Sarcopenic patients "get even": The impact of COVID-19 vaccination on mortality
CONCLUSIONS: Our study represents the first attempt to analyze the vaccine's effect on survival in sarcopenic hospitalized older adults with COVID-19. The administration of vaccination to sarcopenic patients proves pivotal, as its omission could lead to notably unfavorable outcomes within this specific population.PMID:38369251 | DOI:10.1016/j.exger.2024.112382 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 18, 2024 Category: Geriatrics Authors: Chiara Ceolin Marina De Rui Cristina Simonato Margherita Vergadoro Sara Cazzavillan Vittorio Acunto Mario Virgilio Papa Giulia Salerno Trapella Bruno Micael Zanforlini Chiara Curreri Anna Bertocco Maria Devita Alessandra Coin Giuseppe Sergi Source Type: research
Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the training IMCT study
In conclusion, we found that a resistance training intervention in which one weekly training session is replaced by plyometric training is feasible and as effective as a program consisting solely of conventional strength training sessions for inducing gains in muscle strength and function in older adults. Muscle size and architecture improved only in the MULTI group. German Clinical Trials: DRKS00015750.PMID:38355067 | DOI:10.1016/j.exger.2024.112378 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 14, 2024 Category: Geriatrics Authors: Gustavo Z Schaun Matthias Gumpenberger Leonie Konermann Alexandra Graf Peter Raidl Barbara Wessner Robert Csapo Source Type: research
Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the training IMCT study
In conclusion, we found that a resistance training intervention in which one weekly training session is replaced by plyometric training is feasible and as effective as a program consisting solely of conventional strength training sessions for inducing gains in muscle strength and function in older adults. Muscle size and architecture improved only in the MULTI group. German Clinical Trials: DRKS00015750.PMID:38355067 | DOI:10.1016/j.exger.2024.112378 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 14, 2024 Category: Geriatrics Authors: Gustavo Z Schaun Matthias Gumpenberger Leonie Konermann Alexandra Graf Peter Raidl Barbara Wessner Robert Csapo Source Type: research
Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the training IMCT study
In conclusion, we found that a resistance training intervention in which one weekly training session is replaced by plyometric training is feasible and as effective as a program consisting solely of conventional strength training sessions for inducing gains in muscle strength and function in older adults. Muscle size and architecture improved only in the MULTI group. German Clinical Trials: DRKS00015750.PMID:38355067 | DOI:10.1016/j.exger.2024.112378 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 14, 2024 Category: Geriatrics Authors: Gustavo Z Schaun Matthias Gumpenberger Leonie Konermann Alexandra Graf Peter Raidl Barbara Wessner Robert Csapo Source Type: research
Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the training IMCT study
In conclusion, we found that a resistance training intervention in which one weekly training session is replaced by plyometric training is feasible and as effective as a program consisting solely of conventional strength training sessions for inducing gains in muscle strength and function in older adults. Muscle size and architecture improved only in the MULTI group. German Clinical Trials: DRKS00015750.PMID:38355067 | DOI:10.1016/j.exger.2024.112378 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 14, 2024 Category: Geriatrics Authors: Gustavo Z Schaun Matthias Gumpenberger Leonie Konermann Alexandra Graf Peter Raidl Barbara Wessner Robert Csapo Source Type: research
Does excess body weight accelerate immune aging?
CONCLUSION: The odds ratios (OR) for CD4/CD8 ratio in the normal body mass vs obesity model (OR = 16.1, 95%CI 3.8-93.6) indicated a potential diagnostic value of T lymphocytes for clinical prognosis of immune aging in relation to excess body weight in older adults. High values of AUC obtained for the following models: CD4/CD8 + BAI (AUC = 0.927), CD4/CD8 + LAP (AUC = 1.00), CD4/CD8 + ABSI (AUC = 0.865) proved to provide excellent discrimination between older adults with obesity and with normal body mass.PMID:38346543 | DOI:10.1016/j.exger.2024.112377 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 12, 2024 Category: Geriatrics Authors: Anna Tylutka Barbara Morawin Łukasz Walas Agnieszka Zembron-Lacny Source Type: research
Alterations in the diversity, composition and function of the gut microbiota in Uyghur individuals with sarcopenia
CONCLUSIONS: There were significant differences in the composition and function of the gut microbiota between Xinjiang Uyghur sarcopenia individuals and healthy individuals. These findings might aid in the development of probiotics or microbial-based therapies for sarcopenia in Uyhur individuals.PMID:38331300 | DOI:10.1016/j.exger.2024.112376 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 8, 2024 Category: Geriatrics Authors: Qiuxi Zhang Xin Li Ting Huang Shuang Zhang Kunchen Teng Namuna Rousitemu Ting Lan Youfeng Wen Source Type: research
Identification of genes and key pathways underlying the pathophysiological association between sarcopenia and chronic obstructive pulmonary disease
CONCLUSION: This study uncovers potential common mechanisms of COPD complicated by sarcopenia. The hub gene SAA1 and the NF-κB signaling pathway could be involved, and oxidative phosphorylation and ferroptosis might be important contributors to this comorbidity.PMID:38320732 | DOI:10.1016/j.exger.2024.112373 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 6, 2024 Category: Geriatrics Authors: Weixi Wang Weiying Ren Lin Zhu Yu Hu Cong Ye Source Type: research
Exhaustive exercise decreases tau phosphorylation and modifies biological processes associated with the protein translation and electron transport chain in P301L tau transgenic mice
In conclusion, our study suggests that the observed decrease in tau phosphorylation resulting from EE treatment may primarily be attributed to its regulation of the translation process and enhancement of mitochondrial function.PMID:38320733 | DOI:10.1016/j.exger.2024.112375 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 6, 2024 Category: Geriatrics Authors: Kaiwu He Lulin Nie Chen Yang Zizhen Liu Xinfeng Huang Shupeng Li Xifei Yang Source Type: research
Bioinformatics identification of potential biomarkers and therapeutic targets for ischemic stroke and vascular dementia
In this study, we screened new potential biomarkers and analyzed new therapeutic targets for both diseases from the perspective of immune infiltration. Two gene expression profiles on ischemic stroke and vascular dementia were obtained from the NCBI GEO database, and key genes were identified by LASSO regression and SVM-RFE algorithms, and key genes were analyzed by GO and KEGG enrichment. The CIBERSORT algorithm was applied to the gene expression profile species of the two diseases to quantify the 24 subpopulations of immune cells. Moreover, logistic regression modeling analysis was applied to illustrate the stability of ...
Source: Experimental Gerontology - February 6, 2024 Category: Geriatrics Authors: Ding Zhang Ni Jia Zhihan Hu Zhou Keqing Song Chenxi Sun Chunying Canrong Chen Wei Chen Yueqiang Hu Ziyun Ruan Source Type: research
Risk stratification for frailty, impairment and assessment of sleep disorders in community-dwelling older adults
CONCLUSION: This study reveals a modest risk of frailty and impairment with sleep quality and the risk of obstructive sleep apnea, but not with excessive daytime sleepiness in community-dwelling older adults.PMID:38310982 | DOI:10.1016/j.exger.2024.112370 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 4, 2024 Category: Geriatrics Authors: Breno Caldas Ribeiro Anselmo de Athayde Costa E Silva Leonardo Brynne Ramos de Souza Janine Brasil de Ara újo Moraes Saul Rassy Carneiro Laura Maria Tomazi Neves Source Type: research
Causal relationship between circulating immune cells and the risk of Alzheimer's disease: A Mendelian randomization study
CONCLUSIONS: These findings demonstrated seven immune phenotypes were significantly associated with AD risk. This may provide researchers with a new perspective in exploring the biological mechanisms of AD and may lead to the exploration of earlier treatment.PMID:38301877 | DOI:10.1016/j.exger.2024.112371 (Source: Experimental Gerontology)
Source: Experimental Gerontology - February 1, 2024 Category: Geriatrics Authors: Hua Xue Jiajia Chen Li Zeng Wenhui Fan Source Type: research
P16 < sup > INK4a < /sup > deletion alleviates contrast-induced acute kidney injury by ameliorating renal cell apoptosis and suppressing inflammation and oxidative stress
In this study, we used p16 knockout (p16KO) mice and wild-type (WT) littermates to establish CI-AKI mice model to elucidate the impact of p16 on CI-AKI. The results showed that serum creatinine (SCr), blood urea nitrogen (BUN), and serum neutrophil gelatinase-associated lipocalin (NGAL) levels were markedly reduced in p16KO CI-AKI mice. Both immunohistochemistry and western blot analyses confirmed that p16 knockout alleviated renal cell apoptosis. Furthermore, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were attenuated by downregulating NLRP3 and NF-κB inflammasomes. Additionally, ROS levels were dim...
Source: Experimental Gerontology - February 1, 2024 Category: Geriatrics Authors: Xiaodong Zhang Guangyi Huang Zhixuan Zhang Fen Wang Qian Liu Yingqiang Du Xiaoyan Wang Xin Gu Source Type: research
Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies
Exp Gerontol. 2024 Feb 6;187:112366. doi: 10.1016/j.exger.2024.112366. Online ahead of print.ABSTRACTsynucleinopathies are diseases characterized by the aggregation of α-synuclein (α-syn), which forms fibrils through misfolding and accumulates in a prion-like manner. To detect the presence of these α-syn aggregates in clinical samples, seed amplification assays (SAAs) have been developed. These SAAs are capable of amplifying the α-syn seeds, allowing for their detection. αSyn-SAAs have been reported under the names 'protein misfolding cyclic amplification' (αSyn-PMCA) and 'real-time quaking-induced conversion'α-Syn-...
Source: Experimental Gerontology - January 27, 2024 Category: Geriatrics Authors: Juan Huang Xingxing Yuan Lin Chen Binbin Hu Hui Wang Ye Wang Wei Huang Source Type: research
Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies
In conclusion, after a mHealth exercise intervention, we demonstrated changes with moderate to large effect sizes in several CpG sites in the TNFα promoter region. Exercise levels were correlated with increases in TNFα promoter methylation. Larger exercise trials are needed to better evaluate TNFα regulation to inform interventions to augment TNFα regulation in order to improve outcomes in older adults with cancer.PMID:38266886 | DOI:10.1016/j.exger.2024.112364 (Source: Experimental Gerontology)
Source: Experimental Gerontology - January 24, 2024 Category: Geriatrics Authors: Kah Poh Loh Ying Wang Chandrika Sanapala Nikesha Gilmore Colleen Netherby-Winslow Jason H Mendler Jane Liesveld Eric Huselton AnnaLynn M Williams Heidi D Klepin Marielle Jensen-Battaglia Karen Mustian Paula Vertino Martha Susiarjo Michelle C Janelsins Source Type: research
