Concurrent validation of the OMNI-Resistance Exercise Scale of perceived exertion with elastic bands in the elderly.
CONCLUSION: A strong positive and linear relationship was observed between the rating of perceived exertion and both heart rate and applied force. The OMNI-RES scale with elastic bands demonstrated to be a valid method for assessing the perceived exertion during resistance exercises and consequently represent a useful tool for prescribing exercise intensity to the elderly. PMID: 29262307 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 17, 2017 Category: Geriatrics Authors: Colado JC, Pedrosa FM, Juesas A, Gargallo P, Carrasco JJ, Flandez J, Chupel MU, Teixeira AM, Naclerio F Tags: Exp Gerontol Source Type: research

Multiple-modality exercise and mind-motor training to improve mobility in older adults: A randomized controlled trial.
CONCLUSIONS: Our results suggest that additional mind-motor training was not effective to improve mobility outcomes. In fact, participants in the active control group experienced greater benefits as a result of the intervention. PMID: 29262308 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 17, 2017 Category: Geriatrics Authors: Boa Sorte Silva NC, Gill DP, Gregory MA, Bocti J, Petrella RJ Tags: Exp Gerontol Source Type: research

The impact of ageing on male reproductive success in Drosophila melanogaster.
Abstract Male reproductive ageing has been mainly explained by a reduction in sperm quality with negative effects on offspring development and quality. In addition to sperm, males transfer seminal fluid proteins (Sfps) at mating; Sfps are important determinants of male reproductive success. Receipt of Sfps leads to female post-mating changes including physiological changes, and affects sperm competition dynamics. Using the fruit fly Drosophila melanogaster we studied ageing males' ability to induce female post-mating responses and determined the consequences of male ageing on their reproductive success. We aged ma...
Source: Experimental Gerontology - December 16, 2017 Category: Geriatrics Authors: Ruhmann H, Koppik M, Wolfner MF, Fricke C Tags: Exp Gerontol Source Type: research

VEGF attenuates 2-VO induced cognitive impairment and neuronal injury associated with the activation of PI3K/Akt and Notch1 pathway.
In this study, we intended to investigate the signaling mechanisms of VEGF in cognitive protection and anti-apoptosis in a rat model of chronic global cerebral ischemia induced by permanent bilateral common carotid artery occlusion (2-VO). The results showed that intranasal administration of VEGF (72h post-ischemia for 6 successive days) caused a significant improvement in the cognitive deficits induced by 2-VO, accompanied by a reversal of oxidative stress and VEGF depletion in the hippocampus. In addition, VEGF-treatment decreased the expression of Bax and Caspase-3, increased the expression of anti-apoptotic Bcl-xl and ...
Source: Experimental Gerontology - December 14, 2017 Category: Geriatrics Authors: Wang L, Wang F, Liu S, Yang X, Yang J, Ming D Tags: Exp Gerontol Source Type: research

Explosive type of contractions should not be avoided during resistance training in elderly.
rdo M PMID: 29247789 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 13, 2017 Category: Geriatrics Authors: Cadore EL, Pinto RS, Reischak-Oliveira Á, Izquierdo M Tags: Exp Gerontol Source Type: research

Age-related reduction in single muscle fiber calcium sensitivity is associated with decreased muscle power in men and women.
This study examined the contractile properties of single vastus lateralis muscle fibers with various myosin heavy chain (MHC) isoforms (I, I/IIA, IIA and IIAX) across a range of Ca2+ concentrations in 11 young (24.1±1.1years) and 10 older (68.8±0.8years) men and women. The normalized pCa-force curve shifted rightward with age, leading to decreased activation threshold (pCa10) and/or Ca2+ sensitivity (pCa50) for all MHC isoforms examined. In older adults, the slope of the pCa-force curve was unchanged in MHC I-containing fibers (I, I/IIA), but was steeper in MHC II-containing fibers (IIA, IIAX), indicating gre...
Source: Experimental Gerontology - December 13, 2017 Category: Geriatrics Authors: Straight CR, Ades PA, Toth MJ, Miller MS Tags: Exp Gerontol Source Type: research

Immune senescence and biomarkers profile of Bambu í aged population-based cohort.
Immune senescence and biomarkers profile of Bambuí aged population-based cohort. Exp Gerontol. 2017 Dec 13;: Authors: Torres KCL, de Rezende VB, Lima-Silva ML, de Souza Santos LJ, Costa CG, de Melo Mambrini JV, Peixoto SWV, Tarazona-Santos E, Filho OAM, Lima-Costa MF, Teixeira-Carvalho A Abstract During immunosenescence many proinflammatory markers such as cytokines and chemokines are increased. This process called by Franceschi and colleagues as inflammaging is associated with chronic inflammation and the ethiology and pathophysiolgy of many ageing diseases as Alzheimer's and atherosclerosis. ...
Source: Experimental Gerontology - December 13, 2017 Category: Geriatrics Authors: Torres KCL, de Rezende VB, Lima-Silva ML, de Souza Santos LJ, Costa CG, de Melo Mambrini JV, Peixoto SWV, Tarazona-Santos E, Filho OAM, Lima-Costa MF, Teixeira-Carvalho A Tags: Exp Gerontol Source Type: research

Age-related changes of skeletal muscle mass and strength among Italian and Taiwanese older people: Results from the Milan EXPO 2015 survey and the I-Lan Longitudinal Aging Study.
CONCLUSION: Muscle mass and strength declined with age in both ethnic groups. Caucasians showed greater muscle mass and performed better than their Asian counterparts. However, the age at which declines began to appear and the rate of decline during aging were comparable between the two populations. PMID: 29246506 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 12, 2017 Category: Geriatrics Authors: Marzetti E, Hwang AC, Tosato M, Peng LN, Calvani R, Picca A, Chen LK, Landi F Tags: Exp Gerontol Source Type: research

The association between C-reactive protein, Interleukin-6 and depression among older adults in the community: A systematic review and meta-analysis.
Abstract Previous research indicates there may be an association between inflammation and depression in older adults but results are inconsistent. Therefore, the aim of this review was to determine the cross-sectional and longitudinal associations of two inflammatory markers C-reactive protein (CRP) and Interleukin-6 (IL-6) with depression in older adults. We searched five databases for cross-sectional and longitudinal studies reporting an association between CRP or IL-6 with depression among adults sampled from the community aged 50 or older. We found 32 studies (23 cross-sectional, 7 longitudinal, and 2 assessin...
Source: Experimental Gerontology - December 10, 2017 Category: Geriatrics Authors: Smith KJ, Au B, Ollis L, Schmitz N Tags: Exp Gerontol Source Type: research

Pioglitazone attenuates aging-related disorders in aged apolipoprotein E deficient mice.
In conclusion, Piog treatment is effective to modulate the oxidative and inflammatory status, cell senescence, and lipid metabolism, contributing to attenuate several aging-related disorders in the aged apoE-/- mice, thereby maybe a promising protective therapy of aging and age-related diseases. PMID: 29221940 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 5, 2017 Category: Geriatrics Authors: Shen D, Li H, Zhou R, Liu MJ, Yu H, Wu DF Tags: Exp Gerontol Source Type: research

Are Human Development Index dimensions associated with gait performance in older adults? A systematic review.
CONCLUSION: No studies were found using HDI as a main variable. Systematic evidence showed a strong relationship with all three HDI dimensions: education, income, and life expectancy, suggesting that social factors at individual level affect gait performance. PMID: 29221941 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 5, 2017 Category: Geriatrics Authors: Freire RC, Pieruccini-Faria F, Montero-Odasso M Tags: Exp Gerontol Source Type: research

Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection.
Abstract Post-viral pneumococcal pneumonia is a leading morbidity and mortality in older patients (≥65years of age). The goal of our current study is to understand the impact of chronological aging on innate immune responses to a secondary, post viral infection with Streptococcus pneumoniae, a causative agent of bacterial pneumonia. Using aged murine models of infection, our findings demonstrate increased morbidity and mortality in aged mice within 48h post-secondary S. pneumoniae infection. Increased susceptibility of aged mice was associated with decreased TLR1, TLR6, and TLR9 mRNA expression and diminished I...
Source: Experimental Gerontology - December 1, 2017 Category: Geriatrics Authors: Cho SJ, Plataki M, Mitzel D, Lowry G, Rooney K, Stout-Delgado H Tags: Exp Gerontol Source Type: research

Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers.
Abstract Aging is associated with decreased mitochondrial content and function in skeletal muscle, possibly due to compromised biogenesis and autophagic removal of dysfunctional mitochondria. The aim of this study was to compare markers of mitochondrial content and biogenesis and of autophagy between skeletal muscle from young and aged American Quarter Horses. Citrate synthase protein and mtDNA copy number were decreased in triceps brachii (TB) muscle (P
Source: Experimental Gerontology - December 1, 2017 Category: Geriatrics Authors: Li C, White SH, Warren LK, Wohlgemuth SE Tags: Exp Gerontol Source Type: research

Lamin A expression in circulating osteoprogenitors as a potential biomarker for frailty: The Nepean Osteoporosis and Frailty (NOF) Study.
In this study, we hypothesized that low lamin A expression is also associated with frailty in humans. We aimed to develop a non-invasive method to quantify lamin A expression in epithelial and circulating osteoprogenitor (COP) cells, and to determine the relationship between lamin A expression and frailty in older individuals. COP cells and buccal swabs were obtained from 66 subjects (median age 74; 60% female; 26 non-frail, 23 pre-frail, and 17 frail) participating at the Nepean Osteoporosis and Frailty (NOF) Study. We quantified physical performance and disability, and stratified frailty in this population. Lamin A expre...
Source: Experimental Gerontology - December 1, 2017 Category: Geriatrics Authors: Al Saedi A, Gunawardene P, Bermeo S, Vogrin S, Boersma D, Phu S, Singh L, Suriyaarachchi P, Duque G Tags: Exp Gerontol Source Type: research

Interventions targeting loneliness and social isolation among the older people: An update systematic review.
Abstract This systematic review aims to summarize and update the current knowledge on the effectiveness of the existing interventions for alleviating loneliness and social isolation among older persons. A search of PubMed, ISI Web of science, SCOPUS, The Cochrane Library, and CINAHL databases was performed. The terminology combined all possible alternatives of the following keywords: social isolation, loneliness, old people, intervention and effectiveness. Eligible studies were published between January 2011 and February 2016 in English or Italian language and regarded the implementation of loneliness/social isola...
Source: Experimental Gerontology - November 30, 2017 Category: Geriatrics Authors: Poscia A, Stojanovic J, La Milia DI, Duplaga M, Grysztar M, Moscato U, Graziano O, Collamati A, Ricciardi W, Magnavita N Tags: Exp Gerontol Source Type: research

Pentraxin-3 and coronary artery disease.
PMID: 29197560 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 29, 2017 Category: Geriatrics Authors: Korzonek-Szlacheta I, Hudzik B, Danikiewicz A, Szkodzinski J, Lekston A, Gąsior M, Zubelewicz-Szkodzinska B Tags: Exp Gerontol Source Type: research

Phase angle is related with inflammatory and oxidative stress biomarkers in older women.
Abstract BACKGROUND: The aim of this study was to examine the relation between phase angle (PhA) and inflammatory and oxidative stress biomarkers in older women. METHODS: One hundred and fifty-five physically independent older women participated in this study (67.7±5.7years, 27.0±4.4kg/m2). Inflammatory markers included interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and acute phase reactive protein (CRP). Oxidative stress biomarkers comprised superoxide dismutase (SOD), catalase (CAT), advanced oxidation protein products (AOPP), and total radical-trapping antioxidant potential ...
Source: Experimental Gerontology - November 29, 2017 Category: Geriatrics Authors: Tomeleri CM, Cavaglieri CR, de Souza MF, Cavalcante EF, Antunes M, Nabbuco HCG, Venturini D, Barbosa DS, Silva AM, Cyrino ES Tags: Exp Gerontol Source Type: research

Various cellular stress components change as the rat ages: An insight into the putative overall age-related cellular stress network.
In this study, we obtained blood from ageing rats upon reaching 20-, 40-, and 72-wk.-old. Subsequently, we measured representative cellular stress-linked biomolecules (H2O2, glutathione reductase, heme, NADPH, NADP, nitric oxide, GADD153) and cell signals [substance P (SP), free fatty acid, calcium, NF-κB] in either or both blood serum and cytosol. Subsequently, network analysis of the overall cellular stress network was performed. Our results show that there are changes affecting stress-linked biomolecules and cell signals as the rat ages. Additionally, based on our network analysis data, we postulate that NADPH, H2...
Source: Experimental Gerontology - November 29, 2017 Category: Geriatrics Authors: Cueno ME, Imai K Tags: Exp Gerontol Source Type: research

Effect of resistance training on muscle strength and rate of force development in healthy older adults: A systematic review and meta-analysis.
Abstract Rapid force capacity, identified by rate of rise in contractile force at the onset of contraction, i.e., the rate of force development (RFD), has been considered an important neuromuscular parameter of physical fitness in elderly individuals. Randomized control studies conducted in adults have found that resistance training may elicit different outcomes in terms of RFD and muscle strength. Thus, the main purpose of this study was to review systematically the literature for studies regarding the influence of resistance training on muscle strength and RFD in elderly persons. A literature search was performe...
Source: Experimental Gerontology - November 28, 2017 Category: Geriatrics Authors: de Camargo Guizelini P, de Aguiar RA, Denadai BS, Caputo F, Greco CC Tags: Exp Gerontol Source Type: research

Immunity and inflammation: From Jekyll to Hyde.
Abstract The immune system is the defense system of the host that protects it from foreign pathogens. Inflammation is one of the key processes that alert the immune system but when loss of regulation occurs, a long-term chronic inflammation settles and is likely to be detrimental to the host. Most age-related diseases are linked to a disequilibrium of circulating inflammatory molecules. We could use the analogy of "Dr Jekyll" representing the expected inflammation and immune response in general and the "Mr. Hyde" effect represented by the other face of inflammation, when it is dysregulated. Thi...
Source: Experimental Gerontology - November 26, 2017 Category: Geriatrics Authors: Xu W, Larbi A Tags: Exp Gerontol Source Type: research

Caloric restriction can improve learning and memory in C57/BL mice probably via regulation of the AMPK signaling pathway.
This study aimed to evaluate the beneficial effects of a caloric restriction diet on learning and memory, and further to elucidate the mechanisms. Thirty 6-week-old male C57/BL mice were randomly divided into three groups: normal control (NC group), high-energy (HE group) and CR group. After 44weeks, the Morris water maze was used to examine learning and memory abilities. Western blotting and immunohistochemistry were used to detect changes in proteins involved in the adenosine monophosphate-activated protein kinase (AMPK) pathway in the mouse hippocampus. Compared with NC group, the swimming distance and escape latency we...
Source: Experimental Gerontology - November 23, 2017 Category: Geriatrics Authors: Ma L, Wang R, Dong W, Zhao Z Tags: Exp Gerontol Source Type: research

Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain.
In conclusion, resveratrol treatment induced a different cellular response in aged animals when they encountered acute inflammatory stimuli. PMID: 29174969 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 23, 2017 Category: Geriatrics Authors: Palomera-Ávalos V, Griñán-Ferré C, Izquierdo V, Camins A, Sanfeliu C, Canudas AM, Pallàs M Tags: Exp Gerontol Source Type: research

Antioxidant action of grape seed polyphenols and aerobic exercise in improving neuronal number in the hippocampus is associated with decrease in lipid peroxidation and hydrogen peroxide in adult and middle-aged rats.
Abstract The present study explored the effects of swimming training and grape seed proanthocyanidin extract (GSPE) on neuronal survival in the hippocampus (HC) of middle-aged rats along with oxidative stress (OS) parameters. Further, the bioavailability of the GSPE, catechin, epicatechin and gallic acid were measured in the HC and plasma. Male Wistar rats were grouped into: sedentary control, SE-C; swimming trained, SW-T; SE-C, supplemented sedentary, SE-C(PA) and swimming trainees, SW-T(PA). The supplement was a daily dose of 400mg GSPE/kg body weight. Swimming training lasted for 2h/day and for 14weeks. Glutath...
Source: Experimental Gerontology - November 22, 2017 Category: Geriatrics Authors: Abhijit S, Tripathi SJ, Bhagya V, Shankaranarayana Rao BS, Subramanyam MV, Asha Devi S Tags: Exp Gerontol Source Type: research

Total body and arm bioimpedance in patients with Alzheimer's disease.
CONCLUSION: Patients with AD show characteristics - lower lean mass/higher percent fat mass - that can be detected by both total body and localized bioimpedance approaches. This suggests the possibility of a new, quicker and simpler procedure for body composition assessment. PMID: 29175393 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 21, 2017 Category: Geriatrics Authors: Mereu E, Succa V, Buffa R, Sanna C, Mereu RM, Catte O, Marini E Tags: Exp Gerontol Source Type: research

Age-related differences in rate of power development exceed differences in peak power.
PMID: 29155242 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 16, 2017 Category: Geriatrics Authors: Van Driessche S, Delecluse C, Bautmans I, Vanwanseele B, Van Roie E Tags: Exp Gerontol Source Type: research

Effects of aquarobic exercise and burdock intake on serum blood lipids and vascular elasticity in Korean elderly women.
Abstract BACKGROUND: The elderly's health issues are often complex and tend to lead to chronic diseases; such issues can be due to a fitness decline resulting from a lack of physical activities. The burdock root is a blood purifier, lymphatic system strengthener, and natural diuretic. The purpose of this study was to analyze the effects of aquarobic exercise and burdock intake on serum blood lipids and vascular elasticity in elderly women by implementing a 12-week program with these interventions. METHODS: Forty elderly female volunteer subjects aged 70 to 80years comprised the control group (n=8), aquarobic ...
Source: Experimental Gerontology - November 14, 2017 Category: Geriatrics Authors: Ha MS, Kim JH, Kim YS, Kim DY Tags: Exp Gerontol Source Type: research

Electrical activity of sensory pathways in female and male geriatric Rhesus monkeys (Macaca mulatta), and its relation to oxidative stress.
lar A, González-Puertos VY, Konigsberg M Abstract Synapses loss during aging has been related to decreased neuronal excitability and reduced electrophysiological activity in the nervous system, as well as to increased brain damage. Those physiological and biochemical alterations have been related to the oxidative stress increase associated with old age. The main substrate of lipid peroxidation (LPX) in the central and peripheral nervous systems are the myelin sheaths, and their damage generates a delayed nerve conduction velocity. However, studies in which the neural conduction velocity is related to change...
Source: Experimental Gerontology - November 13, 2017 Category: Geriatrics Authors: Ibáñez-Contreras A, Hernández-Arciga U, Poblano A, Arteaga-Silva M, Hernández-Godínez B, Mendoza-Cuevas GI, Toledo-Pérez R, Alarcón-Aguilar A, González-Puertos VY, Konigsberg M Tags: Exp Gerontol Source Type: research

Low-dose vitamin D supplementation and incident frailty in older people: An eight year longitudinal study.
In conclusion, low-dose vitamin D supplementation was not associated with any decreased risk of frailty during eight years of follow-up in a large cohort of North American people. Future large-scale trials with high doses of oral vitamin D and longer follow-up are needed to confirm/refute our findings. PMID: 29137947 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 11, 2017 Category: Geriatrics Authors: Bolzetta F, Stubbs B, Noale M, Vaona A, Demurtas J, Celotto S, Cester A, Maggi S, Koyanagi A, Cereda E, Veronese N Tags: Exp Gerontol Source Type: research

Aging affects the response of female rats to a hypercaloric diet.
Abstract Metabolic syndrome is a major risk factor for the development of cardiovascular diseases and diabetes, among other conditions. Studies have shown that aging and metabolic syndrome share several metabolic alterations, and that aged individuals, in particular females, are at an increased risk of developing metabolic disorders. Although several studies have investigated the effects of hypercaloric diets in the development of obesity and metabolic syndrome in young animals, few studies have investigated these parameters in aged animals, especially in females. Therefore, the aim of this study was to investigat...
Source: Experimental Gerontology - November 10, 2017 Category: Geriatrics Authors: Arbo BD, Niches G, Zanini P, Bassuino DM, Driemeier D, Ribeiro MF, Cecconello AL Tags: Exp Gerontol Source Type: research

Arterial stiffness and cerebral hemodynamic pulsatility during cognitive engagement in younger and older adults.
This study examined central artery stiffness and hemodynamic pulsatility during cognitive engagement in younger and older adults. METHODS: Vascular-hemodynamic measures were completed in 19 younger (age 35±1yrs) and 20 older (age 69±2yrs) adults at rest and during a Stroop task. Aortic stiffness (carotid-femoral pulse wave velocity, PWV) and carotid pulse pressure (PP) were assessed using applanation tonometry. Carotid stiffness was assessed as a single-point PWV using Doppler Ultrasound. Middle cerebral artery (MCA) mean flow and flow pulsatility index (PI) were assessed using transcranial Doppler. Cogn...
Source: Experimental Gerontology - November 9, 2017 Category: Geriatrics Authors: Heffernan KS, Augustine JA, Lefferts WK, Spartano NL, Hughes WE, Jorgensen RS, Gump BB Tags: Exp Gerontol Source Type: research

Role of D-galactose-induced brain aging and its potential used for therapeutic interventions.
Abstract Aging is a phenomenon that all living organisms inevitably face. Every year, 9.9million people, globally, suffer from dementia, an indicator of the aging brain. Brain aging is significantly associated with mitochondrial dysfunction. This is characterized by a decrease in the activity of respiratory chain enzymes and ATP production, and increased free radical generation, mitochondrial deoxyribonucleic acid (DNA) mutations, and impaired mitochondrial structures. To get a better understanding of aging and to prevent its effects on many organs, chronic systemic administration of D-galactose was used to artifi...
Source: Experimental Gerontology - November 9, 2017 Category: Geriatrics Authors: Thazin-Shwe, Pratchayasakul W, Chattipakorn N, Chattipakorn SC Tags: Exp Gerontol Source Type: research

Endotoxemia is modulated by quantity and quality of dietary fat in older adults.
CONCLUSION: Our results, together with those obtained in a previous study, support the concept that the consumption of the Med Diet, in contrast to a low-fat PUFA diet, constitutes a more suitable dietary lifestyle for preventing the development of atherosclerosis in a population at risk, such as older adults. PMID: 29129737 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 9, 2017 Category: Geriatrics Authors: Lopez-Moreno J, Garcia-Carpintero S, Gomez-Delgado F, Jimenez-Lucena R, Vals-Delgado C, Alcala-Diaz JF, Roncero-Ramos I, Rangel-Zuñiga OA, Yubero-Serrano EM, Malagon MM, Ordovas JM, Perez-Martinez P, Lopez-Miranda J, Camargo A Tags: Exp Gerontol Source Type: research

Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis.
Abstract The study investigated strain specificities in age-related differences in CD8+ T cell- and microglial cell-mediated mechanisms implicated in induction/perpetuation and/or control of neuroinflammation in experimental autoimmune encephalomyelitis (EAE) in Albino Oxford (AO) and Dark Agouti (DA) rats exhibiting age-related changes in the susceptibility to EAE in the opposite direction (increase in relatively resistant AO rats vs decrease in DA rats). In the inductive phase of EAE, the greater number of fully differentiated effector CD8+ T lymphocytes was found in draining lymph nodes (dLNs) from aged rats of...
Source: Experimental Gerontology - November 8, 2017 Category: Geriatrics Authors: Stojić-Vukanić Z, Pilipović I, Djikić J, Vujnović I, Nacka-Aleksić M, Bufan B, Arsenović-Ranin N, Kosec D, Leposavić G Tags: Exp Gerontol Source Type: research

Region-specific glial hyperplasia and neuronal stability of rat lateral geniculate nucleus during aging.
In this study, we used design-based stereology to estimate the number of neurons, glial cells, the glia/neuron ratio and the volume of the LGN of Wistar rats from 3, 13 or 23months of age. We examined each LGN subdivision processed by immunohistochemistry for NeuN and Nissl counterstain. We observed no significant age-related neuronal loss in any nuclei and a 21% and 33% significant increase in dLGN and IGL glial cells of 23month-old rats. We also observed the glia/neuron relation increases in dLGN of 13month-old rats and in dLGN, IGL and vLGN internal portion of 23month-old ones. Moreover, we report an age-related increas...
Source: Experimental Gerontology - November 4, 2017 Category: Geriatrics Authors: Fiuza FP, Queiroz ACA, Câmara DA, Cavalcanti JRLP, Nascimento Júnior ES, Lima RH, Engelberth RCGJ, Cavalcante JS Tags: Exp Gerontol Source Type: research

Mild cognitive impairment and physical activity in the general population: Findings from six low- and middle-income countries.
CONCLUSIONS: MCI was associated with an increased odds of not meeting the recommended PA levels. If replicated in longitudinal studies, these findings will offer new targets and strategies for prevention and treatment programs in people at risk for MCI and dementia. PMID: 29104092 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 2, 2017 Category: Geriatrics Authors: Vancampfort D, Stubbs B, Lara E, Vandenbulcke M, Swinnen N, Koyanagi A Tags: Exp Gerontol Source Type: research

Integrin-linked kinase: A new actor in the ageing process?
es MP Abstract Integrin-linked kinase (ILK) is a protein located in focal adhesion complexes that is linked to the cytoplasmic domain of integrin receptors. Together with PINCH and parvin, ILK forms the IPP complex, which is associated with conserved intracellular signalling pathways and integrin regulation of the actin cytoskeleton. ILK plays an essential role in a wide variety of cellular functions, including cell migration, differentiation, survival, and division. The present review summarizes recent evidence, suggesting a new role for ILK in organismal ageing and cellular senescence, indicating that ILK is a k...
Source: Experimental Gerontology - October 31, 2017 Category: Geriatrics Authors: Olmos G, López-Ongil S, Ruiz Torres MP Tags: Exp Gerontol Source Type: research

DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system.
Abstract The aging process is the major driver of morbidity and mortality, steeply increasing the risk to succumb to cancer, cardiovascular disease, infection and neurodegeneration. Inflammation is a common denominator in age-related pathologies, identifying the immune system as a gatekeeper in aging overall. Among immune cells, T cells are long-lived and exposed to intense replication pressure, making them sensitive to aging-related abnormalities. In successful T cell aging, numbers of naïve cells, repertoire diversity and activation threshold are preserved as long as possible; in maladaptive T cell aging, p...
Source: Experimental Gerontology - October 31, 2017 Category: Geriatrics Authors: Li Y, Goronzy JJ, Weyand CM Tags: Exp Gerontol Source Type: research

Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes.
Abstract This prospective study aimed to address changes in inflammatory response between different aged populations of patients who sustained burn and inhalation injury. Plasma and bronchoalveolar lavage (BAL) samples were collected from 104 patients within 15h of their estimated time of burn injury. Clinical variables, laboratory parameters, and immune mediator profiles were examined in association with clinical outcomes. Older patients were at higher odds for death after burn injury (odds ratio (OR)=7.37 per 10years, p=0.004). In plasma collected within 15h after burn injury, significant increases in the concen...
Source: Experimental Gerontology - October 25, 2017 Category: Geriatrics Authors: Frankel JH, Boe DM, Albright JM, O'Halloran EB, Carter SR, Davis CS, Ramirez L, Burnham EL, Gamelli RL, Afshar M, Kovacs EJ Tags: Exp Gerontol Source Type: research

Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3 β pathway.
In this study, we showed that MANF up-regulates the expression of nuclear factor erythroid 2-related factor (Nrf2) and promotes its translocation into the nucleus. The anti-oxidation and anti-apoptotic effects of MANF could be partially blocked by inhibitor or shRNA-mediated knockdown of Nrf2. Furthermore, MANF activated phospoinositide-3-kinase (PI3K)/Akt signaling and suppressed glycogen synthase kinase (GSK3β) activation. PI3K inhibitor (LY49002) abolished effects of MANF on AKT phosphorylation, GSK3β inactivation, Nrf2 nuclear translocation and subsequently abrogated MANF-mediates cytoprotection. Collectively...
Source: Experimental Gerontology - October 24, 2017 Category: Geriatrics Authors: Zhang J, Tong W, Sun H, Jiang M, Shen Y, Liu Y, Gu H, Guo J, Fang J, Jin L Tags: Exp Gerontol Source Type: research

Epigenetic effects of physical activity in elderly patients with cardiovascular disease.
eri F Abstract Cardiovascular disease (CVD) is an important public health problem affecting especially the elderly. Over the past 20years, an increasing number of studies have examined its underlying pathophysiological mechanisms and new therapies are continually being discovered. However, despite considerable progress in CVD management, mortality and morbidity remain a major healthcare concern, and frequent hospital admissions compromise the daily life and social activities of these patients. Physical activity has emerged as an important non-pharmacological adjunctive therapy for CVD in older patients, especially...
Source: Experimental Gerontology - October 23, 2017 Category: Geriatrics Authors: Recchioni R, Marcheselli F, Antonicelli R, Mensà E, Lazzarini R, Procopio AD, Olivieri F Tags: Exp Gerontol Source Type: research

Beneficial effects of resistance training on the protein profile of the calcaneal tendon during aging.
This study contributes to a better understanding of molecular aspects of the tendon. The down regulation of proteins linked to mechanical function and extracellular matrix remodeling of the tendon during aging can contribute to the increase of injury and weakness in the tendon. Nevertheless, RT proved to be a tool to prevent these adverse effects during aging by increasing proteins involved in the functionality of the tendon. PMID: 29066418 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 21, 2017 Category: Geriatrics Authors: Barin FR, Durigan JLQ, Oliveira KS, Migliolo L, de Almeida JA, Carvalho M, Petriz B, de Araujo HSS, Fontes W, Franco OL, Marqueti RC Tags: Exp Gerontol Source Type: research

The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging.
Abstract Augmented apoptotic signaling can result in degradation of skeletal muscle proteins and loss of myonuclei, ultimately contributing to muscle atrophy and contractile dysfunction. Apoptosis repressor with caspase recruitment domain (ARC) is an anti-apoptotic protein highly expressed in skeletal muscle. Here we examined the role of ARC on age-related skeletal muscle apoptosis and wasting by utilizing an ARC-deficient mouse model. Aged mice displayed a number of morphological, phenotypic, and contractile alterations in both soleus and plantaris muscle with aging. Although no differences were found in proteoly...
Source: Experimental Gerontology - October 19, 2017 Category: Geriatrics Authors: Vorobej K, Mitchell AS, Smith IC, Donath S, Russell Tupling A, Quadrilatero J Tags: Exp Gerontol Source Type: research

Study of insulin vascular sensitivity in aortic rings and endothelial cells from aged rats subjected to caloric restriction: Role of perivascular adipose tissue.
In conclusion, a moderate protocol of CR improves insulin vascular sensitivity and prevents the aging induced overexpression of pro-inflammatory cytokines in PVAT. PMID: 29055722 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 18, 2017 Category: Geriatrics Authors: Amor S, Martín-Carro B, Rubio C, Carrascosa JM, Hu W, Huang Y, García-Villalón AL, Granado M Tags: Exp Gerontol Source Type: research

Mechanisms driving the ageing heart.
Abstract Cardiovascular disease (CVD) is the leading cause of death globally. Although the number one risk factor for CVD is age, the detrimental biological processes that occur in the heart during ageing remain elusive. It is therefore vitality important to understand the fundamental mechanisms driving heart ageing to enable the development of preventions and treatments targeting these processes. Cellular senescence has been described more than fifty years ago as the irreversible cell-cycle arrest which occurs in somatic cells. Emerging evidence suggests that cellular senescence plays a key role in heart ageing, ...
Source: Experimental Gerontology - October 17, 2017 Category: Geriatrics Authors: Anderson R, Richardson GD, Passos JF Tags: Exp Gerontol Source Type: research

Adipose tissue inflammation in aging.
Abstract Adipose tissue has traditionally been viewed as an organ of interest within studies of obesity and diet-associated metabolic disorders. However, as studies reveal the role white adipose tissue plays as an energy storage, a lipid metabolism site, and an adipokine secretor, it has become recognized as an organ of importance for metabolic health in both the young obese and the old obese. Within the realms of aging research, the pursuit of senolytics has taken the field's spotlight, where the clearance of senescent cells has shown to attenuate aspects of age-related disorders. More interestingly, these senoly...
Source: Experimental Gerontology - October 17, 2017 Category: Geriatrics Authors: Mau T, Yung R Tags: Exp Gerontol Source Type: research

Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer's pathology in MCI and mild dementia.
CONCLUSION: Lower BMI is associated with cerebral AD pathology rather than with cognitive impairment in elderly subjects with MCI and mild dementia. Along with other clinical factors, decreasing BMI may help the clinician to identify patients with cognitive impairment due to AD. PMID: 29054536 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 17, 2017 Category: Geriatrics Authors: Mathys J, Gholamrezaee M, Henry H, von Gunten A, Popp J Tags: Exp Gerontol Source Type: research

Proteodynamics in aging human T cells - The need for its comprehensive study to understand the fine regulation of T lymphocyte functions.
Abstract Cellular life depends mostly on the creation, modification, interactions and destruction of proteins. This is true for every cell, including human T lymphocytes. One way these cells can ascertain the fidelity and at least partial functionality of their proteomes under constant attack of irreversible modulations (e.g., ROS- or glycation-dependent) is proteostasis. However, with cellular aging proteostasis progressively fails and proteostenosis (decreased amounts and functionalities of remaining proteins) occurs. There are several mechanisms involved in the modulation and protection of the proteome in the T...
Source: Experimental Gerontology - October 13, 2017 Category: Geriatrics Authors: Witkowski JM, Mikosik A, Bryl E, Fulop T Tags: Exp Gerontol Source Type: research

Tumor necrosis factor-alpha and soluble TNF-alpha receptor responses in young vs. middle-aged males following eccentric exercise.
Abstract BACKGROUND: Tumor necrosis factor-alpha (TNF-α) has been shown to be implicated in both muscle regeneration and muscle wasting. However, it remains unclear whether TNF-α is responsible for the age-related losses in muscle size and function. Also, due to the high clearance rate of TNF-α from circulation, analyzing the circulating levels of soluble TNF-α receptors 1 and 2 (STNFR1 and STNFR2) may provide a better indication of inflammatory events. The aim of this study was to examine changes in circulating concentrations of TNF-α, STNFR1, and STNFR2 following acute eccentric exe...
Source: Experimental Gerontology - October 13, 2017 Category: Geriatrics Authors: Arroyo E, Wells AJ, Gordon JA, Varanoske AN, Gepner Y, Coker NA, Church DD, Fukuda DH, Stout JR, Hoffman JR Tags: Exp Gerontol Source Type: research

DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly.
Abstract Elderly residents of long-term care commonly exhibit a number of age-related health deficits, including impaired physical and cognitive function, chronic illnesses, and chronic inflammation. Given our previous data relating the phenotype and function of innate and adaptive leukocytes from the nursing home elderly to chronic conditions and inflammatory biomarkers, we hypothesized that these factors would influence the regulatory programming of immune cells, thereby contributing to immune dysfunction. Since DNA methylation represents both an important regulatory mechanism of cells as well as a biomarker of ...
Source: Experimental Gerontology - October 12, 2017 Category: Geriatrics Authors: Verschoor CP, McEwen LM, Kobor MS, Loeb MB, Bowdish DME Tags: Exp Gerontol Source Type: research

The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila.
Abstract Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure. The mechanisms driving age-related tissue fibrosis and cardiac dysfunction are unclear, yet clinically important. Drosophila is amenable to the study of cardiac ageing as well as collagen deposition; however it is unclear whether collagen accumulates in the ageing Drosophila heart. This work examined collagen deposition and cardiac function in ageing Drosophila, in the context of reduced expression of collagen-interacting prote...
Source: Experimental Gerontology - October 12, 2017 Category: Geriatrics Authors: Vaughan L, Marley R, Miellet S, Hartley PS Tags: Exp Gerontol Source Type: research