Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies

In conclusion, after a mHealth exercise intervention, we demonstrated changes with moderate to large effect sizes in several CpG sites in the TNFα promoter region. Exercise levels were correlated with increases in TNFα promoter methylation. Larger exercise trials are needed to better evaluate TNFα regulation to inform interventions to augment TNFα regulation in order to improve outcomes in older adults with cancer.PMID:38266886 | DOI:10.1016/j.exger.2024.112364

Source: Experimental Gerontology - January 24, 2024 Category: Geriatrics Authors: Kah Poh Loh Ying Wang Chandrika Sanapala Nikesha Gilmore Colleen Netherby-Winslow Jason H Mendler Jane Liesveld Eric Huselton AnnaLynn M Williams Heidi D Klepin Marielle Jensen-Battaglia Karen Mustian Paula Vertino Martha Susiarjo Michelle C Janelsins Source Type: research