p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6
Exp Gerontol. 2024 Mar 2:112391. doi: 10.1016/j.exger.2024.112391. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only promotes the development of diabetes and its complications, but also aggravates the occurrence of senescence. Previous studies have shown that DR is associated with senescence, but the specific mechanism has not been fully elucidated. Here, we first detected the differentially expressed genes (DEGs) and cellular senescence level of db/db mouse retinas by bulk RNA sequencing. Then, we used single-cell sequencin...
Source: Experimental Gerontology - March 4, 2024 Category: Geriatrics Authors: Ying Cheng Man Zhang Rong Xu Lingli Fu Mei Xue Chaofei Xu Chao Tang Ting Fang Xiaohuan Liu Bei Sun Liming Chen Source Type: research
Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF- α in older adults: A case-control study
CONCLUSION: Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF-α in a community-dwelling population of older adults in Xinjiang.PMID:38437928 | DOI:10.1016/j.exger.2024.112390 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 4, 2024 Category: Geriatrics Authors: Saiyare Xuekelati Zhuoya Maimaitiwusiman Xue Bai Hong Xiang Yangjing Li Hongmei Wang Source Type: research
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6
Exp Gerontol. 2024 Mar 2:112391. doi: 10.1016/j.exger.2024.112391. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only promotes the development of diabetes and its complications, but also aggravates the occurrence of senescence. Previous studies have shown that DR is associated with senescence, but the specific mechanism has not been fully elucidated. Here, we first detected the differentially expressed genes (DEGs) and cellular senescence level of db/db mouse retinas by bulk RNA sequencing. Then, we used single-cell sequencin...
Source: Experimental Gerontology - March 4, 2024 Category: Geriatrics Authors: Ying Cheng Man Zhang Rong Xu Lingli Fu Mei Xue Chaofei Xu Chao Tang Ting Fang Xiaohuan Liu Bei Sun Liming Chen Source Type: research
Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF- α in older adults: A case-control study
CONCLUSION: Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF-α in a community-dwelling population of older adults in Xinjiang.PMID:38437928 | DOI:10.1016/j.exger.2024.112390 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 4, 2024 Category: Geriatrics Authors: Saiyare Xuekelati Zhuoya Maimaitiwusiman Xue Bai Hong Xiang Yangjing Li Hongmei Wang Source Type: research
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6
Exp Gerontol. 2024 Mar 2:112391. doi: 10.1016/j.exger.2024.112391. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only promotes the development of diabetes and its complications, but also aggravates the occurrence of senescence. Previous studies have shown that DR is associated with senescence, but the specific mechanism has not been fully elucidated. Here, we first detected the differentially expressed genes (DEGs) and cellular senescence level of db/db mouse retinas by bulk RNA sequencing. Then, we used single-cell sequencin...
Source: Experimental Gerontology - March 4, 2024 Category: Geriatrics Authors: Ying Cheng Man Zhang Rong Xu Lingli Fu Mei Xue Chaofei Xu Chao Tang Ting Fang Xiaohuan Liu Bei Sun Liming Chen Source Type: research
Fatigue and perceived energy in a sample of older adults over 10 years: A resting state functional connectivity study of neural correlates
CONCLUSIONS: In this cohort of older adults, the cortico-striatal functional connectivity of declining SEL appears distinct from that underlying fatigue. Studies to further assess the neural correlates of energy and fatigue, and their independent contribution to neurodegenerative conditions are warranted.PMID:38432051 | DOI:10.1016/j.exger.2024.112388 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 3, 2024 Category: Geriatrics Authors: James B Hengenius Rebecca Ehrenkranz Xiaonan Zhu Nancy W Glynn Theodore J Huppert Caterina Rosano Source Type: research
Kaempferol: Paving the path for advanced treatments in aging-related diseases
Exp Gerontol. 2024 Mar 1:112389. doi: 10.1016/j.exger.2024.112389. Online ahead of print.ABSTRACTAging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, and pharmacokinetics, and highlights its potential therapeutic utility against ARDs. Kaempferol's therapeutic potential is underpinned by its distinctive chemical structure, which confers antioxidative and anti-...
Source: Experimental Gerontology - March 3, 2024 Category: Geriatrics Authors: Md Sadique Hussain Abdulmalik Saleh Alfawaz Altamimi Muhammad Afzal Waleed Hassan Almalki Imran Kazmi Sami I Alzarea Gaurav Gupta Moyad Shahwan Neelima Kukreti Ling Shing Wong Vinoth Kumarasamy Vetriselvan Subramaniyan Source Type: research
CircHIVEP2 alleviates Parkinson's nerve damage and inflammatory response by targeting miR-485-3p
CONCLUSION: circHIVEP2 is a potential diagnostic biomarker for PD, and its upregulation mitigated MPP+-induced nerve damage and inflammation and this may be through targeted by the miR-485-3p.PMID:38431178 | DOI:10.1016/j.exger.2024.112387 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 2, 2024 Category: Geriatrics Authors: Xia Lin Lingqun Mao Qiuyue Chen Tianyu Wang Taotao Tao Luping Pan Source Type: research
Pulmonary function and trajectories of cognitive decline in aging population
CONCLUSIONS: In this large multi-national longitudinal study, the PEF score was independently associated with lower levels of cognitive functions, but it did not predict a future decline. The results suggest that pre-existing differences in lung functions are responsible for variability in cognitive functions and that these differences remained stable across aging.PMID:38428543 | DOI:10.1016/j.exger.2024.112386 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 1, 2024 Category: Geriatrics Authors: Albert J Ksinan Andrea Daleck á Tatyana Court Hynek Pikhart Martin Bob ák Source Type: research
Pulmonary function and trajectories of cognitive decline in aging population
CONCLUSIONS: In this large multi-national longitudinal study, the PEF score was independently associated with lower levels of cognitive functions, but it did not predict a future decline. The results suggest that pre-existing differences in lung functions are responsible for variability in cognitive functions and that these differences remained stable across aging.PMID:38428543 | DOI:10.1016/j.exger.2024.112386 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 1, 2024 Category: Geriatrics Authors: Albert J Ksinan Andrea Daleck á Tatyana Court Hynek Pikhart Martin Bob ák Source Type: research
Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration
CONCLUSION: This bibliometric analysis of research on inflammatory mechanisms in IVDD provides insights into the current status, hotspots, and potential future trends. These findings can serve as a valuable reference and guide for researchers in the field.PMID:38382680 | DOI:10.1016/j.exger.2024.112380 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 21, 2024 Category: Geriatrics Authors: Nan Wang Weihao Rong Yimin Xie Shuang Chen Zhipeng Xi Rongrong Deng Source Type: research
Laboratory-assessed gait cycle entropy for classifying walking limitations among community-dwelling older adults
Exp Gerontol. 2024 Feb 22;188:112381. doi: 10.1016/j.exger.2024.112381. Online ahead of print.ABSTRACTAmong older people, walking difficulty results from actual and perceived declines in physical capacities and environmental requirements for walking. We investigated whether the physiological complexity of the gait cycle covaries with experience of walking difficulty. Walking difficulty, gait speed, and gait cycle complexity were evaluated among 702 community-dwelling older people aged 75, 80, and 85 years who took part in the six-minute walking test in the research laboratory. Walking difficulty for 500 m was self-reported...
Source: Experimental Gerontology - February 21, 2024 Category: Geriatrics Authors: Olli-Pekka Mattila Taina Rantanen Merja Rantakokko Laura Karavirta Neil Cronin Timo Rantalainen Source Type: research
Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration
CONCLUSION: This bibliometric analysis of research on inflammatory mechanisms in IVDD provides insights into the current status, hotspots, and potential future trends. These findings can serve as a valuable reference and guide for researchers in the field.PMID:38382680 | DOI:10.1016/j.exger.2024.112380 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 21, 2024 Category: Geriatrics Authors: Nan Wang Weihao Rong Yimin Xie Shuang Chen Zhipeng Xi Rongrong Deng Source Type: research
Laboratory-assessed gait cycle entropy for classifying walking limitations among community-dwelling older adults
Exp Gerontol. 2024 Feb 22;188:112381. doi: 10.1016/j.exger.2024.112381. Online ahead of print.ABSTRACTAmong older people, walking difficulty results from actual and perceived declines in physical capacities and environmental requirements for walking. We investigated whether the physiological complexity of the gait cycle covaries with experience of walking difficulty. Walking difficulty, gait speed, and gait cycle complexity were evaluated among 702 community-dwelling older people aged 75, 80, and 85 years who took part in the six-minute walking test in the research laboratory. Walking difficulty for 500 m was self-reported...
Source: Experimental Gerontology - February 21, 2024 Category: Geriatrics Authors: Olli-Pekka Mattila Taina Rantanen Merja Rantakokko Laura Karavirta Neil Cronin Timo Rantalainen Source Type: research
Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration
CONCLUSION: This bibliometric analysis of research on inflammatory mechanisms in IVDD provides insights into the current status, hotspots, and potential future trends. These findings can serve as a valuable reference and guide for researchers in the field.PMID:38382680 | DOI:10.1016/j.exger.2024.112380 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 21, 2024 Category: Geriatrics Authors: Nan Wang Weihao Rong Yimin Xie Shuang Chen Zhipeng Xi Rongrong Deng Source Type: research
