Introduction to Special Issue on 'Physiological and PA Evolutionary Mechanisms of Aging'
Exp Gerontol. 2023 Nov 6:112324. doi: 10.1016/j.exger.2023.112324. Online ahead of print.ABSTRACTWhat are the structural components and physiological mechanisms determining the aging process? Can the different mechanisms described in aging biology converge into a core of coordinated aging effectors? Why some human beings, for instance, can reach 115-122 years of age while rats can live at best a maximum of 4 years? Can the aging rate be modified? How much can human lifespan be extended? Is aging a programmed or non-programmed process? This special issue includes invited articles to explore the physiological mechanisms of a...
Source: Experimental Gerontology - November 8, 2023 Category: Geriatrics Authors: Gustavo Barja Reinald Pamplona Source Type: research
Introduction to Special Issue on 'Physiological and PA Evolutionary Mechanisms of Aging'
Exp Gerontol. 2023 Nov 6:112324. doi: 10.1016/j.exger.2023.112324. Online ahead of print.ABSTRACTWhat are the structural components and physiological mechanisms determining the aging process? Can the different mechanisms described in aging biology converge into a core of coordinated aging effectors? Why some human beings, for instance, can reach 115-122 years of age while rats can live at best a maximum of 4 years? Can the aging rate be modified? How much can human lifespan be extended? Is aging a programmed or non-programmed process? This special issue includes invited articles to explore the physiological mechanisms of a...
Source: Experimental Gerontology - November 8, 2023 Category: Geriatrics Authors: Gustavo Barja Reinald Pamplona Source Type: research
Introduction to Special Issue on 'Physiological and PA Evolutionary Mechanisms of Aging'
Exp Gerontol. 2023 Nov 6:112324. doi: 10.1016/j.exger.2023.112324. Online ahead of print.ABSTRACTWhat are the structural components and physiological mechanisms determining the aging process? Can the different mechanisms described in aging biology converge into a core of coordinated aging effectors? Why some human beings, for instance, can reach 115-122 years of age while rats can live at best a maximum of 4 years? Can the aging rate be modified? How much can human lifespan be extended? Is aging a programmed or non-programmed process? This special issue includes invited articles to explore the physiological mechanisms of a...
Source: Experimental Gerontology - November 8, 2023 Category: Geriatrics Authors: Gustavo Barja Reinald Pamplona Source Type: research
Introduction to Special Issue on 'Physiological and PA Evolutionary Mechanisms of Aging'
Exp Gerontol. 2023 Nov 6:112324. doi: 10.1016/j.exger.2023.112324. Online ahead of print.ABSTRACTWhat are the structural components and physiological mechanisms determining the aging process? Can the different mechanisms described in aging biology converge into a core of coordinated aging effectors? Why some human beings, for instance, can reach 115-122 years of age while rats can live at best a maximum of 4 years? Can the aging rate be modified? How much can human lifespan be extended? Is aging a programmed or non-programmed process? This special issue includes invited articles to explore the physiological mechanisms of a...
Source: Experimental Gerontology - November 8, 2023 Category: Geriatrics Authors: Gustavo Barja Reinald Pamplona Source Type: research
An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia
CONCLUSION: Imaging parameters PDFF, R2*, and T2 can be used to sensitively evaluate early pathological changes in sarcopenia. The successful construction of a sarcopenia rat model can be assessed when PDFF exceeds 1.25, R2* exceeds 53.85, and T2 exceeds 33.88.PMID:37929293 | DOI:10.1016/j.exger.2023.112322 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 6, 2023 Category: Geriatrics Authors: Xin-Chen Huang Yi-Long Huang Yi-Tong Guo Si-Yu Li Chao Gao Jia-Xin Chen Ji-Yao Ma Bo He Source Type: research
An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia
CONCLUSION: Imaging parameters PDFF, R2*, and T2 can be used to sensitively evaluate early pathological changes in sarcopenia. The successful construction of a sarcopenia rat model can be assessed when PDFF exceeds 1.25, R2* exceeds 53.85, and T2 exceeds 33.88.PMID:37929293 | DOI:10.1016/j.exger.2023.112322 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 6, 2023 Category: Geriatrics Authors: Xin-Chen Huang Yi-Long Huang Yi-Tong Guo Si-Yu Li Chao Gao Jia-Xin Chen Ji-Yao Ma Bo He Source Type: research
An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia
CONCLUSION: Imaging parameters PDFF, R2*, and T2 can be used to sensitively evaluate early pathological changes in sarcopenia. The successful construction of a sarcopenia rat model can be assessed when PDFF exceeds 1.25, R2* exceeds 53.85, and T2 exceeds 33.88.PMID:37929293 | DOI:10.1016/j.exger.2023.112322 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 6, 2023 Category: Geriatrics Authors: Xin-Chen Huang Yi-Long Huang Yi-Tong Guo Si-Yu Li Chao Gao Jia-Xin Chen Ji-Yao Ma Bo He Source Type: research
Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination
Exp Gerontol. 2023 Nov 2;183:112318. doi: 10.1016/j.exger.2023.112318. Online ahead of print.ABSTRACTSarcopenia involves in the loss of muscle mass associated with aging, which is the major cause of progressive muscle weakness and deterioration in older adults. Muscle atrophy is a direct presentation of sarcopenia, and it greatly contributes to the decline in quality of life among older adults. Neuromuscular junction (NMJ) stability is the key link to maintain muscle function. Besides, the degenerative change of NMJ promotes the process of muscle atrophy in the elderly. Based on previous transcriptome sequencing and bioinf...
Source: Experimental Gerontology - November 1, 2023 Category: Geriatrics Authors: Jintao Chen Qun Xu Xinyi Wang Zherong Xu Xujiao Chen Source Type: research
Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination
Exp Gerontol. 2023 Oct 30:112318. doi: 10.1016/j.exger.2023.112318. Online ahead of print.ABSTRACTSarcopenia involves in the loss of muscle mass associated with aging, which is the major cause of progressive muscle weakness and deterioration in older adults. Muscle atrophy is a direct presentation of sarcopenia, and it greatly contributes to the decline in quality of life among older adults. Neuromuscular junction (NMJ) stability is the key link to maintain muscle function. Besides, the degenerative change of NMJ promotes the process of muscle atrophy in the elderly. Based on previous transcriptome sequencing and bioinform...
Source: Experimental Gerontology - November 1, 2023 Category: Geriatrics Authors: Jintao Chen Qun Xu Xinyi Wang Zherong Xu Xujiao Chen Source Type: research
Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination
Exp Gerontol. 2023 Oct 30:112318. doi: 10.1016/j.exger.2023.112318. Online ahead of print.ABSTRACTSarcopenia involves in the loss of muscle mass associated with aging, which is the major cause of progressive muscle weakness and deterioration in older adults. Muscle atrophy is a direct presentation of sarcopenia, and it greatly contributes to the decline in quality of life among older adults. Neuromuscular junction (NMJ) stability is the key link to maintain muscle function. Besides, the degenerative change of NMJ promotes the process of muscle atrophy in the elderly. Based on previous transcriptome sequencing and bioinform...
Source: Experimental Gerontology - November 1, 2023 Category: Geriatrics Authors: Jintao Chen Qun Xu Xinyi Wang Zherong Xu Xujiao Chen Source Type: research
Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination
Exp Gerontol. 2023 Oct 30:112318. doi: 10.1016/j.exger.2023.112318. Online ahead of print.ABSTRACTSarcopenia involves in the loss of muscle mass associated with aging, which is the major cause of progressive muscle weakness and deterioration in older adults. Muscle atrophy is a direct presentation of sarcopenia, and it greatly contributes to the decline in quality of life among older adults. Neuromuscular junction (NMJ) stability is the key link to maintain muscle function. Besides, the degenerative change of NMJ promotes the process of muscle atrophy in the elderly. Based on previous transcriptome sequencing and bioinform...
Source: Experimental Gerontology - November 1, 2023 Category: Geriatrics Authors: Jintao Chen Qun Xu Xinyi Wang Zherong Xu Xujiao Chen Source Type: research
Corrigendum to "Daily behavioral and sleep patterns are associated with aging-induced male-specific disorders in individuals with reduced renal function" [Exp. Gerontol. 16 (2022) 1-7 (111717)]
Exp Gerontol. 2023 Oct 28:112315. doi: 10.1016/j.exger.2023.112315. Online ahead of print.NO ABSTRACTPMID:37903700 | DOI:10.1016/j.exger.2023.112315 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 30, 2023 Category: Geriatrics Authors: Masaki Yoshioka Keisei Kosaki Shunta Noma Masahiro Matsui Makoto Kuro-O Ai Shibata Chie Saito Kunihiro Yamagata Koichiro Oka Seiji Maeda Source Type: research
Corrigendum to "Daily behavioral and sleep patterns are associated with aging-induced male-specific disorders in individuals with reduced renal function" [Exp. Gerontol. 16 (2022) 1-7 (111717)]
Exp Gerontol. 2023 Oct 28:112315. doi: 10.1016/j.exger.2023.112315. Online ahead of print.NO ABSTRACTPMID:37903700 | DOI:10.1016/j.exger.2023.112315 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 30, 2023 Category: Geriatrics Authors: Masaki Yoshioka Keisei Kosaki Shunta Noma Masahiro Matsui Makoto Kuro-O Ai Shibata Chie Saito Kunihiro Yamagata Koichiro Oka Seiji Maeda Source Type: research
Age-dependent down-regulation of orexin receptors in trigeminal nucleus caudalis correlated with attenuation of orexinergic analgesia in rats
In conclusion, the older age-related reduction of the antinociceptive effect of orexin may be due to the downregulation of its receptors and inability of orexin signaling to inhibit the expression of nociceptive neuropeptides such as SP and CGRP in aged rats.PMID:37898178 | DOI:10.1016/j.exger.2023.112321 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 28, 2023 Category: Geriatrics Authors: Shima Torkzadeh-Mahani Mehdi Abbasnejad Maryam Raoof Ghizlane Aarab Saeed Esmaeili-Mahani Frank Lobbezoo Source Type: research
Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease
Exp Gerontol. 2023 Oct 26:112319. doi: 10.1016/j.exger.2023.112319. Online ahead of print.ABSTRACTThe intricate interplay between gut microbiota and the host is pivotal in maintaining homeostasis and health. Dietary tryptophan (TRP) metabolism initiates a cascade of essential endogenous metabolites, including kynurenine, kynurenic acid, serotonin, and melatonin, as well as microbiota-derived Trp metabolites like tryptamine, indole propionic acid (IPA), and other indole derivatives. Notably, tryptamine and IPA, among the indole metabolites, exert crucial roles in modulating immune, metabolic, and neuronal responses at both ...
Source: Experimental Gerontology - October 28, 2023 Category: Geriatrics Authors: Sonu Kumar Gupta Sagar Vyavahare Ian L Duchesne Blanes Ford Berger Carlos Isales Sadanand Fulzele Source Type: research
