Relationship between quadriceps femoris echotexture biomarkers and muscle strength and physical function in older adults with heart failure with preserved ejection fraction
CONCLUSIONS: Echotexture biomarkers are related to women's muscle strength and physical function, especially muscle energy, contrast, and entropy. Echotexture biomarkers assessed by the US could facilitate the management of older adults with HFpEF, monitor its progression and assess the effectiveness of treatments on the musculoskeletal structure.TRIAL REGISTRATION: NCT03909919. April 10, 2019. Retrospectively registered.PMID:38570057 | DOI:10.1016/j.exger.2024.112412 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 3, 2024 Category: Geriatrics Authors: Iv án José Fuentes-Abolafio Michele Ricci Mar ía Rosa Bernal-López Ricardo G ómez-Huelgas Antonio Ignacio Cuesta-Vargas Luis Miguel P érez-Belmonte Source Type: research
Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study
CONCLUSION: Emo intervention mitigates bone loss and cartilage damage in OP-OA rats and promotes the osteogenic and chondrogenic differentiation of BMSCs.PMID:38570055 | DOI:10.1016/j.exger.2024.112413 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 3, 2024 Category: Geriatrics Authors: Yibao Wei Junfeng Kang Zhenyuan Ma Taiyang Liao Peng Wu Peimin Wang Zhengquan Huang Source Type: research
The characteristics of the body mass frequency index in dysmobility syndrome: A pilot study
CONCLUSION: The measurement of BMFI has demonstrated disparities in musculoskeletal status among older adults with and without DS. Notably, BMFI exhibits a unique predictive capacity for DS among the elderly population.PMID:38570056 | DOI:10.1016/j.exger.2024.112414 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 3, 2024 Category: Geriatrics Authors: Wen Sun Peige Wang Yongfang Zhao Source Type: research
Relationship between quadriceps femoris echotexture biomarkers and muscle strength and physical function in older adults with heart failure with preserved ejection fraction
CONCLUSIONS: Echotexture biomarkers are related to women's muscle strength and physical function, especially muscle energy, contrast, and entropy. Echotexture biomarkers assessed by the US could facilitate the management of older adults with HFpEF, monitor its progression and assess the effectiveness of treatments on the musculoskeletal structure.TRIAL REGISTRATION: NCT03909919. April 10, 2019. Retrospectively registered.PMID:38570057 | DOI:10.1016/j.exger.2024.112412 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 3, 2024 Category: Geriatrics Authors: Iv án José Fuentes-Abolafio Michele Ricci Mar ía Rosa Bernal-López Ricardo G ómez-Huelgas Antonio Ignacio Cuesta-Vargas Luis Miguel P érez-Belmonte Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes
CONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.PMID:38527636 | DOI:10.1016/j.exger.2024.112410 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 25, 2024 Category: Geriatrics Authors: Robert G Memelink Rose Njemini Minse J J de Bos Kuil Suzan Wopereis Johan de Vogel-van den Bosch Josje D Schoufour Michael Tieland Peter J M Weijs Ivan Bautmans Source Type: research
The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes
CONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.PMID:38527636 | DOI:10.1016/j.exger.2024.112410 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 25, 2024 Category: Geriatrics Authors: Robert G Memelink Rose Njemini Minse J J de Bos Kuil Suzan Wopereis Johan de Vogel-van den Bosch Josje D Schoufour Michael Tieland Peter J M Weijs Ivan Bautmans Source Type: research
The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes
CONCLUSION: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.PMID:38527636 | DOI:10.1016/j.exger.2024.112410 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 25, 2024 Category: Geriatrics Authors: Robert G Memelink Rose Njemini Minse J J de Bos Kuil Suzan Wopereis Johan de Vogel-van den Bosch Josje D Schoufour Michael Tieland Peter J M Weijs Ivan Bautmans Source Type: research
Chuanzhitongluo capsule improves cognitive impairment in mice with chronic cerebral hypoperfusion via the cholinergic anti-inflammatory pathway
In conclusion, CZTL may alleviate neuroinflammation induced by CCH and improve cognitive impairment in CCH mice by regulating the cholinergic anti-inflammatory pathway (CAIP) involving ChAT/α7nAChR/NF-κB.PMID:38522309 | DOI:10.1016/j.exger.2024.112407 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 24, 2024 Category: Geriatrics Authors: Zhiyuan Wang Bin Han Jianjiao Qi Xuelei Cao Huali Gu Jinping Sun Source Type: research
Microbiome interactions with different risk factors in development of myocardial infarction
Exp Gerontol. 2024 Mar 22:112409. doi: 10.1016/j.exger.2024.112409. Online ahead of print.ABSTRACTAmong all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % of all deaths. The intricate web of risk factors for MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by the human gut and oral microbiota, their diversity, richness, and dysbiosis, along with their respective metabolites. Host genetic factors...
Source: Experimental Gerontology - March 24, 2024 Category: Geriatrics Authors: Manisha Bijla Sunil Kumar Saini Ajai Pathak Kamal Prakash Bharadwaj Katyayani Sukhavasi Ayurshi Patil Diksha Saini Rakesh Yadav Shalini Singh Christiaan Leeuwenburgh Pramod Kumar Source Type: research
Chuanzhitongluo capsule improves cognitive impairment in mice with chronic cerebral hypoperfusion via the cholinergic anti-inflammatory pathway
In conclusion, CZTL may alleviate neuroinflammation induced by CCH and improve cognitive impairment in CCH mice by regulating the cholinergic anti-inflammatory pathway (CAIP) involving ChAT/α7nAChR/NF-κB.PMID:38522309 | DOI:10.1016/j.exger.2024.112407 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 24, 2024 Category: Geriatrics Authors: Zhiyuan Wang Bin Han Jianjiao Qi Xuelei Cao Huali Gu Jinping Sun Source Type: research
