Age-dependent down-regulation of orexin receptors in trigeminal nucleus caudalis correlated with attenuation of orexinergic analgesia in rats
In conclusion, the older age-related reduction of the antinociceptive effect of orexin may be due to the downregulation of its receptors and inability of orexin signaling to inhibit the expression of nociceptive neuropeptides such as SP and CGRP in aged rats.PMID:37898178 | DOI:10.1016/j.exger.2023.112321 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 28, 2023 Category: Geriatrics Authors: Shima Torkzadeh-Mahani Mehdi Abbasnejad Maryam Raoof Ghizlane Aarab Saeed Esmaeili-Mahani Frank Lobbezoo Source Type: research
Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease
Exp Gerontol. 2023 Oct 26:112319. doi: 10.1016/j.exger.2023.112319. Online ahead of print.ABSTRACTThe intricate interplay between gut microbiota and the host is pivotal in maintaining homeostasis and health. Dietary tryptophan (TRP) metabolism initiates a cascade of essential endogenous metabolites, including kynurenine, kynurenic acid, serotonin, and melatonin, as well as microbiota-derived Trp metabolites like tryptamine, indole propionic acid (IPA), and other indole derivatives. Notably, tryptamine and IPA, among the indole metabolites, exert crucial roles in modulating immune, metabolic, and neuronal responses at both ...
Source: Experimental Gerontology - October 28, 2023 Category: Geriatrics Authors: Sonu Kumar Gupta Sagar Vyavahare Ian L Duchesne Blanes Ford Berger Carlos Isales Sadanand Fulzele Source Type: research
Metabolic syndrome accelerates epigenetic ageing in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA)
This study hypothesised that those with MetS have 'accelerated ageing' (biological age greater than their chronological age) as indexed by GrimAge. This study examined MetS's association with GrimAge age acceleration (AA) using data from a subsample of 469 participants of the Irish Longitudinal Study on Ageing (TILDA). MetS was defined by National Cholesterol Education Program Third Adult Treatment Panel (ATP III) and International Diabetes Foundation (IDF) criteria, operationalised using the conventional binary cut-off, and as a count variable ranging from 0 to 5, based on the presence of individual components. This study...
Source: Experimental Gerontology - October 26, 2023 Category: Geriatrics Authors: Kevin McCarthy Aisling M O'Halloran Padraic Fallon Rose Anne Kenny Cathal McCrory Source Type: research
Metabolic syndrome accelerates epigenetic ageing in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA)
This study hypothesised that those with MetS have 'accelerated ageing' (biological age greater than their chronological age) as indexed by GrimAge. This study examined MetS's association with GrimAge age acceleration (AA) using data from a subsample of 469 participants of the Irish Longitudinal Study on Ageing (TILDA). MetS was defined by National Cholesterol Education Program Third Adult Treatment Panel (ATP III) and International Diabetes Foundation (IDF) criteria, operationalised using the conventional binary cut-off, and as a count variable ranging from 0 to 5, based on the presence of individual components. This study...
Source: Experimental Gerontology - October 26, 2023 Category: Geriatrics Authors: Kevin McCarthy Aisling M O'Halloran Padraic Fallon Rose Anne Kenny Cathal McCrory Source Type: research
Metabolic syndrome accelerates epigenetic ageing in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA)
This study hypothesised that those with MetS have 'accelerated ageing' (biological age greater than their chronological age) as indexed by GrimAge. This study examined MetS's association with GrimAge age acceleration (AA) using data from a subsample of 469 participants of the Irish Longitudinal Study on Ageing (TILDA). MetS was defined by National Cholesterol Education Program Third Adult Treatment Panel (ATP III) and International Diabetes Foundation (IDF) criteria, operationalised using the conventional binary cut-off, and as a count variable ranging from 0 to 5, based on the presence of individual components. This study...
Source: Experimental Gerontology - October 26, 2023 Category: Geriatrics Authors: Kevin McCarthy Aisling M O'Halloran Padraic Fallon Rose Anne Kenny Cathal McCrory Source Type: research
Polypharmacy, physical activity, and sedentary time in older adults: A scoping review
CONCLUSIONS: Limited evidence suggests an inverse association between physical activity and polypharmacy in older adults. However, the relationship between PIM use, physical activity, and sedentary time remains unknown. Longitudinal studies utilizing objectively-measured physical activity and sedentary time are needed to better clarify the relationship between these movement behaviors and polypharmacy and/or PIM use in older adults.PMID:37879421 | DOI:10.1016/j.exger.2023.112317 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 25, 2023 Category: Geriatrics Authors: Isabela Karoliny Calixto de Souza Francisco Jos é Rosa de Souza Charles Phillipe de Lucena Alves Todd A Duhamel Debra L Waters Rand Randall Martins Eduardo Caldas Costa Source Type: research
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022
CONCLUSION: This is the first bibliometric analysis of inflammation in sarcopenia. The interaction between oxidative stress, insulin resistance and inflammation in sarcopenia is regarded as the current research priorities. As sarcopenia becomes more prevalent, a focus will be placed on determining the molecular mechanisms and therapeutic targets for regulating inflammation to intervene in sarcopenia.PMID:37862732 | DOI:10.1016/j.exger.2023.112316 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 20, 2023 Category: Geriatrics Authors: Yujie Zhang Ye Zhao Jiaqi Rong Kaoqiang Liu Yunfan Zhan Yongli Chai Jiawei Ning Wei'an Yuan Source Type: research
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022
CONCLUSION: This is the first bibliometric analysis of inflammation in sarcopenia. The interaction between oxidative stress, insulin resistance and inflammation in sarcopenia is regarded as the current research priorities. As sarcopenia becomes more prevalent, a focus will be placed on determining the molecular mechanisms and therapeutic targets for regulating inflammation to intervene in sarcopenia.PMID:37862732 | DOI:10.1016/j.exger.2023.112316 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 20, 2023 Category: Geriatrics Authors: Yujie Zhang Ye Zhao Jiaqi Rong Kaoqiang Liu Yunfan Zhan Yongli Chai Jiawei Ning Wei'an Yuan Source Type: research
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022
CONCLUSION: This is the first bibliometric analysis of inflammation in sarcopenia. The interaction between oxidative stress, insulin resistance and inflammation in sarcopenia is regarded as the current research priorities. As sarcopenia becomes more prevalent, a focus will be placed on determining the molecular mechanisms and therapeutic targets for regulating inflammation to intervene in sarcopenia.PMID:37862732 | DOI:10.1016/j.exger.2023.112316 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 20, 2023 Category: Geriatrics Authors: Yujie Zhang Ye Zhao Jiaqi Rong Kaoqiang Liu Yunfan Zhan Yongli Chai Jiawei Ning Wei'an Yuan Source Type: research
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022
CONCLUSION: This is the first bibliometric analysis of inflammation in sarcopenia. The interaction between oxidative stress, insulin resistance and inflammation in sarcopenia is regarded as the current research priorities. As sarcopenia becomes more prevalent, a focus will be placed on determining the molecular mechanisms and therapeutic targets for regulating inflammation to intervene in sarcopenia.PMID:37862732 | DOI:10.1016/j.exger.2023.112316 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 20, 2023 Category: Geriatrics Authors: Yujie Zhang Ye Zhao Jiaqi Rong Kaoqiang Liu Yunfan Zhan Yongli Chai Jiawei Ning Wei'an Yuan Source Type: research
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022
CONCLUSION: This is the first bibliometric analysis of inflammation in sarcopenia. The interaction between oxidative stress, insulin resistance and inflammation in sarcopenia is regarded as the current research priorities. As sarcopenia becomes more prevalent, a focus will be placed on determining the molecular mechanisms and therapeutic targets for regulating inflammation to intervene in sarcopenia.PMID:37862732 | DOI:10.1016/j.exger.2023.112316 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 20, 2023 Category: Geriatrics Authors: Yujie Zhang Ye Zhao Jiaqi Rong Kaoqiang Liu Yunfan Zhan Yongli Chai Jiawei Ning Wei'an Yuan Source Type: research
Effect of exercise on inflammatory markers in postmenopausal women with overweight and obesity: A systematic review and meta-analysis
CONCLUSION: These results suggest that exercise may be an effective intervention for reducing pro-inflammatory markers and increasing adiponectin in postmenopausal women impacted by overweight and obesity. The findings may provide clinicians and healthcare professionals with insights into the implementation of exercise programs for postmenopausal women living with overweight and obesity.PMID:37844768 | DOI:10.1016/j.exger.2023.112310 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 16, 2023 Category: Geriatrics Authors: Liang Tan Weihua Yan Weilin Yang Agata Kamionka Mariusz Lipowski Zijian Zhao Gang Zhao Source Type: research
Effect of exercise on inflammatory markers in postmenopausal women with overweight and obesity: A systematic review and meta-analysis
CONCLUSION: These results suggest that exercise may be an effective intervention for reducing pro-inflammatory markers and increasing adiponectin in postmenopausal women impacted by overweight and obesity. The findings may provide clinicians and healthcare professionals with insights into the implementation of exercise programs for postmenopausal women living with overweight and obesity.PMID:37844768 | DOI:10.1016/j.exger.2023.112310 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 16, 2023 Category: Geriatrics Authors: Liang Tan Weihua Yan Weilin Yang Agata Kamionka Mariusz Lipowski Zijian Zhao Gang Zhao Source Type: research
Effect of exercise on inflammatory markers in postmenopausal women with overweight and obesity: A systematic review and meta-analysis
CONCLUSION: These results suggest that exercise may be an effective intervention for reducing pro-inflammatory markers and increasing adiponectin in postmenopausal women impacted by overweight and obesity. The findings may provide clinicians and healthcare professionals with insights into the implementation of exercise programs for postmenopausal women living with overweight and obesity.PMID:37844768 | DOI:10.1016/j.exger.2023.112310 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 16, 2023 Category: Geriatrics Authors: Liang Tan Weihua Yan Weilin Yang Agata Kamionka Mariusz Lipowski Zijian Zhao Gang Zhao Source Type: research
Effect of exercise on inflammatory markers in postmenopausal women with overweight and obesity: A systematic review and meta-analysis
CONCLUSION: These results suggest that exercise may be an effective intervention for reducing pro-inflammatory markers and increasing adiponectin in postmenopausal women impacted by overweight and obesity. The findings may provide clinicians and healthcare professionals with insights into the implementation of exercise programs for postmenopausal women living with overweight and obesity.PMID:37844768 | DOI:10.1016/j.exger.2023.112310 (Source: Experimental Gerontology)
Source: Experimental Gerontology - October 16, 2023 Category: Geriatrics Authors: Liang Tan Weihua Yan Weilin Yang Agata Kamionka Mariusz Lipowski Zijian Zhao Gang Zhao Source Type: research
