Sex differences in frailty among older adults
Exp Gerontol. 2023 Nov 20:112333. doi: 10.1016/j.exger.2023.112333. Online ahead of print.ABSTRACTBy definition, aging is a natural, gradual and continuous process. On the other hand, frailty reflects the increase in vulnerability to stressors and shortens the time without disease (health span) while longevity refers to the length of life (lifespan). The average life expectancy has significantly increased during the last few decades. A longer lifespan has been accompanied by an increase in frailty and decreased independence in older adults, with major differences existing between men and women. For example, women tend to l...
Source: Experimental Gerontology - November 22, 2023 Category: Geriatrics Authors: Rola S Zeidan Taylor McElroy Laxmi Rathor Matthew S Martenson Yi Lin Robert T Mankowski Source Type: research
Sex differences in frailty among older adults
Exp Gerontol. 2023 Nov 20:112333. doi: 10.1016/j.exger.2023.112333. Online ahead of print.ABSTRACTBy definition, aging is a natural, gradual and continuous process. On the other hand, frailty reflects the increase in vulnerability to stressors and shortens the time without disease (health span) while longevity refers to the length of life (lifespan). The average life expectancy has significantly increased during the last few decades. A longer lifespan has been accompanied by an increase in frailty and decreased independence in older adults, with major differences existing between men and women. For example, women tend to l...
Source: Experimental Gerontology - November 22, 2023 Category: Geriatrics Authors: Rola S Zeidan Taylor McElroy Laxmi Rathor Matthew S Martenson Yi Lin Robert T Mankowski Source Type: research
Sex differences in frailty among older adults
Exp Gerontol. 2023 Nov 20:112333. doi: 10.1016/j.exger.2023.112333. Online ahead of print.ABSTRACTBy definition, aging is a natural, gradual and continuous process. On the other hand, frailty reflects the increase in vulnerability to stressors and shortens the time without disease (health span) while longevity refers to the length of life (lifespan). The average life expectancy has significantly increased during the last few decades. A longer lifespan has been accompanied by an increase in frailty and decreased independence in older adults, with major differences existing between men and women. For example, women tend to l...
Source: Experimental Gerontology - November 22, 2023 Category: Geriatrics Authors: Rola S Zeidan Taylor McElroy Laxmi Rathor Matthew S Martenson Yi Lin Robert T Mankowski Source Type: research
Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy
Exp Gerontol. 2023 Nov 18:112335. doi: 10.1016/j.exger.2023.112335. Online ahead of print.ABSTRACTSkeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degradation. At the histological level, it is mainly characterized by a reduction in muscle mass and fiber cross-sectional area (CSA). Patients with skeletal muscle atrophy present with reduced motor ability, easy fatigue, and poor life quality. Heme oxygenase-1 (HO-1) is an inducible enzyme that catalyzes the degradation of heme and has attracted much attention for its anti-oxidation effects. In addition, there ...
Source: Experimental Gerontology - November 20, 2023 Category: Geriatrics Authors: Qin Xiao Chen-Chen Sun Chang-Fa Tang Source Type: research
Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy
Exp Gerontol. 2023 Nov 18:112335. doi: 10.1016/j.exger.2023.112335. Online ahead of print.ABSTRACTSkeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degradation. At the histological level, it is mainly characterized by a reduction in muscle mass and fiber cross-sectional area (CSA). Patients with skeletal muscle atrophy present with reduced motor ability, easy fatigue, and poor life quality. Heme oxygenase-1 (HO-1) is an inducible enzyme that catalyzes the degradation of heme and has attracted much attention for its anti-oxidation effects. In addition, there ...
Source: Experimental Gerontology - November 20, 2023 Category: Geriatrics Authors: Qin Xiao Chen-Chen Sun Chang-Fa Tang Source Type: research
Old age as a risk factor for liver diseases: Modern therapeutic approaches
Exp Gerontol. 2023 Nov 15:112334. doi: 10.1016/j.exger.2023.112334. Online ahead of print.ABSTRACTRecent scientific interest has been directed towards age-related diseases, driven by the significant increase in global life expectancy and the growing population of individuals aged 65 and above. The ageing process encompasses various biological, physiological, environmental, psychological, behavioural, and social changes, leading to an augmented susceptibility to chronic illnesses. Cardiovascular, neurological, musculoskeletal, liver and oncological diseases are prevalent in the elderly. Moreover, ageing individuals demonstr...
Source: Experimental Gerontology - November 17, 2023 Category: Geriatrics Authors: Milena Georgieva Charilaos Xenodochidis Natalia Krasteva Source Type: research
Old age as a risk factor for liver diseases: Modern therapeutic approaches
Exp Gerontol. 2023 Nov 15:112334. doi: 10.1016/j.exger.2023.112334. Online ahead of print.ABSTRACTRecent scientific interest has been directed towards age-related diseases, driven by the significant increase in global life expectancy and the growing population of individuals aged 65 and above. The ageing process encompasses various biological, physiological, environmental, psychological, behavioural, and social changes, leading to an augmented susceptibility to chronic illnesses. Cardiovascular, neurological, musculoskeletal, liver and oncological diseases are prevalent in the elderly. Moreover, ageing individuals demonstr...
Source: Experimental Gerontology - November 17, 2023 Category: Geriatrics Authors: Milena Georgieva Charilaos Xenodochidis Natalia Krasteva Source Type: research
Old age as a risk factor for liver diseases: Modern therapeutic approaches
Exp Gerontol. 2023 Nov 15:112334. doi: 10.1016/j.exger.2023.112334. Online ahead of print.ABSTRACTRecent scientific interest has been directed towards age-related diseases, driven by the significant increase in global life expectancy and the growing population of individuals aged 65 and above. The ageing process encompasses various biological, physiological, environmental, psychological, behavioural, and social changes, leading to an augmented susceptibility to chronic illnesses. Cardiovascular, neurological, musculoskeletal, liver and oncological diseases are prevalent in the elderly. Moreover, ageing individuals demonstr...
Source: Experimental Gerontology - November 17, 2023 Category: Geriatrics Authors: Milena Georgieva Charilaos Xenodochidis Natalia Krasteva Source Type: research
Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty
CONCLUSION: The 2-minute walk test is a valid tool for estimating cardiorespiratory fitness among older adults with CF. However, it should be further tested across a larger population.PMID:37967590 | DOI:10.1016/j.exger.2023.112326 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Azianah Ibrahim Arimi Fitri Mat Ludin Suzana Shahar Noor Hazfalinda Hamzah Chin Ai-Vyrn Devinder Kaur Ajit Singh Source Type: research
Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Exp Gerontol. 2023 Nov 13:112332. doi: 10.1016/j.exger.2023.112332. Online ahead of print.ABSTRACTFermented food is commonly viewed as healthy, mostly due to its probiotic and digestion-enhancing properties and recently it has been examined with regard to the development of new therapeutic and preventive measures for Alzheimer's disease. Fermented food has been shown to have anti-inflammatory and antioxidant properties and to alter the gut microbiota. However, the exact pathogenesis of Alzheimer's disease is still unknown and its connections to systemic inflammation and gut dysbiosis, as potential targets of fermented food...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Micha ł Tyliszczak Benita Wiatrak Maciej Danielewski Adam Szel ąg Alicja Z Kucharska Tomasz Soza ński Source Type: research
MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia
Exp Gerontol. 2023 Nov 13:112330. doi: 10.1016/j.exger.2023.112330. Online ahead of print.ABSTRACTHyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis (AS). Some reports have shown that homocysteine (Hcy) could accelerate the development of AS by promoting endothelial cell senescence. miRNAs were widely involved in the pathophysiology of HHcy. However, few studies have focused on the changes of miRNA-mRNA networks in the artery of HHcy patients. For this reason, RNA-sequencing was adopted to investigate the expression of miRNA and mRNA in HHcy model mouse arteries. We found that the expression of 21...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Hao Qin Longlong Hu Wenjun Wang Zuozhong Yu Yang Chen Yuanbin Zhao Yanhui Liao Weilin Zhang Renqiang Yang Source Type: research
Metformin attenuates inflammation and boosts autophagy in the liver and intestine of chronologically aged rats
CONCLUSIONS: Metformin intervention can boost the autophagy level in the liver and intestine and reduce the expression of aging-related inflammatory factors in aged rats, and these effects may be related to the increase of the AMPK phosphorylation level.PMID:37967593 | DOI:10.1016/j.exger.2023.112331 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Zheng Kuai Xin Chao Yuting He Weiying Ren Source Type: research
Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty
CONCLUSION: The 2-minute walk test is a valid tool for estimating cardiorespiratory fitness among older adults with CF. However, it should be further tested across a larger population.PMID:37967590 | DOI:10.1016/j.exger.2023.112326 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Azianah Ibrahim Arimi Fitri Mat Ludin Suzana Shahar Noor Hazfalinda Hamzah Chin Ai-Vyrn Devinder Kaur Ajit Singh Source Type: research
Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Exp Gerontol. 2023 Nov 13:112332. doi: 10.1016/j.exger.2023.112332. Online ahead of print.ABSTRACTFermented food is commonly viewed as healthy, mostly due to its probiotic and digestion-enhancing properties and recently it has been examined with regard to the development of new therapeutic and preventive measures for Alzheimer's disease. Fermented food has been shown to have anti-inflammatory and antioxidant properties and to alter the gut microbiota. However, the exact pathogenesis of Alzheimer's disease is still unknown and its connections to systemic inflammation and gut dysbiosis, as potential targets of fermented food...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Micha ł Tyliszczak Benita Wiatrak Maciej Danielewski Adam Szel ąg Alicja Z Kucharska Tomasz Soza ński Source Type: research
MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia
Exp Gerontol. 2023 Nov 13:112330. doi: 10.1016/j.exger.2023.112330. Online ahead of print.ABSTRACTHyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis (AS). Some reports have shown that homocysteine (Hcy) could accelerate the development of AS by promoting endothelial cell senescence. miRNAs were widely involved in the pathophysiology of HHcy. However, few studies have focused on the changes of miRNA-mRNA networks in the artery of HHcy patients. For this reason, RNA-sequencing was adopted to investigate the expression of miRNA and mRNA in HHcy model mouse arteries. We found that the expression of 21...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Hao Qin Longlong Hu Wenjun Wang Zuozhong Yu Yang Chen Yuanbin Zhao Yanhui Liao Weilin Zhang Renqiang Yang Source Type: research
