Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease

In conclusion, our results indicate that treadmill exercise improves spatial learning memory and prevents network hyperexcitability in mEC by reducing pyramidal neuronal intrinsic excitability and normalizing excitatory and inhibitory synaptic transmission in 3xTg-AD mice.PMID:37832802 | DOI:10.1016/j.exger.2023.112309

Source: Experimental Gerontology - October 13, 2023 Category: Geriatrics Authors: Huimin Chen Jiajia Cai Aozhe Wang Wantang Su Chunyan Ji Li Zhao Source Type: research