Association between sarcopenia and multimorbidity among middle-aged and older adults in China: Findings from the China health and retirement longitudinal study
CONCLUSIONS: Possible sarcopenia is associated with the development of multimorbidity in middle-aged and older Chinese populations. Health screening of populations with possible sarcopenia can facilitate early detection of multimorbidity.PMID:38128847 | DOI:10.1016/j.exger.2023.112348 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 21, 2023 Category: Geriatrics Authors: Mingming Deng Ye Lu Xuelian Li Xiaoming Zhou Gang Hou Source Type: research

Relationship between systemic immune inflammation index and mortality among US adults with different diabetic status: Evidence from NHANES 1999-2018
CONCLUSION: The SII is closely associated with the risk of all-cause and cardiovascular mortality. These associations vary among individuals with different diabetic states. Therefore, monitoring systemic inflammation and SII values is crucial in mitigating the risk of mortality.PMID:38128848 | DOI:10.1016/j.exger.2023.112350 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 21, 2023 Category: Geriatrics Authors: Yujie Tang Xiaojin Feng Na Liu Yuan Zhou Yadi Wang Zhenna Chen Yongping Liu Source Type: research

Cognitive and functional evolution in older adults with and without intellectual disability using a multicomponent intervention: A prospective longitudinal study
CONCLUSIONS AND IMPLICATIONS: This study demonstrated that older people with Intellectual Disability who have supports to cope with this life stage can improve their cognitive and functional abilities.PMID:38128849 | DOI:10.1016/j.exger.2023.112352 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 21, 2023 Category: Geriatrics Authors: Estela Calatayud B árbara Oliván-Blázquez Marta S ánchez Peña Alejandra Aguilar-Latorre Olga Tena-Bernal Source Type: research

Association between sarcopenia and multimorbidity among middle-aged and older adults in China: Findings from the China health and retirement longitudinal study
CONCLUSIONS: Possible sarcopenia is associated with the development of multimorbidity in middle-aged and older Chinese populations. Health screening of populations with possible sarcopenia can facilitate early detection of multimorbidity.PMID:38128847 | DOI:10.1016/j.exger.2023.112348 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 21, 2023 Category: Geriatrics Authors: Mingming Deng Ye Lu Xuelian Li Xiaoming Zhou Gang Hou Source Type: research

Relationship between systemic immune inflammation index and mortality among US adults with different diabetic status: Evidence from NHANES 1999-2018
CONCLUSION: The SII is closely associated with the risk of all-cause and cardiovascular mortality. These associations vary among individuals with different diabetic states. Therefore, monitoring systemic inflammation and SII values is crucial in mitigating the risk of mortality.PMID:38128848 | DOI:10.1016/j.exger.2023.112350 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 21, 2023 Category: Geriatrics Authors: Yujie Tang Xiaojin Feng Na Liu Yuan Zhou Yadi Wang Zhenna Chen Yongping Liu Source Type: research

Cognitive and functional evolution in older adults with and without intellectual disability using a multicomponent intervention: A prospective longitudinal study
CONCLUSIONS AND IMPLICATIONS: This study demonstrated that older people with Intellectual Disability who have supports to cope with this life stage can improve their cognitive and functional abilities.PMID:38128849 | DOI:10.1016/j.exger.2023.112352 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 21, 2023 Category: Geriatrics Authors: Estela Calatayud B árbara Oliván-Blázquez Marta S ánchez Peña Alejandra Aguilar-Latorre Olga Tena-Bernal Source Type: research

Differences in acute neuromuscular response after single session of resistance exercise between young and older adults
DISCUSSION: These results showed that young adults exhibited a greater acute response in the peripheral component, whereas older adults showed a greater acute response in the central component of the neuromuscular system, and the acute response in MUs with a high recruitment threshold following resistance exercise was smaller than in those with a low recruitment threshold in older adults. These findings may partly explain why there are different chronic adaptations to resistance training between young and older adults.PMID:38104744 | DOI:10.1016/j.exger.2023.112346 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 17, 2023 Category: Geriatrics Authors: Taichi Nishikawa Ryosuke Takeda Tetsuya Hirono Masamichi Okudaira Toshiyuki Ohya Kohei Watanabe Source Type: research

Differences in acute neuromuscular response after single session of resistance exercise between young and older adults
DISCUSSION: These results showed that young adults exhibited a greater acute response in the peripheral component, whereas older adults showed a greater acute response in the central component of the neuromuscular system, and the acute response in MUs with a high recruitment threshold following resistance exercise was smaller than in those with a low recruitment threshold in older adults. These findings may partly explain why there are different chronic adaptations to resistance training between young and older adults.PMID:38104744 | DOI:10.1016/j.exger.2023.112346 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 17, 2023 Category: Geriatrics Authors: Taichi Nishikawa Ryosuke Takeda Tetsuya Hirono Masamichi Okudaira Toshiyuki Ohya Kohei Watanabe Source Type: research

Differences in acute neuromuscular response after single session of resistance exercise between young and older adults
DISCUSSION: These results showed that young adults exhibited a greater acute response in the peripheral component, whereas older adults showed a greater acute response in the central component of the neuromuscular system, and the acute response in MUs with a high recruitment threshold following resistance exercise was smaller than in those with a low recruitment threshold in older adults. These findings may partly explain why there are different chronic adaptations to resistance training between young and older adults.PMID:38104744 | DOI:10.1016/j.exger.2023.112346 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 17, 2023 Category: Geriatrics Authors: Taichi Nishikawa Ryosuke Takeda Tetsuya Hirono Masamichi Okudaira Toshiyuki Ohya Kohei Watanabe Source Type: research

Differences in acute neuromuscular response after single session of resistance exercise between young and older adults
DISCUSSION: These results showed that young adults exhibited a greater acute response in the peripheral component, whereas older adults showed a greater acute response in the central component of the neuromuscular system, and the acute response in MUs with a high recruitment threshold following resistance exercise was smaller than in those with a low recruitment threshold in older adults. These findings may partly explain why there are different chronic adaptations to resistance training between young and older adults.PMID:38104744 | DOI:10.1016/j.exger.2023.112346 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 17, 2023 Category: Geriatrics Authors: Taichi Nishikawa Ryosuke Takeda Tetsuya Hirono Masamichi Okudaira Toshiyuki Ohya Kohei Watanabe Source Type: research

Col1a1 mediates the focal adhesion pathway affecting hearing in miR-29a mouse model by RNA-seq analysis
Exp Gerontol. 2023 Dec 14:112349. doi: 10.1016/j.exger.2023.112349. Online ahead of print.ABSTRACTAge-related hearing loss (ARHL) is a common neurodegenerative disease. Its molecular mechanisms have not been fully elucidated. In the present study, we obtained differential mRNA expression in the cochlea of 2-month-old miR-29a+/+ mice and miR-29a-/- mice by RNA-seq. Gene ontology (GO) analysis was used to identify molecular functions associated with hearing in miR-29a-/- mice, including being actin binding (GO: 0003779) and immune processes. We focused on the intersection of differential genes, miR-29a target genes and the s...
Source: Experimental Gerontology - December 16, 2023 Category: Geriatrics Authors: Shuli Wang Mulan Li Pengcheng Liu Yaning Dong Ruishuang Geng Tihua Zheng Qingyin Zheng Bo Li Peng Ma Source Type: research

Col1a1 mediates the focal adhesion pathway affecting hearing in miR-29a mouse model by RNA-seq analysis
Exp Gerontol. 2023 Dec 14:112349. doi: 10.1016/j.exger.2023.112349. Online ahead of print.ABSTRACTAge-related hearing loss (ARHL) is a common neurodegenerative disease. Its molecular mechanisms have not been fully elucidated. In the present study, we obtained differential mRNA expression in the cochlea of 2-month-old miR-29a+/+ mice and miR-29a-/- mice by RNA-seq. Gene ontology (GO) analysis was used to identify molecular functions associated with hearing in miR-29a-/- mice, including being actin binding (GO: 0003779) and immune processes. We focused on the intersection of differential genes, miR-29a target genes and the s...
Source: Experimental Gerontology - December 16, 2023 Category: Geriatrics Authors: Shuli Wang Mulan Li Pengcheng Liu Yaning Dong Ruishuang Geng Tihua Zheng Qingyin Zheng Bo Li Peng Ma Source Type: research

Analysis of bone metabolic alterations linked with osteoporosis progression in type 2 diabetic db/db mice
Exp Gerontol. 2023 Dec 12:112347. doi: 10.1016/j.exger.2023.112347. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is a common chronic disease, characterized by persistent hyperglycemia and insulin resistance. This disorder is associated with decreased bone quality and an elevated risk of bone fractures. However, evidence on the relationship between systemic metabolic change and the development of type 2 diabetic osteoporosis (T2DOP) remains elusive. Herein, we investigate the changes of bone metabolites with bone loss in db/db mice (an animal model of T2DOP exhibited bone loss with age progression), and explore the p...
Source: Experimental Gerontology - December 14, 2023 Category: Geriatrics Authors: Kefeng Wu Pan Wang Luming Deng Yancai Li Qian Zhang Haiyan Hou Yuzhen Zhu Hua Ye Si Mei Liao Cui Source Type: research

Analysis of bone metabolic alterations linked with osteoporosis progression in type 2 diabetic db/db mice
Exp Gerontol. 2023 Dec 12:112347. doi: 10.1016/j.exger.2023.112347. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is a common chronic disease, characterized by persistent hyperglycemia and insulin resistance. This disorder is associated with decreased bone quality and an elevated risk of bone fractures. However, evidence on the relationship between systemic metabolic change and the development of type 2 diabetic osteoporosis (T2DOP) remains elusive. Herein, we investigate the changes of bone metabolites with bone loss in db/db mice (an animal model of T2DOP exhibited bone loss with age progression), and explore the p...
Source: Experimental Gerontology - December 14, 2023 Category: Geriatrics Authors: Kefeng Wu Pan Wang Luming Deng Yancai Li Qian Zhang Haiyan Hou Yuzhen Zhu Hua Ye Si Mei Liao Cui Source Type: research

Correlation of serum VEGF-C, ANGPTL4, and activin A levels with frailty
CONCLUSION: Elevated serum levels of VEGF-C, ANGPTL4, and ACV-A are associated with frailty status.PMID:38092160 | DOI:10.1016/j.exger.2023.112345 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 13, 2023 Category: Geriatrics Authors: Hung-Chen Chang Xiaojun Wang Xuchao Gu Shuai Jiang Wenhao Wang Tao Wu Maoqing Ye Xinkai Qu Zhijun Bao Source Type: research