Microbiome interactions with different risk factors in development of myocardial infarction
Exp Gerontol. 2024 Mar 22:112409. doi: 10.1016/j.exger.2024.112409. Online ahead of print.ABSTRACTAmong all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % of all deaths. The intricate web of risk factors for MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by the human gut and oral microbiota, their diversity, richness, and dysbiosis, along with their respective metabolites. Host genetic factors...
Source: Experimental Gerontology - March 24, 2024 Category: Geriatrics Authors: Manisha Bijla Sunil Kumar Saini Ajai Pathak Kamal Prakash Bharadwaj Katyayani Sukhavasi Ayurshi Patil Diksha Saini Rakesh Yadav Shalini Singh Christiaan Leeuwenburgh Pramod Kumar Source Type: research
Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice
CONCLUSIONS: The present study revealed the ameliorative effects of eldecalcitol on senescence and the associated ferroptosis of osteocytes, contributing to its preservation against osteoporosis of D-gal-induced senescent ovariectomized mice.PMID:38521178 | DOI:10.1016/j.exger.2024.112408 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 23, 2024 Category: Geriatrics Authors: Yong-Fang Fu Yi-Xun Guo Shi-Hui Xia Ting-Ting Zhou Yun-Chao Zhao Zhen-Hua Jia Yan Zhang Source Type: research
Corrigendum to "Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults" [Exp. Gerontol. 181 (2023) 112278]
Exp Gerontol. 2024 Mar 18:112398. doi: 10.1016/j.exger.2024.112398. Online ahead of print.NO ABSTRACTPMID:38503641 | DOI:10.1016/j.exger.2024.112398 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 19, 2024 Category: Geriatrics Authors: Yujiro Asano Taishi Tsuji Tomohiro Okura Source Type: research
Corrigendum to "Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults" [Exp. Gerontol. 181 (2023) 112278]
Exp Gerontol. 2024 Mar 18:112398. doi: 10.1016/j.exger.2024.112398. Online ahead of print.NO ABSTRACTPMID:38503641 | DOI:10.1016/j.exger.2024.112398 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 19, 2024 Category: Geriatrics Authors: Yujiro Asano Taishi Tsuji Tomohiro Okura Source Type: research
Corrigendum to "Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults" [Exp. Gerontol. 181 (2023) 112278]
Exp Gerontol. 2024 Mar 18:112398. doi: 10.1016/j.exger.2024.112398. Online ahead of print.NO ABSTRACTPMID:38503641 | DOI:10.1016/j.exger.2024.112398 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 19, 2024 Category: Geriatrics Authors: Yujiro Asano Taishi Tsuji Tomohiro Okura Source Type: research
Corrigendum to "Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults" [Exp. Gerontol. 181 (2023) 112278]
Exp Gerontol. 2024 Mar 18:112398. doi: 10.1016/j.exger.2024.112398. Online ahead of print.NO ABSTRACTPMID:38503641 | DOI:10.1016/j.exger.2024.112398 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 19, 2024 Category: Geriatrics Authors: Yujiro Asano Taishi Tsuji Tomohiro Okura Source Type: research
Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43
CONCLUSION: Remazolam affects the phenotype and function of astrocytes to improve TBI via regulating Cx43, and plays a role in protecting the neurological function of TBI rats.PMID:38492656 | DOI:10.1016/j.exger.2024.112404 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 16, 2024 Category: Geriatrics Authors: Jing Xia Yang Tan Congli Mao Wenting Shen Ying Zhao Source Type: research
Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43
CONCLUSION: Remazolam affects the phenotype and function of astrocytes to improve TBI via regulating Cx43, and plays a role in protecting the neurological function of TBI rats.PMID:38492656 | DOI:10.1016/j.exger.2024.112404 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 16, 2024 Category: Geriatrics Authors: Jing Xia Yang Tan Congli Mao Wenting Shen Ying Zhao Source Type: research
Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43
CONCLUSION: Remazolam affects the phenotype and function of astrocytes to improve TBI via regulating Cx43, and plays a role in protecting the neurological function of TBI rats.PMID:38492656 | DOI:10.1016/j.exger.2024.112404 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 16, 2024 Category: Geriatrics Authors: Jing Xia Yang Tan Congli Mao Wenting Shen Ying Zhao Source Type: research
Visuospatial cognition predicts performance on an obstructed vision obstacle walking task in older adults
This study lays the groundwork for using the OBVIO task in future assessment and intervention studies.PMID:38490285 | DOI:10.1016/j.exger.2024.112403 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 15, 2024 Category: Geriatrics Authors: Steven P Winesett Sudeshna A Chatterjee Brianne Borgia Brigette A Cox Kelly A Hawkins Jon W Miles Clayton W Swanson Julia T Choi Rachael D Seidler Emily J Fox David J Clark Source Type: research
Endoplasmic reticulum stress-induced necroptosis promotes cochlear inflammation: Implications for age-related hearing loss
In this study, we found that the inflammation, endoplasmic reticulum (ER) stress and necroptosis signalings are activated in the cochlea of aged C57BL/6 mice. ER stress activator tunicamycin (TM) induced necroptosis in cochlear HEI-OC1 cells and cochlear explants, while necroptosis inhibitors protected cochlear cells from ER stress-induced cell death. The antioxidants inhibited necroptosis and protected HEI-OC1 cells from TM insults. Necroptotic HEI-OC1 cells promoted the activation of the co-cultured macrophages via Myd88 signaling. Moreover, necroptosis inhibitor protected from TM-induced hearing loss, and inhibited infl...
Source: Experimental Gerontology - March 15, 2024 Category: Geriatrics Authors: Zhongwu Su Yi Liu Weijian Zhang Wenhui Liang Yuyan Chen Jinyuan Cao Yu Liu Yiqing Zheng Qi Li Source Type: research
Visuospatial cognition predicts performance on an obstructed vision obstacle walking task in older adults
This study lays the groundwork for using the OBVIO task in future assessment and intervention studies.PMID:38490285 | DOI:10.1016/j.exger.2024.112403 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 15, 2024 Category: Geriatrics Authors: Steven P Winesett Sudeshna A Chatterjee Brianne Borgia Brigette A Cox Kelly A Hawkins Jon W Miles Clayton W Swanson Julia T Choi Rachael D Seidler Emily J Fox David J Clark Source Type: research
Endoplasmic reticulum stress-induced necroptosis promotes cochlear inflammation: Implications for age-related hearing loss
In this study, we found that the inflammation, endoplasmic reticulum (ER) stress and necroptosis signalings are activated in the cochlea of aged C57BL/6 mice. ER stress activator tunicamycin (TM) induced necroptosis in cochlear HEI-OC1 cells and cochlear explants, while necroptosis inhibitors protected cochlear cells from ER stress-induced cell death. The antioxidants inhibited necroptosis and protected HEI-OC1 cells from TM insults. Necroptotic HEI-OC1 cells promoted the activation of the co-cultured macrophages via Myd88 signaling. Moreover, necroptosis inhibitor protected from TM-induced hearing loss, and inhibited infl...
Source: Experimental Gerontology - March 15, 2024 Category: Geriatrics Authors: Zhongwu Su Yi Liu Weijian Zhang Wenhui Liang Yuyan Chen Jinyuan Cao Yu Liu Yiqing Zheng Qi Li Source Type: research
Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice
This study explored the effects of outer membrane vesicles (OMVs) from the gut microbiota of AD patients on learning and memory abilities and Tau protein phosphorylation in mice. In contrast to the OMVs from healthy controls and the PBS treatment group, mice treated with AD-OMVs exhibited notable declines in learning and memory capabilities, as evidenced by results from the Morris water maze, Y-maze, and novel object recognition tests. Immunohistochemistry and Western blot assessments unveiled elevated levels of hyperphosphorylated Tau in the cortex and hippocampus of mice treated with AD-OMVs. However, there were no alter...
Source: Experimental Gerontology - March 14, 2024 Category: Geriatrics Authors: Zhongying Shao Yanjun Lu Aihong Xing Xiying He Hongyan Xie Ming Hu Source Type: research
Impact of combined alpha-lipoic acid and mitoquinone supplementation on myocardial infarction in aged rats: Heart performance and molecular mechanisms
CONCLUSION: The study revealed that combined intervention synergistically mitigated cardiac dysfunction by suppressing inflammatory and apoptotic pathways in aged rats with MI. Further research is needed to validate the potential of ALA and Mito Q as therapeutic options for elderly people at risk of heart attacks.PMID:38484905 | DOI:10.1016/j.exger.2024.112402 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 14, 2024 Category: Geriatrics Authors: Samira Nemati Zohreh Zavvari-Oskuye Soleyman Bafadam Behnaz Mokhtari Reza Badalzadeh Abedin Vakili Source Type: research
