Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease
In conclusion, our results indicate that treadmill exercise improves spatial learning memory and prevents network hyperexcitability in mEC by reducing pyramidal neuronal intrinsic excitability and normalizing excitatory and inhibitory synaptic transmission in 3xTg-AD mice.PMID:37832802 | DOI:10.1016/j.exger.2023.112309 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 13, 2023 Category: Geriatrics Authors: Huimin Chen Jiajia Cai Aozhe Wang Wantang Su Chunyan Ji Li Zhao Source Type: research
Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease
In conclusion, our results indicate that treadmill exercise improves spatial learning memory and prevents network hyperexcitability in mEC by reducing pyramidal neuronal intrinsic excitability and normalizing excitatory and inhibitory synaptic transmission in 3xTg-AD mice.PMID:37832802 | DOI:10.1016/j.exger.2023.112309 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 13, 2023 Category: Geriatrics Authors: Huimin Chen Jiajia Cai Aozhe Wang Wantang Su Chunyan Ji Li Zhao Source Type: research
Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease
In conclusion, our results indicate that treadmill exercise improves spatial learning memory and prevents network hyperexcitability in mEC by reducing pyramidal neuronal intrinsic excitability and normalizing excitatory and inhibitory synaptic transmission in 3xTg-AD mice.PMID:37832802 | DOI:10.1016/j.exger.2023.112309 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 13, 2023 Category: Geriatrics Authors: Huimin Chen Jiajia Cai Aozhe Wang Wantang Su Chunyan Ji Li Zhao Source Type: research
Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
In this study, 50 SD adult male mice were used to create an Alzheimer's disease model. The mice's learning and memory abilities were evaluated using an eight-arm radial maze experiment, and changes in body weight and food intake were noted. This helped to better validate the improvement of Alzheimer's disease caused by pine nut peptide-zinc chelate (Korean pine). For a more thorough investigation, mice's brains were dissected, Endogenous mercaptan antioxidants (enzymes), which are markers of brain tissue, were assessed, and mouse gut flora was analyzed. The findings demonstrated that pine nut peptide-zinc chelate (Korean p...
Source: Experimental Gerontology - October 11, 2023 Category: Geriatrics Authors: Jiajia Sun Zhi Zhang Kexin Yang Gang Wei Yanxia Li Shenglong Zhang Source Type: research
The multi-tissue benefits of exercise on aging human physiology
Exp Gerontol. 2023 Oct 9:112304. doi: 10.1016/j.exger.2023.112304. Online ahead of print.NO ABSTRACTPMID:37821321 | DOI:10.1016/j.exger.2023.112304 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 11, 2023 Category: Geriatrics Authors: Andrew Philp Paul M Coen Source Type: research
Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
In this study, 50 SD adult male mice were used to create an Alzheimer's disease model. The mice's learning and memory abilities were evaluated using an eight-arm radial maze experiment, and changes in body weight and food intake were noted. This helped to better validate the improvement of Alzheimer's disease caused by pine nut peptide-zinc chelate (Korean pine). For a more thorough investigation, mice's brains were dissected, Endogenous mercaptan antioxidants (enzymes), which are markers of brain tissue, were assessed, and mouse gut flora was analyzed. The findings demonstrated that pine nut peptide-zinc chelate (Korean p...
Source: Experimental Gerontology - October 11, 2023 Category: Geriatrics Authors: Jiajia Sun Zhi Zhang Kexin Yang Gang Wei Yanxia Li Shenglong Zhang Source Type: research
The multi-tissue benefits of exercise on aging human physiology
Exp Gerontol. 2023 Oct 9:112304. doi: 10.1016/j.exger.2023.112304. Online ahead of print.NO ABSTRACTPMID:37821321 | DOI:10.1016/j.exger.2023.112304 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 11, 2023 Category: Geriatrics Authors: Andrew Philp Paul M Coen Source Type: research
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3 β and inflammation pathway
In conclusion, trelagliptin improved the cognitive lesion in DM rats by suppressing the activation of the inflammatory route and by activating the PI3K/Akt/GSK-3β pathway at the same time, as well as interacting with the pathways that protect neurons, which still need further research.PMID:37804920 | DOI:10.1016/j.exger.2023.112307 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 7, 2023 Category: Geriatrics Authors: Min Lei Xiying Guo Yue Yao Ting Shu Zhanhong Ren Xiaosong Yang Changhan Ouyang Qingjie Chen Chao Liu Xiufen Liu Source Type: research
Interaction of Klotho and sirtuins
Exp Gerontol. 2023 Oct 6;182:112306. doi: 10.1016/j.exger.2023.112306. Online ahead of print.ABSTRACTOBJECTIVE: In this article, we review the articles that have reported the interaction between Klotho and sirtuins.RECENT FINDINGS: Sirtuins are a family of histone deacetylase enzymes that are considered to be the main regulators of biological processes. This family is one of the essential factors for postponing aging and increasing the life span of organisms. Sirtuins play a role in regulating the function of various cellular processes such as cellular metabolism, oxidative stress, apoptosis, and inflammation. It has also ...
Source: Experimental Gerontology - October 7, 2023 Category: Geriatrics Authors: Farzaneh Rostamzadeh Yasamin Moosavi-Saeed Mahboobeh Yeganeh-Hajahmadi Source Type: research
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3 β and inflammation pathway
In conclusion, trelagliptin improved the cognitive lesion in DM rats by suppressing the activation of the inflammatory route and by activating the PI3K/Akt/GSK-3β pathway at the same time, as well as interacting with the pathways that protect neurons, which still need further research.PMID:37804920 | DOI:10.1016/j.exger.2023.112307 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 7, 2023 Category: Geriatrics Authors: Min Lei Xiying Guo Yue Yao Ting Shu Zhanhong Ren Xiaosong Yang Changhan Ouyang Qingjie Chen Chao Liu Xiufen Liu Source Type: research
Interaction of Klotho and sirtuins
Exp Gerontol. 2023 Oct 6;182:112306. doi: 10.1016/j.exger.2023.112306. Online ahead of print.ABSTRACTOBJECTIVE: In this article, we review the articles that have reported the interaction between Klotho and sirtuins.RECENT FINDINGS: Sirtuins are a family of histone deacetylase enzymes that are considered to be the main regulators of biological processes. This family is one of the essential factors for postponing aging and increasing the life span of organisms. Sirtuins play a role in regulating the function of various cellular processes such as cellular metabolism, oxidative stress, apoptosis, and inflammation. It has also ...
Source: Experimental Gerontology - October 7, 2023 Category: Geriatrics Authors: Farzaneh Rostamzadeh Yasamin Moosavi-Saeed Mahboobeh Yeganeh-Hajahmadi Source Type: research
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3 β and inflammation pathway
In conclusion, trelagliptin improved the cognitive lesion in DM rats by suppressing the activation of the inflammatory route and by activating the PI3K/Akt/GSK-3β pathway at the same time, as well as interacting with the pathways that protect neurons, which still need further research.PMID:37804920 | DOI:10.1016/j.exger.2023.112307 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 7, 2023 Category: Geriatrics Authors: Min Lei Xiying Guo Yue Yao Ting Shu Zhanhong Ren Xiaosong Yang Changhan Ouyang Qingjie Chen Chao Liu Xiufen Liu Source Type: research
Interaction of Klotho and sirtuins
Exp Gerontol. 2023 Oct 6;182:112306. doi: 10.1016/j.exger.2023.112306. Online ahead of print.ABSTRACTOBJECTIVE: In this article, we review the articles that have reported the interaction between Klotho and sirtuins.RECENT FINDINGS: Sirtuins are a family of histone deacetylase enzymes that are considered to be the main regulators of biological processes. This family is one of the essential factors for postponing aging and increasing the life span of organisms. Sirtuins play a role in regulating the function of various cellular processes such as cellular metabolism, oxidative stress, apoptosis, and inflammation. It has also ...
Source: Experimental Gerontology - October 7, 2023 Category: Geriatrics Authors: Farzaneh Rostamzadeh Yasamin Moosavi-Saeed Mahboobeh Yeganeh-Hajahmadi Source Type: research
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3 β and inflammation pathway
In conclusion, trelagliptin improved the cognitive lesion in DM rats by suppressing the activation of the inflammatory route and by activating the PI3K/Akt/GSK-3β pathway at the same time, as well as interacting with the pathways that protect neurons, which still need further research.PMID:37804920 | DOI:10.1016/j.exger.2023.112307 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 7, 2023 Category: Geriatrics Authors: Min Lei Xiying Guo Yue Yao Ting Shu Zhanhong Ren Xiaosong Yang Changhan Ouyang Qingjie Chen Chao Liu Xiufen Liu Source Type: research
Interaction of Klotho and sirtuins
Exp Gerontol. 2023 Oct 5:112306. doi: 10.1016/j.exger.2023.112306. Online ahead of print.ABSTRACTOBJECTIVE: In this article, we review the articles that have reported the interaction between Klotho and sirtuins.RECENT FINDINGS: Sirtuins are a family of histone deacetylase enzymes that are considered to be the main regulators of biological processes. This family is one of the essential factors for postponing aging and increasing the life span of organisms. Sirtuins play a role in regulating the function of various cellular processes such as cellular metabolism, oxidative stress, apoptosis, and inflammation. It has also been...
Source: Experimental Gerontology - October 7, 2023 Category: Geriatrics Authors: Farzaneh Rostamzadeh Yasamin Moosavi-Saeed Mahboobeh Yeganeh-Hajahmadi Source Type: research
