Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty
CONCLUSION: The 2-minute walk test is a valid tool for estimating cardiorespiratory fitness among older adults with CF. However, it should be further tested across a larger population.PMID:37967590 | DOI:10.1016/j.exger.2023.112326 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Azianah Ibrahim Arimi Fitri Mat Ludin Suzana Shahar Noor Hazfalinda Hamzah Chin Ai-Vyrn Devinder Kaur Ajit Singh Source Type: research
Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Exp Gerontol. 2023 Nov 13:112332. doi: 10.1016/j.exger.2023.112332. Online ahead of print.ABSTRACTFermented food is commonly viewed as healthy, mostly due to its probiotic and digestion-enhancing properties and recently it has been examined with regard to the development of new therapeutic and preventive measures for Alzheimer's disease. Fermented food has been shown to have anti-inflammatory and antioxidant properties and to alter the gut microbiota. However, the exact pathogenesis of Alzheimer's disease is still unknown and its connections to systemic inflammation and gut dysbiosis, as potential targets of fermented food...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Micha ł Tyliszczak Benita Wiatrak Maciej Danielewski Adam Szel ąg Alicja Z Kucharska Tomasz Soza ński Source Type: research
MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia
Exp Gerontol. 2023 Nov 13:112330. doi: 10.1016/j.exger.2023.112330. Online ahead of print.ABSTRACTHyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis (AS). Some reports have shown that homocysteine (Hcy) could accelerate the development of AS by promoting endothelial cell senescence. miRNAs were widely involved in the pathophysiology of HHcy. However, few studies have focused on the changes of miRNA-mRNA networks in the artery of HHcy patients. For this reason, RNA-sequencing was adopted to investigate the expression of miRNA and mRNA in HHcy model mouse arteries. We found that the expression of 21...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Hao Qin Longlong Hu Wenjun Wang Zuozhong Yu Yang Chen Yuanbin Zhao Yanhui Liao Weilin Zhang Renqiang Yang Source Type: research
Metformin attenuates inflammation and boosts autophagy in the liver and intestine of chronologically aged rats
CONCLUSIONS: Metformin intervention can boost the autophagy level in the liver and intestine and reduce the expression of aging-related inflammatory factors in aged rats, and these effects may be related to the increase of the AMPK phosphorylation level.PMID:37967593 | DOI:10.1016/j.exger.2023.112331 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Zheng Kuai Xin Chao Yuting He Weiying Ren Source Type: research
Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty
CONCLUSION: The 2-minute walk test is a valid tool for estimating cardiorespiratory fitness among older adults with CF. However, it should be further tested across a larger population.PMID:37967590 | DOI:10.1016/j.exger.2023.112326 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Azianah Ibrahim Arimi Fitri Mat Ludin Suzana Shahar Noor Hazfalinda Hamzah Chin Ai-Vyrn Devinder Kaur Ajit Singh Source Type: research
Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Exp Gerontol. 2023 Nov 13:112332. doi: 10.1016/j.exger.2023.112332. Online ahead of print.ABSTRACTFermented food is commonly viewed as healthy, mostly due to its probiotic and digestion-enhancing properties and recently it has been examined with regard to the development of new therapeutic and preventive measures for Alzheimer's disease. Fermented food has been shown to have anti-inflammatory and antioxidant properties and to alter the gut microbiota. However, the exact pathogenesis of Alzheimer's disease is still unknown and its connections to systemic inflammation and gut dysbiosis, as potential targets of fermented food...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Micha ł Tyliszczak Benita Wiatrak Maciej Danielewski Adam Szel ąg Alicja Z Kucharska Tomasz Soza ński Source Type: research
MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia
Exp Gerontol. 2023 Nov 13:112330. doi: 10.1016/j.exger.2023.112330. Online ahead of print.ABSTRACTHyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis (AS). Some reports have shown that homocysteine (Hcy) could accelerate the development of AS by promoting endothelial cell senescence. miRNAs were widely involved in the pathophysiology of HHcy. However, few studies have focused on the changes of miRNA-mRNA networks in the artery of HHcy patients. For this reason, RNA-sequencing was adopted to investigate the expression of miRNA and mRNA in HHcy model mouse arteries. We found that the expression of 21...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Hao Qin Longlong Hu Wenjun Wang Zuozhong Yu Yang Chen Yuanbin Zhao Yanhui Liao Weilin Zhang Renqiang Yang Source Type: research
Metformin attenuates inflammation and boosts autophagy in the liver and intestine of chronologically aged rats
CONCLUSIONS: Metformin intervention can boost the autophagy level in the liver and intestine and reduce the expression of aging-related inflammatory factors in aged rats, and these effects may be related to the increase of the AMPK phosphorylation level.PMID:37967593 | DOI:10.1016/j.exger.2023.112331 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Zheng Kuai Xin Chao Yuting He Weiying Ren Source Type: research
Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty
CONCLUSION: The 2-minute walk test is a valid tool for estimating cardiorespiratory fitness among older adults with CF. However, it should be further tested across a larger population.PMID:37967590 | DOI:10.1016/j.exger.2023.112326 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Azianah Ibrahim Arimi Fitri Mat Ludin Suzana Shahar Noor Hazfalinda Hamzah Chin Ai-Vyrn Devinder Kaur Ajit Singh Source Type: research
Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Exp Gerontol. 2023 Nov 13:112332. doi: 10.1016/j.exger.2023.112332. Online ahead of print.ABSTRACTFermented food is commonly viewed as healthy, mostly due to its probiotic and digestion-enhancing properties and recently it has been examined with regard to the development of new therapeutic and preventive measures for Alzheimer's disease. Fermented food has been shown to have anti-inflammatory and antioxidant properties and to alter the gut microbiota. However, the exact pathogenesis of Alzheimer's disease is still unknown and its connections to systemic inflammation and gut dysbiosis, as potential targets of fermented food...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Micha ł Tyliszczak Benita Wiatrak Maciej Danielewski Adam Szel ąg Alicja Z Kucharska Tomasz Soza ński Source Type: research
MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia
Exp Gerontol. 2023 Nov 13:112330. doi: 10.1016/j.exger.2023.112330. Online ahead of print.ABSTRACTHyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis (AS). Some reports have shown that homocysteine (Hcy) could accelerate the development of AS by promoting endothelial cell senescence. miRNAs were widely involved in the pathophysiology of HHcy. However, few studies have focused on the changes of miRNA-mRNA networks in the artery of HHcy patients. For this reason, RNA-sequencing was adopted to investigate the expression of miRNA and mRNA in HHcy model mouse arteries. We found that the expression of 21...
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Hao Qin Longlong Hu Wenjun Wang Zuozhong Yu Yang Chen Yuanbin Zhao Yanhui Liao Weilin Zhang Renqiang Yang Source Type: research
Metformin attenuates inflammation and boosts autophagy in the liver and intestine of chronologically aged rats
CONCLUSIONS: Metformin intervention can boost the autophagy level in the liver and intestine and reduce the expression of aging-related inflammatory factors in aged rats, and these effects may be related to the increase of the AMPK phosphorylation level.PMID:37967593 | DOI:10.1016/j.exger.2023.112331 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 15, 2023 Category: Geriatrics Authors: Zheng Kuai Xin Chao Yuting He Weiying Ren Source Type: research
Smaller grey matter volume in the central olfactory system in mild cognitive impairment
Exp Gerontol. 2023 Nov 11;183:112325. doi: 10.1016/j.exger.2023.112325. Online ahead of print.ABSTRACTOne of the major challenges in the diagnosis of Alzheimer's disease (AD) is to increase the specificity of the early diagnosis. While episodic memory impairment is a sensitive AD marker, other measures are needed to improve diagnostic specificity. A promising biomarker might be a cerebral atrophy of the central olfactory processing areas in the early stages of the disease since an impairment of olfactory identification is present at the clinical stage of AD. Our goal was therefore, (1) to evaluate the grey matter volume (G...
Source: Experimental Gerontology - November 12, 2023 Category: Geriatrics Authors: Beno ît Jobin Benjamin Boller Johannes Frasnelli CIMA-Q group Source Type: research
Smaller grey matter volume in the central olfactory system in mild cognitive impairment
Exp Gerontol. 2023 Nov 11;183:112325. doi: 10.1016/j.exger.2023.112325. Online ahead of print.ABSTRACTOne of the major challenges in the diagnosis of Alzheimer's disease (AD) is to increase the specificity of the early diagnosis. While episodic memory impairment is a sensitive AD marker, other measures are needed to improve diagnostic specificity. A promising biomarker might be a cerebral atrophy of the central olfactory processing areas in the early stages of the disease since an impairment of olfactory identification is present at the clinical stage of AD. Our goal was therefore, (1) to evaluate the grey matter volume (G...
Source: Experimental Gerontology - November 12, 2023 Category: Geriatrics Authors: Beno ît Jobin Benjamin Boller Johannes Frasnelli CIMA-Q group Source Type: research
Smaller grey matter volume in the central olfactory system in mild cognitive impairment
Exp Gerontol. 2023 Nov 10:112325. doi: 10.1016/j.exger.2023.112325. Online ahead of print.ABSTRACTOne of the major challenges in the diagnosis of Alzheimer's disease (AD) is to increase the specificity of the early diagnosis. While episodic memory impairment is a sensitive AD marker, other measures are needed to improve diagnostic specificity. A promising biomarker might be a cerebral atrophy of the central olfactory processing areas in the early stages of the disease since an impairment of olfactory identification is present at the clinical stage of AD. Our goal was therefore, (1) to evaluate the grey matter volume (GMV) ...
Source: Experimental Gerontology - November 12, 2023 Category: Geriatrics Authors: B Jobin B Boller J Frasnelli CIMA-Q group Source Type: research
