Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3 β and inflammation pathway

In conclusion, trelagliptin improved the cognitive lesion in DM rats by suppressing the activation of the inflammatory route and by activating the PI3K/Akt/GSK-3β pathway at the same time, as well as interacting with the pathways that protect neurons, which still need further research.PMID:37804920 | DOI:10.1016/j.exger.2023.112307

Source: Experimental Gerontology - October 7, 2023 Category: Geriatrics Authors: Min Lei Xiying Guo Yue Yao Ting Shu Zhanhong Ren Xiaosong Yang Changhan Ouyang Qingjie Chen Chao Liu Xiufen Liu Source Type: research