceptible to both LPS alone and the combination of LPS and low tidal volume MV as compared to their young adult counterparts. The synergism between LPS and MV was amplified in middle-old mice. PMID: 28676373 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - July 1, 2017 Category: Geriatrics Authors: Voiriot G, Contou D, Van Nhieu JT, Amsellem V, Marcos E, Latiri M, Adnot S, Maitre B, Dessap AM Tags: Exp Gerontol Source Type: research

Bidirectional factors impact the migration of NK cells to draining lymph node in aged mice during influenza virus infection.
Abstract Natural killer (NK) cells play an important role in controlling several viral diseases. Our previous studies demonstrated an age-dependent susceptibility to mousepox due to defective NK cell responses and trafficking. However, the mechanisms that underlie the age-related impairment in NK cell migration have yet to be identified. In the present study, we demonstrated that after influenza A virus (IAV) infection, NK cells from aged mice (17-19months old) failed to accumulate in draining lymph node (D-LN). We found that both environmental and intrinsic factors played roles for this defect. After infection, i...
Source: Experimental Gerontology - June 29, 2017 Category: Geriatrics Authors: Duan X, Lu J, Wang H, Liu X, Wang J, Zhou K, Jiang W, Wang Y, Fang M Tags: Exp Gerontol Source Type: research

Diet enrichment with a specific essential free amino acid mixture improves healing of undressed wounds in aged rats.
Abstract Chronic wounds are a major, often underestimated, health problem for the elderly. Standard wound care products are not usually manufactured to meet the increased demand of nutrients by skin cells in order to regenerate new tissue and accelerate healing. This work was therefore undertaken to establish whether wound healing could be accelerated by nutritional supplementation with a specific mixture tailored to human need of essential amino acids (EAAs) without topical medication. To this end, using a skin full-thickness excisional model in aged rats, we compared the closure dynamics of undressing wounds in ...
Source: Experimental Gerontology - June 29, 2017 Category: Geriatrics Authors: Corsetti G, Romano C, Pasini E, Marzetti E, Calvani R, Picca A, Flati V, Dioguardi FS Tags: Exp Gerontol Source Type: research

Blood count parameters as a marker for metabolic syndrome in older adults.
CONCLUSION: Leukocyte count can be used as a screening indicator to identify individuals with a higher risk of developing MS. Older adults with high leukocyte count and no associated chronic diseases should receive attention, as they are individuals with a potential risk for MS. PMID: 28669822 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 29, 2017 Category: Geriatrics Authors: De Oliveira CC, Roriz AKC, Ramos LB, Neto MG Tags: Exp Gerontol Source Type: research

Life-extending dietary restriction and ovariectomy each increase leucine oxidation and alter leucine allocation in grasshoppers.
This study suggests that the oxidation of branched-chain amino acids may be an underappreciated mechanism underlying lifespan extension. PMID: 28668481 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 28, 2017 Category: Geriatrics Authors: Hatle JD, Awan A, Nicholas J, Koch R, Vokrri JR, McCue MD, Williams CM, Davidowitz G, Hahn DA Tags: Exp Gerontol Source Type: research

Aberrant signaling and senescence associated protein degradation.
Abstract Senescent cells accumulate with age and contribute to pathologies associated to old age. The senescent program can be induced by pro-cancer stimuli or is developmentally controlled. In cells forced to senesce by expression of oncogenes or short telomeres, aberrant activation of the ERK/MAP kinase signaling pathway leads to selective protein degradation by the ubiquitin proteasome system. The proteins affected by this process control key cellular processes known to be defective in senescent cells. We discuss the evidence supporting a general role for aberrant signaling and senescence associated protein deg...
Source: Experimental Gerontology - June 25, 2017 Category: Geriatrics Authors: Ferbeyre G Tags: Exp Gerontol Source Type: research

Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules.
Abstract Cardiovascular aging is a highly dynamic process. Despite the fact that cardiovascular function and structure change with age, they can still be modulated even in aged humans. The most prominent approaches to improve age-dependent vascular changes include dietary restriction and pharmacologic agents interacting with signaling pathways implicated in this context. These include inhibition of TOR, glycolysis, and GH/IGF-1, activation of sirtuins, and AMPK, as well as modulators of inflammation, epigenetic pathways, and telomeres. Promising nutritional approaches include Mediterranean diet and novel dietary b...
Source: Experimental Gerontology - June 25, 2017 Category: Geriatrics Authors: Heiss C, Spyridopoulos I, Haendeler J Tags: Exp Gerontol Source Type: research

Senescence-associated microRNAs target cell cycle regulatory genes in normal human lung fibroblasts.
Abstract Senescence recapitulates the ageing process at the cell level. A senescent cell stops dividing and exits the cell cycle. MicroRNAs (miRNAs) acting as master regulators of transcription, have been implicated in senescence. In the current study we investigated and compared the expression of miRNAs in young versus senescent human fibroblasts (HDFs), and analysed the role of mRNAs expressed in replicative senescent HFL-1 HDFs. Cell cycle analysis confirmed that HDFs accumulated in G1/S cell cycle phase. Nanostring analysis of isolated miRNAs from young and senescent HFL-1 showed that a distinct set of 15 miRN...
Source: Experimental Gerontology - June 25, 2017 Category: Geriatrics Authors: Markopoulos GS, Roupakia E, Tokamani M, Vartholomatos G, Tzavaras T, Hatziapostolou M, Fackelmayer FO, Sandaltzopoulos R, Polytarchou C, Kolettas E Tags: Exp Gerontol Source Type: research

Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases.
Abstract Prevalence of age-associated cardiovascular diseases (CVD) has dramatically increased as a result of improvements in life expectancy. Chronic inflammation is a shared pathophysiological feature of age-associated CVDs, indicating a role for the immune system in the onset and development of CVDs. Indeed, ageing elicits profound changes in both the cardiovascular and immune system, especially in the T cell compartment. Although such changes have been well described at the cellular level, the molecular mechanisms underlying immune-mediated cardiovascular ageing remain largely unexplored. Non-coding RNAs (ncRN...
Source: Experimental Gerontology - June 23, 2017 Category: Geriatrics Authors: Coelho-Lima J, Spyridopoulos I Tags: Exp Gerontol Source Type: research

Serum levels of Dickkopf-1 are a potential negative biomarker of survival in geriatric patients.
Abstract Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little attention was given to the Wnt-catenin signaling pathway and its role in the posttraumatic course of disease. We studied 238 geriatric patients (175 women (mean age 84yrs) and 63 men (mean age 82yrs)) in total that were admitted to a department of Acute Geriatric Care. 150 out of these patients h...
Source: Experimental Gerontology - June 23, 2017 Category: Geriatrics Authors: Dovjak P, Heinze G, Rainer A, Sipos W, Pietschmann P Tags: Exp Gerontol Source Type: research

Is sarcopenia associated with an increased risk of all-cause mortality and functional disability?
CONCLUSION: These results provide additional and more accurate evidence in support of an association between sarcopenia and an increased risk for both all-cause mortality and functional decline. PMID: 28647519 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 21, 2017 Category: Geriatrics Authors: Kelley GA, Kelley KS Tags: Exp Gerontol Source Type: research

Exercise training improves functional status in hypertensive older adults under angiotensin converting enzymes inhibitors medication.
ns RA Abstract BACKGROUND: The study aims to analyze the effect of three types of treatment on functional status, and cardiovascular risk outcomes in hypertensive older adults with comorbidities. METHODS: Participants (n=418) underwent one of the following 3 conditions: i) multicomponent exercise training 3times/week (MEX; n=116); ii) angiotensin converting enzyme inhibitors used mono-dose daily (ACEi; n=70); iii) combined exercise and ACEi drugs (ACEiMEX; n=232). The trial was completed by 82% of the participants (n=342): MEX (n=90); ACEi (n=66); ACEiMEX (n=186). Baseline and 2-year follow-up evaluations inc...
Source: Experimental Gerontology - June 20, 2017 Category: Geriatrics Authors: Baptista LC, Machado-Rodrigues AM, Veríssimo MT, Martins RA Tags: Exp Gerontol Source Type: research

Comment on "Serum uric acid is associated with better executive function in men but not in women: Baseline assessment of the ELSA-Brasil study".
Comment on "Serum uric acid is associated with better executive function in men but not in women: Baseline assessment of the ELSA-Brasil study". Exp Gerontol. 2017 Jun 19;: Authors: Soysal P PMID: 28642074 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 19, 2017 Category: Geriatrics Authors: Soysal P Tags: Exp Gerontol Source Type: research

Corrigendum to "Neural correlates of reduced awareness in instrumental activities of daily living in frontotemporal dementia" [Exp. Gerontol. 83 (2016) 158-164].
Corrigendum to "Neural correlates of reduced awareness in instrumental activities of daily living in frontotemporal dementia" [Exp. Gerontol. 83 (2016) 158-164]. Exp Gerontol. 2017 Jun 17;: Authors: Amanzio M, D'Agata F, Palermo S, Rubino E, Zucca M, Galati A, Pinessi L, Castellano G, Rainero I PMID: 28633865 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - June 17, 2017 Category: Geriatrics Authors: Amanzio M, D'Agata F, Palermo S, Rubino E, Zucca M, Galati A, Pinessi L, Castellano G, Rainero I Tags: Exp Gerontol Source Type: research