Multicomponent and power training with elastic bands improve metabolic and inflammatory parameters, body composition and anthropometry, and physical function in older women with metabolic syndrome: A 20-week randomized, controlled trial
CONCLUSION: Therefore, multicomponent and power training with EBs are plausible strategies for improving the cardiometabolic health status and physical function in older women with MS.PMID:38061437 | DOI:10.1016/j.exger.2023.112340 (Source: Experimental Gerontology)
Source: Experimental Gerontology - December 7, 2023 Category: Geriatrics Authors: Pedro Gargallo Eva Tamayo Pablo Jim énez-Martínez Alvaro Juesas Jose Casa ña Josep C Benitez-Martinez Javier Gene-Morales Julio Fernandez-Garrido Guillermo T Saez Juan C Colado Source Type: research
Role of the Hippo pathway in autoimmune diseases
Exp Gerontol. 2023 Nov 30:112336. doi: 10.1016/j.exger.2023.112336. Online ahead of print.ABSTRACTThe immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under normal physiological conditions, the steady state of the immune system should be sustained to play normal immune response and immune function. Exploring the molecular mechanism of maintaining immune homeostasis under physiological and pathological conditions will provides understanding of the pathogenesis of autoimmune diseases, infections, metabolic disorders, and tumors, as wel...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Hui Kong Juan-Juan Han Leonid Kapilevich Xin-An Zhang Source Type: research
Experimental models for elderly patients with membranous nephropathy: Application and advancements
Exp Gerontol. 2023 Nov 30:112341. doi: 10.1016/j.exger.2023.112341. Online ahead of print.ABSTRACTMembranous nephropathy (MN) occurs predominantly in middle-aged and elderly individuals and ranks among the most prevalent etiologies of elderly nephrotic syndrome. As an autoimmune glomerular disorder characterized by glomerular basement membrane thickening and immune complex deposition, conventional MN animal models, including the Heymann nephritis rat model and the c-BSA mouse model, have laid a foundation for MN pathogenesis research. However, differences in target antigens between rodents and humans have impeded this work...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Xinyue Tang Haoran Dai Yuehong Hu Wenbin Liu Qihan Zhao Hanxue Jiang Zhendong Feng Naiqian Zhang Hongliang Rui Baoli Liu Source Type: research
Role of the Hippo pathway in autoimmune diseases
Exp Gerontol. 2023 Nov 30:112336. doi: 10.1016/j.exger.2023.112336. Online ahead of print.ABSTRACTThe immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under normal physiological conditions, the steady state of the immune system should be sustained to play normal immune response and immune function. Exploring the molecular mechanism of maintaining immune homeostasis under physiological and pathological conditions will provides understanding of the pathogenesis of autoimmune diseases, infections, metabolic disorders, and tumors, as wel...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Hui Kong Juan-Juan Han Leonid Kapilevich Xin-An Zhang Source Type: research
Experimental models for elderly patients with membranous nephropathy: Application and advancements
Exp Gerontol. 2023 Nov 30:112341. doi: 10.1016/j.exger.2023.112341. Online ahead of print.ABSTRACTMembranous nephropathy (MN) occurs predominantly in middle-aged and elderly individuals and ranks among the most prevalent etiologies of elderly nephrotic syndrome. As an autoimmune glomerular disorder characterized by glomerular basement membrane thickening and immune complex deposition, conventional MN animal models, including the Heymann nephritis rat model and the c-BSA mouse model, have laid a foundation for MN pathogenesis research. However, differences in target antigens between rodents and humans have impeded this work...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Xinyue Tang Haoran Dai Yuehong Hu Wenbin Liu Qihan Zhao Hanxue Jiang Zhendong Feng Naiqian Zhang Hongliang Rui Baoli Liu Source Type: research
Role of the Hippo pathway in autoimmune diseases
Exp Gerontol. 2023 Nov 30:112336. doi: 10.1016/j.exger.2023.112336. Online ahead of print.ABSTRACTThe immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under normal physiological conditions, the steady state of the immune system should be sustained to play normal immune response and immune function. Exploring the molecular mechanism of maintaining immune homeostasis under physiological and pathological conditions will provides understanding of the pathogenesis of autoimmune diseases, infections, metabolic disorders, and tumors, as wel...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Hui Kong Juan-Juan Han Leonid Kapilevich Xin-An Zhang Source Type: research
Experimental models for elderly patients with membranous nephropathy: Application and advancements
Exp Gerontol. 2023 Nov 30:112341. doi: 10.1016/j.exger.2023.112341. Online ahead of print.ABSTRACTMembranous nephropathy (MN) occurs predominantly in middle-aged and elderly individuals and ranks among the most prevalent etiologies of elderly nephrotic syndrome. As an autoimmune glomerular disorder characterized by glomerular basement membrane thickening and immune complex deposition, conventional MN animal models, including the Heymann nephritis rat model and the c-BSA mouse model, have laid a foundation for MN pathogenesis research. However, differences in target antigens between rodents and humans have impeded this work...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Xinyue Tang Haoran Dai Yuehong Hu Wenbin Liu Qihan Zhao Hanxue Jiang Zhendong Feng Naiqian Zhang Hongliang Rui Baoli Liu Source Type: research
Role of the Hippo pathway in autoimmune diseases
Exp Gerontol. 2023 Nov 30:112336. doi: 10.1016/j.exger.2023.112336. Online ahead of print.ABSTRACTThe immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under normal physiological conditions, the steady state of the immune system should be sustained to play normal immune response and immune function. Exploring the molecular mechanism of maintaining immune homeostasis under physiological and pathological conditions will provides understanding of the pathogenesis of autoimmune diseases, infections, metabolic disorders, and tumors, as wel...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Hui Kong Juan-Juan Han Leonid Kapilevich Xin-An Zhang Source Type: research
Experimental models for elderly patients with membranous nephropathy: Application and advancements
Exp Gerontol. 2023 Nov 30:112341. doi: 10.1016/j.exger.2023.112341. Online ahead of print.ABSTRACTMembranous nephropathy (MN) occurs predominantly in middle-aged and elderly individuals and ranks among the most prevalent etiologies of elderly nephrotic syndrome. As an autoimmune glomerular disorder characterized by glomerular basement membrane thickening and immune complex deposition, conventional MN animal models, including the Heymann nephritis rat model and the c-BSA mouse model, have laid a foundation for MN pathogenesis research. However, differences in target antigens between rodents and humans have impeded this work...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Xinyue Tang Haoran Dai Yuehong Hu Wenbin Liu Qihan Zhao Hanxue Jiang Zhendong Feng Naiqian Zhang Hongliang Rui Baoli Liu Source Type: research
Role of the Hippo pathway in autoimmune diseases
Exp Gerontol. 2023 Nov 30:112336. doi: 10.1016/j.exger.2023.112336. Online ahead of print.ABSTRACTThe immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under normal physiological conditions, the steady state of the immune system should be sustained to play normal immune response and immune function. Exploring the molecular mechanism of maintaining immune homeostasis under physiological and pathological conditions will provides understanding of the pathogenesis of autoimmune diseases, infections, metabolic disorders, and tumors, as wel...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Hui Kong Juan-Juan Han Leonid Kapilevich Xin-An Zhang Source Type: research
Experimental models for elderly patients with membranous nephropathy: Application and advancements
Exp Gerontol. 2023 Nov 30:112341. doi: 10.1016/j.exger.2023.112341. Online ahead of print.ABSTRACTMembranous nephropathy (MN) occurs predominantly in middle-aged and elderly individuals and ranks among the most prevalent etiologies of elderly nephrotic syndrome. As an autoimmune glomerular disorder characterized by glomerular basement membrane thickening and immune complex deposition, conventional MN animal models, including the Heymann nephritis rat model and the c-BSA mouse model, have laid a foundation for MN pathogenesis research. However, differences in target antigens between rodents and humans have impeded this work...
Source: Experimental Gerontology - December 2, 2023 Category: Geriatrics Authors: Xinyue Tang Haoran Dai Yuehong Hu Wenbin Liu Qihan Zhao Hanxue Jiang Zhendong Feng Naiqian Zhang Hongliang Rui Baoli Liu Source Type: research
The combined deleterious effects of multiple sclerosis and ageing on neuromuscular function
CONCLUSION: The combined negative effects of MS and ageing on neuromuscular function were especially present in the PF but also substantial in the KE. RFD showed large deficits for pwMS compared to HC across age groups. The findings can partly be explained by a reduction in VA and RT, but further investigations of neural regulation are needed to explain large RFD deficits.PMID:38029888 | DOI:10.1016/j.exger.2023.112339 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 29, 2023 Category: Geriatrics Authors: Tobias Gaemelke Marie-Louise K J ørgensen Morten Riemenschneider Ulrik Dalgas Lars G Hvid Source Type: research
The combined deleterious effects of multiple sclerosis and ageing on neuromuscular function
CONCLUSION: The combined negative effects of MS and ageing on neuromuscular function were especially present in the PF but also substantial in the KE. RFD showed large deficits for pwMS compared to HC across age groups. The findings can partly be explained by a reduction in VA and RT, but further investigations of neural regulation are needed to explain large RFD deficits.PMID:38029888 | DOI:10.1016/j.exger.2023.112339 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 29, 2023 Category: Geriatrics Authors: Tobias Gaemelke Marie-Louise K J ørgensen Morten Riemenschneider Ulrik Dalgas Lars G Hvid Source Type: research
The combined deleterious effects of multiple sclerosis and ageing on neuromuscular function
CONCLUSION: The combined negative effects of MS and ageing on neuromuscular function were especially present in the PF but also substantial in the KE. RFD showed large deficits for pwMS compared to HC across age groups. The findings can partly be explained by a reduction in VA and RT, but further investigations of neural regulation are needed to explain large RFD deficits.PMID:38029888 | DOI:10.1016/j.exger.2023.112339 (Source: Experimental Gerontology)
Source: Experimental Gerontology - November 29, 2023 Category: Geriatrics Authors: Tobias Gaemelke Marie-Louise K J ørgensen Morten Riemenschneider Ulrik Dalgas Lars G Hvid Source Type: research
Effects of free versus restricted arm movements on postural control in normal and modified sensory conditions in young and older adults
Exp Gerontol. 2023 Nov 26:112338. doi: 10.1016/j.exger.2023.112338. Online ahead of print.ABSTRACTThe purpose of this study was to explore the effects of arm movements on postural control when standing under different sensory conditions in healthy young and older adults. Fifteen young (mean ± SD age; 21.3 ± 4.2 years) and 15 older (mean ± SD age; 73.3 ± 5.0 years) adults completed the modified Romberg test, which uses four task manipulations (i.e. eyes open and eyes closed on a firm and foam surface) to compromise the fidelity of sensory feedback mechanisms. Each participant completed the tasks under two arm movement c...
Source: Experimental Gerontology - November 28, 2023 Category: Geriatrics Authors: E Johnson T J Ellmers T Muehlbauer S R Lord M W Hill Source Type: research
