Stretch-shortening cycles protect against the age-related loss of power generation in rat single muscle fibres
Exp Gerontol. 2024 Apr 10:112423. doi: 10.1016/j.exger.2024.112423. Online ahead of print.ABSTRACTAging is associated with impaired strength and power during isometric and shortening contractions, however, during lengthening (i.e., eccentric) contractions, strength is maintained. During daily movements, muscles undergo stretch-shortening cycles (SSCs). It is unclear whether the age-related maintenance of eccentric strength offsets age-related impairments in power generation during SSCs owing to the utilization of elastic energy or other cross-bridge based mechanisms. Here we investigated how aging influences SSC performanc...
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: Makenna A Patterson Avery Hinks Binta S Njai Benjamin E Dalton Emma F Hubbard Geoffrey A Power Source Type: research
Cardiorespiratory fitness mediates the relationship between depressive symptomatology and cognition in older but not younger adults
Exp Gerontol. 2024 Apr 10:112429. doi: 10.1016/j.exger.2024.112429. Online ahead of print.ABSTRACTAging is commonly associated with emotional, physical, and cognitive changes, with the latter, particularly affecting executive functioning. Further, such changes may interact. For instance, depressive symptomatology is a known risk factor for developing cognitive deficits, especially at older ages. In contrast, an active lifestyle, reflected in high cardiorespiratory fitness (CRF) levels, has proven to protect against adverse effects on cognition across the adult lifespan. Hence, this study aimed to investigate the relationsh...
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: Catarina Barros Adriana Sampaio Diego Pinal Source Type: research
The effect of tamoxifen on estradiol, SHBG, IGF-1, and CRP in women with breast cancer or at risk of developing breast cancer: a meta-analysis of randomized controlled trials
CONCLUSION: Tamoxifen administration seems to increase estradiol and SHBG levels and reduce CRP and IGF-1 levels in women with breast cancer or at risk of developing breast cancer. Further studies are needed to determine whether these changes have any clinical relevance.PMID:38608792 | DOI:10.1016/j.exger.2024.112431 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: XingDa Li XueJiao Hou Benjamin Hern ández-Wolters Kousalya Prabahar Hamed Kord-Varkaneh Bo Mei Source Type: research
Home-based resistance training performed at either fast or slow speeds improves power output in older adults
CONCLUSIONS: Unsupervised, body mass- and home-based resistance training performed at either fast or slow speeds can improve muscle power in older adults, while fast-speed exercise may be preferable over slow-speed owing to the relatively greater improvement of muscle-power, -volume, -architecture, and better time efficiency.PMID:38608793 | DOI:10.1016/j.exger.2024.112430 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 12, 2024 Category: Geriatrics Authors: Kosuke Hirata Mari Ito Yuta Nomura Chiho Kawashima Tsukasa Yoshida Yosuke Yamada Neale A Tillin Geoffrey A Power Ryota Akagi Source Type: research
The associations of daytime napping and motoric cognitive risk syndrome: Findings from the China Health and Retirement Longitudinal Study
CONCLUSION: A moderate nap of 30-89 min could lower the odds of MCR, especially for older adults with a night sleep duration of ≤8 h.PMID:38604250 | DOI:10.1016/j.exger.2024.112426 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Lixing Zhou Yan Zhang Meiling Ge Gongchang Zhang Rui Cheng Yixin Liu Xiaoli Chen Xiaolei Liu Birong Dong Source Type: research
The effect of age and sex on peak oxygen uptake during upper and lower body exercise: A systematic review
CONCLUSIONS: These responses suggest that upper body VO2peak decreases in line with that of the lower body but, due to the lower peak values achieved during ACE, decreases in VO2peak may have more profound functional impact compared to that for the lower body. Using absolute and relative measures of VO2peak results in different age-related profiles when considered below 50 years of age. To further our understanding of whole body ageing more data is required for participants in mid and later life. The association between VO2peak and underlying physiological factors with age needs to be studied further, particularly in conju...
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: M J Price P M Smith L M Bottoms M W Hill Source Type: research
Age-related changes in muscle coordination patterns of stepping responses to recover from loss of balance
CONCLUSION: Although synergy structure was not affected by age, the delayed step onsets and the enhanced early synergy recruitment point at a relative bias towards non-stepping behavior in older adults. They may need more time for accumulating information on the direction of perturbation and making the corresponding sensorimotor transformations before initiating the step. Future work may investigate whether perturbation-based training improves these age-related deficits.PMID:38604252 | DOI:10.1016/j.exger.2024.112424 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Wouter Staring Sarah Zandvliet Digna de Kam Teodoro Solis-Escalante Alexander Geurts Vivian Weerdesteyn Source Type: research
PGC-1 α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway
CONCLUSION: This research demonstrates that PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway.PMID:38604253 | DOI:10.1016/j.exger.2024.112428 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Yimin Fu Lei Tao Xiaojun Wang Binyou Wang Weilin Qin Lei Song Source Type: research
Comparison of ultrasound-guided microwave ablation, laser ablation, and radiofrequency ablation for the treatment of elderly patients with benign thyroid nodules: A meta-analysis
CONCLUSION: LA, RFA, and MWA can markedly reduce the volume of benign thyroid nodules in elderly patients and can safely treat benign thyroid nodules.PMID:38604254 | DOI:10.1016/j.exger.2024.112425 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Ying Qian Zheng Li Chunyun Fan Yong Huang Source Type: research
The associations of daytime napping and motoric cognitive risk syndrome: Findings from the China Health and Retirement Longitudinal Study
CONCLUSION: A moderate nap of 30-89 min could lower the odds of MCR, especially for older adults with a night sleep duration of ≤8 h.PMID:38604250 | DOI:10.1016/j.exger.2024.112426 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Lixing Zhou Yan Zhang Meiling Ge Gongchang Zhang Rui Cheng Yixin Liu Xiaoli Chen Xiaolei Liu Birong Dong Source Type: research
The effect of age and sex on peak oxygen uptake during upper and lower body exercise: A systematic review
CONCLUSIONS: These responses suggest that upper body VO2peak decreases in line with that of the lower body but, due to the lower peak values achieved during ACE, decreases in VO2peak may have more profound functional impact compared to that for the lower body. Using absolute and relative measures of VO2peak results in different age-related profiles when considered below 50 years of age. To further our understanding of whole body ageing more data is required for participants in mid and later life. The association between VO2peak and underlying physiological factors with age needs to be studied further, particularly in conju...
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: M J Price P M Smith L M Bottoms M W Hill Source Type: research
Age-related changes in muscle coordination patterns of stepping responses to recover from loss of balance
CONCLUSION: Although synergy structure was not affected by age, the delayed step onsets and the enhanced early synergy recruitment point at a relative bias towards non-stepping behavior in older adults. They may need more time for accumulating information on the direction of perturbation and making the corresponding sensorimotor transformations before initiating the step. Future work may investigate whether perturbation-based training improves these age-related deficits.PMID:38604252 | DOI:10.1016/j.exger.2024.112424 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Wouter Staring Sarah Zandvliet Digna de Kam Teodoro Solis-Escalante Alexander Geurts Vivian Weerdesteyn Source Type: research
PGC-1 α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway
CONCLUSION: This research demonstrates that PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway.PMID:38604253 | DOI:10.1016/j.exger.2024.112428 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Yimin Fu Lei Tao Xiaojun Wang Binyou Wang Weilin Qin Lei Song Source Type: research
Comparison of ultrasound-guided microwave ablation, laser ablation, and radiofrequency ablation for the treatment of elderly patients with benign thyroid nodules: A meta-analysis
CONCLUSION: LA, RFA, and MWA can markedly reduce the volume of benign thyroid nodules in elderly patients and can safely treat benign thyroid nodules.PMID:38604254 | DOI:10.1016/j.exger.2024.112425 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 11, 2024 Category: Geriatrics Authors: Ying Qian Zheng Li Chunyun Fan Yong Huang Source Type: research
QKL injection ameliorates Alzheimer's disease-like pathology by regulating expression of RAGE
In conclusion, RAGE is a potential target for QKL's therapeutic effect on AD.PMID:38599502 | DOI:10.1016/j.exger.2024.112422 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 10, 2024 Category: Geriatrics Authors: Jinfang Dou Xin'ai Zhang Chaoqun Hu Yuqian Gao Yue Zhao Murong Hei Zhimiao Wang Nan Guo Haiyan Zhu Source Type: research
