Cognitive behavior and sensory function were significantly influenced by restoration of active ovarian function in postreproductive mice.
Abstract In mammals, the relationship between reproductive function and health has been particularly difficult to define. Previously, in old, postreproductive-aged mice, replacement of senescent ovaries with new ovaries from young, actively cycling mice increased life span. We hypothesized that the same factors that increased life span would also influence health span. In the current experiments, we tested two of the seven domains of function/health, sensory function and cognition to determine if exposure of postreproductive female mice to young transplanted ovaries influenced health span. We evaluated control fem...
Source: Experimental Gerontology - March 10, 2017 Category: Geriatrics Authors: Parkinson KC, Peterson RL, Mason JB Tags: Exp Gerontol Source Type: research

Change in muscle strength and muscle mass in older hospitalized patients: A systematic review and meta-analysis.
In conclusion, decrease in muscle strength and muscle mass in older patients is dependent on the type of admission. PMID: 28286250 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 9, 2017 Category: Geriatrics Authors: Van Ancum JM, Scheerman K, Jonkman NH, Smeenk HE, Kruizinga RC, Meskers CG, Maier AB Tags: Exp Gerontol Source Type: research

Treatment effects of Cardiotrophin-1 (CT-1) on streptozotocin-induced memory deficits in mice.
In this study, we evaluated the effects of CT-1 on brain pathological features in intracerebroventrical-streptozotocin (ICV-STZ)-treated mouse model, and explored its potential mechanisms. STZ was injected twice (3mg/kg, ICV) on alternate days (day 1 and day 3) in mice. Daily treatment with CT-1 (1μg/day, ICV) starting from the first dose of STZ for 14days showed that CT-1 significantly improved learning and memory deficits, alleviated mitochondrial dysfunction, and increased synaptic density in the CA1 region of the hippocampus in ICV-STZ-treated mice. Moreover, CT-1 significantly enhanced insulin signaling pathway in ...
Source: Experimental Gerontology - March 8, 2017 Category: Geriatrics Authors: Wang D, Liu X, Liu Y, Shen G, Zhu X, Li S Tags: Exp Gerontol Source Type: research

Lifespan differences between queens and workers are not explained by rates of molecular damage.
Abstract The biological processes that underlie senescence are of universal biological importance, yet they remain poorly understood. A popular theory proposes that senescence is the result of limited investment into mechanisms involved in the prevention and repair of molecular damage, leading to an accumulation of molecular damage with age. In ants, queen and worker lifespans differ by an order of magnitude, and this remarkable difference in lifespan has been shown to be associated with differences in the expression of genes involved in DNA and protein repair. Here we use the comet assay and Western Blotting for ...
Source: Experimental Gerontology - March 8, 2017 Category: Geriatrics Authors: Lucas ER, Augustyniak M, Kędziorski A, Keller L Tags: Exp Gerontol Source Type: research

Protective roles of nanomelatonin in cerebral ischemia-reperfusion of aged brain: Matrixmetalloproteinases as regulators.
Abstract Cerebral ischemia-reperfusion (CIR) injury occurs as a result of oxygen occlusion in the carotid artery through embolus or thrombus formation or cerebrovascular hemorrhage. The oxygen thrust during reperfusion causes the generation of reactive oxidative species (ROS) which exert a potential threat to neuronal survival. ROS may possibly be arrested by antioxidants. After CIR, extracellular matrix remodeling takes place, which is governed by matrix metalloproteinases (MMPs). Augmentation of lipid per oxidation, perturbation of antioxidant enzyme activities and the loss of pyramidal neuronal cells in rat bra...
Source: Experimental Gerontology - March 8, 2017 Category: Geriatrics Authors: Sarkar S, Mukherjee A, Das N, Swarnakar S Tags: Exp Gerontol Source Type: research

Accelerometer-assessed light physical activity is protective of future cognitive ability: A longitudinal study among community dwelling older adults.
CONCLUSION: Our data suggest that light PA may offer a protective influence of future cognitive ability in community dwelling older adults. The promotion of light PA may be a valuable means to maintain cognitive ability in older age. PMID: 28263868 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 3, 2017 Category: Geriatrics Authors: Stubbs B, Chen LJ, Chang CY, Sun WJ, Ku PW Tags: Exp Gerontol Source Type: research

Mutation and catastrophe in the aging genome.
Abstract In the 1960s, Leslie Orgel proposed what is now known as the error catastrophe theory of aging, arguing that errors in protein translation that reduce the fidelity of the protein-translating enzymes would lead to a feedback loop of increasingly inaccurate protein synthesis, terminating in the death of the organism. This mechanism of aging would be consistent with the exponential increase of mortality observed in humans, but the error catastrophe theory of aging has been generally disregarded by researchers due to a lack of evidence for an age-related increase in protein errors. Another theory of aging, pr...
Source: Experimental Gerontology - March 2, 2017 Category: Geriatrics Authors: Milholland B, Suh Y, Vijg J Tags: Exp Gerontol Source Type: research

Does aging alter the molecular substrate of ionotropic neurotransmitter receptors in the rostral ventral lateral medulla? - A short communication.
Abstract Aging alters sympathetic nervous system (SNS) regulation, although central mechanisms are not well understood. In young rats the rostral ventral lateral medulla (RVLM) is critically involved in central SNS regulation and RVLM neuronal activity is mediated by a balance of excitatory and inhibitory ionotropic neurotransmitters and receptors, providing the foundation for hypothesizing that with advanced age the molecular substrate of RVLM ionotropic receptors is characterized by upregulated excitatory and downregulated inhibitory receptor subunits. This hypothesis was tested by comparing the relative mRNA ex...
Source: Experimental Gerontology - March 2, 2017 Category: Geriatrics Authors: Pawar HN, Balivada S, Kenney MJ Tags: Exp Gerontol Source Type: research

The protective properties of Act-Belong-Commit indicators against incident depression, anxiety, and cognitive impairment among older Irish adults: Findings from a prospective community-based study.
Abstract The Act-Belong-Commit campaign is the world's first comprehensive, population-wide, community-based program designed to promote mental health. The campaign targets individuals to engage in mentally healthy activities, while at the same time, encouraging community organizations that offer such activities, to increase participation in their activities. Using nationally-representative data from Ireland, the aim of this study was to prospectively assess the association between indicators of the Act-Belong-Commit behavioral domains and incident depression, anxiety, and cognitive impairment. Data from two conse...
Source: Experimental Gerontology - February 28, 2017 Category: Geriatrics Authors: Santini ZI, Koyanagi A, Tyrovolas S, Haro JM, Donovan RJ, Nielsen L, Koushede V Tags: Exp Gerontol Source Type: research

Association between muscular strength and intrarenal vascular resistance in middle-aged and older individuals.
Abstract A strategy for the preservation of intrarenal vasculature conditions remains obscure in middle-aged and older individuals without the renal disease. In the present study, we sought to identify whether the maintenance of muscular strength is an effective method of preserving the intrarenal vasculature condition of middle-aged and older individuals. Therefore, we applied a cross-sectional approach for investigating the relationship between muscular strength and the condition of the intrarenal vasculature. In 169 middle-aged and older individuals without renal disease, handgrip strength (HGS) and the renal r...
Source: Experimental Gerontology - February 28, 2017 Category: Geriatrics Authors: Kosaki K, Kamijo-Ikemori A, Sugaya T, Tanahashi K, Kumagai H, Sawano Y, Osuka Y, Tanaka K, Kimura K, Shibagaki Y, Maeda S Tags: Exp Gerontol Source Type: research

Resistance training performed at distinct angular velocities elicits velocity-specific alterations in muscle strength and mobility status in older adults.
Abstract BACKGROUND: The purpose of this study was to compare the effects of high and low velocity knee extension training on changes in muscle strength and mobility status in high-functioning older adults. METHODS: Twenty-six (16 female, 10 male) older adults (mean age of 65) were randomized to either 6weeks of low velocity resistance training (LVRT) performed at 75°/s or high velocity resistance training (HVRT) performed at 240°/s. Both groups performed 3 sets of knee extension exercises at maximal effort, 3 times a week. Muscle strength was assessed through a range of testing velocities on an isoki...
Source: Experimental Gerontology - February 22, 2017 Category: Geriatrics Authors: Englund DA, Sharp RL, Selsby JT, Ganesan SS, Franke WD Tags: Exp Gerontol Source Type: research

Impact of maximal strength training on work efficiency and muscle fiber type in the elderly: Implications for physical function and fall prevention.
In conclusion, MST can increase both work efficiency and Type II skeletal muscle fiber size and percentage in the elderly, supporting the potential role of MST as a countermeasure to maintain both physical function and fall prevention in this population. PMID: 28232199 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 20, 2017 Category: Geriatrics Authors: Wang E, Nyberg SK, Hoff J, Zhao J, Leivseth G, Tørhaug T, Husby OS, Helgerud J, Richardson RS Tags: Exp Gerontol Source Type: research

Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease.
This study investigates the neuroprotective properties of berberine (a natural isoquinoline alkaloid isolated from the Rhizoma coptidis) and finds that berberine could promote β-amyloid (Aβ) clearance and inhibit Aβ production in the triple-transgenic mouse model of Alzheimer's disease (3×Tg-AD). During the study, berberine was first administrated to treat 3×Tg-AD mice and primary neurons. Morris water maze assay, western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence staining and histological analysis, transmission electron microscopic analysis were then used to evaluate...
Source: Experimental Gerontology - February 18, 2017 Category: Geriatrics Authors: Huang M, Jiang X, Liang Y, Liu Q, Chen S, Guo Y Tags: Exp Gerontol Source Type: research

Changes in cardiovascular function based on adrenalin and norepinephrine metabolism in ovariectomized rats.
Abstract Menopause is a cardiovascular risk factor in women, and cardiovascular changes during perimenopause can increase the risk. We observed the influence of plasma adrenalin and norepinephrine and their metabolites on the cardiovascular system and the rectification effect of estrogen in ovariectomized rats. Fifty-four adult female Sprague-Dawley rats were randomly divided into sham (Sham), ovariectomized (OVX), or ovariectomized+estrogen treatment groups (OVX+E), with 18 rats in each. The Sham and OVX groups were given normal saline and the OVX+E group was given estradiol valerate beginning 2weeks after ovarie...
Source: Experimental Gerontology - February 17, 2017 Category: Geriatrics Authors: Jiang H, Bai W, Wang W, Zhang J, Wang K, Liu Y, Liu S, Jia J, Qin L Tags: Exp Gerontol Source Type: research

A summary of the Proceedings of the Thirteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 17-22, 2016.
Abstract A summary of the Thirteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging that was held July 17-22, 2016 in Bregenz, Austria, is presented. Twenty-one of the speakers that presented at the conference submitted review papers covering the topic of their presentation as well as an overview of their respective fields and are included in this special issue. The abstracts from each poster presentation as well as twenty-two of the speaker abstracts are also included at the end of the preface to the special issue. PMID: 28216411 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 16, 2017 Category: Geriatrics Authors: Brown-Borg HM, Borg KE Tags: Exp Gerontol Source Type: research

Sex impacts the flow-mediated dilation response to acute aerobic exercise in older adults.
In conclusion, sex and exercise intensity influence the FMD response to acute aerobic exercise in older adults. PMID: 28216412 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 16, 2017 Category: Geriatrics Authors: Yoo JK, Pinto MM, Kim HK, Hwang CL, Lim J, Handberg EM, Christou DD Tags: Exp Gerontol Source Type: research

Does neuromuscular electrical stimulation training of the lower limb have functional effects on the elderly?: A systematic review.
Abstract The lower limb muscle functions of the elderly are known to be preferentially altered by ageing. Traditional training effectively counteracts some of these functional declines but is not always accessible due to its cost and to the accessibility of the training centers and to the incapacities of some seniors to practice some exercises. Neuromuscular electrical stimulation (NMES) could provide an interesting alternative muscle training technique because it is inexpensive and transportable. The aim of this systematic review was to summarize the current evidence on the effect of the use of lower limb NMES as...
Source: Experimental Gerontology - February 16, 2017 Category: Geriatrics Authors: Langeard A, Bigot L, Chastan N, Gauthier A Tags: Exp Gerontol Source Type: research

Spontaneous experimental atherosclerosis in hypercholesterolemic mice advances with ageing and correlates with mitochondrial reactive oxygen species.
Abstract Ageing and atherosclerosis are associated with oxidative stress. Mitochondrial redox function declines with ageing. Here we tested whether ageing LDL receptor knockout mice (LDLr(-/-)) develop spontaneous atherosclerosis and whether mitochondrial reactive oxygen species (mtROS) correlate with atherosclerosis. Compared with young mice, aged LDLr(-/-) mice exhibited 20-fold larger aortic lesion size, although the plasma cholesterol levels did not vary between age groups. The lesion sizes increased exponentially from 3 to 24months of age (r=0.92, p=0.0001) and were correlated with mtROS across the age range ...
Source: Experimental Gerontology - February 14, 2017 Category: Geriatrics Authors: Dorighello GG, Paim BA, Leite AC, Vercesi AE, Oliveira HC Tags: Exp Gerontol Source Type: research

n-3 Fatty acids, Mediterranean diet and cognitive function in normal aging: A systematic review.
CONCLUSIONS: Studies suggest that n-3 fatty acids in the diet and adherence to the MedDiet are beneficial in slowing age-related cognitive decline. However, more high-quality RCTs would be useful to clarify the effect of n-3 fatty acid supplements on cognition. PMID: 28213052 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 14, 2017 Category: Geriatrics Authors: Masana MF, Koyanagi A, Haro JM, Tyrovolas S Tags: Exp Gerontol Source Type: research

CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.
Abstract OBJECTIVE: Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults.We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs). METHODS: Alzheimer's Disease Neuroimaging Initiative cohort (ADNI; n=237) data, combining both multiplexed proteomics CSF and genotype data, were used to assess the association between CSF analytes and risk SNPs in four genes (SNPs): GRN (rs5848), TMEM106B (rs1990622), ABCC9 (rs704180), and KCNMB2 (rs9637454).For controls, non-HS-Aging SNPs in APOE (...
Source: Experimental Gerontology - February 9, 2017 Category: Geriatrics Authors: Fardo DW, Katsumata Y, Kauwe JS, Deming Y, Harari O, Cruchaga C, Alzheimer's Disease Neuroimaging Initiative, Nelson PT Tags: Exp Gerontol Source Type: research

Glutathione metabolic status in the aged rabbit aorta.
In conclusion, glutathione metabolic status is altered in the aged rabbit aorta reflecting depressed γ-GCS- and γ-GT-related GSH biosynthesis and GSSG burden eventually favoring vascular oxidative stress and dysfunction. PMID: 28188813 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 8, 2017 Category: Geriatrics Authors: Lapenna D, Ciofani G, Giamberardino MA Tags: Exp Gerontol Source Type: research

Skin autofluorescence is associated with arterial stiffness and insulin level in endurance runners and healthy controls-Effects of aging and endurance exercise.
on SP Abstract BACKGROUND: Life-long regular endurance exercise yields positive effects on cardiovascular and metabolic function, disease and mortality rate. Glycation may be a major mechanism behind age-related diseases. However, it remains unknown if skin autofluorescence (SAF), which reflects glycation, is related to arterial and metabolic function in life-long endurance runners and sedentary controls. METHODS: Healthy elderly men: 15 life-long endurance runners (OT) (64±4years) and 12 old untrained (OU) (66±4years), and healthy young men; ten young athletes (YT) (26±4years) matched to...
Source: Experimental Gerontology - February 8, 2017 Category: Geriatrics Authors: Couppé C, Dall CH, Svensson RB, Olsen RH, Karlsen A, Praet S, Prescott E, Magnusson SP Tags: Exp Gerontol Source Type: research

Self-motivated and stress-response performance assays in mice are age-dependent.
Abstract Chronic health conditions of the elderly lead to limitations in physical activity with disability, anxiety, and increased need for medical care and assisted living conditions. Physical performance tests are used to screen for pending loss of mobility and can serve as endpoints to monitor the effectiveness of intervention measures. Since limited mobility is associated with the physical and mental health of a person, evaluation of this in preclinical aging studies in mice will provide a translational approach for testing new intervention strategies. We assessed physiological parameters in 4, 12, 20 and 28mo...
Source: Experimental Gerontology - February 8, 2017 Category: Geriatrics Authors: Ge X, Ciol MA, Pettan-Brewer C, Goh J, Rabinovitch P, Ladiges W Tags: Exp Gerontol Source Type: research

Rapamycin and the inhibition of the secretory phenotype.
Abstract Senescent cells contribute to age-related pathology and loss of function, and their selective removal improves physiological function and extends longevity. Cell senescence is a complex process that can be triggered by multiple challenges. Recently it has been observed that the composition of the secretory phenotype or SASP depends on the insult that triggers cell senescence. Rapamycin, an inhibitor of mTOR that increases longevity in several species, inhibits cell senescence in vitro, while silencing the Nrf2 gene induces premature senescence. We have found that rapamycin activates the Nrf2 pathway to re...
Source: Experimental Gerontology - February 3, 2017 Category: Geriatrics Authors: Wang R, Sunchu B, Perez VI Tags: Exp Gerontol Source Type: research

Does high dose vitamin D supplementation enhance cognition?: A randomized trial in healthy adults.
Abstract BACKGROUND: Insufficiency of 25-hydroxyvitamin D [25(OH)D] has been associated with dementia and cognitive decline. However, the effects of vitamin D supplementation on cognition are unclear. It was hypothesized that high dose vitamin D3 supplementation would result in enhanced cognitive functioning, particularly among adults whose 25(OH)D levels were insufficient (
Source: Experimental Gerontology - February 3, 2017 Category: Geriatrics Authors: Pettersen JA Tags: Exp Gerontol Source Type: research

Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC).
Valverde C, Quesada-Gómez JM Abstract Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Interestingly, a novel olive-pomace physical treatment to generate olive oil also yields by-products rich in functional antioxidants. Thus, diet of postmenopausal women was supplemented for two months with one of such by...
Source: Experimental Gerontology - February 3, 2017 Category: Geriatrics Authors: Casado-Díaz A, Túnez-Fiñana I, Mata-Granados JM, Ruiz-Méndez MV, Dorado G, Romero-Sánchez MC, Navarro-Valverde C, Quesada-Gómez JM Tags: Exp Gerontol Source Type: research

Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases.
Abstract Aging is the primary risk factor for many neurodegenerative diseases. Thus, understanding the basic biological changes that take place with aging that lead to the brain being less resilient to disease progression of neurodegenerative diseases such as Parkinson's disease or Alzheimer's disease or insults to the brain such as stroke or traumatic brain injuries. Clearly this will not cure the disease per se, yet increasing the ability of the brain to respond to injury could improve long term outcomes. The focus of this review is examining changes in microglia with age and possible therapeutic interventions i...
Source: Experimental Gerontology - February 2, 2017 Category: Geriatrics Authors: Bickford PC, Flowers A, Grimmig B Tags: Exp Gerontol Source Type: research

Effects of a chronic l-arginine supplementation on the arginase pathway in aged rats.
This study investigated the effect of ageing on arginase activity/expression in target tissues and determined whether l-arginine supplementation modulated the effect of ageing on arginase activity. Arginase activity and expression were measured in the heart, vessel, brain, lung, kidney and liver in young rats (3-months old) and aged Wistar rats (22-24-months-old) with or without l-arginine supplementation (2.25% in drinking water for 6weeks). Plasma levels of l-arginine and l-ornithine were quantified in order to calculate the plasma l-arginine/l-ornithine ratio, considered as a reflection of arginase activity. Cardiovascu...
Source: Experimental Gerontology - January 26, 2017 Category: Geriatrics Authors: Moretto J, Guglielmetti AS, Tournier-Nappey M, Martin H, Prigent-Tessier A, Marie C, Demougeot C Tags: Exp Gerontol Source Type: research

Ageing is not associated with an altered immune response during Trypanosoma cruzi infection: Ageing and Trypanosoma cruzi infection.
do JC Abstract The aims of this work were to evaluate the influence of ageing on the magnitude of the immune response in male Wistar rats infected with the Y strain of Trypanosoma cruzi (T. cruzi). Infected young animals displayed enhanced CD4(+) T cells as compared to uninfected counterparts. Ageing also triggered a significant reduction in CD8(+) T cells compared to young and uninfected groups. The percentage of spleen NKT cells was reduced for all groups, regardless of the infection status. Significant decreased B-cells was noted in aged controls and infected animals as compared to young counterparts. A signifi...
Source: Experimental Gerontology - January 25, 2017 Category: Geriatrics Authors: Colato RP, Brazão V, Santello FH, Toldo MP, do Vale GT, Tirapelli CR, Pereira-da-Silva G, do Prado JC Tags: Exp Gerontol Source Type: research

Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice.
In conclusion, resveratrol was able to modulate the inflammatory, oxidative and apoptotic status related to aging, thereby exerting a protective effect on pancreas age-induced damage. PMID: 28130161 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 24, 2017 Category: Geriatrics Authors: Ginés C, Cuesta S, Kireev R, García C, Rancan L, Paredes SD, Vara E, Tresguerres JA Tags: Exp Gerontol Source Type: research

Korean red ginseng improves testicular ineffectiveness in aging rats by modulating spermatogenesis-related molecules.
This study was performed to investigate the effect of Korean red ginseng water extract (KRG-WE) on the expression level of spermatogenesis-related key biomolecules and sex hormone receptors as well as enzymes regulating oxidation, histone deacetylation, and growth-related activities in aged rat testis. KRG-WE (200mg/kg) mixed with a regular pellet diet was administered to 12-month-old rats for 6months (KRG-AC), whereas the young (YC, 2months) and aged (AC, 12months) controls received the vehicle only. The results showed that the expression levels of spermatogenesis-related key biomolecules (inhibin-α, nectin-2, and c...
Source: Experimental Gerontology - January 23, 2017 Category: Geriatrics Authors: Kopalli SR, Cha KM, Ryu JH, Lee SH, Jeong MS, Hwang SY, Lee YJ, Song HW, Kim SN, Kim JC, Kim SK Tags: Exp Gerontol Source Type: research

Early life stress affects mortality rate more than social behavior, gene expression or oxidative damage in honey bee workers.
Abstract Early life stressors can affect aging and life expectancy in positive or negative ways. Individuals can adjust their behavior and molecular physiology based on early life experiences but relatively few studies have connected such mechanisms to demographic patterns in social organisms. Sociality buffers individuals from environmental influences and it is unclear how much early life stress affects later life history. Workers of the honey bee (Apis mellifera L.) were exposed to two stressors, Varroa parasitism and Paraquat exposure, early in life. Consequences were measured at the molecular, behavioral, and ...
Source: Experimental Gerontology - January 22, 2017 Category: Geriatrics Authors: Rueppell O, Yousefi B, Collazo J, Smith D Tags: Exp Gerontol Source Type: research

Growing more positive with age: The relationship between reproduction and survival in aging flies.
Abstract Populations of laboratory animals that are selected for increased lifespan often show negative correlated responses in early fecundity. However, late fecundity and/or total lifetime fecundity can be higher in the populations selected for increased lifespan. This has been interpreted by some as being at odds with the disposable soma theory, which predicts decreased lifespan to increase total reproductive output. Alternatively, the Y-model explores the effects of variation in resource allocation and acquisition on life histories. In this model, a negative relationship between lifespan and reproduction can b...
Source: Experimental Gerontology - January 22, 2017 Category: Geriatrics Authors: van den Heuvel J, Zandveld J, Brakefield PM, Kirkwood TB, Shanley DP, Zwaan BJ Tags: Exp Gerontol Source Type: research

rBTI reduced β-amyloid-induced toxicity by promoting autophagy-lysosomal degradation via DAF-16 in Caenorhabditis elegans.
rBTI reduced β-amyloid-induced toxicity by promoting autophagy-lysosomal degradation via DAF-16 in Caenorhabditis elegans. Exp Gerontol. 2017 Jan 21;: Authors: Li J, Cui X, Ma X, Wang Z Abstract Alzheimer's disease (AD) is an age-related neurodegenerative disease, of which β-amyloid (Aβ) induced toxicity was suggested as a main cause. Some substances with prolongevity effects have been shown to be protective against AD. In a previous study we demonstrated that a recombinant buckwheat trypsin inhibitor (rBTI) could prolonge the lifespan in Caenorhabditis elegans (C. elegans). Here, we in...
Source: Experimental Gerontology - January 21, 2017 Category: Geriatrics Authors: Li J, Cui X, Ma X, Wang Z Tags: Exp Gerontol Source Type: research

Rapamycin additively extends lifespan in short- and long-lived lines of the nematode Caenorhabditis remanei.
Abstract Despite tremendous progress in finding genes that, when manipulated, affects lifespan, little is known about the genetics underlying natural variation in lifespan. While segregating genetic variants for lifespan has been notoriously difficult to find in genome-wide association studies (GWAS), a complementary approach is to manipulate key genetic pathways in lines that differ in lifespan. If these candidate pathways are down regulated in long-lived lines, these lines can be predicted to respond less to pharmaceutical down-regulation of these pathways than short-lived lines. Experimental studies have identi...
Source: Experimental Gerontology - January 21, 2017 Category: Geriatrics Authors: Lind MI, Chen HY, Cortazar-Chinarro M, Maklakov AA Tags: Exp Gerontol Source Type: research

Positive effects of intermittent fasting in ischemic stroke.
Abstract Intermittent fasting (IF) is a dietary protocol where energy restriction is induced by alternate periods of ad libitum feeding and fasting. Prophylactic intermittent fasting has been shown to extend lifespan and attenuate the progress and severity of age-related diseases such as cardiovascular (e.g. stroke and myocardial infarction), neurodegenerative (e.g. Alzheimer's disease and Parkinson's disease) and cancerous diseases in animal models. Stroke is the second leading cause of death, and lifestyle risk factors such as obesity and physical inactivity have been associated with elevated risks of stroke in ...
Source: Experimental Gerontology - January 20, 2017 Category: Geriatrics Authors: Fann DY, Ng GY, Poh L, Arumugam TV Tags: Exp Gerontol Source Type: research

Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice.
Abstract Exercise is known to have numerous beneficial effects. Recent studies indicate that exercise improves mitochondrial energetics not only in skeletal muscle but also in other tissues. While exercise elicits positive effects on memory, neurogenesis, and synaptic plasticity, the effects of exercise on brain mitochondrial energetics remain relatively unknown. Herein, we studied the effects of exercise training in old and young mice on brain mitochondrial energetics, in comparison to known effects on peripheral tissues that utilize fatty acid oxidation. Exercise improved the capacity for muscle and liver to oxi...
Source: Experimental Gerontology - January 17, 2017 Category: Geriatrics Authors: Gusdon AM, Callio J, DiStefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT Tags: Exp Gerontol Source Type: research

Pleiotropic responses to methionine restriction.
Abstract Methionine restriction (MR) extends lifespan across different species. The main responses of rodent models to MR are well-documented in adipose tissue (AT) and liver, which have reduced mass and improved insulin sensitivity, respectively. Recently, molecular mechanisms that improve healthspan have been identified in both organs during MR. In fat, MR induced a futile lipid cycle concomitant with beige AT accumulation, producing elevated energy expenditure. In liver, MR upregulated fibroblast growth factor 21 and improved glucose metabolism in aged mice and in response to a high-fat diet. Furthermore, MR al...
Source: Experimental Gerontology - January 17, 2017 Category: Geriatrics Authors: Ables G, Johnson J Tags: Exp Gerontol Source Type: research

Factors associated with fear of falling in community-dwelling older adults with and without diabetes mellitus: Findings from the Frailty in Brazilian Older People Study (FIBRA-BR).
CONCLUSION: The factors associated with fear of falling did differ between non-diabetic and diabetic older adults. Health care professionals should consider such differences when planning their therapeutic approaches for a successful management of fear of falling in these older populations. PMID: 28104446 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 16, 2017 Category: Geriatrics Authors: de Souza Moreira B, Sampaio RF, Diz JB, de Carvalho Bastone A, Ferriolli E, Neri AL, Lourenço RA, Dias RC, Kirkwood RN Tags: Exp Gerontol Source Type: research

Celiac disease autoimmunity is associated with leukocyte telomere shortening in older adults: The U.S. National Health and Nutrition Examination Survey.
Abstract PURPOSE: Telomeres are nucleotide sequences, and their function is to maintain cell surveillance. Exaggeration of the attrition rate of leukocyte telomere length (LTL) may result in genomic instability and tumorigenesis. Celiac disease (CD), an autoimmune inflammation of small intestine, has increasing prevalence in the elderly and may lead to lymphomas and gastrointestinal malignancies. We used nationally-representative datasets from the U.S. National Health and Nutrition Examination Survey (NHANES) to investigate if CD autoimmunity in older adults (age≥50years) is associated with shorter LTL. RE...
Source: Experimental Gerontology - January 16, 2017 Category: Geriatrics Authors: Kamycheva E, Goto T, Camargo CA Tags: Exp Gerontol Source Type: research

Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition.
In this study, we investigated the role of autophagy system in MANF-mediated neuroprotection against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. Our results showed that MANF protected SH-SY5Y cells against 6-OHDA-induced cell viability decrease and apoptosis by inhibiting autophagy. Mitochondrion damage and energetic dysfunction triggered by reactive oxidative stress (ROS) accumulation were also alleviated by MANF treatment. Furthermore, MANF downregulated phosphorylation of AMP-activated protein kinase (AMPK), a cellular energy sensor and regulator, but upregulated phosphorylation of Mammalian target of rapamycin (m...
Source: Experimental Gerontology - January 15, 2017 Category: Geriatrics Authors: Zhang J, Cai Q, Jiang M, Liu Y, Gu H, Guo J, Sun H, Fang J, Jin L Tags: Exp Gerontol Source Type: research

Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause.
ne AC Abstract Perimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that results in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant supplementation may be an effective approach to minimizing this stress. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. We hypothesized that MT could minimize oxidative stress du...
Source: Experimental Gerontology - January 14, 2017 Category: Geriatrics Authors: Pereira AA, Tirapeli KG, Neto AH, da Silva Brasilino M, da Rocha CQ, Belló-Klein A, Llesuy SF, Dornelles RC, de Melo Stevanato Nakamune AC Tags: Exp Gerontol Source Type: research

Molecular mechanisms of UVB-induced senescence of dermal fibroblasts and its relevance for photoaging of the human skin.
r P Abstract Due to its ability to cross the epidermis and reach the upper dermis where it causes cumulative DNA damage and increased oxidative stress, UVB is considered the most harmful component of sunlight to the skin. The consequences of chronic exposition to UVB are related to photoaging and photocarcinogenesis. There are limitations to the study of human skin aging and for this reason the use of models is required. Human dermal fibroblasts submitted to mild and repeated doses of UVB are considered a versatile model to study UVB effects in the process of skin photoaging, which depends on the accumulation of s...
Source: Experimental Gerontology - January 13, 2017 Category: Geriatrics Authors: Cavinato M, Jansen-Dürr P Tags: Exp Gerontol Source Type: research

Stem cell therapies in preclinical models of stroke. Is the aged brain microenvironment refractory to cell therapy?
CONCLUSION: While the middle aged brain does not seem to impair drug and cell therapies, in a real clinical practice involving older post-stroke patients, successful regenerative therapies would have to be carried out for a much longer time. PMID: 28093317 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 13, 2017 Category: Geriatrics Authors: Sandu RE, Balseanu A, Bogdan C, Slevin M, Petcu E, Popa-Wagner A Tags: Exp Gerontol Source Type: research

Longevity in Calumma parsonii, the world's largest chameleon.
Abstract Large body size of ectothermic species can be correlated with high life expectancy. We assessed the longevity of the world's largest chameleon, the Parson's chameleon Calumma parsonii from Madagascar by using skeletochronology of phalanges taken from preserved specimens held in European natural history museums. Due to the high bone resorption we can provide only the minimum age of each specimen. The highest minimum age detected was nine years for a male and eight years for a female, confirming that this species is exceptionally long living among chameleons. Our data also show a strong correlation between ...
Source: Experimental Gerontology - January 8, 2017 Category: Geriatrics Authors: Tessa G, Glaw F, Andreone F Tags: Exp Gerontol Source Type: research

Changes of renin-angiotensin system-related aminopeptidases in early stage Alzheimer's disease.
This study aimed to explore the time course and the mechanisms underlying these changes. Serum samples were collected from 45 AD patients at the start of the study, and again 13months later (n=37). The control group was 22 healthy, older, adults. Enzyme activity was determined at two substrate concentrations to allow Michaelis-Menten analysis of the enzyme activity. The results indicated that there was decreased activity of ApA, ApB and ApN amongst AD patients but no difference in serum IRAP activity. There were no associations between enzyme activity and age, gender nor scores on psychomotor tests. Consideration of the da...
Source: Experimental Gerontology - January 6, 2017 Category: Geriatrics Authors: Gard PR, Fidalgo S, Lotter I, Richardson C, Farina N, Rusted J, Tabet N Tags: Exp Gerontol Source Type: research

Genetic variation in WRN and ischemic stroke: General population studies and meta-analyses.
CONCLUSIONS: This study suggests that common genetic variation in WRN is associated with increased risk of ischemic stroke in the general population. PMID: 28063943 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 4, 2017 Category: Geriatrics Authors: Christoffersen M, Frikke-Schmidt R, Nordestgaard BG, Tybjærg-Hansen A Tags: Exp Gerontol Source Type: research

Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson's disease.
In this study, we investigated the effects of treadmill exercise on motor deficits and mitochondrial dysfunction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. Treadmill exercise inhibited dopaminergic neuron loss by promoting the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT) and seemed to improve cell survival by reducing α-Syn expression. Most importantly, treadmill exercise increased expression of the mitochondrial import machinery proteins TOM-40, TOM-20, and TIM-23. This was associated with decreased α-Syn expression and subsequent upregulatio...
Source: Experimental Gerontology - January 3, 2017 Category: Geriatrics Authors: Koo JH, Cho JY, Lee UB Tags: Exp Gerontol Source Type: research

Effects of body mass index and weight change on mortality in older men with impaired glucose regulation.
CONCLUSIONS: Both BMI at baseline and weight change have independent U-shaped associations with all-cause and cardiovascular mortality among older men with IGR. The present study suggests that older men with IGR may ensure their best survival by being overweight at baseline or by maintaining their weight regardless of their baseline weight status. PMID: 28062371 [PubMed - as supplied by publisher] (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 3, 2017 Category: Geriatrics Authors: Li ZB, Wang ML, Dong SY, Sun BR, Miao XY, Fang FS, Dai ZX, Li CL, Tian H Tags: Exp Gerontol Source Type: research

Uric acid may be protective against cognitive impairment in older adults, but only in those without cardiovascular risk factors.
Abstract Uric acid (UA) may not only prevent development of cognitive dysfunction owing to its antioxidant efficacy, but also may worsen cognitive functions by gaining pro-oxidant character. The present study attempts to uncover this paradoxical association between UA and cognitive impairment in elderly. 1374 elderly patients were retrospectively evaluated and included in the study. Participants underwent determination of circulating UA levels and comprehensive geriatric assessment. A serum UA concentration≥7.0mg/dL in males and ≥5.7mg/dL in females were considered hyperuricemia. The mean age of patients was...
Source: Experimental Gerontology - January 3, 2017 Category: Geriatrics Authors: Tuven B, Soysal P, Unutmaz G, Kaya D, Isik AT Tags: Exp Gerontol Source Type: research